Gingipain-dependent degradation of mammalian target of rapamycin pathway proteins by the periodontal pathogen Porphyromonas gingivalis during invasion

Molecular Oral Microbiology

Volumn 28, Issue 5, 2013, Pages 366-378

  Stafford, P ^a   Higham, J ^a   Pinnock, A ^a   Murdoch, C ^a   Douglas, C W I ^a   Stafford, G P ^a   Lambert, D W ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

Degradation; Gingipains; Mammalian target of rapamycin; Periodontitis; Porphyromonas gingivalis

Indexed keywords

CYTOCHALASIN D; GINGIPAIN R; INITIATION FACTOR 4E BINDING PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN; ADHESIN; ARGINGIPAIN, PORPHYROMONAS GINGIVALIS; CARRIER PROTEIN; CYSTEINE PROTEINASE; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MULTIPROTEIN COMPLEX; NUCLEIC ACID SYNTHESIS INHIBITOR; ONCOPROTEIN; RICTOR PROTEIN, HUMAN; RPTOR PROTEIN, HUMAN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TARGET OF RAPAMYCIN KINASE; TOR COMPLEX 2;

ARTICLE; CELL INVASION; CONTROLLED STUDY; EPITHELIUM CELL; HOST CELL; HUMAN; HUMAN CELL; PERIODONTAL DISEASE; PHENOTYPE; PORPHYROMONAS GINGIVALIS; PROTEIN DEGRADATION; SIGNAL TRANSDUCTION; TANNERELLA FORSYTHENSIS; WESTERN BLOTTING; BACTEROIDACEAE INFECTION; BACTEROIDES; BACTEROIDES INFECTION; CELL LINE; DRUG EFFECTS; KERATINOCYTE; METABOLISM; MICROBIOLOGY; MOUTH MUCOSA; PERIODONTITIS; TUMOR CELL LINE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADHESINS, BACTERIAL; BACTEROIDACEAE INFECTIONS; BACTEROIDES; BACTEROIDES INFECTIONS; CARRIER PROTEINS; CELL LINE; CELL LINE, TUMOR; CYSTEINE ENDOPEPTIDASES; CYTOCHALASIN D; EPITHELIAL CELLS; HUMANS; KERATINOCYTES; MOUTH MUCOSA; MULTIPROTEIN COMPLEXES; NUCLEIC ACID SYNTHESIS INHIBITORS; ONCOGENE PROTEIN V-AKT; PERIODONTITIS; PORPHYROMONAS GINGIVALIS; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84882920635     PISSN: 20411006     EISSN: 20411014     Source Type: Journal    
DOI: 10.1111/omi.12030     Document Type: Article

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