Knockdown of N-acetylglucosaminyl transferase V ameliorates hepatotoxin-induced liver fibrosis in mice

Toxicological Sciences

Volumn 135, Issue 1, 2013, Pages 144-155

  Liu, Junyu ^a   Zhang, Zhengping ^a   Tu, Xiaolong ^a   Liu, Jialin ^a   Zhang, Haiyan ^a   Zhang, Jingcheng ^a   Zang, Yuhui ^a   Zhu, Jie ^a   Chen, Jiangning ^a   Dong, Lei ^a   Zhang, Junfeng ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

Adenovirus; Epithelial mesenchymal transition; Hepatic stellate cells; Knockdown; Liver fibrosis; N acetylglucosaminyltransferase V

Indexed keywords

ADENOVIRUS VECTOR; ALPHA 1,3(6) MANNOSYLGLYCOPROTEIN BETA 1,6 N ACETYLGLUCOSAMINYLTRANSFERASE; CARBON TETRACHLORIDE; COLLAGEN; N ACETYLGLUCOSAMINYLTRANSFERASE; PLATELET DERIVED GROWTH FACTOR; SMAD PROTEIN; SMALL INTERFERING RNA; THIOACETAMIDE; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ACTIVATION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; EPITHELIAL MESENCHYMAL TRANSITION; FIBROGENESIS; GENE EXPRESSION; GENE SILENCING; LIVER CELL; LIVER FIBROSIS; MALE; MOUSE; MYOFIBROBLAST; NONHUMAN; PHENOTYPE; PROTEIN GLYCOSYLATION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; STELLATE CELL; UPREGULATION;

ADENOVIRUS; EPITHELIAL-MESENCHYMAL TRANSITION.; HEPATIC STELLATE CELLS; KNOCKDOWN; LIVER FIBROSIS; N-ACETYLGLUCOSAMINYLTRANSFERASE V;

ACTINS; ALANINE TRANSAMINASE; ANIMALS; CARBON TETRACHLORIDE; CELLS, CULTURED; EPITHELIAL-MESENCHYMAL TRANSITION; GLYCOSYLATION; HEPATOCYTES; LIVER CIRRHOSIS; MALE; MICE; MICE, INBRED ICR; MYOFIBROBLASTS; N-ACETYLGLUCOSAMINYLTRANSFERASES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; THIOACETAMIDE;

EID: 84883136861     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kft135     Document Type: Article

References (39)

