Association of dietary and supplemental folate intake and polymorphisms in three FOCM pathway genes with colorectal cancer in a population-based case-control study

Genes Chromosomes and Cancer

Volumn 52, Issue 10, 2013, Pages 945-953

  Ashmore, Joseph H ^a   Lesko, Samuel M ^b   Muscat, Joshua E ^c   Gallagher, Carla J ^c   Berg, Arthur S ^c   Miller, Paige E ^d   Hartman, Terryl J ^e   Lazarus, Philip ^f  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b Northeast Regional Cancer Institute   (United States)

^c PENN STATE COLLEGE OF MEDICINE   (United States)

^d EXPONENT INC   (United States)

^e EMORY UNIVERSITY   (United States)

^f WASHINGTON STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); FOLIC ACID; GENOMIC DNA; METHIONINE; METHYLENETETRAHYDROFOLATE DEHYDROGENASE; THYMIDYLATE SYNTHASE;

ADULT; AGED; ALLELE; ARTICLE; CANCER RISK; CARBON METABOLISM; COLORECTAL CANCER; CONTROLLED STUDY; DIET; DIET HISTORY QUESTIONNAIRE; DIETARY INTAKE; FEMALE; GENE INTERACTION; GENETIC ASSOCIATION; GENOTYPE; HAPLOTYPE; HETEROZYGOTE; HUMAN; INTERVIEW; MAJOR CLINICAL STUDY; MALE; NATIONAL HEALTH ORGANIZATION; POPULATION BASED CASE CONTROL STUDY; PRIORITY JOURNAL; QUESTIONNAIRE; SINGLE NUCLEOTIDE POLYMORPHISM; UNITED STATES; VITAMIN SUPPLEMENTATION;

AGED; CASE-CONTROL STUDIES; COLORECTAL NEOPLASMS; DIET; DIETARY SUPPLEMENTS; FEMALE; FOLIC ACID; GENETIC ASSOCIATION STUDIES; HUMANS; MALE; METHYLENETETRAHYDROFOLATE DEHYDROGENASE (NADP); METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MIDDLE AGED; PENNSYLVANIA; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84883051907     PISSN: 10452257     EISSN: 10982264     Source Type: Journal    
DOI: 10.1002/gcc.22089     Document Type: Article

References (49)

