Development of structural kidney damage in spontaneously hypertensive rats

Journal of Hypertension

Volumn 30, Issue 6, 2012, Pages 1087-1091

  Hultström, Michael ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

afferent arteriole; cilia; glomerulosclerosis; hypertension; kidney damage; media hypertrophy; nephrosclerosis; rat; spontaneously hypertensive rat; tubular atrophy

Indexed keywords

ANGIOTENSIN II; METALLOPROTEINASE;

AUTOREGULATION; BLOOD VESSEL INJURY; BOWMAN CAPSULE; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE MODEL; GLOMERULONEPHRITIS; GLOMERULOPATHY; GLOMERULOSCLEROSIS; GLOMERULUS; GLOMERULUS FILTRATION; HUMAN; HYPERTENSION; HYPOXIA; KIDNEY CORTEX; KIDNEY DISEASE; KIDNEY FIBROSIS; KIDNEY HYPERTROPHY; KIDNEY INJURY; KIDNEY TUBULE; KIDNEY TUBULE DAMAGE; NEPHRON; NONHUMAN; PODOCYTE; PRIORITY JOURNAL; PROTEINURIA; RAT; RENOVASCULAR DISEASE; REVIEW; SPONTANEOUSLY HYPERTENSIVE RAT;

EID: 84861021000     PISSN: 02636352     EISSN: 14735598     Source Type: Journal    
DOI: 10.1097/HJH.0b013e328352b89a     Document Type: Review

References (61)

