Targeting colorectal cancer cells with single-walled carbon nanotubes conjugated to anticancer agent SN-38 and EGFR antibody

Biomaterials

Volumn 34, Issue 34, 2013, Pages 8756-8765

  Lee, Pei Chi ^a   Chiou, Yu Chi ^a   Wong, Jau Min ^a   Peng, Cheng Liang ^a,b   Shieh, Ming Jium ^a,c  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b INSTITUTE OF NUCLEAR ENERGY RESEARCH   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

C225; EGFR; Human carboxylesterase enzyme; Single walled carbon nanotubes; SN38

Indexed keywords

C225; CARBOXYLESTERASES; CHEMOTHERAPEUTIC DRUGS; COLORECTAL CANCER CELL; EGFR; RECEPTOR-MEDIATED ENDOCYTOSIS; SINGLE-WALLED CARBON NANOTUBE (SWNTS); SN38;

ANTIBODIES; CELL CULTURE; DISEASES; ENZYMES; MOLECULAR BIOLOGY; SINGLE-WALLED CARBON NANOTUBES (SWCN);

CELLS;

CARBOXYLESTERASE; CETUXIMAB; EPIDERMAL GROWTH FACTOR RECEPTOR; FIRTECAN; SINGLE WALLED NANOTUBE;

ARTICLE; CANCER CELL; CANCER CELL CULTURE; CHEMICAL BOND; COLORECTAL CANCER; CONFOCAL MICROSCOPY; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; CYTOPLASM; DISSOCIATION; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; DRUG SYNTHESIS; ENDOCYTOSIS; ENZYME ACTIVITY; GENE EXPRESSION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; MEDIATOR; MOLECULARLY TARGETED THERAPY; PRIORITY JOURNAL; PROTEIN FUNCTION;

C225; EGFR; HUMAN CARBOXYLESTERASE ENZYME; SINGLE-WALLED CARBON NANOTUBES; SN38;

ANTIBODIES, MONOCLONAL, HUMANIZED; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CAMPTOTHECIN; CARBOXYLESTERASE; CELL LINE, TUMOR; COLORECTAL NEOPLASMS; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; HCT116 CELLS; HT29 CELLS; HUMANS; IMMUNOCONJUGATES; MICROSCOPY, CONFOCAL; NANOTUBES, CARBON; RECEPTOR, EPIDERMAL GROWTH FACTOR;

EID: 84882872946     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2013.07.067     Document Type: Article

References (41)

