Transcript abundance of the pig stearoyl-CoA desaturase gene has no effect on fatty acid composition in muscle and fat tissues, but its polymorphism within the putative microRNA target site is associated with daily body weight gain and feed conversion ratio

Journal of Animal Science

Volumn 91, Issue 1, 2013, Pages 10-19

  Bartz, M ^a   Szydlowski, M ^a   Kociucka, B ^a   Salamon, S ^a   Jelen H H ^a   Switonski, M ^a  

^a POZNA UNIVERSITY OF LIFE SCIENCES   (Poland)

Author keywords

Daily body weight gain; Fatty acid composition; Feed efficiency; Pig stearoyl CoA desaturase gene; Single nucleotide polymorphism; Transcript abundance

Indexed keywords

ACYL COENZYME A DESATURASE; FATTY ACID; MICRORNA;

ADIPOSE TISSUE; ANIMAL; ANIMAL DISEASE; ANIMAL FOOD; ARTICLE; BODY COMPOSITION; CHEMISTRY; CLASSIFICATION; DIET; ENERGY METABOLISM; GENE EXPRESSION REGULATION; GENETIC MARKER; GENETIC POLYMORPHISM; GENETICS; METABOLISM; PHYSIOLOGY; SKELETAL MUSCLE; SWINE; WEIGHT GAIN;

ADIPOSE TISSUE; ANIMAL FEED; ANIMAL NUTRITIONAL PHYSIOLOGICAL PHENOMENA; ANIMALS; BODY COMPOSITION; DIET; ENERGY METABOLISM; FATTY ACIDS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENETIC MARKERS; MICRORNAS; MUSCLE, SKELETAL; POLYMORPHISM, GENETIC; STEAROYL-COA DESATURASE; SWINE; WEIGHT GAIN;

EID: 84882724325     PISSN: 00218812     EISSN: 15253163     Source Type: Journal    
DOI: 10.2527/jas.2012-5380     Document Type: Article

References (36)

