-
1
-
-
2342471392
-
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
-
Lynch T.J., Bell D.W., Sordella R., Gurubhagavatula S., Okimoto R.A., Brannigan B.W., et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 350 (2004) 2129-2139
-
(2004)
N Engl J Med
, vol.350
, pp. 2129-2139
-
-
Lynch, T.J.1
Bell, D.W.2
Sordella, R.3
Gurubhagavatula, S.4
Okimoto, R.A.5
Brannigan, B.W.6
-
2
-
-
28844449401
-
Epidermal growth factor receptor mutations and gene amplification in non-small-cell lung cancer: molecular analysis of the IDEAL/INTACT gefitinib trials
-
Bell D.W., Lynch T.J., Haserlat S.M., Harris P.L., Okimoto R.A., Brannigan B.W., et al. Epidermal growth factor receptor mutations and gene amplification in non-small-cell lung cancer: molecular analysis of the IDEAL/INTACT gefitinib trials. J Clin Oncol 23 (2005) 8081-8092
-
(2005)
J Clin Oncol
, vol.23
, pp. 8081-8092
-
-
Bell, D.W.1
Lynch, T.J.2
Haserlat, S.M.3
Harris, P.L.4
Okimoto, R.A.5
Brannigan, B.W.6
-
3
-
-
20244389231
-
Somatic mutations of EGFR gene in squamous cell carcinoma of the head and neck
-
Lee J.W., Soung Y.H., Kim S.Y., Nam H.K., Park W.S., Nam S.W., et al. Somatic mutations of EGFR gene in squamous cell carcinoma of the head and neck. Clin Cancer Res 11 (2005) 2879-2882
-
(2005)
Clin Cancer Res
, vol.11
, pp. 2879-2882
-
-
Lee, J.W.1
Soung, Y.H.2
Kim, S.Y.3
Nam, H.K.4
Park, W.S.5
Nam, S.W.6
-
4
-
-
29144520704
-
Low incidence of mutations in EGFR kinase domain in Caucasian patients with head and neck squamous cell carcinoma
-
Loeffler-Ragg J., Witsch-Baumgartner M., Tzankov A., Hilbe W., Schwentner I., Sprinzl G.M., et al. Low incidence of mutations in EGFR kinase domain in Caucasian patients with head and neck squamous cell carcinoma. Eur J Cancer 42 (2006) 109-111
-
(2006)
Eur J Cancer
, vol.42
, pp. 109-111
-
-
Loeffler-Ragg, J.1
Witsch-Baumgartner, M.2
Tzankov, A.3
Hilbe, W.4
Schwentner, I.5
Sprinzl, G.M.6
-
5
-
-
0027183870
-
Elevated levels of transforming growth factor alpha and epidermal growth factor receptor messenger RNA are early markers of carcinogenesis in head and neck cancer
-
Grandis J.R., and Tweardy D.J. Elevated levels of transforming growth factor alpha and epidermal growth factor receptor messenger RNA are early markers of carcinogenesis in head and neck cancer. Cancer Res 53 (1993) 3579-3584
-
(1993)
Cancer Res
, vol.53
, pp. 3579-3584
-
-
Grandis, J.R.1
Tweardy, D.J.2
-
6
-
-
0027432231
-
EGFR and PCNA expression in oral squamous cell carcinomas-a valuable tool in estimating the patient's prognosis
-
Storkel S., Reichert T., Reiffen K.A., and Wagner W. EGFR and PCNA expression in oral squamous cell carcinomas-a valuable tool in estimating the patient's prognosis. Eur J Cancer 29B (1993) 273-277
-
(1993)
Eur J Cancer
, vol.29 B
, pp. 273-277
-
-
Storkel, S.1
Reichert, T.2
Reiffen, K.A.3
Wagner, W.4
-
7
-
-
0030927973
-
Epidermal growth factor receptor immunoreactivity in human laryngeal squamous cell carcinoma
-
Lee C.S., Redshaw A., and Boag G. Epidermal growth factor receptor immunoreactivity in human laryngeal squamous cell carcinoma. Pathology 29 (1997) 251-254
-
(1997)
Pathology
, vol.29
, pp. 251-254
-
-
Lee, C.S.1
Redshaw, A.2
Boag, G.3
-
8
-
-
0032478998
-
Levels of TGF-alpha and EGFR protein in head and neck squamous cell carcinoma and patient survival
-
Grandis J.R., Melhem M.F., Gooding W.E., Day R., Holst V.A., Wagener M.M., et al. Levels of TGF-alpha and EGFR protein in head and neck squamous cell carcinoma and patient survival. J Natl Cancer Inst 90 (1998) 824-832
-
(1998)
J Natl Cancer Inst
, vol.90
, pp. 824-832
-
-
Grandis, J.R.1
Melhem, M.F.2
Gooding, W.E.3
Day, R.4
Holst, V.A.5
Wagener, M.M.6
-
9
-
-
0037115674
-
Impact of epidermal growth factor receptor expression on survival and pattern of relapse in patients with advanced head and neck carcinoma
-
Ang K.K., Berkey B.A., Tu X., Zhang H.Z., Katz R., Hammond E.H., et al. Impact of epidermal growth factor receptor expression on survival and pattern of relapse in patients with advanced head and neck carcinoma. Cancer Res 62 (2002) 7350-7356
-
(2002)
Cancer Res
, vol.62
, pp. 7350-7356
-
-
Ang, K.K.1
Berkey, B.A.2
Tu, X.3
Zhang, H.Z.4
Katz, R.5
Hammond, E.H.6
-
10
-
-
0026620899
-
EGF receptor expression in primary laryngeal cancer: correlation with clinico-pathological features and prognostic significance
-
Maurizi M., Scambia G., Benedetti Panici P., Ferrandina G., Almadori G., Paludetti G., et al. EGF receptor expression in primary laryngeal cancer: correlation with clinico-pathological features and prognostic significance. Int J Cancer 52 (1992) 862-866
-
(1992)
Int J Cancer
, vol.52
, pp. 862-866
-
-
Maurizi, M.1
Scambia, G.2
Benedetti Panici, P.3
Ferrandina, G.4
Almadori, G.5
Paludetti, G.6
-
11
-
-
0027359459
-
Expression of epidermal growth factor receptor and survival in upper aerodigestive tract cancer
-
Dassonville O., Formento J.L., Francoual M., Ramaioli A., Santini J., Schneider M., et al. Expression of epidermal growth factor receptor and survival in upper aerodigestive tract cancer. J Clin Oncol 11 (1993) 1873-1883
-
(1993)
J Clin Oncol
, vol.11
, pp. 1873-1883
-
-
Dassonville, O.1
Formento, J.L.2
Francoual, M.3
Ramaioli, A.4
Santini, J.5
Schneider, M.6
-
12
-
-
0033007588
-
Epidermal growth factor receptor expression in primary laryngeal cancer: an independent prognostic factor of neck node relapse
-
Almadori G., Cadoni G., Galli J., Ferrandina G., Scambia G., Exarchakos G., et al. Epidermal growth factor receptor expression in primary laryngeal cancer: an independent prognostic factor of neck node relapse. Int J Cancer 84 (1999) 188-191
-
(1999)
Int J Cancer
, vol.84
, pp. 188-191
-
-
Almadori, G.1
Cadoni, G.2
Galli, J.3
Ferrandina, G.4
Scambia, G.5
Exarchakos, G.6
-
13
-
-
33748653109
-
Increased epidermal growth factor receptor gene copy number is associated with poor prognosis in head and neck squamous cell carcinomas
-
Chung C.H., Ely K., McGavran L., Varella-Garcia M., Parker J., Parker N., et al. Increased epidermal growth factor receptor gene copy number is associated with poor prognosis in head and neck squamous cell carcinomas. J Clin Oncol 24 (2006) 4170-4176
