Noncovalent functionalization of carbon nanovectors with an antibody enables targeted drug delivery

ACS Nano

Volumn 5, Issue 8, 2011, Pages 6643-6650

  Berlin, Jacob M ^a   Pham, Tam T ^a   Sano, Daisuke ^c   Mohamedali, Khalid A ^a   Marcano, Daniela C ^a   Myers, Jeffrey N ^c   Tour, James M ^a,b  

^a Department of Chemistry ^*  (United States)

^b RICE UNIVERSITY   (United States)

^c UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

drug delivery; nanovectors; noncovalent; paclitaxel; targeted

Indexed keywords

CANCER CELLS; CANCER DRUG; CARBON NANO PARTICLES; CELL KILLING; CETUXIMAB; EPIDERMAL GROWTH FACTOR RECEPTORS; FUNCTIONALIZED; HIGH-THROUGHPUT SCREENING; IN-VITRO; IN-VIVO; NANOVECTORS; NON-COVALENT FUNCTIONALIZATION; NON-COVALENT INTERACTION; NONCOVALENT; NONCOVALENT ASSEMBLIES; PACLITAXEL; SIDE EFFECT; TARGETED; TARGETED DELIVERY; TARGETED DRUG DELIVERY; THREE COMPONENT; TUMOR CELLS;

DISEASES; DRUG INTERACTIONS; ETHYLENE; GLYCOLS; MONOCLONAL ANTIBODIES; NANOPARTICLES; PHYSISORPTION; POLYETHYLENE GLYCOLS; TUMORS;

DRUG DELIVERY;

CARBON; CETUXIMAB; DRUG CARRIER; EPIDERMAL GROWTH FACTOR RECEPTOR; MACROGOL DERIVATIVE; MONOCLONAL ANTIBODY; NANOMATERIAL; PACLITAXEL;

ANIMAL; ARTICLE; CELL STRAIN 3T3; CELL SURVIVAL; CHEMICAL PHENOMENA; CHEMISTRY; DRUG EFFECT; HUMAN; METABOLISM; MOUSE; TUMOR CELL LINE;

ANIMALS; ANTIBODIES, MONOCLONAL; CARBON; CELL LINE, TUMOR; CELL SURVIVAL; DRUG CARRIERS; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MICE; NANOSTRUCTURES; NIH 3T3 CELLS; PACLITAXEL; POLYETHYLENE GLYCOLS; RECEPTOR, EPIDERMAL GROWTH FACTOR;

EID: 80052042016     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn2021293     Document Type: Article

References (30)

