A superoxide dismutase mimetic with catalase activity (EUK-8) reduces the organ injury in endotoxic shock

European Journal of Pharmacology

Volumn 466, Issue 1-2, 2003, Pages 181-189

  McDonald, Michelle C ^a   Di Villa Bianca, Roberta D'Emmanuele ^a,b   Wayman, Nicole S ^a   Pinto, Aldo ^b   Sharpe, Martyn A ^c   Cuzzocrea, Salvatore ^d   Chatterjee, Prabal K ^a   Thiemermann, Christoph ^a  

^a ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

^b Dept of Experimental Pharmacology ^*  (Italy)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d UNIVERSITY OF MESSINA   (Italy)

Author keywords

EUK 134; EUK 8; Multiple organ failure; Oxygen radical; Shock; Superoxide anion; Superoxide dismutase

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; CATALASE; ENDOTOXIN; MANGANESE DERIVATIVE; MANGANESE SALEN CHLORIDE; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATTENUATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG INFUSION; DRUG MEGADOSE; ENDOTOXEMIA; ENZYME ACTIVITY; ESCHERICHIA COLI; HYPOTENSION; KIDNEY DYSFUNCTION; KIDNEY INJURY; LIVER DYSFUNCTION; LIVER INJURY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SEPTIC SHOCK;

EID: 0037432642     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(03)01538-3     Document Type: Article

References (35)