1. Munkhaugen J, Lydersen S, Wideroe TE, Hallan S. Prehypertension, obesity, and risk of kidney disease: 20-year follow-up of the HUNT I study in Norway. Am J Kidney Dis 2009; 54:638-646.
2. Mancia G, Schumacher H, Redon J, Verdecchia P, Schmieder R, Jennings G, et al. Blood pressure targets recommended by guidelines and incidence of cardiovascular and renal events in the Ongoing Telmisartan Alone and in Combination With Ramipril Global Endpoint Trial (ONTARGET). Circulation 2011; 124:1727-1736.
3. Vikse BE, Aasarod K, Bostad L, Iversen BM. Clinical prognostic factors in biopsy-proven benign nephrosclerosis. Nephrol Dial Transplant 2003; 18:517-523.
4. Vikse BE, Bostad L, Aasarod K, Lysebo DE, Iversen BM. Prognostic factors in mesangioproliferative glomerulonephritis. Nephrol Dial Transplant 2002; 17:1603-1613.
5. Okamoto K, Aoki K. Development of a strain of spontaneously hypertensive rats. Jpn Circ J 1963; 27:282-293.
6. Christiansen RE, Roald AB, Tenstad O, Iversen BM. Renal hemodynamics during development of hypertension in young spontaneously hypertensive rats. Kidney Blood Press Res 2002; 25:322-328.
7. Chatziantoniou C, Daniels FH, Arendshorst WJ. Exaggerated renal vascular reactivity to angiotensin and thromboxane in young genetically hypertensive rats. Am J Physiol 1990; 259 (2 Pt 2):F372-F382.
8. Vyas SJ, Jackson EK. Angiotensin II: enhanced renal responsiveness in young genetically hypertensive rats. J Pharmacol Exp Ther 1995; 273:768-777.
9. Iversen BM, Arendshorst WJ. Exaggerated Ca2+ signaling in preglomerular arteriolar smooth muscle cells of genetically hypertensive rats. Am J Physiol 1999; 276 (2 Pt 2):F260-F270.
10. Arendshorst WJ, Chatziantoniou C, Daniels FH. Role of angiotensin in the renal vasoconstriction observed during the development of genetic hypertension. Kidney Int Suppl 1990; 30:S92-S96.
11. Feld LG, Van Liew JB, Galaske RG, Boylan JW. Selectivity of renal injury and proteinuria in the spontaneously hypertensive rat. Kidney Int 1977; 12:332-343.
12. Bakoush O, Tencer J, Torffvit O, Tenstad O, Skogvall I, Rippe B. Increased glomerular albumin permeability in old spontaneously hypertensive rats. Nephrol Dial Transplant 2004; 19:1724-1731.
13. Hultstrom M, Leh S, Skogstrand T, Iversen BM. Upregulation of tissue inhibitor of metalloproteases-1 (TIMP-1) and procollagen-N-peptidase in hypertension-induced renal damage. Nephrol Dial Transplant 2008; 23:896-903.
14. Iversen BM, Amann K, Kvam FI, Wang X, Ofstad J. Increased glomerular capillary pressure and size mediate glomerulosclerosis in SHR juxtamedullary cortex. Am J Physiol Renal Physiol 1998; 274:F365-F373.
15. Roald AB, Ofstad J, Iversen BM. Attenuated buffering of renal perfusion pressure variation in juxtamedullary cortex in SHR. Am J Physiol Renal Physiol 2002; 282:F506-F511.
16. Polichnowski AJ, Cowley AW Jr. Pressure-induced renal injury in angiotensin II versus norepinephrine-induced hypertensive rats. Hypertension 2009; 54:1269-1277.
17. Hayashi K, Sasamura H, Ishiguro K, Sakamaki Y, Azegami T, Itoh H. Regression of glomerulosclerosis in response to transient treatment with angiotensin II blockers is attenuated by blockade of matrix metalloproteinase-2. Kidney Int 2010; 78:69-78.
18. Gattone VH 2nd, Evan AP, Overhage JM, Severs WB. Developing renal innervation in the spontaneously hypertensive rat: evidence for a role of the sympathetic nervous system in renal damage. J Hypertens 1990; 8:423-428.
19. Leh S, Hultström M, Rosenberger C, Iversen B. Afferent arteriolopathy and glomerular collapse but not segmental sclerosis induce tubular atrophy in old spontaneously hypertensive rats. Virchows Arch 2011; 459:99-108.
20. Ofstad J, Iversen BM. Glomerular and tubular damage in normotensive and hypertensive rats. Am J Physiol Renal Physiol 2005; 288:F665-F672.
21. Rodriguez-Iturbe B, Quiroz Y, Ferrebuz A, Parra G, Vaziri ND. Evolution of renal interstitial inflammation and NF-kappaB activation in spontaneously hypertensive rats. Am J Nephrol 2004; 24:587-594.
22. Rodriguez-Iturbe B, Quiroz Y, Nava M, Bonet L, Chavez M, Herrera- Acosta J, et al. Reduction of renal immune cell infiltration results in blood pressure control in genetically hypertensive rats. Am J Physiol Renal Physiol 2002; 282:F191-F201.
23. Olson JL, Wilson SK, Heptinstall RH. Relation of glomerular injury to preglomerular resistance in experimental hypertension. Kidney Int 1986; 29:849-857.
24. Heyeraas KJ, Aukland K. Interlobular arterial resistance: influence of renal arterial pressure and angiotensin II. Kidney Int 1987; 31:1291-1298.
25. Ofstad J, Iversen BM. The interlobular artery: its possible role in preventing and mediating renal disorders. Nephrol Dial Transplant 1988; 3:123-129.
26. Bidani AK, Griffin KA, Williamson G, Wang X, Loutzenhiser R. Protective importance of the myogenic response in the renal circulation. Hypertension 2009; 54:393-398.
27. Kvam FI, Ofstad J, Iversen BM. Role of nitric oxide in the autoregulation of renal blood flow and glomerular filtration rate in aging spontaneously hypertensive rats. Kidney Blood Press Res 2000; 23:376-384.
28. Folkow B, Gothberg G, Lundin S, Ricksten SE. Structural 'resetting' of the renal vascular bed in spontaneously hypertensive rats (SHR). Acta Physiol Scand 1977; 100:270-272.
29. Folkow B. Early structural changes in hypertension: pathophysiology and clinical consequences. J Cardiovasc Pharmacol 1993; 22 (Suppl 1): S1-S6.
30. Anderson WP, Kett MM, Evans RG, Alcorn D. Preglomerular structural changes in the renal vasculature in hypertension. Blood Press Suppl 1995; 2:74-80.