-
(2006)
J Clin Oncol
, vol.24
, pp. 4170-4176
-
-
Chung, C.H.1
Ely, K.2
McGavran, L.3
Varella-Garcia, M.4
Parker, J.5
Parker, N.6
-
14
-
-
34250155320
-
Epidermal growth factor receptor copy number alterations correlate with poor clinical outcome in patients with head and neck squamous cancer
-
Temam S., Kawaguchi H., El-Naggar A.K., Jelinek J., Tang H., Liu D.D., et al. Epidermal growth factor receptor copy number alterations correlate with poor clinical outcome in patients with head and neck squamous cancer. J Clin Oncol 25 (2007) 2164-2170
-
(2007)
J Clin Oncol
, vol.25
, pp. 2164-2170
-
-
Temam, S.1
Kawaguchi, H.2
El-Naggar, A.K.3
Jelinek, J.4
Tang, H.5
Liu, D.D.6
-
15
-
-
22144431886
-
Autocrine, paracrine and juxtacrine signaling by EGFR ligands
-
Singh A.B., and Harris R.C. Autocrine, paracrine and juxtacrine signaling by EGFR ligands. Cell Signal 17 (2005) 1183-1193
-
(2005)
Cell Signal
, vol.17
, pp. 1183-1193
-
-
Singh, A.B.1
Harris, R.C.2
-
16
-
-
0036467826
-
Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer
-
Vogel C.L., Cobleigh M.A., Tripathy D., Gutheil J.C., Harris L.N., Fehrenbacher L., et al. Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer. J Clin Oncol 20 (2002) 719-726
-
(2002)
J Clin Oncol
, vol.20
, pp. 719-726
-
-
Vogel, C.L.1
Cobleigh, M.A.2
Tripathy, D.3
Gutheil, J.C.4
Harris, L.N.5
Fehrenbacher, L.6
-
17
-
-
0031041969
-
Strong correlation between c-erbB-2 overexpression and overall survival of patients with oral squamous cell carcinoma
-
Xia W., Lau Y.K., Zhang H.Z., Liu A.R., Li L., Kiyokawa N., et al. Strong correlation between c-erbB-2 overexpression and overall survival of patients with oral squamous cell carcinoma. Clin Cancer Res 3 (1997) 3-9
-
(1997)
Clin Cancer Res
, vol.3
, pp. 3-9
-
-
Xia, W.1
Lau, Y.K.2
Zhang, H.Z.3
Liu, A.R.4
Li, L.5
Kiyokawa, N.6
-
18
-
-
0036190848
-
Characterization of the HER-2/neu oncogene by immunohistochemical and fluorescence in situ hybridization analysis in oral and oropharyngeal squamous cell carcinoma
-
Khan A.J., King B.L., Smith B.D., Smith G.L., DiGiovanna M.P., Carter D., et al. Characterization of the HER-2/neu oncogene by immunohistochemical and fluorescence in situ hybridization analysis in oral and oropharyngeal squamous cell carcinoma. Clin Cancer Res 8 (2002) 540-548
-
(2002)
Clin Cancer Res
, vol.8
, pp. 540-548
-
-
Khan, A.J.1
King, B.L.2
Smith, B.D.3
Smith, G.L.4
DiGiovanna, M.P.5
Carter, D.6
-
19
-
-
34547397409
-
Prognostic impact of HER-2/neu expression on squamous head and neck carcinomas
-
Cavalot A., Martone T., Roggero N., Brondino G., Pagano M., Cortesina G., et al. Prognostic impact of HER-2/neu expression on squamous head and neck carcinomas. Head Neck 29 (2007) 655-664
-
(2007)
Head Neck
, vol.29
, pp. 655-664
-
-
Cavalot, A.1
Martone, T.2
Roggero, N.3
Brondino, G.4
Pagano, M.5
Cortesina, G.6
-
20
-
-
0033372557
-
Combination of EGFR, HER-2/neu, and HER-3 is a stronger predictor for the outcome of oral squamous cell carcinoma than any individual family members
-
Xia W., Lau Y.K., Zhang H.Z., Xiao F.Y., Johnston D.A., Liu A.R., et al. Combination of EGFR, HER-2/neu, and HER-3 is a stronger predictor for the outcome of oral squamous cell carcinoma than any individual family members. Clin Cancer Res 5 (1999) 4164-4174
-
(1999)
Clin Cancer Res
, vol.5
, pp. 4164-4174
-
-
Xia, W.1
Lau, Y.K.2
Zhang, H.Z.3
Xiao, F.Y.4
Johnston, D.A.5
Liu, A.R.6
-
21
-
-
21444436806
-
Expression of EGFR, HER2, HER3, and HER4 in metastatic squamous cell carcinomas of the oral cavity and base of tongue
-
Ekberg T., Nestor M., Engstrom M., Nordgren H., Wester K., Carlsson J., et al. Expression of EGFR, HER2, HER3, and HER4 in metastatic squamous cell carcinomas of the oral cavity and base of tongue. Int J Oncol 26 (2005) 1177-1185
-
(2005)
Int J Oncol
, vol.26
, pp. 1177-1185
-
-
Ekberg, T.1
Nestor, M.2
Engstrom, M.3
Nordgren, H.4
Wester, K.5
Carlsson, J.6
-
22
-
-
0030799211
-
Anti-tumor activity of monoclonal antibody CIBCNSH3 generated to the human EGF receptor
-
Udayachander M., Dean C.J., Meenakshi A.N., Sivakumar N., Babu P.B., and Sivakumar J. Anti-tumor activity of monoclonal antibody CIBCNSH3 generated to the human EGF receptor. Hum Antibodies 8 (1997) 60-64
-
(1997)
Hum Antibodies
, vol.8
, pp. 60-64
-
-
Udayachander, M.1
Dean, C.J.2
Meenakshi, A.N.3
Sivakumar, N.4
Babu, P.B.5
Sivakumar, J.6
-
23
-
-
0032528051
-
Inhibition of human squamous cell carcinoma growth in vivo by epidermal growth factor receptor antisense RNA transcribed from the U6 promoter
-
He Y., Zeng Q., Drenning S.D., Melhem M.F., Tweardy D.J., Huang L., et al. Inhibition of human squamous cell carcinoma growth in vivo by epidermal growth factor receptor antisense RNA transcribed from the U6 promoter. J Natl Cancer Inst 90 (1998) 1080-1087
-
(1998)
J Natl Cancer Inst
, vol.90
, pp. 1080-1087
-
-
He, Y.1
Zeng, Q.2
Drenning, S.D.3
Melhem, M.F.4
Tweardy, D.J.5
Huang, L.6
-
24
-
-
6044230917
-
Abrogation of head and neck squamous cell carcinoma growth by epidermal growth factor receptor ligand fused to pseudomonas exotoxin transforming growth factor alpha-PE38
-
Thomas S.M., Zeng Q., Epperly M.W., Gooding W.E., Pastan I., Wang Q.C., et al. Abrogation of head and neck squamous cell carcinoma growth by epidermal growth factor receptor ligand fused to pseudomonas exotoxin transforming growth factor alpha-PE38. Clin Cancer Res 10 (2004) 7079-7087
-
(2004)
Clin Cancer Res
, vol.10
, pp. 7079-7087
-
-
Thomas, S.M.1
Zeng, Q.2
Epperly, M.W.3
Gooding, W.E.4
Pastan, I.5
Wang, Q.C.6
-
25
-
-
33749246867
-
Epidermal growth factor receptor-targeted molecular therapeutics for head and neck squamous cell carcinoma
-
Egloff A.M., and Grandis J. Epidermal growth factor receptor-targeted molecular therapeutics for head and neck squamous cell carcinoma. Expert Opin Ther Targets 10 (2006) 639-647
-
(2006)
Expert Opin Ther Targets
, vol.10
, pp. 639-647
-
-
Egloff, A.M.1
Grandis, J.2
-
26
-
-
34147137018
-
Targeted therapies in head and neck cancer
-
Specenier P.M., and Vermorken J.B. Targeted therapies in head and neck cancer. Targ Oncol 2 (2007) 73-88
-
(2007)
Targ Oncol
, vol.2
, pp. 73-88
-
-
Specenier, P.M.1
