Increasing both CoCrMo-alloy particle size and surface irregularity induces increased macrophage inflammasome activation in vitro potentially through lysosomal destabilization mechanisms

Journal of Orthopaedic Research

Volumn 31, Issue 10, 2013, Pages 1633-1642

  Caicedo, Marco S ^a,b   Samelko, Lauryn ^a   McAllister, Kyron ^a   Jacobs, Joshua J ^a   Hallab, Nadim J ^a,b  

^a RUSH UNIVERSITY MEDICAL CENTER   (United States)

^b Orthopedic Analysis LLC   (United States)

Author keywords

Cathepsin B; inflammasome; lysosomal destabilization; metal particles; monocytes macrophages

Indexed keywords

ALLOY; CATHEPSIN B; CHROMIUM; COBALT; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; MOLYBDENUM; NICKEL; NIGERICIN; PROTEINASE;

ARTICLE; CELL DIFFERENTIATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME RELEASE; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IN VITRO STUDY; LYSOSOME; MACROPHAGE; MONOCYTE; PARTICLE SIZE; PHAGOCYTOSIS; PRIORITY JOURNAL; SURFACE PROPERTY;

CATHEPSIN B; INFLAMMASOME; LYSOSOMAL DESTABILIZATION; METAL PARTICLES; MONOCYTES/MACROPHAGES;

ALLOYS; CARRIER PROTEINS; CASPASE 1; CATHEPSIN B; CELLS, CULTURED; CHROMIUM; COBALT; HUMANS; INFLAMMASOMES; INTERLEUKIN-1BETA; LYSOSOMES; MACROPHAGE ACTIVATION; MACROPHAGES; MOLYBDENUM; MONOCYTES; PARTICLE SIZE; PHAGOCYTOSIS; RNA, SMALL INTERFERING; SURFACE PROPERTIES;

EID: 84882840168     PISSN: 07360266     EISSN: 1554527X     Source Type: Journal    
DOI: 10.1002/jor.22411     Document Type: Article

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