Method for screening compounds that influence virulence gene expression in Staphylococcus aureus

Antimicrobial Agents and Chemotherapy

Volumn 54, Issue 1, 2010, Pages 509-512

  Nielsen, Anita ^a   Nielsen, Kristian F ^b   Frees, Dorte ^a   Larsen, Thomas O ^b   Ingmer, Hanne ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

1,3,5,6 TRIHYDROXY 8 METHYL XANTHONE; 5 BROMO 4 CHLORO 3 INDOLYL BETA DEXTRO GALACTOPYRANOSIDE; AGAR; BETA GALACTOSIDASE; ERYTHROMYCIN; IBT 24414; NORLICHEXANTHONE; PENICILLIN DERIVATIVE; PYRANOSIDE; UNCLASSIFIED DRUG; XANTHONE DERIVATIVE;

ARTICLE; ASPERGILLUS; ASSAY; BACTERIAL GENE; BACTERIAL STRAIN; BACTERIAL VIRULENCE; CONTROLLED STUDY; GENE EXPRESSION; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS; TRICHODERMA; YEAST;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BETA-GALACTOSIDASE; DRUG EVALUATION, PRECLINICAL; FUNGI; GENE EXPRESSION REGULATION, BACTERIAL; GLUCOSE; LAC OPERON; QUORUM SENSING; RNA, BACTERIAL; STAPHYLOCOCCUS AUREUS; TRANS-ACTIVATORS; VIRULENCE FACTORS;

EID: 73849146423     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00940-09     Document Type: Article

References (24)

1. Abdel-Lateff, A., C. Klemke, G. M. König, and A. D. Wright. 2003. Two new xanthone derivatives from algicolous marine fungus Wardomyces anomalus. J. Nat. Prod. 66:706-708.
2. Archer, G. L. 1998. Staphylococcus aureus: a well-armed pathogen. Clin. Infect. Dis. 26:1179-1181.
3. Balaban, N., T. Goldkorn, R. T. Nhan, L. B. Dang, S. Scott, R. M. Ridgley, A. Rasooly, S. C. Wright, J. W. Larrick, R. Rasooly, and J. R. Carlson. 1998. Autoinducer of virulence as a target for vaccine and therapy against Staphylococcus aureus. Science 280:438-440.
4. Belofsky, G. N., K. B. Gloer, J. B. Gloer, D. T. Wicklow, and P. F. Dowd. 1998. New p-terphenyl and polyketide metabolites from the sclerotia of Penicillium raistrickii. J. Nat. Prod. 61:1115-1119.
5. Chan, P. F., and S. J. Foster. 1998. The role of environmental factors in the regulation of virulence-determinant expression in Staphylococcus aureus 8325-4. Microbiology 144:2469-2479.
6. Clatworthy, A. E., E. Pierson, and D. T. Hung. 2007. Targeting virulence: a new paradigm for antimicrobial therapy. Nat. Chem. Biol. 3:541-548.
7. Reference deleted.
8. Frisvad, J. C., J. Smedsgaard, T. O. Larsen, and R. A. Samson. 2004. Mycotoxins, drugs and other extrolites produced by species in Penicillium subgenus Penicillium. Stud. Mycol. 49:201-241.
9. B modulates virulence determinant expression and stress resistance: characterization of a functional rsbU strain derived from Staphylococcus aureus 8325-4. J. Bacteriol. 184:5457-5467.
10. Jarraud, S., G. J. Lyon, A. M. Figueiredo, L. Gerard, F. Vandenesch, J. Etienne, T. W. Muir, and R. P. Novick. 2000. Exfoliatin-producing strains define a fourth agr specificity group in Staphylococcus aureus. J. Bacteriol. 182:6517-6522.
11. Ji, G., R. Beavis, and R. P. Novick. 1997. Bacterial interference caused by autoinducing peptide variants. Science 276:2027-2030.
12. Larsen, T. O., J. Smedsgaard, K. F. Nielsen, M. E. Hansen, and J. C. Frisvad. 2005. Phenotypic taxonomy and metabolite profiling in microbial drug discovery. Nat. Prod. Rep. 22:672-695.
13. Nielsen, K. F., T. Graefenhan, D. Zafari, and U. Thrane. 2005. Trichothecene production by Trichoderma brevicompactum. J. Agric. Food Chem. 53:8190-8196.
14. Nielsen, K. F., and J. Smedsgaard. 2003. Fungal metabolite screening: database of 474 mycotoxins and fungal metabolites for dereplication by standardised liquid chromatography-UV-mass spectrometry methodology. J. Chromatogr. A 1002:111-136.
15. Novick, R. P. 2003. Autoinduction and signal transduction in the regulation of staphylococcal virulence. Mol. Microbiol. 48:1429-1449.
16. Novick, R. P., and S. I. Morse. 1967. In vivo transmission of drug resistance factors between strains of Staphylococcus aureus. J. Exp. Med. 125:45-59.
17. Novick, R. P., H. F. Ross, S. J. Projan, J. Kornblum, B. Kreiswirth, and S. Moghazeh. 1993. Synthesis of staphylococcal virulence factors is controlled by a regulatory RNA molecule. EMBO J. 12:3967-3975.
18. Peng, H. L., R. P. Novick, B. Kreiswirth, J. Kornblum, and P. Schlievert. 1988. Cloning, characterization, and sequencing of an accessory gene regulator (agr) in Staphylococcus aureus. J. Bacteriol. 170:4365-4372.
19. Rank, C., R. K. Phipps, P. Harris, J. C. Frisvad, C. H. Gotfredsen, and T. O. Larsen. 2006. epi-Aszonalenins A, B, and C from Aspergillus novofumigatus. Tetrahedron Lett. 47:6099-6102.
20. Rebacz, B., T. O. Larsen, M. H. Clausen, M. H. Rønnest, H. Löffler, A. D. Ho, and A. Krämer. 2007. Identification of griseofulvin as an inhibitor of centrosomal clustering in a phenotype-based screen. Cancer Res. 67:6342-6350.
21. Regassa, L. B., R. P. Novick, and M. J. Betley. 1992. Glucose and nonmaintained pH decrease expression of the accessory gene regulator (agr) in Staphylococcus aureus. Infect. Immun. 60:3381-3388.
22. Sakoulas, G., and R. C. Moellering, Jr. 2008. Increasing antibiotic resistance among methicillin-resistant Staphylococcus aureus strains. Clin. Infect. Dis. 46(Suppl. 5):S360-S367.
23. Samson, R. A., E. S. Hoekstra, J. C. Frisvad, and O. Filtenborg. Introduction to food- and airborne fungi. Centraalbureau voor Schimmelcultures, Utrecht, The Netherlands.
24. Seidl, K., M. Stucki, M. Ruegg, C. Goerke, C. Wolz, L. Harris, B. Berger-Bachi, and M. Bischoff. 2006. Staphylococcus aureus CcpA affects virulence determinant production and antibiotic resistance. Antimicrob. Agents Chemother. 50:1183-1194.