Vermorken, J.B.2
-
28
-
-
32144433159
-
Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck
-
Bonner J.A., Harari P.M., Giralt J., Azarnia N., Shin D.M., Cohen R.B., et al. Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N Engl J Med 354 (2006) 567-578
-
(2006)
N Engl J Med
, vol.354
, pp. 567-578
-
-
Bonner, J.A.1
Harari, P.M.2
Giralt, J.3
Azarnia, N.4
Shin, D.M.5
Cohen, R.B.6
-
29
-
-
33144461661
-
Phase III randomized trial of cisplatin plus placebo compared with cisplatin plus cetuximab in metastatic/recurrent head and neck cancer: an Eastern Cooperative Oncology Group study
-
Burtness B., Goldwasser M.A., Flood W., Mattar B., and Forastiere A.A. Phase III randomized trial of cisplatin plus placebo compared with cisplatin plus cetuximab in metastatic/recurrent head and neck cancer: an Eastern Cooperative Oncology Group study. J Clin Oncol 23 (2005) 8646-8654
-
(2005)
J Clin Oncol
, vol.23
, pp. 8646-8654
-
-
Burtness, B.1
Goldwasser, M.A.2
Flood, W.3
Mattar, B.4
Forastiere, A.A.5
-
30
-
-
36048934209
-
Cetuximab extends survival of patients with recurrent or metastatis SCCHN when added to first line platinum based therapy-results of a randomized phase III (Extreme) study [abstract]
-
Vermorken J., Mesia R., Vega V., Remenar E., Hitt R., Kawecki A., et al. Cetuximab extends survival of patients with recurrent or metastatis SCCHN when added to first line platinum based therapy-results of a randomized phase III (Extreme) study [abstract]. J Clin Oncol Proc Am Soc Clin Oncol 25 (2007) 6091
-
(2007)
J Clin Oncol Proc Am Soc Clin Oncol
, vol.25
, pp. 6091
-
-
Vermorken, J.1
Mesia, R.2
Vega, V.3
Remenar, E.4
Hitt, R.5
Kawecki, A.6
-
31
-
-
24944490558
-
Phase II multicenter study of the epidermal growth factor receptor antibody cetuximab and cisplatin for recurrent and refractory squamous cell carcinoma of the head and neck
-
Herbst R.S., Arquette M., Shin D.M., Dicke K., Vokes E.E., Azarnia N., et al. Phase II multicenter study of the epidermal growth factor receptor antibody cetuximab and cisplatin for recurrent and refractory squamous cell carcinoma of the head and neck. J Clin Oncol 23 (2005) 5578-5587
-
(2005)
J Clin Oncol
, vol.23
, pp. 5578-5587
-
-
Herbst, R.S.1
Arquette, M.2
Shin, D.M.3
Dicke, K.4
Vokes, E.E.5
Azarnia, N.6
-
32
-
-
23844523253
-
Phase II multicenter study of the antiepidermal growth factor receptor monoclonal antibody cetuximab in combination with platinum-based chemotherapy in patients with platinum-refractory metastatic and/or recurrent squamous cell carcinoma of the head and neck
-
Baselga J., Trigo J.M., Bourhis J., Tortochaux J., Cortes-Funes H., Hitt R., et al. Phase II multicenter study of the antiepidermal growth factor receptor monoclonal antibody cetuximab in combination with platinum-based chemotherapy in patients with platinum-refractory metastatic and/or recurrent squamous cell carcinoma of the head and neck. J Clin Oncol 23 (2005) 5568-5577
-
(2005)
J Clin Oncol
, vol.23
, pp. 5568-5577
-
-
Baselga, J.1
Trigo, J.M.2
Bourhis, J.3
Tortochaux, J.4
Cortes-Funes, H.5
Hitt, R.6
-
33
-
-
34250180582
-
Open-label, uncontrolled, multicenter phase II study to evaluate the efficacy and toxicity of cetuximab as a single agent in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck who failed to respond to platinum-based therapy
-
Vermorken J.B., Trigo J., Hitt R., Koralewski P., Diaz-Rubio E., Rolland F., et al. Open-label, uncontrolled, multicenter phase II study to evaluate the efficacy and toxicity of cetuximab as a single agent in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck who failed to respond to platinum-based therapy. J Clin Oncol 25 (2007) 2171-2177
-
(2007)
J Clin Oncol
, vol.25
, pp. 2171-2177
-
-
Vermorken, J.B.1
Trigo, J.2
Hitt, R.3
Koralewski, P.4
Diaz-Rubio, E.5
Rolland, F.6
-
34
-
-
33144461661
-
Phase III randomized trial of cisplatin plus placebo compared with cisplatin plus cetuximab in metastatic/recurrent head and neck cancer: an Eastern Cooperative Oncology Group study
-
Group ECO
-
Burtness B.G.M., Flood W., Mattar B., Forastiere A.A., and Group ECO. Phase III randomized trial of cisplatin plus placebo compared with cisplatin plus cetuximab in metastatic/recurrent head and neck cancer: an Eastern Cooperative Oncology Group study. J Clin Oncol 23 (2005) 8646-8654
-
(2005)
J Clin Oncol
, vol.23
, pp. 8646-8654
-
-
Burtness, B.G.M.1
Flood, W.2
Mattar, B.3
Forastiere, A.A.4
-
35
-
-
20144381957
-
Cetuximab shows activity in colorectal cancer patients with tumors that do not express the epidermal growth factor receptor by immunohistochemistry
-
Chung K.Y., Shia J., Kemeny N.E., Shah M., Schwartz G.K., Tse A., et al. Cetuximab shows activity in colorectal cancer patients with tumors that do not express the epidermal growth factor receptor by immunohistochemistry. J Clin Oncol 23 (2005) 1803-1810
-
(2005)
J Clin Oncol
, vol.23
, pp. 1803-1810
-
-
Chung, K.Y.1
Shia, J.2
Kemeny, N.E.3
Shah, M.4
Schwartz, G.K.5
Tse, A.6
-
36
-
-
2142641698
-
Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor
-
Saltz L.B., Meropol N.J., Loehrer Sr. P.J., Needle M.N., Kopit J., and Mayer R.J. Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor. J Clin Oncol 22 (2004) 1201-1208
-
(2004)
J Clin Oncol
, vol.22
, pp. 1201-1208
-
-
Saltz, L.B.1
Meropol, N.J.2
Loehrer Sr., P.J.3
Needle, M.N.4
Kopit, J.5
Mayer, R.J.6
-
37
-
-
34548289390
-
FDA drug approval summary: panitumumab (Vectibix)
-
Giusti R.M., Shastri K.A., Cohen M.H., Keegan P., and Pazdur R. FDA drug approval summary: panitumumab (Vectibix). Oncologist 12 (2007) 577-583
-
(2007)
Oncologist
, vol.12
, pp. 577-583
-
-
Giusti, R.M.1
Shastri, K.A.2
Cohen, M.H.3
Keegan, P.4
Pazdur, R.5
-
38
-
-
4444233396
-
-
Bleeker WK, Lammerts van Bueren JJ, van Ojik HH, Gerritsen AF, Pluyter M, et al. Dual mode of action of a human anti-epidermal growth factor receptor monoclonal antibody for cancer therapy. J Immunol. 12004;73:4699-707.
-
Bleeker WK, Lammerts van Bueren JJ, van Ojik HH, Gerritsen AF, Pluyter M, et al. Dual mode of action of a human anti-epidermal growth factor receptor monoclonal antibody for cancer therapy. J Immunol. 12004;73:4699-707.
