A role for lipid rafts in the protection afforded by docosahexaenoic acid against ethanol toxicity in primary rat hepatocytes

Food and Chemical Toxicology

Volumn 60, Issue , 2013, Pages 286-296

  Aliche Djoudi, Fatiha ^a,b   Podechard, Normand ^a,b   Collin, Aurore ^a,b   Chevanne, Martine ^a,b   Provost, Emilie ^a,b,c   Poul, Martine ^c   Le Hégarat, Ludovic ^c   Catheline, Daniel ^d   Legrand, Philippe ^d   Dimanche Boitrel, Marie Thérèse ^a,b   Lagadic Gossmann, Dominique ^a,b   Sergent, Odile ^a,b  

^a UNIVERSITÉ DE RENNES 1   (France)

^b UNIVERSITÉ DE RENNES 1   (France)

^c FRENCH AGENCY FOR FOOD   (France)

^d AGROCAMPUS OUEST   (France)

Author keywords

Docosahexaenoic acid; Ethanol; Lipid peroxidation; Lipid rafts; N 3 Polyunsaturated fatty acids; Oxidative stress

Indexed keywords

ALCOHOL; COPPER ZINC SUPEROXIDE DISMUTASE; DOCOSAHEXAENOIC ACID; FLOTILLIN 1; GLUTATHIONE; GLUTATHIONE PEROXIDASE; IRON; LOW MOLECULAR WEIGHT IRON; MANGANESE SUPEROXIDE DISMUTASE; MONOUNSATURATED FATTY ACID; PHOSPHOLIPASE C GAMMA; POLYUNSATURATED FATTY ACID; REACTIVE OXYGEN METABOLITE; SATURATED FATTY ACID; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; BIOACCUMULATION; CELL PROTECTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DISULFIDE BOND; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME LOCALIZATION; LIPID COMPOSITION; LIPID PEROXIDATION; LIPID RAFT; LIVER CELL; LYSOSOME; MEMBRANE DAMAGE; MEMBRANE FLUIDITY; NONHUMAN; OXIDATIVE STRESS; PHYSICAL CHEMISTRY; PROTEIN EXPRESSION; PROTEIN LIPID INTERACTION; PROTEIN PROTEIN INTERACTION; RAT;

4-HYDROXYNONENAL; DHA; DIHYDROFLUORESCEIN DIACETATE; DOCOSAHEXAENOIC ACID; EICOSAPENTAENOIC ACID; ELECTRON PARAMAGNETIC RESONANCE; EPA; EPR; ETHANOL; GLYCOSYLPHOSPHATIDYLINOSITOL; GM1; GPI; H(2)FDA; HNE; LIPID PEROXIDATION; LIPID RAFTS; LMW IRON; LOW-MOLECULAR-WEIGHT IRON; MAL-6; MONOSIALOTETRAHEXOSYL GANGLIOSIDE; N-3 POLYUNSATURATED FATTY ACID; N-3 POLYUNSATURATED FATTY ACIDS; N-3 PUFA; O-(2,3,4,5,6-PENTAFLUOROBENZYL)HYDROXYLAMINE HYDROCHLORIDE; O-PFB; OXIDATIVE STRESS; PENTAFLUOROBENZYL-OXIME; PFBHA·HCL; PHOSPHOLIPASE C Γ1; PLCΓ1; REACTIVE OXYGEN SPECIES, GSH: REDUCED GLUTATHIONE; ROS; TETRAMETHYL-4-MALEIMIDOPIPERIDINE-1-OXYL;

ANIMALS; CELL DEATH; CELLS, CULTURED; DOCOSAHEXAENOIC ACIDS; ETHANOL; GLUTATHIONE; GLUTATHIONE PEROXIDASE; HEPATOCYTES; LIPID PEROXIDATION; MEMBRANE MICRODOMAINS; MEMBRANE PROTEINS; MOLECULAR WEIGHT; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SUPEROXIDE DISMUTASE; TYPE C PHOSPHOLIPASES;

EID: 84883032007     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2013.07.061     Document Type: Article

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