1. Ashmore JH, Lesko SM, Miller PE, Cross AJ, Muscat JE, Zhu J, Liao J, Harper G, Lazarus P, Hartman TJ. 2013. Association of dietary and supplemental iron and colorectal cancer in a population-based study. Eur J Cancer Prevention. [Epub ahead of print]
2. Barrett JC, Fry B, Maller J, Daly MJ. 2005. Haploview: Analysis and visualization of LD and haplotype maps. Bioinformatics 21:263-265.
3. Brown CC, Kipnis V, Freedman LS, Hartman AM, Schatzkin A, Wacholder S. 1994. Energy adjustment methods for nutritional epidemiology: The effect of categorization. Am J Epidemiol 139:323-338.
4. Chen J, Giovannucci EL, Hunter DJ. 1999. MTHFR polymorphism, methyl-replete diets and the risk of colorectal carcinoma and adenoma among U.S. men and women: an example of gene-environment interactions in colorectal tumorigenesis. J Nutr 129:560S-564S.
5. Chen J, Kyte C, Valcin M, Chan W, Wetmur JG, Selhub J, Hunter DJ, Ma J. 2004. Polymorphisms in the one-carbon metabolic pathway, plasma folate levels and colorectal cancer in a prospective study. Int J Cancer 110:617-620.
6. Clapin HF, Fritschi L, Iacopetta B, Heyworth JS. 2012. Dietary and supplemental folate and the risk of left- and right-sided colorectal cancer. Nutr Cancer 64:937-945.
7. Curtin K, Bigler J, Slattery ML, Caan B, Potter JD, Ulrich CM. 2004. MTHFR C677T and A1298C polymorphisms: Diet, estrogen, and risk of colon cancer. Cancer Epidemiol Biomarkers Prev 13:285-292.
8. Curtin K, Slattery ML, Ulrich CM, Bigler J, Levin TR, Wolff RK, Albertsen H, Potter JD, Samowitz WS. 2007. Genetic polymorphisms in one-carbon metabolism: Associations with CpG island methylator phenotype (CIMP) in colon cancer and the modifying effects of diet. Carcinogenesis 28:1672-1679.
9. de Vogel S, Dindore V, van Engeland M, Goldbohm RA, van den Brandt PA, Weijenberg MP. 2008. Dietary folate, methionine, riboflavin, and vitamin B-6 and risk of sporadic colorectal cancer. J Nutr 138:2372-2378.
10. Figueiredo JC, Mott LA, Giovannucci E, Wu K, Cole B, Grainge MJ, Logan RF, Baron JA. 2011. Folic acid and prevention of colorectal adenomas: A combined analysis of randomized clinical trials. Int J Cancer 129:192-203.
11. Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, Boers GJ, den Heijer M, Kluijtmans LA, van den Heuvel LP, et al. 1995. A candidate genetic risk factor for vascular disease: A common mutation in methylenetetrahydrofolate reductase. Nat Genet 10:111-113.
12. Giovannucci E, Stampfer MJ, Colditz GA, Hunter DJ, Fuchs C, Rosner BA, Speizer FE, Willett WC. 1998. Multivitamin use, folate, and colon cancer in women in the Nurses' Health Study. Ann Intern Med 129:517-524.
13. Han SS, Sue LY, Berndt SI, Selhub J, Burdette LA, Rosenberg PS, Ziegler RG. 2012. Associations between genes in the one-carbon metabolism pathway and advanced colorectal adenoma risk in individuals with low folate intake. Cancer Epidemiol Biomarkers Prev 21:417-427.
14. Hu J, Morrison H, Mery L, DesMeules M, Macleod M. 2007. Diet and vitamin or mineral supplementation and risk of colon cancer by subsite in Canada. Eur J Cancer Prev 16:275-291.
15. Hubner RA, Houlston RS. 2007. MTHFR C677T and colorectal cancer risk: A meta-analysis of 25 populations. Int J Cancer 120:1027-1035.
16. Hubner RA, Liu JF, Sellick GS, Logan RF, Houlston RS, Muir KR. 2007. Thymidylate synthase polymorphisms, folate and B-vitamin intake, and risk of colorectal adenoma. Br J Cancer 97:1449-1456.
17. Hum DW, Bell AW, Rozen R, MacKenzie RE. 1988. Primary structure of a human trifunctional enzyme. Isolation of a cDNA encoding methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase. J Biol Chem 263:15946-15950.
18. Ishihara J, Otani T, Inoue M, Iwasaki M, Sasazuki S, Tsugane S. 2007. Low intake of vitamin B-6 is associated with increased risk of colorectal cancer in Japanese men. J Nutr 137:1808-1814.
19. Kennedy DA, Stern SJ, Moretti M, Matok I, Sarkar M, Nickel C, Koren G. 2011. Folate intake and the risk of colorectal cancer: A systematic review and meta-analysis. Cancer Epidemiol 35:2-10.
20. Kim YI. 2003. Role of folate in colon cancer development and progression. J Nutr 133:3731S-3739S.
21. Kim YI. 2004. Will mandatory folic acid fortification prevent or promote cancer? Am J Clin Nutr 80:1123-1128.
22. Kim YI. 2007. Folate and colorectal cancer: An evidence-based critical review. Mol Nutr Food Res 51:267-292.
23. Kune G, Watson L. 2006. Colorectal cancer protective effects and the dietary micronutrients folate, methionine, vitamins B6, B12, C, E, selenium, and lycopene. Nutr Cancer 56:11-21.
24. Levi F, Pasche C, Lucchini F, La Vecchia C. 2000. Selected micronutrients and colorectal cancer. A case-control study from the canton of Vaud, Switzerland. Eur J Cancer 36:2115-2119.
25. Levine AJ, Figueiredo JC, Lee W, Conti DV, Kennedy K, Duggan DJ, Poynter JN, Campbell PT, Newcomb P, Martinez ME, Hopper JL, Le Marchand L, Baron JA, Limburg PJ, Ulrich CM, Haile RW. 2010. A candidate gene study of folate-associated one carbon metabolism genes and colorectal cancer risk. Cancer Epidemiol Biomarkers Prev 19:1812-1821.