-
-
-
-
39
-
-
2442704412
-
Use of the humanized anti-epidermal growth factor receptor monoclonal antibody h-R3 in combination with radiotherapy in the treatment of locally advanced head and neck cancer patients
-
Crombet T., Osorio M., Cruz T., Roca C., del Castillo R., Mon R., et al. Use of the humanized anti-epidermal growth factor receptor monoclonal antibody h-R3 in combination with radiotherapy in the treatment of locally advanced head and neck cancer patients. J Clin Oncol 22 (2004) 1646-1654
-
(2004)
J Clin Oncol
, vol.22
, pp. 1646-1654
-
-
Crombet, T.1
Osorio, M.2
Cruz, T.3
Roca, C.4
del Castillo, R.5
Mon, R.6
-
40
-
-
33644842102
-
Gefitinib (ZD1839, Iressa) as palliative treatment in recurrent or metastatic head and neck cancer
-
Kirby A.M., A'Hern R.P., D'Ambrosio C., Tanay M., Syrigos K.N., Rogers S.J., et al. Gefitinib (ZD1839, Iressa) as palliative treatment in recurrent or metastatic head and neck cancer. Br J Cancer 94 (2006) 631-636
-
(2006)
Br J Cancer
, vol.94
, pp. 631-636
-
-
Kirby, A.M.1
A'Hern, R.P.2
D'Ambrosio, C.3
Tanay, M.4
Syrigos, K.N.5
Rogers, S.J.6
-
41
-
-
1842772526
-
Multicenter phase II study of erlotinib, an oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with recurrent or metastatic squamous cell cancer of the head and neck
-
Soulieres D., Senzer N.N., Vokes E.E., Hidalgo M., Agarwala S.S., and Siu L.L. Multicenter phase II study of erlotinib, an oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with recurrent or metastatic squamous cell cancer of the head and neck. J Clin Oncol 22 (2004) 77-85
-
(2004)
J Clin Oncol
, vol.22
, pp. 77-85
-
-
Soulieres, D.1
Senzer, N.N.2
Vokes, E.E.3
Hidalgo, M.4
Agarwala, S.S.5
Siu, L.L.6
-
42
-
-
0037674062
-
E. Phase II trial of ZD1839 in recurrent or metastatic squamous cell carcinoma of the head and neck
-
Cohen E.E., Rosen F., Stadler W.M., Recant W., Stenson K., et al. E. Phase II trial of ZD1839 in recurrent or metastatic squamous cell carcinoma of the head and neck. J Clin Oncol 21 (2003) 1980-1987
-
(2003)
J Clin Oncol
, vol.21
, pp. 1980-1987
-
-
Cohen, E.E.1
Rosen, F.2
Stadler, W.M.3
Recant, W.4
Stenson, K.5
-
43
-
-
84908554144
-
-
Accessed April 3, 2008
-
FDA Approval for Erlotinib Hydrochloride. http://www.cancer.gov/cancertopics/druginfo/fda-erlotinib-hydrochloride Accessed April 3, 2008
-
FDA Approval for Erlotinib Hydrochloride
-
-
-
44
-
-
34250208469
-
Phase I/II trial of erlotinib and cisplatin in patients with recurrent or metastatic squamous cell carcinoma of the head and neck: a Princess Margaret Hospital phase II consortium and National Cancer Institute of Canada Clinical Trials Group Study
-
Siu L.L., Soulieres D., Chen E.X., Pond G.R., Chin S.F., Francis P., et al. Phase I/II trial of erlotinib and cisplatin in patients with recurrent or metastatic squamous cell carcinoma of the head and neck: a Princess Margaret Hospital phase II consortium and National Cancer Institute of Canada Clinical Trials Group Study. J Clin Oncol 25 (2007) 2178-2183
-
(2007)
J Clin Oncol
, vol.25
, pp. 2178-2183
-
-
Siu, L.L.1
Soulieres, D.2
Chen, E.X.3
Pond, G.R.4
Chin, S.F.5
Francis, P.6
-
46
-
-
44649128868
-
Updated results of a phase II trial integrating gefitinib (G) into concurrent chemoradiation (CRT) followed by G adjuvant therapy for locally advanced head and neck cancer (HNC) [abstract]
-
Ahmed S.M., Cohen E.E., Haraf D.J., Stenson K.M., Blair E., Brockstein B.E., et al. Updated results of a phase II trial integrating gefitinib (G) into concurrent chemoradiation (CRT) followed by G adjuvant therapy for locally advanced head and neck cancer (HNC) [abstract]. J Clin Oncol Proc Am Soc Clin Oncol 25 (2007) 6028
-
(2007)
J Clin Oncol Proc Am Soc Clin Oncol
, vol.25
, pp. 6028
-
-
Ahmed, S.M.1
Cohen, E.E.2
Haraf, D.J.3
Stenson, K.M.4
Blair, E.5
Brockstein, B.E.6
-
47
-
-
44649166054
-
-
AACR, Los Angeles, CA
-
Stewart J.S.W., Cohen E.E., Licitra L., Van Herpen C.M.L., Khorprasert C., Soulieres D., et al. A phase III randomized parallel-group study of gefitinib (IRESSA) versus methotrexate (IMEX) in patients with recurrent squamous cell carcinoma of the head and neck [abstract 3522]. American Association for Cancer Research Annual Meeting: Proceedings (2007), AACR, Los Angeles, CA
-
(2007)
A phase III randomized parallel-group study of gefitinib (IRESSA) versus methotrexate (IMEX) in patients with recurrent squamous cell carcinoma of the head and neck [abstract 3522]. American Association for Cancer Research Annual Meeting: Proceedings
-
-
Stewart, J.S.W.1
Cohen, E.E.2
Licitra, L.3
Van Herpen, C.M.L.4
Khorprasert, C.5
Soulieres, D.6
-
48
-
-
0142250356
-
Antitumor effects of epidermal growth factor receptor antisense oligonucleotides in combination with docetaxel in squamous cell carcinoma of the head and neck
-
Niwa H., Wentzel A.L., Li M., Gooding W.E., Lui V.W., and Grandis J.R. Antitumor effects of epidermal growth factor receptor antisense oligonucleotides in combination with docetaxel in squamous cell carcinoma of the head and neck. Clin Cancer Res 9 (2003) 5028-5035
-
(2003)
Clin Cancer Res
, vol.9
, pp. 5028-5035
-
-
Niwa, H.1
Wentzel, A.L.2
Li, M.3
Gooding, W.E.4
Lui, V.W.5
Grandis, J.R.6
-
49
-
-
0036847719
-
Enhanced antiangiogenic therapy of squamous cell carcinoma by combined endostatin and epidermal growth factor receptor-antisense therapy
-
Li M., Ye C., Feng C., Riedel F., Liu X., Zeng Q., et al. Enhanced antiangiogenic therapy of squamous cell carcinoma by combined endostatin and epidermal growth factor receptor-antisense therapy. Clin Cancer Res 8 (2002) 3570-3578
-
(2002)
Clin Cancer Res
, vol.8
, pp. 3570-3578
-
-
Li, M.1
Ye, C.2
Feng, C.3
Riedel, F.4
Liu, X.5
Zeng, Q.6
-
50
-
-
84885351733
-
-
Accessed April 3, 2008
-
FDA Approval for Lapatinib Ditosylate. http://www.cancer.gov/cancertopics/druginfo/fda-lapatinib Accessed April 3, 2008
-
FDA Approval for Lapatinib Ditosylate
-
-
-
51
-
-
0035476866
-
The characterization of novel, dual ErbB-2/EGFR, tyrosine kinase inhibitors: potential therapy for cancer
-
Rusnak D.W., Affleck K., Cockerill S.G., Stubberfield C., Harris R., Page M., et al. The characterization of novel, dual ErbB-2/EGFR, tyrosine kinase inhibitors: potential therapy for cancer. Cancer Res 61 (2001) 7196-7203
-
(2001)
Cancer Res
, vol.61
, pp. 7196-7203
-
-
Rusnak, D.W.1
Affleck, K.2
Cockerill, S.G.3
Stubberfield, C.4
Harris, R.5
Page, M.6
-
52
-
-
4644289313
-
A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells
-
Wood E.R., Truesdale A.T., McDonald O.B., Yuan D., Hassell A., Dickerson S.H., et al. A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells. Cancer Res 64 (2004) 6652-6659
