The antimicrobial lysine-peptoid hybrid LP5 inhibits DNA replication and induces the SOS response in Staphylococcus aureus

BMC Microbiology

Volumn 13, Issue 1, 2013, Pages

  Gottschalk, Sanne ^a,d   Ifrah, Dan ^a   Lerche, Sandra ^a,d   Gottlieb, Caroline T ^b,e   Cohn, Marianne T ^a,f   Hiasa, Hiroshi ^c   Hansen, Paul R ^a   Gram, Lone ^b   Ingmer, Hanne ^a   Thomsen, Line E ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^c UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^d NOVO NORDISK A S   (Denmark)

^e CHR HANSEN A S   (Denmark)

^f NOVOZYMES A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; DNA TOPOISOMERASE (ATP HYDROLYSING); DNA TOPOISOMERASE IV; LP5 PROTEIN; LYSINE; PEPTOID; PLASMID DNA; POLYPEPTIDE ANTIBIOTIC AGENT; SYNTHETIC PEPTIDE; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL CELL; BACTERIAL GROWTH; BACTERIAL MEMBRANE; BACTERICIDAL ACTIVITY; CHEMICAL STRUCTURE; DNA REPAIR; DNA REPLICATION; DRUG DNA BINDING; GROWTH INHIBITION; IN VITRO STUDY; MACROMOLECULE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PEPTIDE SYNTHESIS; STAPHYLOCOCCUS AUREUS;

ADENOSINE TRIPHOSPHATE; ANTIMICROBIAL CATIONIC PEPTIDES; DNA GYRASE; DNA REPLICATION; MICROBIAL SENSITIVITY TESTS; PEPTOIDS; SOS RESPONSE (GENETICS); STAPHYLOCOCCUS AUREUS;

EID: 84882798678     PISSN: None     EISSN: 14712180     Source Type: Journal    
DOI: 10.1186/1471-2180-13-192     Document Type: Article

References (43)