1. Iijima S. Helical microtubules of graphitic carbon. Nature 1991, 354(6348):56-58.
2. Smith A.M., Mancini M.C., Nie S. Bioimaging: second window for invivo imaging. Nat Nanotechnol 2009, 4(11):710-711.
3. Kam N.W., O'Connell M., Wisdom J.A., Dai H. Carbon nanotubes as multifunctional biological transporters and near-infrared agents for selective cancer cell destruction. Proc Natl Acad Sci USA 2005, 102(33):11600-11605.
4. Shim M., Kam N.W.S., Chen R.J., Li Y., Dai H. Functionalization of carbon nanotubes for biocompatibility and biomolecular recognition. Nano Lett 2002, 2(4):285-288.
5. Podesta J.E., Al-Jamal K.T., Herrero M.A., Tian B., Ali-Boucetta H., Hegde V., et al. Antitumor activity and prolonged survival by carbon-nanotube-mediated therapeutic siRNA silencing in a human lung xenograft model. Small 2009, 5(10):1176-1185.
6. Lacerda L., Raffa S., Prato M., Bianco A., Kostarelos K. Cell-penetrating CNTs for delivery of therapeutics. Nano Today 2007, 2(6):38-43.
7. Marianna F. Carbon nanotubes as functional excipients for nanomedicines:I. pharmaceutical properties. Nanomedicine 2008, 4:173-182.
8. Marianna F. Carbon nanotubes as functional excipients for nanomedicines: II. Drug delivery and biocompatibility issues. Nanomedicine 2008, 4:183-200.
9. Kam N.W., Dai H. Carbon nanotubes as intracellular protein transporters: generality and biological functionality. JAm Chem Soc 2005, 127:6021-6026.
10. Kam N.W., Liu Z., Dai H. Functionalization of carbon nanotubes via cleavable disulfide bonds for efficient intracellular delivery of siRNA and potent gene silencing. JAm Chem Soc 2005, 127:12492-12493.
11. Cai D., Mataraza J.M., Qin Z.H., Huang Z., Huang J., Chiles T.C., et al. Highly efficient molecular delivery into mammalian cells using carbon nanotube spearing. Nat Methods 2005, 2:449-454.
12. Moore V., Strano M., Haroz E., Hauge R., Smalley R. Individually suspended single-walled carbon nanotubes in various surfactants. Nano Lett 2003, 3:1379-1382.
13. Singh R., Pantarotto D., Lacerda L., Pastorin G., Klumpp C., Prato M., et al. Tissue biodistribution and blood clearance rates of intravenously administered carbon nanotube radiotracers. Proc Natl Acad Sci USA 2006, 103(9):3357-3362.
14. Gerrits C.J., de Jonge M.J., Schellens J.H., Stoter G., Verweij J. Topoisomerase I inhibitors: the relevance of prolonged exposure for present clinical development. Br J Cancer 1997, 76:952-962.
15. Koizumi F., Kitagawa M., Negishi T., Onda T., Matsumoto S., Hamaguchi T., et al. Novel SN-38-incorporating polymeric micelles, NK012, eradicate vascular endothelial growth factor-secreting bulky tumors. Cancer Res 2006, 66(20):10048-10056.
16. Rocio G.C., Jeffrey G.S. Current perspectives on the clinical experience, pharmacology, and continued development of the camptothecins. Clin Cancer Res 2002, 8:641-661.
17. Takimoto C.H., Arbuck S.G. Topoisomerase I targeting agents: the camptothecins. Cancer chemotherapy and biotherapy: principal and practice 2001, 579-646. Lippincott Williams & Wilkins, Philadelphia. 3rd ed. B.A. Chabner, D.L. Lango (Eds.).
18. Matsumura Y. Preclinical and clinical studies of NK012, an SN-38-incorporating polymeric micelles, which is designed based on EPR effect. Adv Drug Deliv Rev 2011, 63:184-192.
19. Pal A., Khan S., Wang Y.F., Kamath N., Sarkar A.K., Ahmad A., et al. Preclinical safety, pharmacokinetics and antitumor efficacy profile of liposome-entrapped SN-38 formulation. Anticancer Res 2005, 25:331-341.
20. Owonikoko T.K., Sun S.Y., Ramalingam S.S. The role of cetuximab in the management of non-small-cell lung cancer. Clin Lung Cancer 2009, 10:230-238.
21. Egloff A.M., Grandis J.R. Targeting epidermal growth factor receptor and SRC pathways in head and neck cancer. Semin Oncol 2008, 35(3):286-297.
22. Ciardiello F., Tortora G. Anovel approach in the treatment of cancer: targeting the epidermal growth factor receptor. Clin Cancer Res 2001, 7(10):2958-2970.
23. Chen R.J., Zhang Y., Wang D., Dai H. Noncovalent sidewall functionalization of single-walled carbon nanotubes for protein immobilization. JAm Chem Soc 2001, 123:3838-3839.
24. Chaudhuri P., Soni S., Sengupta S. Single-walled carbon nanotube-conjugated chemotherapy exhibits increased therapeutic index in melanoma. Nanotechnology 2010, 21(2):025102.
25. Liu J., Rinzler A.G., Dai H., Hafner J.H., Bradley R.K., Boul P.J., et al. Fullerene pipes. Science 1998, 280(5367):1253-1256.
26. Zhang J., Zou H., Qing Q., Yang Y., Li Q., Liu Z., et al. Effect of chemical oxidation on the structure of single-walled carbon nanotubes. JPhys Chem B 2003, 107(16):3712-3718.
27. Liu Z., Tabakman S., Sherlock S., Li X., Chen Z., Jiang K., et al. Multiplexed five-color molecular imaging of cancer cells and tumor tissues with carbon nanotube Raman tags in the near-infrared. Nano Res 2010, 3(3):222-233.
28. Imai T., Imoto M., Sakamoto H., Hashimoto M. Identification of esterases expressed in Caco-2 cells and effects of their hydrolyzing activity in predicting human intestinal absorption. Drug Metab Dispos 2005, 33(8):1185-1190.
29. Redinbo M.R., Potter P.M. Mammalian carboxylesterases: from drug targets to protein therapeutics. Drug Discov Today 2005, 10(5):313-325.
30. Xu G., Zhang W., Ma M.K., McLeod H.L. Human carboxylesterase 2 is commonly expressed in tumor tissue and is correlated with activation of irinotecan. Clin Cancer Res 2002, 8(8):2605-2611.
31. Sanghani S.P., Quinney S.K., Fredenburg T.B., Sun Z., Davis W.I., Murry D.J., et al. Carboxylesterases expressed in human colon tumor tissue and their role in CPT-11 hydrolysis. Clin Cancer Res 2003, 9(13):4983-4991.
32. Wu W., Li R., Bian X., Zhu Z., Ding D., Li X., et al. Covalently combining carbon nanotubes with anticancer agent: preparation and antitumor activity. ACS Nano 2009, 3(9):2740-2750.
33. Sharpe M.A., Marcano D.C., Berlin J.M., Widmayer M.A., Baskin D.S., Tour J.M. Antibody-targeted nanovectors for the treatment of brain cancers. ACS Nano 2012, 6(4):3114-3120.
34. Berlin J.M., Pham T.T., Sano D., Mohamedali K.A., Marcano D.C., Myers J.N., et al. Noncovalent functionalization of carbon nanovectors with an antibody enables targeted drug delivery. ACS Nano 2011, 5(8):6643-6650.
35. Wang R., Mikoryak C., Chen E., Li S., Pantano P., Draper R.K. Gel electrophoresis method to measure the concentration of single-walled carbon nanotubes extracted from biological tissue. Anal Chem 2009, 81(8):2944-2952.
36. Peng C.L., Lai P.S., Lin F.H., Steven W.Y.H., Shieh M.J. Dual chemotherapy and photodynamic therapy in an HT-29 human colon cancer xenograft model using SN-38-loaded chlorin-core star block copolymer micelles. Biomaterials 2009, 30(21):3614-3625.
37. Mukherjee S., Ghosh R.N., Maxfield F.R. Endocytosis. Physiol Rev 1997, 77(3):759-803.
38. Kam N.W.S., Jessop T.C., Wender P.A., Dai H. Nanotube molecular transporters: internalization of carbon nanotube-protein conjugates into mammalian cells. JAm Chem Soc 2004, 126(22):6850-6851.
39. Kam N.W., Liu Z., Dai H. Carbon nanotubes as intracellular transporters for proteins and DNA: an investigation of the uptake mechanism and pathway. Angew Chem Int Ed Engl 2006, 45(4):577-581.
40. Goldstein J.L., Anderson R.G.W., Brown M.S. Coated pits, coated vesicles, and receptor-mediated endocytosis. Nature 1979, 279(5715):679-685.
41. Heuser J.E., Anderson R. Hypertonic media inhibit receptor-mediated endocytosis by blocking clathrin-coated pit formation. JCell Biol 1989, 108(2):389-400.