-
(2004)
Cancer Res
, vol.64
, pp. 6652-6659
-
-
Wood, E.R.1
Truesdale, A.T.2
McDonald, O.B.3
Yuan, D.4
Hassell, A.5
Dickerson, S.H.6
-
53
-
-
33748636081
-
A phase II study of lapatinib (GW572016) in recurrent/metastatic (R/M) squamous cell carcinoma of the head and neck (SCCHN) [abstract]
-
Abidoye O.O., Cohen E.E., Wong S.J., Kozloff M.F., Nattam S.R., Stenson K.M., et al. A phase II study of lapatinib (GW572016) in recurrent/metastatic (R/M) squamous cell carcinoma of the head and neck (SCCHN) [abstract]. J Clin Oncol Proc Am Soc Clin Oncol 24 (2006) 5568
-
(2006)
J Clin Oncol Proc Am Soc Clin Oncol
, vol.24
, pp. 5568
-
-
Abidoye, O.O.1
Cohen, E.E.2
Wong, S.J.3
Kozloff, M.F.4
Nattam, S.R.5
Stenson, K.M.6
-
54
-
-
33846566408
-
Dual inhibition of ErbB1 (EGFR/HER1) and ErbB2 (HER2/neu)
-
Reid A., Vidal L., Shaw H., and de Bono J. Dual inhibition of ErbB1 (EGFR/HER1) and ErbB2 (HER2/neu). Eur J Cancer 43 (2007) 481-489
-
(2007)
Eur J Cancer
, vol.43
, pp. 481-489
-
-
Reid, A.1
Vidal, L.2
Shaw, H.3
de Bono, J.4
-
55
-
-
0034722893
-
From oncogene to drug: development of small molecule tyrosine kinase inhibitors as anti-tumor and anti-angiogenic agents
-
Morin M.J. From oncogene to drug: development of small molecule tyrosine kinase inhibitors as anti-tumor and anti-angiogenic agents. Oncogene 19 (2000) 6574-6583
-
(2000)
Oncogene
, vol.19
, pp. 6574-6583
-
-
Morin, M.J.1
-
56
-
-
11244258222
-
Epidermal growth factor receptor inhibition strategies in oncology
-
Harari P.M. Epidermal growth factor receptor inhibition strategies in oncology. Endocr Rel Cancer 11 (2004) 689-708
-
(2004)
Endocr Rel Cancer
, vol.11
, pp. 689-708
-
-
Harari, P.M.1
-
57
-
-
0029121267
-
Potentiation of epidermal growth factor receptor-mediated oncogenesis by c-Src: implications for the etiology of multiple human cancers
-
Maa M.C., Leu T.H., McCarley D.J., Schatzman R.C., and Parsons S.J. Potentiation of epidermal growth factor receptor-mediated oncogenesis by c-Src: implications for the etiology of multiple human cancers. Proc Natl Acad Sci U S A 92 (1995) 6981-6985
-
(1995)
Proc Natl Acad Sci U S A
, vol.92
, pp. 6981-6985
-
-
Maa, M.C.1
Leu, T.H.2
McCarley, D.J.3
Schatzman, R.C.4
Parsons, S.J.5
-
58
-
-
0033573921
-
Mechanism of biological synergy between cellular Src and epidermal growth factor receptor
-
Tice D.A., Biscardi J.S., Nickles A.L., and Parsons S.J. Mechanism of biological synergy between cellular Src and epidermal growth factor receptor. Proc Natl Acad Sci U S A 96 (1999) 1415-1420
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 1415-1420
-
-
Tice, D.A.1
Biscardi, J.S.2
Nickles, A.L.3
Parsons, S.J.4
-
59
-
-
33749316418
-
The epidermal growth factor receptor pathway: a model for targeted therapy
-
Scaltriti M., and Baselga J. The epidermal growth factor receptor pathway: a model for targeted therapy. Clin Cancer Res 12 (2006) 5268-5272
-
(2006)
Clin Cancer Res
, vol.12
, pp. 5268-5272
-
-
Scaltriti, M.1
Baselga, J.2
-
60
-
-
4544235743
-
c-Src and cooperating partners in human cancer
-
Ishizawar R., and Parsons S.J. c-Src and cooperating partners in human cancer. Cancer Cell 6 (2004) 209-214
-
(2004)
Cancer Cell
, vol.6
, pp. 209-214
-
-
Ishizawar, R.1
Parsons, S.J.2
-
61
-
-
0142227019
-
Targeting the PI3K-Akt pathway in human cancer: rationale and promise
-
Luo J., Manning B.D., and Cantley L.C. Targeting the PI3K-Akt pathway in human cancer: rationale and promise. Cancer Cell 4 (2003) 257-262
-
(2003)
Cancer Cell
, vol.4
, pp. 257-262
-
-
Luo, J.1
Manning, B.D.2
Cantley, L.C.3
-
62
-
-
0037205048
-
The phosphoinositide 3-kinase pathway
-
Cantley L.C. The phosphoinositide 3-kinase pathway. Science 296 (2002) 1655-1657
-
(2002)
Science
, vol.296
, pp. 1655-1657
-
-
Cantley, L.C.1
-
63
-
-
0032533225
-
Glysogen symthase kinase-3 beta regulates cyclin D1 proteolysis and subcellular localization
-
Diehl J.A., Cheng M., Roussel M.F., and Sherr C.J. Glysogen symthase kinase-3 beta regulates cyclin D1 proteolysis and subcellular localization. Genes Dev 12 (1998) 3499-3511
-
(1998)
Genes Dev
, vol.12
, pp. 3499-3511
-
-
Diehl, J.A.1
Cheng, M.2
Roussel, M.F.3
Sherr, C.J.4
-
64
-
-
0034306997
-
Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability
-
Sears R., Nuckolls F., Haura E., Taya Y., Tamai K., and Nevins J.R. Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability. Genes Dev 14 (2000) 2501-2514
-
(2000)
Genes Dev
, vol.14
, pp. 2501-2514
-
-
Sears, R.1
Nuckolls, F.2
Haura, E.3
Taya, Y.4
Tamai, K.5
Nevins, J.R.6
-
65
-
-
0013689209
-
Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor-mediated cell growth in vitro
-
Grandis J.R., Drenning S.D., Chakraborty A., Zhou M.Y., Zeng Q., Pitt A.S., and Tweardy D.J. Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor-mediated cell growth in vitro. J Clin Invest 102 (1998) 1385-1392
-
(1998)
J Clin Invest
, vol.102
, pp. 1385-1392
-
-
Grandis, J.R.1
Drenning, S.D.2
Chakraborty, A.3
Zhou, M.Y.4
Zeng, Q.5
Pitt, A.S.6
Tweardy, D.J.7
-
66
-
-
12944272024
-
Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo
-
Grandis J.R., Drenning S.D., Zeng Q., Watkins S.C., Melhem M.F., Endo S., et al. Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo. Proc Natl Acad Sci U S A 97 (2000) 4227-4232
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 4227-4232
-
-
Grandis, J.R.1
Drenning, S.D.2
Zeng, Q.3
Watkins, S.C.4
Melhem, M.F.5
Endo, S.6
-
67
-
-
0036024855
-
STAT3 activation abrogates growth factor dependence and contributes to head and neck squamous cell carcinoma tumor growth in vivo
-
Kijima T., Niwa H., Steinman R.A., Drenning S.D., Gooding W.E., Wentzel A.L., et al. STAT3 activation abrogates growth factor dependence and contributes to head and neck squamous cell carcinoma tumor growth in vivo. Cell Growth Differ 13 (2002) 355-362
-
(2002)
Cell Growth Differ
, vol.13
, pp. 355-362
-
-
Kijima, T.1
Niwa, H.2
Steinman, R.A.3
Drenning, S.D.4
Gooding, W.E.5
Wentzel, A.L.6
-
68
-
-
33646468634
-
Phosphorylation of TNF-alpha converting enzyme by gastrin-releasing peptide induces amphiregulin release and EGF receptor activation
-
Zhang Q., Thomas S.M., Lui V.W., Xi S., Siegfried J.M., Fan H., et al. Phosphorylation of TNF-alpha converting enzyme by gastrin-releasing peptide induces amphiregulin release and EGF receptor activation. Proc Natl Acad Sci U S A 103 (2006) 6901-6906
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 6901-6906
-
-
Zhang, Q.1
Thomas, S.M.2
Lui, V.W.3
Xi, S.4
Siegfried, J.M.5
Fan, H.6
-
69
-
-
4344610825
-
