Structure-based engineering of streptavidin monomer with a reduced biotin dissociation rate

Proteins: Structure, Function and Bioinformatics

Volumn 81, Issue 9, 2013, Pages 1621-1633

  Demonte, Daniel ^a   Drake, Eric J ^b   Lim, Kok Hong ^a,d   Gulick, Andrew M ^b,c   Park, Sheldon ^a  

^a State University of New York   (United States)

^b HAUPTMAN WOODWARD MEDICAL RESEARCH INSTITUTE   (United States)

^c UNIVERSITY AT BUFFALO   (United States)

^d Johns Hopkins University   (United States)

Author keywords

Molecular dynamics; Protein ligand interaction; Rational design; Streptavidin; Yeast display

Indexed keywords

BACTERIAL PROTEIN; BIOTIN; MONOMER; SHWANAVIDIN; STREPTAVIDIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING KINETICS; COMPARATIVE STUDY; CRYSTAL STRUCTURE; DISSOCIATION; HYDROGEN BOND; LIGAND BINDING; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ENGINEERING; PROTEIN STRUCTURE;

MOLECULAR DYNAMICS; PROTEIN-LIGAND INTERACTION; RATIONAL DESIGN; STREPTAVIDIN; YEAST DISPLAY;

BINDING SITES; BIOTIN; KINETICS; MOLECULAR DYNAMICS SIMULATION; PROTEIN BINDING; PROTEIN ENGINEERING; STREPTAVIDIN;

EID: 84882832274     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.24320     Document Type: Article

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