1. Bartoň, L., T. Kott, D. Bureš, D. Řehák, R. Zahrádková, and B. Kottová. 2010. The polymorphisms of stearoyl-CoA desaturase (SCD1) and sterol regulatory element binding protein-1 (SREBP-1) genes and their association with the fatty acid profile of muscle and subcutaneous fat in Fleckvieh bulls. Meat Sci. 85:15-20.
2. Burgos, C., A. Galve, C. Moreno, J. Altarriba, R. Reina, C. García, and P. López-Buesa. 2012. The effects of 2 alleles of IGF2 on fat content in pig carcasses and pork. Meat Sci. 90:309-313.
3. Cánovas, A., J. Estany, M. Tor, R. N. Pena, and O. Doran. 2009. Acetyl CoA carboxylase and stearoyl-CoA desaturase protein expression in subcutaneous adipose tissue is reduced in pigs selected for decreased backfat thickness at constant intramuscular fat content. J. Anim. Sci. 87:3905-3914.
4. Clop, A., C. Ovilo, M. Perez-Enciso, A. Cercos, A. Tomas, A. Fernandez, A. Coll, J. M. Folch, C. Barragan, I. Diaz, M. A. Oliver, L. Varona, L. Silio, A. Sanchez, and J. L. Noguera. 2003. Detection of QTL affecting fatty acid composition in the pig. Mamm. Genome 14:650-656.
5. Davoli, R., G. Gandolfi, S. Braglia, M. Comella, P. Zambonelli, L. Buttazzoni, and V. Russo. 2011. New SNP of the porcine perilipin 2 (PLIN2) gene, association with carcass traits and expression analysis in skeletal muscle. Mol. Biol. Rep. 38:1575-1583.
6. Dobrzyn, A., and J. M. Ntambi. 2004. The role of stearoyl-CoA desaturase in body weight regulation. Trends Cardiovasc. Med. 14:77-81.
7. Folch, J. M., M. Lees, and G. H. S. Stanley. 1957. A simple method for the isolation and purification of lipids from animal tissues. J. Biol. Chem. 226:497-509.
8. Guo, T., J. Ren, K. Yang, J. Ma, Z. Zhang, and L. Huang. 2009. Quantitative trait loci for fatty acid composition in longissimus dorsi and abdominal fat: Results from a White Duroc × Erhualian intercross F2 population. Anim. Genet. 40:185-191.
9. Houston, R. D., C. S. Haley, A. L. Archibald, N. D. Cameron, G. S. Plastow, and K. A. Rance. 2006. A polymorphism in the 5′-untranslated region of the porcine cholecystokinin type a receptor gene affects feed intake and growth. Genetics 174:1555-1563.
10. Huang, T.-H., M.-J. Zhu, X.-Y. Li, and S.-H. Zhao. 2008. Discovery of porcine microRNAs and profiling from skeletal muscle tissues during development. PLoS ONE 3:e3225.
11. Klensporf-Pawlik, D., M. Szydlowski, A. Kaczmarek, J. Nowacka-Woszuk, M. Switonski, and H. H. Jeleń. 2012. The fatty acid composition of the Longissimus dorsi muscle, subcutaneous and visceral fats differ in four commercial pig breeds. J. Anim. Feed Sci. 21:661-676.
12. Lee, S. H., Y. M. Choi, J. H. Choe, J. M. Kim, K. C. Hong, H. C. Park, and B. C. Kim. 2010. Association between polymorphisms of the heart fatty acid binding protein gene and intramuscular fat content, fatty acid composition, and meat quality in Berkshire breed. Meat Sci. 86:794-800.
13. Li, C., N. Aldai, M. Vinsky, M. E. R. Dugan, and T. A. McAllister. 2012. Association analyses of single nucleotide polymorphisms in bovine stearoyl-CoA desaturase and fatty acid synthase genes with fatty acid composition in commercial cross-bred beef steers. Anim. Genet. 43:93-97.
14. Li, G., Y. Li, X. Li, X. Ning, M. Li, and G. Yang. 2011. MicroRNA identity and abundance in developing swine adipose tissue as determined by Solexa sequencing. J. Cell. Biochem. 112:1318-1328.
15. Matsuhashi, T., S. Maruyama, Y. Uemoto, N. Kobayashi, H. Mannen, T. Abe, S. Sakaguchi, and E. Kobayashi. 2011. Effects of bovine fatty acid synthase, stearoyl-coenzyme A desaturase, sterol regulatory element-binding protein 1, and growth hormone gene polymorphisms on fatty acid composition and carcass traits in Japanese Black cattle. J. Anim. Sci. 89:12-22.
16. Ntambi, J. M., M. Miyazaki, J. P. Stoehr, H. Lan, C. M. Kendziorski, B. S. Yandell, Y. Song, P. Cohen, J. M. Friedman, and A. D. Attie. 2002. Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity. Proc. Natl. Acad. Sci. USA 99:11482-11486.