SRC family kinases mediate epidermal growth factor receptor ligand cleavage, proliferation, and invasion of head and neck cancer cells
-
Zhang Q., Thomas S.M., Xi S., Smithgall T.E., Siegfried J.M., Kamens J., et al. SRC family kinases mediate epidermal growth factor receptor ligand cleavage, proliferation, and invasion of head and neck cancer cells. Cancer Res 64 (2004) 6166-6173
-
(2004)
Cancer Res
, vol.64
, pp. 6166-6173
-
-
Zhang, Q.1
Thomas, S.M.2
Xi, S.3
Smithgall, T.E.4
Siegfried, J.M.5
Kamens, J.6
-
70
-
-
34249326610
-
c-Src modulates ErbB2 and ErbB3 heterocomplex formation and function
-
Ishizawar R.C., Miyake T., and Parsons S.J. c-Src modulates ErbB2 and ErbB3 heterocomplex formation and function. Oncogene 36 (2007) 3503-3510
-
(2007)
Oncogene
, vol.36
, pp. 3503-3510
-
-
Ishizawar, R.C.1
Miyake, T.2
Parsons, S.J.3
-
71
-
-
0031439247
-
Cellular functions regulated by Src family kinases
-
Thomas S.M., and Brugge J.S. Cellular functions regulated by Src family kinases. Ann Rev Cell Dev Biol 13 (1997) 513-609
-
(1997)
Ann Rev Cell Dev Biol
, vol.13
, pp. 513-609
-
-
Thomas, S.M.1
Brugge, J.S.2
-
72
-
-
0032932248
-
Activating SRC mutation in a subset of advanced human colon cancers
-
Irby R.B., Mao W., Coppola D., Kang J., Loubeau J.M., Trudeau W., et al. Activating SRC mutation in a subset of advanced human colon cancers. Nat Genet 21 (1999) 187-190
-
(1999)
Nat Genet
, vol.21
, pp. 187-190
-
-
Irby, R.B.1
Mao, W.2
Coppola, D.3
Kang, J.4
Loubeau, J.M.5
Trudeau, W.6
-
73
-
-
0033199696
-
Absence of genetic alteration at codon 531 of the human c-src gene in 479 advanced colorectal cancers from Japanese and Caucasian patients
-
Daigo Y., Furukawa Y., Kawasoe T., Ishiguro H., Fujita M., Sugai S., et al. Absence of genetic alteration at codon 531 of the human c-src gene in 479 advanced colorectal cancers from Japanese and Caucasian patients. Cancer Res 59 (1999) 4222-4224
-
(1999)
Cancer Res
, vol.59
, pp. 4222-4224
-
-
Daigo, Y.1
Furukawa, Y.2
Kawasoe, T.3
Ishiguro, H.4
Fujita, M.5
Sugai, S.6
-
74
-
-
0033848230
-
Lack of activating c-SRC mutations at codon 531 in rectal cancer
-
Nilbert M., and Fernebro E. Lack of activating c-SRC mutations at codon 531 in rectal cancer. Cancer Genet Cytogenet 121 (2000) 94-95
-
(2000)
Cancer Genet Cytogenet
, vol.121
, pp. 94-95
-
-
Nilbert, M.1
Fernebro, E.2
-
75
-
-
0034693877
-
Role of Src expression and activation in human cancer
-
Irby R.B., and Yeatman T.J. Role of Src expression and activation in human cancer. Oncogene 19 (2000) 5636-5642
-
(2000)
Oncogene
, vol.19
, pp. 5636-5642
-
-
Irby, R.B.1
Yeatman, T.J.2
-
76
-
-
0038386613
-
Src family kinases in tumor progression and metastasis
-
Summy J.M., and Gallick G.E. Src family kinases in tumor progression and metastasis. Cancer Metast Rev 22 (2003) 337-358
-
(2003)
Cancer Metast Rev
, vol.22
, pp. 337-358
-
-
Summy, J.M.1
Gallick, G.E.2
-
77
-
-
0042357187
-
Src kinases mediate STAT growth pathways in squamous cell carcinoma of the head and neck
-
Xi S., Zhang Q., Dyer K.F., Lerner E.C., Smithgall T.E., Gooding W.E., et al. Src kinases mediate STAT growth pathways in squamous cell carcinoma of the head and neck. J Biol Chem 278 (2003) 31574-31583
-
(2003)
J Biol Chem
, vol.278
, pp. 31574-31583
-
-
Xi, S.1
Zhang, Q.2
Dyer, K.F.3
Lerner, E.C.4
Smithgall, T.E.5
Gooding, W.E.6
-
78
-
-
10744219536
-
The epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 (Iressa) suppresses c-Src and Pak1 pathways and invasiveness of human cancer cells
-
Yang Z., Bagheri-Yarmand R., Wang R.A., Adam L., Papadimitrakopoulou V.V., Clayman G.L., et al. The epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 (Iressa) suppresses c-Src and Pak1 pathways and invasiveness of human cancer cells. Clin Cancer Res 10 (2004) 658-667
-
(2004)
Clin Cancer Res
, vol.10
, pp. 658-667
-
-
Yang, Z.1
Bagheri-Yarmand, R.2
Wang, R.A.3
Adam, L.4
Papadimitrakopoulou, V.V.5
Clayman, G.L.6
-
79
-
-
19944428353
-
Discovery of N- (2-chloro-6-methyl- phenyl)-2- (6- (4- (2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays
-
Lombardo L.J., Lee F.Y., Chen P., Norris D., Barrish J.C., Behnia K., et al. Discovery of N- (2-chloro-6-methyl- phenyl)-2- (6- (4- (2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays. J Med Chem 47 (2004) 6658-6661
-
(2004)
J Med Chem
, vol.47
, pp. 6658-6661
-
-
Lombardo, L.J.1
Lee, F.Y.2
Chen, P.3
Norris, D.4
Barrish, J.C.5
Behnia, K.6
-
81
-
-
26444468152
-
Dasatinib (BMS-354825) tyrosine kinase inhibitor suppresses invasion and induces cell cycle arrest and apoptosis of head and neck squamous cell carcinoma and non-small cell lung cancer cells
-
Johnson F.M., Saigal B., Talpaz M., and Donato N.J. Dasatinib (BMS-354825) tyrosine kinase inhibitor suppresses invasion and induces cell cycle arrest and apoptosis of head and neck squamous cell carcinoma and non-small cell lung cancer cells. Clin Cancer Res 11 (2005) 6924-6932
-
(2005)
Clin Cancer Res
, vol.11
, pp. 6924-6932
-
-
Johnson, F.M.1
Saigal, B.2
Talpaz, M.3
Donato, N.J.4
-
82
-
-
33846827051
-
Pyrazolo-pyrimidine-derived c-Src inhibitor reduces angiogenesis and survival of squamous cell carcinoma cells by suppressing vascular endothelial growth factor production and signaling
-
Donnini S., Monti M., Castagnini C., Solito R., Botta M.S., Giachetti A., et al. Pyrazolo-pyrimidine-derived c-Src inhibitor reduces angiogenesis and survival of squamous cell carcinoma cells by suppressing vascular endothelial growth factor production and signaling. Int J Cancer 120 (2007) 995-1004
-
(2007)
Int J Cancer
, vol.120
, pp. 995-1004
-
-
Donnini, S.1
Monti, M.2
Castagnini, C.3
Solito, R.4
Botta, M.S.5
Giachetti, A.6
-
83
-
-
30344460024
-
AP23846, a novel and highly potent Src family kinase inhibitor, reduces vascular endothelial growth factor and interleukin-8 expression in human solid tumor cell lines and abrogates downstream angiogenic processes
-
Summy J.M., Trevino J.G., Lesslie D.P., Baker C.H., Shakespeare W.C., Wang Y., et al. AP23846, a novel and highly potent Src family kinase inhibitor, reduces vascular endothelial growth factor and interleukin-8 expression in human solid tumor cell lines and abrogates downstream angiogenic processes. Mol Cancer Ther 4 (2005) 1900-1911
-
(2005)
Mol Cancer Ther
, vol.4
, pp. 1900-1911
-
-
Summy, J.M.1
Trevino, J.G.2
Lesslie, D.P.3
Baker, C.H.4
Shakespeare, W.C.5
Wang, Y.6
-
84
-
-
0031985127
-
Down-regulation of vascular endothelial growth factor in a human colon carcinoma cell line transfected with an antisense expression vector specific for c-Src
-