1. Baker K., Marcus K.B., Huffman K., Kruk H., Malfroy B., Doctron S.R. Synthetic combined superoxide dismutase/catalase mimetics are protective as a delayed treatment in a rat stroke model: a key role for reactive oxygen species in ischemic brain injury. J. Pharmacol Exp. Ther. 284:1998;215-221.
2. Baue A.E. The multiple organ or system failure syndrome. Schlag G., Redl H. Pathophysiology of Shock, Sepsis, and Organ Failure. 1993;1004-1018 Springer-Verlag, Berlin.
3. Beckman J.S., Beckman T.W., Chen J., Marshall P.A., Freeman B.A. Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc. Natl. Acad. Sci. U. S. A. 87:1990;1620-1624.
4. Brackett D.J., Lai E.K., Lerner M.R., Wilson M.F., McCay P.B. Spin trapping of free radicals produced "in vivo" in heart and liver during endotoxemia. Free Radic. Res. Commun. 7:1989;315-324.
5. Broner C.W., Shenep J.L., Stidham G.L., Stokes D.C., Fairclough D., Schonbaum G.R., Rehg J.E., Hildener W.K. Effect of antioxidants in experimental Escherichia coli septicemia. Circ. Shock. 29:1989;77-92.
6. Cuzzocrea S., Zingarelli B., Hake P., Salzman A.L., Szabo C. Antiinflammatory effects of mercaptoethylguanidine, a combined inhibitor of nitric oxide synthase and peroxynitrite scavenger, in carrageenan-induced models of inflammation. Free Radic. Biol. Med. 24:1998;450-459.
7. Eiserich J.P., Hristova M., Cross C.E., Jones A.D., Freeman B.A., Halliwell B., Van Der Vliet A. Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils. Nature. 391:1998;393-397.
8. Fridovich I. Superoxide radical and superoxide dismutases. Annu. Rev. Biochem. 64:1995;97-112.
9. Gianello P., Saliez A., Bufkens X., Petinger R., Misseleyn D., Hori S., Malfroy B. EUK-134, a synthetic superoxide dismutase and catalase mimetic, protects rat kidneys from ischemia-reperfusion-induced damage. Transplantation. 62:1996;1664-1666.
10. Gonzalez P.K., Zhuang J., Doctrow S.R., Malfroy B., Benson P.F., Menconi M.J., Fink M.P. EUK-8, a synthetic superoxide dismutase and catalase mimetic, ameliorates acute lung injury in endotoxemic swine. J. Pharmacol. Exp. Ther. 275:1995;798-806.
11. Goode H.F., Webster N.R. Free radicals and antioxidants in sepsis. Crit. Care Med. 21:1993;1770-1776.
12. Jung C., Rong Y., Doctrow S., Baudry M., Malfroy B., Xu Z. Synthetic superoxide dismutase/catalase mimetics reduce oxidative stress and prolong survival in a mouse amyotrophic lateral sclerosis model. Neurosci. Lett. 304:2001;157-160.
13. Kunimoto F., Morita T., Ogawa R., Fujita T. Inhibition of lipid peroxidation improves survival rate of endotoxemic rats. Circ. Shock. 21:1987;15-22.
14. Leach M., Frank S., Olbrich A., Pfeilschifter J., Thiemermann C. Decline in the expression of copper/zinc superoxide dismutase in the kidney of rats with endotoxic shock: effects of the superoxide anion radical scavenger, tempol, on organ injury. Br. J. Pharmacol. 125:1998;817-825.
15. MacArthur H., Westfall T.C., Riley D.P., Misko M.P., Salvemini D. Inactivation of catecholamines by superoxide gives new insights on the pathogenesis of septic shock. Proc. Natl. Acad. Sci. U. S. A. 97:2000;9753-9758.
16. McDonald M.C., Zacharowski K., Bowes J., Cuzzocrea S., Thiemermann C. Tempol reduces infarct size in rodent models of regional myocardial ischaemia and reperfusion. Free Radic. Biol. Med. 27:1999;493-503.
17. McKechnie K., Furman B.L., Parratt J.R. Modification by oxygen free radical scavengers of the metabolic and cardiovascular effects of endotoxin infusion in conscious rats. Circ. Shock. 19:1986;429-439.
18. Mota-Filipe H., McDonald M.C., Cuzzocrea S., Thiemermann C. A membrane-permeable radical scavenger reduces the organ injury in hemorrhagic shock. Shock. 12:1999;255-261.
19. Novotny M.J., Laighlin M.H., Adams H.R. Evidence of lack of importance of oxygen free radicals in Escherichia coli endotoxemia in dogs. Am. J. Physiol. 254:1988;H954-H962.
20. Olson N.C., Grizzle M.K., Anderson D.L. Effect of polyethylene glycol-superoxide dismutase and catalase on endotoxemia in pigs. J. Appl. Physiol. 63:1987;1526-1532.
21. Pucheu S., Boucher F., Sulpice T., Tressallet N., Bonhomme Y., Malfroy B., de Leiris J. EUK-8 a synthetic catalytic scavenger of reactive oxygen species protects isolated, iron-overloaded rat heart from functional and structural damage induced by ischemia-reperfusion. Cardiovasc. Drugs Ther. 10:1996;331-339.
22. Redl H., Lieners C., Baheartrateami S., Schlag G., van Bebber I.P., Goris R.J. SOD in rat models of shock and organ failure. Adv. Exp. Med. Biol. 264:1990;17-27.
23. Redl H., Gasser H., Schlag G., Marzi I. Involvement of oxygen radicals in shock related cell injury. Br. Med. Bull. 49:1993;556-565.
24. Schineder J., Friderichs E., Giertz H. Protection by recombinant human superoxide dismutase in lethal rat endotoxemia. Prog. Clin. Biol. Res. 308:1989;913-917.
25. Simon H.M., Scalea T., Paskanik A., Yang B. Superoxide dismutase (SOD) prevents hypotension after hemorrhagic shock and aortic cross clamping. Am. J. Med. Sci. 312:1996;155-159.
26. Simons R.K., Maier R.V., Lennards E.S. Neutrophil function in a rat model of endotoxin-induced lung injury. Arch. Surg. 122:1987;197-203.
27. Sledzinski Z., Wozniak M., Antosiewicz J., Lezoche E., Familiari M., Bertoli E., Greci L., Brunelli A., Mazera N., Wajda Z. Protective effect of 4-hydroxy-TEMPO, a low molecular weight superoxide dismutase mimic, on free radical toxicity in experimental pancreatitis. Int. J. Pancreatol. 18:1995;153-160.
28. Szabo C., Virag L., Cuzzocrea S., Scott G.S., Hake P., O'Connor M.P., Zingarelli B., Salzman A., Kun E. Protection against peroxynitrite-induced fibroblast injury and artheart rateitis development by inhibition of poly(ADP-ribose) synthase. Proc. Natl. Acad. Sci. U. S. A. 95:1998;3867-3872.
29. Thiemermann C., Ruetten H., Wu C.C., Vane J.R. The multiple organ dysfunction syndrome caused by endotoxin in the rat: attenuation of liver dysfunction by inhibitors of nitric oxide synthase. Br. J. Pharmacol. 116:1995;2845-2851.
30. Traber D.L., Adams T., Sziebvert L., Stein M., Traber L. Potentiation of lung vascular response to endotoxin by superoxide dismutase. J. Appl. Physiol. 58:1985;1005-1009.
31. Vespasiano M.C., Lewandoski J.R., Zimmerman J.J. Longitudinal analysis of neutrophil superoxide anion generation in patients with septic shock. Crit. Care Med. 21:1993;666-672.
32. Warner B.W., Hasselgren P.O., Fischer J.E. Effect of allopurinol and superoxide dismutase in rats with sepsis. Curr. Surg. 43:1986;292-293.
33. Yim M.B., Chock P.B., Stadtman E.R. Copper, zinc superoxide dismutase catalyses hydroxyl radical production from hydrogen peroxide. Proc. Natl. Acad. Sci. U. S. A. 87:1990;5006-5010.
34. Zingarelli B., Day B.J., Crapo J.D., Salzman A.L., Szabo C. The potential role of peroxynitrite in the vascular contractile and cellular energetic failure in endotoxic shock. Br. J. Pharmacol. 120:1997;259-267.
35. Zingarelli B., Virag L., Szabo A., Cuzzocrea S., Salzman A.L., Szabo C. Oxidation, tyrosine nitration and cytostasis induction in the absence of inducible nitric oxide synthase. Int. J. Mol. Med. 1:1998;787-795.