1. Antimicrobial peptides of multicellular organisms. Zasloff M, Nature 2002 415 389 395 10.1038/415389a 11807545 (Pubitemid 34100944)
2. Cationic host defense (antimicrobial) peptides. Brown KL, Hancock RE, Curr Opin Immunol 2006 18 24 30 10.1016/j.coi.2005.11.004 16337365 (Pubitemid 43049644)
3. AMPed up immunity: how antimicrobial peptides have multiple roles in immune defense. Lai Y, Gallo RL, Trends Immunol 2009 30 131 141 10.1016/j.it.2008.12.003 19217824
4. Antimicrobial peptides: key components of the innate immune system. Pasupuleti M, Schmidtchen A, Malmsten M, Crit Rev Biotechnol 2012 32 143 171 10.3109/07388551.2011.594423 22074402
5. Peptide antimicrobial agents. Jenssen H, Hamill P, Hancock RE, Clin Microbiol Rev 2006 19 491 511 10.1128/CMR.00056-05 16847082 (Pubitemid 44137212)
6. Antibacterial peptides for therapeutic use: obstacles and realistic outlook. Marr AK, Gooderham WJ, Hancock RE, Curr Opin Pharmacol 2006 6 468 472 10.1016/j.coph.2006.04.006 16890021 (Pubitemid 44340665)
7. Peptoids that mimic the structure, function, and mechanism of helical antimicrobial peptides. Chongsiriwatana NP, Patch JA, Czyzewski AM, Dohm MT, Ivankin A, Gidalevitz D, Zuckermann RN, Barron AE, Proc Natl Acad Sci U S A 2008 105 2794 2799 10.1073/pnas.0708254105 18287037 (Pubitemid 351723623)
8. Antimicrobial peptide mimics for improved therapeutic properties. Rotem S, Mor A, Biochim Biophys Acta 2009 1788 1582 1592 10.1016/j.bbamem.2008.10.020 19028449
9. De novo designed synthetic mimics of antimicrobial peptides. Scott RW, DeGrado WF, Tew GN, Curr Opin Biotechnol 2008 19 620 627 10.1016/j.copbio.2008. 10.013 18996193
10. Peptoids: a modular approach to drug discovery. Simon RJ, Kania RS, Zuckermann RN, Huebner VD, Jewell DA, Banville S, Ng S, Wang L, Rosenberg S, Marlowe CK, Proc Natl Acad Sci U S A 1992 89 9367 9371 10.1073/pnas.89.20.9367 1409642
11. Efficient method for the preparation of peptoids [oligo(N-substituted glycines)] by submonomer solid-phase synthesis. Zuckermann RN, Kerr JM, Kent SBH, Moos WH, J Am Chem Soc 1992 114 10646 10647 10.1021/ja00052a076
12. Beyond natural antimicrobial peptides: multimeric peptides and other peptidomimetic approaches. Giuliani A, Rinaldi AC, Cell Mol Life Sci 2011 68 2255 2266 10.1007/s00018-011-0717-3 21598022
13. Proteolytic studies of homologous peptide and N-substituted glycine peptoid oligomers. Miller SM, Simon RJ, Ng S, Zuckermann RN, Kerr JM, Moos WH, Bioorg Med Chem Lett 1994 4 2657 2662 10.1016/S0960-894X(01)80691-0 (Pubitemid 24352734)
14. Antimicrobial activities of twenty lysine-peptoid hybrids against clinically relevant bacteria and fungi. Ryge TS, Frimodt-Moller N, Hansen PR, Chemotherapy 2008 54 152 156 10.1159/000119707 18332629 (Pubitemid 351448603)
15. Novel lysine-peptoid hybrids with antibacterial properties. Ryge TS, Hansen PR, J Pept Sci 2005 11 727 734 10.1002/psc.705 16161020 (Pubitemid 41684259)
16. Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America. Boucher HW, Talbot GH, Bradley JS, Edwards JE, Gilbert D, Rice LB, Scheld M, Spellberg B, Bartlett J, Clin Infect Dis 2009 48 1 12 10.1086/595011 19035777
17. Alternative mechanisms of action of cationic antimicrobial peptides on bacteria. Hale JDF, Hancock REW, Expert Rev Anti infect Ther 2007 5 951 959 10.1586/14787210.5.6.951 18039080 (Pubitemid 350303026)
18. The co-evolution of host cationic antimicrobial peptides and microbial resistance. Peschel A, Sahl HG, Nat Rev Microbiol 2006 4 529 536 10.1038/nrmicro1441 16778838 (Pubitemid 43905612)
19. Analogous oligo-acyl-lysines with distinct antibacterial mechanisms. Rotem S, Radzishevsky IS, Bourdetsky D, Navon-Venezia S, Carmeli Y, Mor A, FASEB J 2008 22 2652 2661 10.1096/fj.07-105015 18385215
20. Mechanisms mediating bactericidal properties and conditions that enhance the potency of a broad-spectrum oligo-acyl-lysyl. Sarig H, Goldfeder Y, Rotem S, Mor A, Antimicrob Agents Chemother 2011 55 688 695 10.1128/AAC.00666-10 21078924
21. DNA repair, a novel antibacterial target: Holliday junction-trapping peptides induce DNA damage and chromosome segregation defects. Gunderson CW, Segall AM, Mol Microbiol 2006 59 1129 1148 10.1111/j.1365-2958.2005.05009.x 16430689
22. The bacterial LexA transcriptional repressor. Butala M, Zgur-Bertok D, Busby SJ, Cell Mol Life Sci 2009 66 82 93 10.1007/s00018-008-8378-6 18726173
23. Regulation of bacterial RecA protein function. Cox MM, Crit Rev Biochem Mol Biol 2007 42 41 63 10.1080/10409230701260258 17364684 (Pubitemid 46391133)
24. Properties of a cryptic high-frequency transducing phage in Staphylococcus aureus. Novick R, Virology 1967 33 155 166 10.1016/0042-6822(67) 90105-5 4227577