Ellis L.M., Staley C.A., Liu W., Fleming R.Y., Parikh N.U., Bucana C.D., et al. Down-regulation of vascular endothelial growth factor in a human colon carcinoma cell line transfected with an antisense expression vector specific for c-Src. J Biol Chem 273 (1998) 1052-1057
-
(1998)
J Biol Chem
, vol.273
, pp. 1052-1057
-
-
Ellis, L.M.1
Staley, C.A.2
Liu, W.3
Fleming, R.Y.4
Parikh, N.U.5
Bucana, C.D.6
-
85
-
-
0027772325
-
Interaction of tyrosine kinase oncoproteins with cellular membranes
-
Resh M.D. Interaction of tyrosine kinase oncoproteins with cellular membranes. Biochim Biophys Acta 1155 (1993) 307-322
-
(1993)
Biochim Biophys Acta
, vol.1155
, pp. 307-322
-
-
Resh, M.D.1
-
86
-
-
0031452274
-
Structures of Src-family tyrosine kinases
-
Sicheri F., and Kuriyan J. Structures of Src-family tyrosine kinases. Curr Opin Struct Biol 7 (1997) 777-785
-
(1997)
Curr Opin Struct Biol
, vol.7
, pp. 777-785
-
-
Sicheri, F.1
Kuriyan, J.2
-
87
-
-
0033001789
-
Crystal structures of c-Src reveal features of its autoinhibitory mechanism
-
Xu W., Doshi A., Lei M., Eck M.J., and Harrison S.C. Crystal structures of c-Src reveal features of its autoinhibitory mechanism. Mol Cell 3 (1990) 629-638
-
(1990)
Mol Cell
, vol.3
, pp. 629-638
-
-
Xu, W.1
Doshi, A.2
Lei, M.3
Eck, M.J.4
Harrison, S.C.5
-
88
-
-
0031962265
-
SH2- and SH3-mediated interactions between focal adhesion kinase and Src
-
Thomas J.W., Ellis B., Boerner R.J., Knight W.B., White II G.C., and Schaller M.D. SH2- and SH3-mediated interactions between focal adhesion kinase and Src. J Biol Chem 273 (1998) 577-583
-
(1998)
J Biol Chem
, vol.273
, pp. 577-583
-
-
Thomas, J.W.1
Ellis, B.2
Boerner, R.J.3
Knight, W.B.4
White II, G.C.5
Schaller, M.D.6
-
89
-
-
0028898383
-
Sequence requirements for binding of Src family tyrosine kinases to activated growth factor receptors
-
Alonso G., Koegl M., Mazurenko N., and Courtneidge S.A. Sequence requirements for binding of Src family tyrosine kinases to activated growth factor receptors. J Biol Chem 270 (1995) 9840-9848
-
(1995)
J Biol Chem
, vol.270
, pp. 9840-9848
-
-
Alonso, G.1
Koegl, M.2
Mazurenko, N.3
Courtneidge, S.A.4
-
90
-
-
33947128720
-
C-terminal Src kinase controls development and maintenance of mouse squamous epithelium
-
Yagi R., Waguri S., Sumikawa Y., Nada S., Oneyama C., Itami S., et al. C-terminal Src kinase controls development and maintenance of mouse squamous epithelium. EMBO J 26 (2007) 1234-1244
-
(2007)
EMBO J
, vol.26
, pp. 1234-1244
-
-
Yagi, R.1
Waguri, S.2
Sumikawa, Y.3
Nada, S.4
Oneyama, C.5
Itami, S.6
-
91
-
-
0026355723
-
CSK: a protein kinase involved in regulation of src family kinases
-
Okada M., Nada S., Yamanashi Y., Yamamoto T., and Nakagawa H. CSK: a protein kinase involved in regulation of src family kinases. J Biol Chem 266 (1991) 24249-24252
-
(1991)
J Biol Chem
, vol.266
, pp. 24249-24252
-
-
Okada, M.1
Nada, S.2
Yamanashi, Y.3
Yamamoto, T.4
Nakagawa, H.5
-
92
-
-
17444374230
-
Src kinase regulation by phosphorylation and dephosphorylation
-
Roskoski Jr. R. Src kinase regulation by phosphorylation and dephosphorylation. Biochem Biophys Res Commun 331 (2005) 1-14
-
(2005)
Biochem Biophys Res Commun
, vol.331
, pp. 1-14
-
-
Roskoski Jr., R.1
-
93
-
-
85047696594
-
Src kinase contributes to the metastatic spread of carcinoma cells
-
Boyer B., Bourgeois Y., and Poupon M.F. Src kinase contributes to the metastatic spread of carcinoma cells. Oncogene 21 (2002) 2347-2356
-
(2002)
Oncogene
, vol.21
, pp. 2347-2356
-
-
Boyer, B.1
Bourgeois, Y.2
Poupon, M.F.3
-
94
-
-
0033810059
-
Overexpression of the csk gene suppresses tumor metastasis in vivo
-
Nakagawa T., Tanaka S., Suzuki H., Takayanagi H., Miyazaki T., Nakamura K., et al. Overexpression of the csk gene suppresses tumor metastasis in vivo. Int J Cancer 88 (2000) 384-391
-
(2000)
Int J Cancer
, vol.88
, pp. 384-391
-
-
Nakagawa, T.1
Tanaka, S.2
Suzuki, H.3
Takayanagi, H.4
Miyazaki, T.5
Nakamura, K.6
-
95
-
-
0035395989
-
Reduced C-terminal Src kinase activity is correlated inversely with pp60 (c-src) activity in colorectal carcinoma
-
Cam W.R., Masaki T., Shiratori Y., Kato N., Ikenoue T., Okamoto M., et al. Reduced C-terminal Src kinase activity is correlated inversely with pp60 (c-src) activity in colorectal carcinoma. Cancer 92 (2001) 61-70
-
(2001)
Cancer
, vol.92
, pp. 61-70
-
-
Cam, W.R.1
Masaki, T.2
Shiratori, Y.3
Kato, N.4
Ikenoue, T.5
Okamoto, M.6
-
96
-
-
0032987119
-
Reduced C-terminal Src kinase (Csk) activities in hepatocellular carcinoma
-
Masaki T., Okada M., Tokuda M., Shiratori Y., Hatase O., Shirai M., et al. Reduced C-terminal Src kinase (Csk) activities in hepatocellular carcinoma. Hepatology 29 (1999) 379-384
-
(1999)
Hepatology
, vol.29
, pp. 379-384
-
-
Masaki, T.1
Okada, M.2
Tokuda, M.3
Shiratori, Y.4
Hatase, O.5
Shirai, M.6
-
97
-
-
0034731372
-
Identification of protein-tyrosine phosphatase 1B as the major tyrosine phosphatase activity capable of dephosphorylating and activating c-Src in several human breast cancer cell lines
-
Bjorge J.D., Pang A., and Fujita D.J. Identification of protein-tyrosine phosphatase 1B as the major tyrosine phosphatase activity capable of dephosphorylating and activating c-Src in several human breast cancer cell lines. J Biol Chem 275 (2000) 41439-41446
-
(2000)
J Biol Chem
, vol.275
, pp. 41439-41446
-
-
Bjorge, J.D.1
Pang, A.2
Fujita, D.J.3
-
98
-
-
29144464371
-
Advances in the structural biology, design and clinical development of Bcr-Abl kinase inhibitors for the treatment of chronic myeloid leukaemia
-
Manley P.W., Cowan-Jacob S.W., and Mestan J. Advances in the structural biology, design and clinical development of Bcr-Abl kinase inhibitors for the treatment of chronic myeloid leukaemia. Biochim Biophys Acta 1754 (2005) 3-13
-
(2005)
Biochim Biophys Acta
, vol.1754
, pp. 3-13
-
-
Manley, P.W.1
Cowan-Jacob, S.W.2
Mestan, J.3
-
99
-
-
44649155379
-
Effect of dasatinib, a Src kinase inhibitor, on lung cancer cells with defined epidermal growth factor receptor status [abstract]
-
Haura E.B., Song L., Lee F., Jove R., et al. Effect of dasatinib, a Src kinase inhibitor, on lung cancer cells with defined epidermal growth factor receptor status [abstract]. J Clin Oncol Proc Am Soc Clin Oncol 24 (2006) 3019
-
(2006)
J Clin Oncol Proc Am Soc Clin Oncol
, vol.24
, pp. 3019
-
-
Haura, E.B.1
Song, L.2
Lee, F.3
Jove, R.4
-
100
-
-
44649110547
-
-
Koppikar P, Choi SH, Egloff AM, Suzuki S, Freilino M, Cai Q, et al. Combined inhibition of c-Src and epidermal growth factor receptor abrogates growth and invasion of head and neck squamous cell carcinoma. Clin Cancer Res. In press.