1. O'Driscoll, C. M.; Griffin, B. T. Biopharmaceutical Challenges Associated with Drugs with Low Aqueous Solubility: The Potential Impact of Lipid-Based Formulations Adv. Drug Delivery Rev. 2008, 60, 617-624
2. Stinchcombe, T. E. Nanoparticle Albumin-Bound Paclitaxel: A Novel Cremphor-EL(R)-Free Formulation of Paclitaxel Nanomedicine 2007, 2, 415-423 (Pubitemid 47365124)
3. Gradishar, W. J.; Tjulandin, S.; Davidson, N.; Shaw, H.; Desai, N.; Bhar, P.; Hawkins, M.; O'Shaughnessy, J. Phase III Trial of Nanoparticle Albumin-Bound Paclitaxel Compared with Polyethylated Castor Oil-Based Paclitaxel in Women with Breast Cancer J. Clin. Oncol. 2005, 23, 7794-7803 (Pubitemid 46657376)
4. Gursoy, N.; Garrigue, J. S.; Razafindratsita, A.; Lambert, G.; Benita, S. Excipient Effects on In Vitro Cytotoxicity of a Novel Paclitaxel Self-Emulsifying Drug Delivery System J. Pharm. Sci. 2003, 92, 2411-2418 (Pubitemid 37484767)
5. Chen, H. M.; Zhang, Z.; McNulty, C.; Olbert, C.; Yoon, H. J.; Lee, J. W.; Kim, S. C.; Seo, M. H.; Oh, H. S.; Lemmo, A. V. et al. A High-Throughput Combinatorial Approach for the Discovery of a Cremophor EL-Free Paclitaxel Formulation Pharm. Res. 2003, 20, 1302-1308 (Pubitemid 36951856)
6. Crosasso, P.; Ceruti, M.; Brusa, P.; Arpicco, S.; Dosio, F.; Cattel, L. Preparation, Characterization and Properties of Sterically Stabilized Paclitaxel-Containing Liposomes J. Controlled Release 2000, 63, 19-30 (Pubitemid 30046939)
7. Shuai, X. T.; Merdan, T.; Schaper, A. K.; Xi, F.; Kissel, T. Core-Cross-Linked Polymeric Micelles as Paclitaxel Carriers Bioconjugate Chem. 2004, 15, 441-448 (Pubitemid 38657848)
8. Ruan, G.; Feng, S. S. Preparation and Characterization of Poly(lactic acid)-Poly(ethylene glycol)-Poly(lactic acid) (PLA-PEG-PLA) Microspheres for Controlled Release of Paclitaxel Biomaterials 2003, 24, 5037-5044 (Pubitemid 37242983)
9. Ferrari, M. Cancer Nanotechnology: Opportunities and Challenges Nat. Rev. Cancer 2005, 5, 161-171 (Pubitemid 40314948)
10. Riehemann, K.; Schneider, S. W.; Luger, T. A.; Godin, B.; Ferrari, M.; Fuchs, H. Nanomedicine: Challenge and Perspectives Angew. Chem., Int. Ed. 2009, 48, 872-897
11. Berlin, J. M.; Leonard, A. D.; Pham, T. T.; Sano, D.; Marcano, D. C.; Yan, S. Y.; Fiorentino, S.; Milas, Z. L.; Kosynkin, D. V.; Price, B. K. et al. Effective Drug Delivery, In Vitro and In Vivo, by Carbon-Based Nanovectors Noncovalently Loaded with Unmodified Paclitaxel ACS Nano 2010, 4, 4621-4636
12. Berlin, J. M.; Pham, T. T.; Marcano, D. C.; Sano, D.; Lu, W.; Myers, J. N.; Tour, J. M. In Vitro Drug Delivery of Unmodified Paclitaxel Non-covalently Loaded on Carbon Nanovectors of Diverse Shape and Composition. Chem. Mater. 2011, in press.
13. Peer, D.; Karp, J. M.; Hong, S.; Farokhzad, O. C.; Margalit, R.; Langer, R. Nanocarriers as an Emerging Platform for Cancer Therapy Nat. Nanotechnol. 2007, 2, 751-760 (Pubitemid 350223348)
14. Alley, S. C.; Okeley, N. M.; Senter, P. D. Antibody-Drug Conjugates: Targeted Drug Delivery for Cancer Curr. Opin. Chem. Biol. 2010, 14, 529-537
15. Fay, F.; Scott, C. J. Antibody-Targeted Nanoparticles for Cancer Therapy Immunotherapy 2011, 3, 381-394
16. Bonner, J. A.; Raisch, K. P.; Trummell, H. Q.; Robert, F.; Meredith, R. F.; Spencer, S. A.; Buchsbaum, D. J.; Saleh, M. N.; Stackhouse, M. A.; LoBuglio, A. F. et al. Enhanced Apoptosis with Combination C225/Radiation Treatment Serves as the Impetus for Clinical Investigation in Head and Neck Cancers J. Clin. Oncol. 2000, 18, 47s-53s