31. Iversen BM, Kvam FI, Matre K, Ofstad J. Resetting of renal blood autoregulation during acute blood pressure reduction in hypertensive rats. Am J Physiol 1998; 275 (Pt 2):R343-R349.
32. Wang X, Aukland K, Iversen BM. Autoregulation of total and zonal glomerular filtration rate in spontaneously hypertensive rats during antihypertensive therapy. J Cardiovasc Pharmacol 1996; 28:833-841.
33. Takabatake T, Ushiogi Y, Ohta K, Hattori N. Attenuation of enhanced tubuloglomerular feedback activity in SHR by renal denervation. Am J Physiol 1990; 258 (Pt 2):F980-F985.
34. Ren Y, D'Ambrosio MA, Liu R, Pagano PJ, Garvin JL, Carretero OA. Enhanced myogenic response in the afferent arteriole of spontaneously hypertensive rats. Am J Physiol Heart Circ Physiol 2010; 298:H1769-H1775.
35. de las Heras N, Ruiz-Ortega M, Miana M, Ruperez M, Sanz-Rosa D, Aragoncillo P, et al. Interactions between aldosterone and connective tissue growth factor in vascular and renal damage in spontaneously hypertensive rats. J Hypertens 2007; 25:629-638.
36. Head RJ. Hypernoradrenergic innervation: its relationship to functional and hyperplastic changes in the vasculature of the spontaneously hypertensive rat. Blood Vessels 1989; 26:1-20.
37. Ochodnicky P, Henning RH, Buikema HJ, de Zeeuw D, Provoost AP, van Dokkum RP. Renal vascular dysfunction precedes the development of renal damage in the hypertensive Fawn-Hooded rat. Am J Physiol Renal Physiol 2010; 298:F625-F633.
38. Wang X, Aukland K, Iversen BM. Acute effects of angiotensin II receptor antagonist on autoregulation of zonal glomerular filtration rate in renovascular hypertensive rats. Kidney Blood Press Res 1997; 20:225-232.
39. Rizzoni D, Rossi GP, Porteri E, Sticchi D, Rodella L, Rezzani R, et al. Bradykinin and matrix metalloproteinases are involved the structural alterations of rat small resistance arteries with inhibition of ACE and NEP. J Hypertens 2004; 22:759-766.
40. Tran ED, DeLano FA, Schmid-Schonbein GW. Enhanced matrix metalloproteinase activity in the spontaneously hypertensive rat: VEGFR-2 cleavage, endothelial apoptosis, and capillary rarefaction. J Vasc Res 2010; 47:423-431.
41. Rodrigues SF, Tran ED, Fortes ZB, Schmid-Schonbein GW. Matrix metalloproteinases cleave the beta2-adrenergic receptor in spontaneously hypertensive rats. Am J Physiol Heart Circ Physiol 2010; 299:H25-H35.
42. Hill GS. Hypertensive nephrosclerosis. Curr Opin Nephrol Hypertens 2008; 17:266-270.
43. Bell PD, Fitzgibbon W, Sas K, Stenbit AE, Amria M, Houston A, et al. Loss of primary cilia upregulates renal hypertrophic signaling and promotes cystogenesis. J Am Soc Nephrol 2011; 22:839-848.
44. Verghese E, Ricardo SD, Weidenfeld R, Zhuang J, Hill PA, Langham RG, et al. Renal primary cilia lengthen after acute tubular necrosis. J Am Soc Nephrol 2009; 20:2147-2153.
45. Palm F, Nordquist L. Renal oxidative stress, oxygenation and hypertension. Am J Physiol Regul Integr Comp Physiol 2011; 301:R1229-R1241.
46. Welch WJ. Intrarenal oxygen and hypertension. Clin Exp Pharmacol Physiol 2006; 33:1002-1005.
47. Biswas SK, de Faria JB. Which comes first: renal inflammation or oxidative stress in spontaneously hypertensive ratš Free Radic Res 2007; 41:216-224.
48. Hostetter TH, Olson JL, Rennke HG, Venkatachalam MA, Brenner BM. Hyperfiltration in remnant nephrons: a potentially adverse response to renal ablation. Am J Physiol 1981; 241:F85-F93.
49. Abbate M, Zoja C, Remuzzi G. How does proteinuria cause progressive renal damage? J Am Soc Nephrol 2006; 17:2974-2984.
50. Reckelhoff JF, Zhang H, Granger JP. Decline in renal hemodynamic function in aging SHR: role of androgens. Hypertension 1997; 30 (Pt 2): 677-681.
51. Kobori H, Ozawa Y, Suzaki Y, Nishiyama A. Enhanced intrarenal angiotensinogen contributes to early renal injury in spontaneously hypertensive rats. J Am Soc Nephrol 2005; 16:2073-2080.
52. Vincent M, Dupont J, Sassard J. Plasma renin activity as a function of age in two new strains of spontaneously hypertensive and normotensive rats. Clin Sci Mol Med 1976; 50:103-107.
53. Christiansen RE, Tenstad O, Leh S, Iversen BM. Glomerular charge selectivity is impaired in hypertensive nephropathy. Nephrol Dial Transplant 2004; 19:1083-1091.
54. Hoyer JR, Fogo AB, Terrell CH, Delaney MM. Immunomorphometric studies of proteinuria in individual deep and superficial nephrons of rats. Lab Invest 2000; 80:1691-1700.
55. Haraldsson B, Jeansson M. Glomerular filtration barrier. Curr Opin Nephrol Hypertens 2009; 18:331-335.
56. Wang G, Lai FM, Kwan BC, Lai KB, Chow KM, Li PK, et al. Podocyte loss in human hypertensive nephrosclerosis. Am J Hypertens 2009; 22:300-306.
57. LeHir M, Kriz W. New insights into structural patterns encountered in glomerulosclerosis. Curr Opin Nephrol Hypertens 2007; 16:184-191.
58. Hertzan-Levy S, Skutelsky E, Arad T, Wollman Y, Chernihovsky T, Polak-Charcon S, et al. Glomerular basement membrane polyanion distribution and nitric oxide in spontaneous hypertensive rats: effects of salt loading and antihypertensive therapy with propranolol. Am J Hypertens 2000; 13:838-845.
59. Wu CH, Chi JC, Jerng JS, Lin SJ, Jan KM, Wang DL, et al. Transendothelial macromolecular transport in the aorta of spontaneously hypertensive rats. Hypertension 1990; 16:154-161.
60. Polichnowski AJ, Lu L, Cowley AW Jr. Renal injury in angiotensin II+LNAME- induced hypertensive rats is independent of elevated blood pressure. Am J Physiol Renal Physiol 2011; 300:F1008-F1016.
61. Dornas WC, Silva ME. Animal models for the study of arterial hypertension. J Biosci 2011; 36:731-737.