-
Koppikar P, Choi SH, Egloff AM, Suzuki S, Freilino M, Cai Q, et al. Combined inhibition of c-Src and epidermal growth factor receptor abrogates growth and invasion of head and neck squamous cell carcinoma. Clin Cancer Res. In press.
-
-
-
-
101
-
-
34249776956
-
Src kinase promotes adhesion-independent activation of FAK and enhances cellular migration in tamoxifen-resistant breast cancer cells
-
Hiscox S., Jordan N.J., Morgan L., Green T.P., and Nicholson R.I. Src kinase promotes adhesion-independent activation of FAK and enhances cellular migration in tamoxifen-resistant breast cancer cells. Clin Exp Metast 24 (2007) 157-167
-
(2007)
Clin Exp Metast
, vol.24
, pp. 157-167
-
-
Hiscox, S.1
Jordan, N.J.2
Morgan, L.3
Green, T.P.4
Nicholson, R.I.5
-
102
-
-
33846870586
-
Src as a therapeutic target in anti-hormone/anti-growth factor-resistant breast cancer
-
Hiscox S., Morgan L., Green T., and Nicholson R.I. Src as a therapeutic target in anti-hormone/anti-growth factor-resistant breast cancer. Endocr Relat Cancer 13 (2006) S53-S59
-
(2006)
Endocr Relat Cancer
, vol.13
-
-
Hiscox, S.1
Morgan, L.2
Green, T.3
Nicholson, R.I.4
-
103
-
-
33846235881
-
Cooperative action of tamoxifen and c-Src inhibition in preventing the growth of estrogen receptor-positive human breast cancer cells
-
Herynk M.H., Beyer A.R., Cui Y., Weiss H., Anderson E., Green T.P., et al. Cooperative action of tamoxifen and c-Src inhibition in preventing the growth of estrogen receptor-positive human breast cancer cells. Mol Cancer Ther 5 (2006) 3023-3031
-
(2006)
Mol Cancer Ther
, vol.5
, pp. 3023-3031
-
-
Herynk, M.H.1
Beyer, A.R.2
Cui, Y.3
Weiss, H.4
Anderson, E.5
Green, T.P.6
-
104
-
-
37549008466
-
Preclinical evaluation of the dual specific Src/Abl kinase inhibitor AZD0530 in lung cancer [abstract]
-
Gautschi O., Purnell P., Evans C.P., Yang J.C., Holland W.S., Bold R.J., et al. Preclinical evaluation of the dual specific Src/Abl kinase inhibitor AZD0530 in lung cancer [abstract]. J Clin Oncol Proc Am Soc Clin Oncol 24 (2006) 13108
-
(2006)
J Clin Oncol Proc Am Soc Clin Oncol
, vol.24
, pp. 13108
-
-
Gautschi, O.1
Purnell, P.2
Evans, C.P.3
Yang, J.C.4
Holland, W.S.5
Bold, R.J.6
-
105
-
-
29144523093
-
Phase I ascending single and multiple dose studies to assess the safety, tolerability and pharmacokinetics of AZD0530, a highly selective, dual-specific Src-Abl inhibitor [abstract]
-
Lockton J.A., Smethurst D., Macpherson M., Tootell R., Marshall A.L., Clack G., et al. Phase I ascending single and multiple dose studies to assess the safety, tolerability and pharmacokinetics of AZD0530, a highly selective, dual-specific Src-Abl inhibitor [abstract]. J Clin Oncol Proc Am Soc Clin Oncol 23 (2005) 3125
-
(2005)
J Clin Oncol Proc Am Soc Clin Oncol
, vol.23
, pp. 3125
-
-
Lockton, J.A.1
Smethurst, D.2
Macpherson, M.3
Tootell, R.4
Marshall, A.L.5
Clack, G.6
-
106
-
-
36048947549
-
Phase I study of AZD00530, an oral potent inhibitor of Src kinase: first demonstration of inhibition of Src activity in human cancers
-
Tabernero J., Cervanter A., Hoekman K., Hurwitz H.I., Jodrell D.I., Hamberg P., et al. Phase I study of AZD00530, an oral potent inhibitor of Src kinase: first demonstration of inhibition of Src activity in human cancers. J Clin Oncol Proc Am Soc Clin Oncol 25 (2007) 3520
-
(2007)
J Clin Oncol Proc Am Soc Clin Oncol
, vol.25
, pp. 3520
-
-
Tabernero, J.1
Cervanter, A.2
Hoekman, K.3
Hurwitz, H.I.4
Jodrell, D.I.5
Hamberg, P.6
-
107
-
-
37549042561
-
A phase I study (CA180021-Segment 2) of dasatinib in patients (pts) with advanced solid tumors [abstract]
-
Johnson F.M., Chiappori A., Burris H., Rosen L., McCann B., Luo F.R., et al. A phase I study (CA180021-Segment 2) of dasatinib in patients (pts) with advanced solid tumors [abstract]. J Clin Oncol Proc Am Soc Clin Oncol 25 (2007) 14042
-
(2007)
J Clin Oncol Proc Am Soc Clin Oncol
, vol.25
, pp. 14042
-
-
Johnson, F.M.1
Chiappori, A.2
Burris, H.3
Rosen, L.4
McCann, B.5
Luo, F.R.6
-
108
-
-
44649123074
-
-
Hiscox S, Morgan L, Green TP, Barrow D, Gee J, Nicholson RI. Elevated Src activity promotes cellular invasion and motility in tamoxifen resistant breast cancer cells. Breast Cancer Res Treat. 20051-12
-
Hiscox S, Morgan L, Green TP, Barrow D, Gee J, Nicholson RI. Elevated Src activity promotes cellular invasion and motility in tamoxifen resistant breast cancer cells. Breast Cancer Res Treat. 20051-12
-
-
-
-
109
-
-
44649097896
-
-
Am Soc Clin Oncol Gastrointestinal Cancers Symposium. Orlando, FL, January 19-21
-
Kopetz S., Wu J., Davies M., Johnson F., and Donato N. Synergistic effects of combination therapy with anti-EGFR and anti-Src therapy in vitro in colon cancer [abstract 406]. Am Soc Clin Oncol Gastrointestinal Cancers Symposium. Orlando, FL, January 19-21 (2007)
-
(2007)
Synergistic effects of combination therapy with anti-EGFR and anti-Src therapy in vitro in colon cancer [abstract 406]
-
-
Kopetz, S.1
Wu, J.2
Davies, M.3
Johnson, F.4
Donato, N.5
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