17. Grandis, J. R.; Melhem, M. F.; Gooding, W. E.; Day, R.; Holst, V. A.; Wagener, M. M.; Drenning, S. D.; Tweardy, D. J. Levels of TGF-α and EGFR Protein in Head and Neck Squamous Cell Carcinoma and Patient Survival J. Natl. Cancer Inst. 1998, 90, 824-832 (Pubitemid 28280548)
18. Bonner, J. A.; Maihle, N. J.; Folven, B. R.; Christianson, T. J. H.; Spain, K. The Interaction of Epidermal Growth-Factor and Radiation in Human Head and Neck Squamous-Cell Carcinoma Cell-Lines with Vastly Different Radiosensitivities Int. J. Radiat. Oncol. 1994, 29, 243-247 (Pubitemid 24166526)
19. Huang, S. M.; Bock, J. M.; Harari, P. M. Epidermal Growth Factor Receptor Blockade with C225 Modulates Proliferation, Apoptosis, and Radiosensitivity in Squamous Cell Carcinomas of the Head and Neck Cancer Res. 1999, 59, 1935-1940 (Pubitemid 29186168)
20. Saleh, M. N.; Raisch, K. P.; Stackhouse, M. A.; Grizzle, W. E.; Bonner, J. A.; Mayo, M. S.; Kim, H. G.; Meredith, R. F.; Wheeler, R. H.; Buchsbaum, D. J. Combined Modality Therapy of A431 Human Epidermoid Cancer Using Anti-EGFr Antibody C225 and Radiation Cancer Biother. Radiopharm. 1999, 14, 451-463 (Pubitemid 30029793)
21. Vermorken, J. B.; Mesia, R.; Rivera, F.; Remenar, E.; Kawecki, A.; Rottey, S.; Erfan, J.; Zabolotnyy, D.; Kienzer, H. R.; Cupissol, D. et al. Platinum-Based Chemotherapy Plus Cetuximab in Head and Neck Cancer N. Engl. J. Med. 2008, 359, 1116-1127
22. Bonner, J. A.; Harari, P. M.; Giralt, J.; Azarnia, N.; Shin, D. M.; Cohen, R. B.; Jones, C. U.; Sur, R.; Raben, D.; Jassem, J. et al. Radiotherapy Plus Cetuximab for Squamous-Cell Carcinoma of the Head and Neck N. Engl. J. Med. 2006, 354, 567-578 (Pubitemid 43209104)
23. Low, K.; Wacker, M.; Wagner, S.; Langer, K.; von Briesen, H. Targeted Human Serum Albumin Nanoparticles for Specific Uptake in EGFR-Expressing Colon Carcinoma Cells. Nanomedicine 2011, DOI: 10.1016/j.nano.2010.12.003.
24. Glazer, E. S.; Curley, S. A. Radiofrequency Field-Induced Thermal Cytotoxicity in Cancer Cells Treated with Fluorescent Nanoparticles Cancer 2010, 116, 3285-3293
25. Curley, S. A.; Cherukuri, P.; Briggs, K.; Patra, C. R.; Upton, M.; Dolson, E.; Mukherjee, P. Noninvasive Radiofrequency Field-Induced Hyperthermic Cytotoxicity in Human Cancer Cells Using Cetuximab-Targeted Gold Nanoparticles J. Exp. Ther. Oncol. 2008, 7, 313-326
26. Bhirde, A. A.; Patel, V.; Gavard, J.; Zhang, G.; Sousa, A. A.; Masedunskas, A.; Leapman, R. D.; Weigert, R.; Gutkind, J. S.; Rusling, J. F. Targeted Killing of Cancer Cells in Vivo and in Vitro with EGF-Directed Carbon Nanotube-Based Drug Delivery ACS Nano 2009, 3, 307-316
27. Price, B. K.; Lomeda, J. R.; Tour, J. M. Aggressively Oxidized Ultra-short Single-Walled Carbon Nanotubes Having Oxidized Sidewalls Chem. Mater. 2009, 21, 3917-3923
28. Stephenson, J. J.; Hudson, J. L.; Leonard, A. D.; Price, B. K.; Tour, J. M. Repetitive Functionalization of Water-Soluble Single-Walled Carbon Nanotubes. Addition of Acid-Sensitive Addends Chem. Mater. 2007, 19, 3491-3498 (Pubitemid 47155029)
29. Chen, Z. Y.; Kobashi, K.; Rauwald, U.; Booker, R.; Fan, H.; Hwang, W. F.; Tour, J. M. Soluble Ultra-short Single-Walled Carbon Nanotubes J. Am. Chem. Soc. 2006, 128, 10568-10571 (Pubitemid 44265099)
30. Zhou, G.; Xie, T. X.; Zhao, M.; Jasser, S. A.; Younes, M. N.; Sano, D.; Lin, J.; Kupferman, M. E.; Santillan, A. A.; Patel, V. et al. Reciprocal Negative Regulation between S100A7/Psoriasin and β-Catenin Signaling Plays an Important Role in Tumor Progression of Squamous Cell Carcinoma of Oral Cavity Oncogene 2008, 27, 3527-3538 (Pubitemid 351793795)