Merkel cells are essential for light-touch responses

Science

Volumn 324, Issue 5934, 2009, Pages 1580-1582

  Maricich, Stephen M ^a,d   Wellnitz, Scott A ^a   Nelson, Aislyn M ^a   Lesniak, Daine R ^b   Gerling, Gregory J ^b   Lumpkin, Ellen A ^a   Zoghbi, Huda Y ^a,c  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^d CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKERATIN 8; TRANSCRIPTION FACTOR;

GENE EXPRESSION; NERVOUS SYSTEM; PHYSIOLOGICAL RESPONSE; RODENT; SKIN; TEMPERATURE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; EMBRYO; EPIDERMIS; EX VIVO STUDY; FOOT PAD; IMMUNOCYTOCHEMISTRY; MERKEL CELL; MOUSE; NEURITE; NEUROPHYSIOLOGY; NONHUMAN; PRIORITY JOURNAL; SKIN; SOMATOSENSORY SYSTEM; TOUCH;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; FEMALE; FOOT; MALE; MERKEL CELLS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; SKIN; SKIN PHYSIOLOGICAL PHENOMENA; TOUCH;

ANIMALIA; MUS;

EID: 67649239048     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1172890     Document Type: Article

References (31)

1. K. O. Johnson, Curr. Opin. Neurobiol. 11, 455 (2001).
2. K. O. Johnson, G. D. Lamb, J. Physiol. 310, 117 (1981).
3. K. O. Johnson, T. Yoshioka, F. Vega-Bermudez, J. Clin. Neurophysiol. 17, 539 (2000).
4. A. Iggo, A. R. Muir, J. Physiol. 200, 763 (1969).
5. C. J. Woodbury, H. R. Koerber, J. Comp. Neurol. 505, 547 (2007).
6. F. S. Merkel, Arch. Mikrosk. Anat. 11, 636 (1875).
7. Z. Halata, M. Grim, K. I. Bauman, Anat. Rec. A Discov. Mol. Cell. Evol. Biol. 271A, 225 (2003).
8. H. Haeberle et al., Proc. Natl. Acad. Sci. U.S.A. 101, 14503 (2004).
9. W. Hartschuh, E. Weihe, J. Invest. Dermatol. 75, 159 (1980).
10. P. M. Cahusac, S. S. Senok, Synapse 59, 235 (2006).
11. J. Diamond, L. R. Mills, K. M. Mearow, Prog. Brain Res. 74, 51 (1988).
12. B. M. Fagan, P. M. Cahusac, Neuroreport 12, 341 (2001).
13. K. M. Gottschaldt, C. Vahle-Hinz, Science 214, 183 (1981).
14. I. Kinkelin, C. L. Stucky, M. Koltzenburg, Eur. J. Neurosci. 11, 3963 (1999).
15. E. G. Pacitti, G. S. Findlater, Prog. Brain Res. 74, 37 (1988).
16. S. S. Senok, K. I. Baumann, Z. Halata, Exp. Brain Res. 110, 325 (1996).
17. N. Ben-Arie et al., Development 127, 1039 (2000).
18. B. R. Arenkiel, G. O. Gaufo, M. R. Capecchi, Dev. Dyn. 227, 379 (2003).
19. N. F. Shroyer et al., Gastroenterology 132, 2478 (2007).
20. Materials and methods are available as supporting material on Science Online.
21. A. W. Helms, A. L. Abney, N. Ben-Arie, H. Y. Zoghbi, J. E. Johnson, Development 127, 1185 (2000).
22. N. Ben-Arie et al., Nature 390, 169 (1997).
23. R. Moll, I. Moll, W. W. Franke, Differentiation 28, 136 (1984).
24. U. Vielkind, M. K. Sebzda, I. R. Gibson, M. H. Hardy, Acta Anat. (Basel) 152, 93 (1995).
25. I. S. Hitchcock, P. G. Genever, P. M. Cahusac, Neurosci. Lett. 362, 196 (2004).
26. M. G. Nunzi, A. Pisarek, E. Mugnaini, J. Neurocytol. 33, 359 (2004).
27. J. R. Meyers et al., J. Neurosci. 23, 4054 (2003).
28. K. M. Cronk et al., Development 129, 3739 (2002).
29. B. T. Fundin et al., Dev. Biol. 190, 94 (1997).
30. E. A. Lumpkin, M. J. Caterina, Nature 445, 858 (2007).
31. We thank M. Capecchi for generously providing us with Hoxb1Cre animals; N. Ao, K. Firozi, E. Mathes, K. Morrison, and S. Vaishav for technical assistance; and G. Landreth, L. Landmesser, and R. Miller for critical reading of the manuscript. Funding sources are as follows: NIH grant 5K08NS53419 (to S.M.M.), McNair Scholars Program (to A.M.N.), National Library of Medicine grant T15LM009462 (to D.R.L.), Defense Advanced Research Projects Agency grant HR0011-08-1- 0072 (to G.J.G.), NIH grant HD024064, and NIH grant AR051219 (to E.A.L.). H.Y.Z. is an investigator with HHMI.