25. Complete genome sequence of USA300, an epidemic clone of community-acquired meticillin-resistant Staphylococcus aureus. Diep BA, Gill SR, Chang RF, Phan TH, Chen JH, Davidson MG, Lin F, Lin J, Carleton HA, Mongodin EF, Sensabaugh GF, Perdreau-Remington F, Lancet 2006 367 731 739 10.1016/S0140-6736(06)68231-7 16517273 (Pubitemid 43326291)
26. Molecular mechanism of antimicrobial peptides: The origin of cooperativity. Huang HW, Biochim Biophys Acta 2006 1758 1292 1302 10.1016/j.bbamem.2006.02.001 16542637 (Pubitemid 44436067)
27. Structural and DNA-binding studies on the bovine antimicrobial peptide, indolicidin: evidence for multiple conformations involved in binding to membranes and DNA. Hsu CH, Chen C, Jou ML, Lee AY, Lin YC, Yu YP, Huang WT, Wu SH, Nucleic Acids Res 2005 33 4053 4064 10.1093/nar/gki725 16034027 (Pubitemid 41487266)
28. The oligo-acyl lysyl antimicrobial peptide C12K-2beta12 exhibits a dual mechanism of action and demonstrates strong in vivo efficacy against Helicobacter pylori. Makobongo MO, Gancz H, Carpenter BM, McDaniel DP, Merrell DS, Antimicrob Agents Chemother 2012 56 378 390 10.1128/AAC.00689-11 22064541
29. Mechanism of interaction of different classes of cationic antimicrobial peptides with planar bilayers and with the cytoplasmic membrane of Escherichia coli. Wu M, Maier E, Benz R, Hancock RE, Biochemistry 1999 38 7235 7242 10.1021/bi9826299 10353835 (Pubitemid 29262785)
30. Sublethal Concentrations of pleurocidin-derived antimicrobial peptides inhibit macromolecular synthesis in Escherichia coli. Patrzykat A, Friedrich CL, Zhang L, Mendoza V, Hancock REW, Antimicrob Agents Chemother 2002 46 605 614 10.1128/AAC.46.3.605-614.2002 11850238 (Pubitemid 34162506)
31. Mechanism of antimicrobial action of indolicidin. Subbalakshmi C, Sitaram N, FEMS Microbiol Lett 1998 160 91 96 10.1111/j.1574-6968.1998.tb12896.x 9495018 (Pubitemid 28098557)
32. Cell selectivity and mechanism of action of antimicrobial model peptides containing peptoid residues. Song YM, Park Y, Lim SS, Yang ST, Woo ER, Park IS, Lee JS, Kim JI, Hahm KS, Kim Y, Shin SY, Biochemistry 2005 44 12094 12106 10.1021/bi050765p 16142907 (Pubitemid 41285707)
33. Two distinct modes of strand unlinking during theta-type DNA replication. Hiasa H, Marians KJ, J Biol Chem 1996 271 21529 21535 10.1074/jbc.271.35.21529 8702938 (Pubitemid 26293020)
34. In vivo and in vitro patterns of the activity of simocyclinone D8, an angucyclinone antibiotic from Streptomyces antibioticus. Oppegard LM, Hamann BL, Streck KR, Ellis KC, Fiedler HP, Khodursky AB, Hiasa H, Antimicrob Agents Chemother 2009 53 2110 2119 10.1128/AAC.01440-08 19273673
35. Escherichia coli DinB inhibits replication fork progression without significantly inducing the SOS response. Mori T, Nakamura T, Okazaki N, Furukohri A, Maki H, Akiyama MT, Genes Genet Syst 2012 87 75 87 10.1266/ggs.87.75 22820381
36. Method for screening compounds that influence virulence gene expression in Staphylococcus aureus. Nielsen A, Nielsen KF, Frees D, Larsen TO, Ingmer H, Antimicrob Agents Chemother 2010 54 509 512 10.1128/AAC.00940-09 19917763
37. Complete and SOS-mediated response of Staphylococcus aureus to the antibiotic ciprofloxacin. Cirz RT, Jones MB, Gingles NA, Minogue TD, Jarrahi B, Peterson SN, Romesberg FE, J Bacteriol 2007 189 531 539 10.1128/JB.01464-06 17085555 (Pubitemid 46106385)
38. Potent antibacterial lysine-peptoid hybrids identified from a positional scanning combinatorial library. Ryge TS, Hansen PR, Bioorg Med Chem 2006 14 4444 4451 10.1016/j.bmc.2006.02.034 16524733 (Pubitemid 43728672)
39. The heme sensing response regulator HssR in Staphylococcus aureus but not the homologous RR23 in Listeria monocytogenes modulates susceptibility to the antimicrobial peptide plectasin. Thomsen LE, Gottlieb CT, Gottschalk S, Wodskou TT, Kristensen HH, Gram L, Ingmer H, BMC Microbiol 2010 10 307 10.1186/1471-2180-10-307 21122114
40. Mechanism of action of the antimicrobial peptide buforin II: buforin II kills microorganisms by penetrating the cell membrane and inhibiting cellular functions. Park CB, Kim HS, Kim SC, Biochem Biophys Res Commun 1998 244 253 257 10.1006/bbrc.1998.8159 9514864 (Pubitemid 28419934)
41. An improved tetracycline-inducible expression vector for Staphylococcus aureus. Corrigan RM, Foster TJ, Plasmid 2009 61 126 129 10.1016/j.plasmid.2008. 10.001 18996145
42. Improved single-copy integration vectors for Staphylococcus aureus. Luong TT, Lee CY, J Microbiol Methods 2007 70 186 190 10.1016/j.mimet.2007.04.007 17512993 (Pubitemid 46962783)
43. Improved method for electroporation of Staphylococcus aureus. Schenk S, Laddaga RA, FEMS Microbiol Lett 1992 73 133 138 1521761