Synthesis and biological evaluation of 3,4-diaryl-5-aminoisoxazole derivatives

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 17, 2009, Pages 6279-6285

  Liu, Tao ^a   Dong, Xiaowu ^a   Xue, Na ^a   Wu, Rui ^a   He, Qiaojun ^a   Yang, Bo ^a   Hu, Yongzhou ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

3,4 Diaryl 5 aminoisoxazole; Cytotoxic activities; Tubulin polymerization inhibition

Indexed keywords

4 (4 METHOXYPHENYL) 3 (3,4,5 TRIMETHOXYPHENYL)ISOXAZOL 5 AMINE; ACETAMIDE DERIVATIVE; ANTINEOPLASTIC AGENT; BENZYL CYANIDE DERIVATIVE; COMBRETASTATIN A4; CYANOKETONE; ISOXAZOLE DERIVATIVE; N ACETYL N [4 (4 METHOXYPHENYL) 3 (3,4,5 TRIMETHOXYPHENYL)ISOXAZOL 5 YL]ACETAMIDE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; MICROTUBULE ASSEMBLY; MOLECULAR MODEL; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; BINDING SITES; CELL LINE, TUMOR; COMPUTER SIMULATION; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; ISOXAZOLES; TUBULIN MODULATORS;

EID: 68649090729     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.07.040     Document Type: Article

References (20)

1. Bhattacharayya B., Panda D., Gupta S., and Banerjee M. Med. Res. Rev. 28 (2008) 155
2. Attard G., Greystoke A., Kaye S., and De Bono J. Pathol. Biol. 54 (2006) 72
3. Li Q., and Sham H.L. Exp. Opin. Ther. Pat. 12 (2002) 1663
4. Jordan M.A. Curr. Med. Chem. 2 (2002) 1
5. Lin C.M., Ho H.H., Pettit G.R., and Hamel E. Biochemistry 28 (1989) 6984
6. Pettit G.R., Singh S.G., Boyd M.R., Hamel E., Pettit R.K., Schmidt J.M., and Hogan F. J. Med. Chem. 38 (1995) 1666
7. Tozer G.M., Kanthou C., and Baguley B.C. Nat. Rev. Cancer 5 (2005) 423
8. Tron G.C., Pirali T., Sorba G., Pagliali F., Busacca S., and Genazzani A.A. J. Med. Chem. 49 (2006) 3033
9. Wu M.-J., Sun Q.-M., Yang C.-H., Chen D.-D., Ding J., Chen Y., Lin L.-P., and Xie Y.-Y. Bioorg. Med. Chem. Lett. 17 (2007) 869
10. Bellina F., Cauteruccio S., Monti S., and Rossi R. Bioorg. Med. Chem. Lett. 16 (2006) 5757
11. Odlo K., Hentzen J., Chabert J.F., Ducki S., Gani A.B.S.M.O., Sylte I., Skrede M., Flørenes V.A., and Hansen T.V. Bioorg. Med. Chem. 16 (2008) 4829
12. Xue N., Yang X.-C., Wu R., Chen J., He Q.-J., Yang B., Lu X.-Y., and Hu Y.-Z. Bioorg. Med. Chem. 16 (2008) 2550
13. Zhong R.-Q., Zhou Y., Zhang X.-J., Wang Z.-X., and Ling H.-Z. Chin. J. Pharm. 36 (2005) 328
14. Sundaresan A.K., and Ramamurthy V. Org. Lett. 9 (2007) 3575
15. Logemann G. Chem. Ber. 87 (1954) 1175
16. Wu, R.; Ding, W.-J.; Liu, T.; Zhu, H.; Hu, Y.-Z.; Yang, B.; He, Q.-J. Cancer Lett., in press.
17. Chen J., Lou J.-S., Liu T., Wu R., Dong X., He Q.-J., Yang B., and Hu Y.-Z. Arch. Pharm. Chem. Life Sci. 342 (2009) 165
18. Carmichael J., DeGraff W.G., Gadzar A.F., Minna J.D., and Mitchell J.B. Cancer Res. 47 (1987) 936
19. Yang B., and Reynolds C.P. Clin. Cancer Res. 11 (2005) 2774
20. Ravelli R.B., Gigant B., Curmi P.A., Jourdain I., Lachkar S., Sobel A., and Knossow M. Nature 428 (2004) 198