1. Bataller, R., and Brenner, D. A. (2005). Liver fibrosis. J. Clin. Invest. 115, 209-218.
2. Caja, L., Ortiz, C., Bertran, E., Murillo, M. M., Miró-Obradors, M. J., Palacios, E., and Fabregat, I. (2007). Differential intracellular signalling induced by TGF-beta in rat adult hepatocytes and hepatoma cells: Implications in liver carcinogenesis. Cell. Signal. 19, 683-694.
3. Chiariotti, L., Salvatore, P., Frunzio, R., and Bruni, C. B. (2004). Galectin genes: Regulation of expression. Glycoconj. J. 19, 441-449.
4. Choi, S. S., and Diehl, A. M. (2009). Epithelial-to-mesenchymal transitions in the liver. Hepatology 50, 2007-2013.
5. Cummings, R. D., and Kornfeld, S. (1982). Characterization of the structural determinants required for the high affinity interaction of asparagine-linked oligosaccharides with immobilized Phaseolus vulgaris leukoagglutinating and erythroagglutinating lectins. J. Biol. Chem. 257, 11230-11234.
6. Demetriou, M., Granovsky, M., Quaggin, S., and Dennis, J. W. (2001). Negative regulation of T-cell activation and autoimmunity by Mgat5 N-glycosylation. Nature 409, 733-739.
7. Dooley, S., Hamzavi, J., Ciuclan, L., Godoy, P., Ilkavets, I., Ehnert, S., Ueberham, E., Gebhardt, R., Kanzler, S., Geier, A., et al. (2008). Hepatocytespecific Smad7 expression attenuates TGF-beta-mediated fibrogenesis and protects against liver damage. Gastroenterology 135, 642-659.
8. Friedman, S. L. (2000). Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J. Biol. Chem. 275, 2247-2250.
9. Gordon, K. J., and Blobe, G. C. (2008). Role of transforming growth factorbeta superfamily signaling pathways in human disease. Biochim. Biophys. Acta 1782, 197-228.
10. Guo, H., Nairn, A., dela Rosa, M., Nagy, T., Zhao, S., Moremen, K., and Pierce, M. (2012). Transcriptional regulation of the protocadherin β cluster during Her-2 protein-induced mammary tumorigenesis results from altered N-glycan branching. J. Biol. Chem. 287, 24941-24954.
11. Guo, H. B., Lee, I., Kamar, M., Akiyama, S. K., and Pierce, M. (2002). Aberrant N-glycosylation of beta1 integrin causes reduced alpha5beta1 integrin clustering and stimulates cell migration. Cancer Res. 62, 6837-6845.
12. Guo, H. B., Lee, I., Kamar, M., and Pierce, M. (2003). N-acetylglucosaminyltransferase V expression levels regulate cadherin-associated homotypic cell-cell adhesion and intracellular signaling pathways. J. Biol. Chem. 278, 52412-52424.
13. Guo, H. B., Randolph, M., and Pierce, M. (2007). Inhibition of a specific N-glycosylation activity results in attenuation of breast carcinoma cell invasiveness-related phenotypes: Inhibition of epidermal growth factorinduced dephosphorylation of focal adhesion kinase. J. Biol. Chem. 282, 22150-22162.
14. Henderson, N. C., Mackinnon, A. C., Farnworth, S. L., Poirier, F., Russo, F. P., Iredale, J. P., Haslett, C., Simpson, K. J., and Sethi, T. (2006). Galectin-3 regulates myofibroblast activation and hepatic fibrosis. Proc. Natl. Acad. Sci. U. S. A. 103, 5060-5065.
15. Hirabayashi, J., Hashidate, T., Arata, Y., Nishi, N., Nakamura, T., Hirashima, M., Urashima, T., Oka, T., Futai, M., Muller, W. E., et al. (2002). Oligosaccharide specificity of galectins: A search by frontal affinity chromatography. Biochim. Biophys. Acta 1572, 232-254.
16. Jiménez, W., Clária, J., Arroyo, V., and Rodés, J. (1992). Carbon tetrachloride induced cirrhosis in rats: A useful tool for investigating the pathogenesis of ascites in chronic liver disease. J. Gastroenterol. Hepatol. 7, 90-97.
17. Kadrofske, M. M., Openo, K. P., and Wang, J. L. (1998). The human LGALS3 (galectin-3) gene: Determination of the gene structure and functional characterization of the promoter. Arch. Biochem. Biophys. 349, 7-20.
18. Kaimori, A., Potter, J., Kaimori, J. Y., Wang, C., Mezey, E., and Koteish, A. (2007). Transforming growth factor-beta1 induces an epithelial-to-mesenchymal transition state in mouse hepatocytes in vitro. J. Biol. Chem. 282, 22089-22101.
19. Kasai, H., Allen, J. T., Mason, R. M., Kamimura, T., and Zhang, Z. (2005). TGF-beta1 induces human alveolar epithelial to mesenchymal cell transition (EMT). Respir. Res. 6, 56.
20. Kinoshita, K., Iimuro, Y., Otogawa, K., Saika, S., Inagaki, Y., Nakajima, Y., Kawada, N., Fujimoto, J., Friedman, S. L., and Ikeda, K. (2007). Adenovirusmediated expression of BMP-7 suppresses the development of liver fibrosis in rats. Gut 56, 706-714.