26. Lindzon GM, Medline A, Sohn KJ, Depeint F, Croxford R, Kim YI. 2009. Effect of folic acid supplementation on the progression of colorectal aberrant crypt foci. Carcinogenesis 30:1536-1543.
27. Liu AY, Scherer D, Poole E, Potter JD, Curtin K, Makar K, Slattery ML, Caan BJ, Ulrich CM. 2013. Gene-diet-interactions in folate-mediated one-carbon metabolism modify colon cancer risk. Mol Nutr Food Res. 57:721-734.
28. Long JC, Williams RC, Urbanek M. 1995. An E-M algorithm and testing strategy for multiple-locus haplotypes. Am J Hum Genet 56:799-810.
29. Ma J, Stampfer MJ, Hennekens CH, Frosst P, Selhub J, Horsford J, Malinow MR, Willett WC, Rozen R. 1996. Methylenetetrahydrofolate reductase polymorphism, plasma folate, homocysteine, and risk of myocardial infarction in US physicians. Circulation 94:2410-2416.
30. Ma J, Stampfer MJ, Giovannucci E, Artigas C, Hunter DJ, Fuchs C, Willett WC, Selhub J, Hennekens CH, Rozen R. 1997. Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer. Cancer Res 57:1098-1102.
31. Miller PE, Lazarus P, Lesko SM, Muscat JE, Harper G, Cross AJ, Sinha R, Ryczak K, Escobar G, Mauger DT, Hartman TJ. 2010. Diet index-based and empirically derived dietary patterns are associated with colorectal cancer risk. J Nutr 140:1267-1273.
32. Otani T, Iwasaki M, Hanaoka T, Kobayashi M, Ishihara J, Natsukawa S, Shaura K, Koizumi Y, Kasuga Y, Yoshimura K, Yoshida T, Tsugane S. 2005. Folate, vitamin B6, vitamin B12, and vitamin B2 intake, genetic polymorphisms of related enzymes, and risk of colorectal cancer in a hospital-based case-control study in Japan. Nutr Cancer 53:42-50.
33. Razzak AA, Oxentenko AS, Vierkant RA, Tillmans LS, Wang AH, Weisenberger DJ, Laird PW, Lynch CF, Anderson KE, French AJ, Haile RW, Harnack LJ, Potter JD, Slager SL, Smyrk TC, Thibodeau SN, Cerhan JR, Limburg PJ. 2012. Associations between intake of folate and related micronutrients with molecularly defined colorectal cancer risks in the Iowa Women's Health Study. Nutr Cancer 64:899-910.
34. Sharp L, Little J. 2004. Polymorphisms in genes involved in folate metabolism and colorectal neoplasia: A HuGE review. Am J Epidemiol 159:423-443.
35. Siegel R, Ward E, Brawley O, Jemal A. 2011. Cancer statistics, 2011: The impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer J Clin 61:212-236.
36. Slattery ML, Potter JD, Samowitz W, Schaffer D, Leppert M. 1999. Methylenetetrahydrofolate reductase, diet, and risk of colon cancer. Cancer Epidemiol Biomarkers Prev 8:513-518.
37. Subar AF, Thompson FE, Kipnis V, Midthune D, Hurwitz P, McNutt S, McIntosh A, Rosenfeld S. 2001. Comparative validation of the Block, Willett, and National Cancer Institute food frequency questionnaires: The Eating at America's Table Study. Am J Epidemiol 154:1089-1099.
38. Suitor CW, Bailey LB. 2000. Dietary folate equivalents: Interpretation and application. J Am Diet Assoc 100:88-94.
39. Thompson FE, Subar AF, Brown CC, Smith AF, et al. 2002. Cognitive research enhances accuracy of food frequency questionnaire reports: Results of an experimental validation study. American Dietetic Association. J Am Dietetic Assoc 102:212.
40. Ueland PM, Hustad S, Schneede J, Refsum H, Vollset SE. 2001. Biological and clinical implications of the MTHFR C677T polymorphism. Trends Pharmacol Sci 22:195-201.
41. Ulrich CM. 2005. Nutrigenetics in cancer research-Folate metabolism and colorectal cancer. J Nutr 135:2698-2702.
42. Ulrich CM, Potter JD. 2006. Folate supplementation: Too much of a good thing? Cancer Epidemiol Biomarkers Prev 15:189-193.
43. Ulrich CM, Kampman E, Bigler J, Schwartz SM, Chen C, Bostick R, Fosdick L, Beresford SA, Yasui Y, Potter JD. 1999. Colorectal adenomas and the C677T MTHFR polymorphism: Evidence for gene-environment interaction? Cancer Epidemiol Biomarkers Prev 8:659-668.
44. Ulrich CM, Bigler J, Bostick R, Fosdick L, Potter JD. 2002. Thymidylate synthase promoter polymorphism, interaction with folate intake, and risk of colorectal adenomas. Cancer Res 62:3361-3364.
45. Ulrich CM, Curtin K, Potter JD, Bigler J, Caan B, Slattery ML. 2005. Polymorphisms in the reduced folate carrier, thymidylate synthase, or methionine synthase and risk of colon cancer. Cancer Epidemiol Biomarkers Prev 14:2509-2516.
46. van der Put NM, Steegers-Theunissen RP, Frosst P, Trijbels FJ, Eskes TK, van den Heuvel LP, Mariman EC, den Heyer M, Rozen R, Blom HJ. 1995. Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida. Lancet 346:1070-1071.
47. Vargas AJ, Thompson PA. 2012. Diet and nutrient factors in colorectal cancer risk. Nutr Clin Pract 27:613-623.
48. Waksberg J. 1978. Sampling methods for random digit dialing. J Am Stat Assoc 73:40-46.
49. WCRF/AICR. 2007. Food, Nutrition, Physical Actvitiy, and the Prevenion of Cancer: A Global Perspective. Washington D.C.