21. Lau, K. S., Partridge, E. A., Grigorian, A., Silvescu, C. I., Reinhold, V. N., Demetriou, M., and Dennis, J. W. (2007). Complex N-glycan number and degree of branching cooperate to regulate cell proliferation and differentiation. Cell 129, 123-134.
22. Li, Y., Yang, J., Dai, C., Wu, C., and Liu, Y. (2003). Role for integrin-linked kinase in mediating tubular epithelial to mesenchymal transition and renal interstitial fibrogenesis. J. Clin. Invest. 112, 503-516.
23. Mendelsohn, R., Cheung, P., Berger, L., Partridge, E., Lau, K., Datti, A., Pawling, J., and Dennis, J. W. (2007). Complex N-glycan and metabolic control in tumor cells. Cancer Res. 67, 9771-9780.
24. Miyoshi, E., Ihara, Y., Nishikawa, A., Saito, H., Uozumi, N., Hayashi, N., Fusamoto, H., Kamada, T., and Taniguchi, N. (1995). Gene expression of N-acetylglucosaminyltransferases III and V: A possible implication for liver regeneration. Hepatology 22, 1847-1855.
25. Müller, A., Machnik, F., Zimmermann, T., and Schubert, H. (1988). Thioacetamide-induced cirrhosis-like liver lesions in rats-usefulness and reliability of this animal model. Exp. Pathol. 34, 229-236.
26. Pan, X., Wang, X., Lei, W., Min, L., Yang, Y., Wang, X., and Song, J. (2009). Nitric oxide suppresses transforming growth factor-beta1-induced epithelialto- mesenchymal transition and apoptosis in mouse hepatocytes. Hepatology 50, 1577-1587.
27. Partridge, E. A., Le Roy, C., Di Guglielmo, G. M., Pawling, J., Cheung, P., Granovsky, M., Nabi, I. R., Wrana, J. L., and Dennis, J. W. (2004). Regulation of cytokine receptors by Golgi N-glycan processing and endocytosis. Science 306, 120-124.
28. Peinado, H., Olmeda, D., and Cano, A. (2007). Snail, Zeb and bHLH factors in tumour progression: An alliance against the epithelial phenotype? Nat. Rev. Cancer 7, 415-428.
29. Pinzani, M., Milani, S., Herbst, H., DeFranco, R., Grappone, C., Gentilini, A., Caligiuri, A., Pellegrini, G., Ngo, D. V., Romanelli, R. G., et al. (1996). Expression of platelet-derived growth factor and its receptors in normal human liver and during active hepatic fibrogenesis. Am. J. Pathol. 148, 785-800.
30. Salguero Palacios, R., Roderfeld, M., Hemmann, S., Rath, T., Atanasova, S., Tschuschner, A., Gressner, O. A., Weiskirchen, R., Graf, J., and Roeb, E. (2008). Activation of hepatic stellate cells is associated with cytokine expression in thioacetamide-induced hepatic fibrosis in mice. Lab. Invest. 88, 1192-1203.
31. Schrum, L. W., Black, D., Iimuro, Y., Rippe, R. A., Brenner, D. A., and Behrns, K. E. (2000). c-Jun does not mediate hepatocyte apoptosis following NFkappaB inhibition and partial hepatectomy. J. Surg. Res. 88, 142-149.
32. Terao, M., Ishikawa, A., Nakahara, S., Kimura, A., Kato, A., Moriwaki, K., Kamada, Y., Murota, H., Taniguchi, N., Katayama, I., et al. (2011). Enhanced epithelial-mesenchymal transition-like phenotype in N-acetylglucosaminyltransferase V transgenic mouse skin promotes wound healing. J. Biol. Chem. 286, 28303-28311.
33. Thiery, J. P., Acloque, H., Huang, R. Y., and Nieto, M. A. (2009). Epithelialmesenchymal transitions in development and disease. Cell 139, 871-890.
34. Thiery, J. P., and Sleeman, J. P. (2006). Complex networks orchestrate epithelial- mesenchymal transitions. Nat. Rev. Mol. Cell Biol. 7, 131-142.
35. Vega, S., Morales, A. V., Ocaña, O. H., Valdés, F., Fabregat, I., and Nieto, M. A. (2004). Snail blocks the cell cycle and confers resistance to cell death. Genes Dev. 18, 1131-1143.
36. Weiskirchen, R., and Gressner, A. M. (2005). Isolation and culture of hepatic stellate cells. Methods Mol. Med. 117, 99-113.
37. Yue, H. Y., Yin, C., Hou, J. L., Zeng, X., Chen, Y. X., Zhong, W., Hu, P. F., Deng, X., Tan, Y. X., Zhang, J. P., et al. (2010). Hepatocyte nuclear factor 4alpha attenuates hepatic fibrosis in rats. Gut 59, 236-246.
38. Zeisberg, M., Yang, C., Martino, M., Duncan, M. B., Rieder, F., Tanjore, H., and Kalluri, R. (2007). Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition. J. Biol. Chem. 282, 23337-23347.
39. Zhao, Y. Y., Takahashi, M., Gu, J. G., Miyoshi, E., Matsumoto, A., Kitazume, S., and Taniguchi, N. (2008). Functional roles of N-glycans in cell signaling and cell adhesion in cancer. Cancer Sci. 99, 1304-1310.