17. Orrù, L., G. F. Cifuni, E. Piasentier, M. Corazzin, S. Bovolenta, and B. Moioli. 2011. Association analyses of single nucleotide polymorphisms in the LEP and SCD1 genes on the fatty acid profile of muscle fat in Simmental bulls. Meat Sci. 87:344-348.
18. Peng, Y. B., B. Fan, X. L. Han, X. W. Xu, M. F. Rothschild, M. Yerle, and B. Liu. 2011. Molecular characterization of the porcine JHDM1A gene associated with average daily gain: Evaluation its role in skeletal muscle development and growth. Mol. Biol. Rep. 38:4697-4704.
19. R Development Core Team. 2008. R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria.
20. Ramos, A. M., K. L. Glenn, T. V. Serenius, K. J. Stalder, and M. F. Rothschild. 2008. Genetic markers for the production of US country hams. J. Anim. Breed. Genet. 125:248-257.
21. Ren, J., C. Knorr, Y.-M. Guo, N. S. Ding, H. S. Ai, B. Brenig, and L.-S. Huang. 2004a. Characterization of five single nucleotide polymorphisms in the porcine stearoyl-CoA desaturase (SCD) gene. Anim. Genet. 35:255-257.
22. Ren, J., C. Knorr, F. Habermann, R. Fries, L. S. Huang, and B. Brenig. 2003. Assignment of the porcine stearoyl-CoA desaturase (SCD) gene to SSC14q27 by fluorescence in situ hybridization and by hybrid panel mapping. Anim. Genet. 34:471-473.
23. Ren, J., C. Knorr, L. Huang, and B. Brenig. 2004b. Isolation and molecular characterization of the porcine stearoyl-CoA desaturase gene. Gene 340:19-30.
24. Rothschild, M. F., Z. Hu, and Z. Jiang. 2007. Advances in QTL mapping in pigs. Int. J. Biol. Sci. 3:192-197.
25. Rusinov, V., V. Baev, I. N. Minkov, and M. Tabler. 2005. MicroInspector: A web tool for detection of miRNA binding sites in an RNA sequence. Nucleic Acids Res. 33:W696-700.
26. Smith, S. B., H. J. Mersmann, E. O. Smith, and K. G. Britain. 1999. Stearoyl-coenzyme A desaturase gene expression during growth in adipose tissue from obese and crossbred pigs. J. Anim. Sci. 77:1710-1716.
27. Switonski, M., M. Stachowiak, J. Cieslak, M. Bartz, and M. Grzes. 2010. Genetics of fat tissue accumulation in pigs: A comparative approach. J. Appl. Genet. 51:153-168.
28. Taniguchi, M., T. Utsugi, K. Oyama, H. Mannen, M. Kobayashi, Y. Tanabe, A. Ogino, and S. Tsuji. 2004. Genotype of stearoyl-CoA desaturase is associated with fatty acid composition in Japanese Black cattle. Mamm. Genome 15:142-148.
29. Tyra, M., and G. Zak. 2012. Analysis of relationships between fattening and slaughter performance of pigs and the level of in tramuscular fat (IMF) in longissimus dorsi muscle. Ann. Anim. Sci. 12:169-178.
30. Uemoto, Y., H. Nakano, T. Kikuchi, S. Sato, M. Ishida, T. Shibata, H. Kadowaski, E. Kobayashi, and K. Suzuki. 2012a. Fine mapping of porcine SSC14 QTL and SCD gene effects on fatty acid composition and melting point of fat in a Duroc purebred population. Anim. Genet. 43:225-228.
31. Uemoto, Y., Y. Soma, S. Sato, M. Ishida, T. Shibata, H. Kadowaki, E. Kobayashi, and K. Suzuki. 2012b. Genome-wide mapping for fatty acid composition and melting point of fat in a purebred Duroc pig population. Anim. Genet. 43:27-34.
32. Wood, J. D., M. Enser, A. V. Fisher, G. R. Nute, P. R. Sheard, R. I. Richardson, S. I. Hughes, and F. M. Whittington. 2008. Fat deposition, fatty acid composition and meat quality: A review. Meat Sci. 78:343-58.
33. Van Laere, A. S., M. Nguyen, M. Braunschweig, C. Nezer, C. Collete, L. Moreau, A. L. Archibald, C. S. Haley, N. Buys, M. Tally, G. Andersson, M. Georges, and L. Andersson. 2003. A regulatory mutation in IGF2 causes a major QTL effect on muscle growth in the pig. Nature 425:832-836.
34. Yu, M., B. Geiger, N. Deeb, and M. F. Rothschild. 2007. Investigation of TXNIP (thioredoxin-interacting protein) and TRX (thioredoxin) genes for growth-related traits in pigs. Mamm. Genome 18:197-209.
35. Zhao, S. M., L. J. Ren, L. Chen, X. Zhang, M. L. Cheng, W. Z. Li, Y. Y. Zhang, and S. Z. Gao. 2009. Differential expression of lipid metabolism related genes in porcine muscle tissue leading to different intramuscular fat deposition. Lipids 44:1029-1037.
36. Zulkifli, R. M., T. Parr, A. M. Salter, and J. M. Brameld. 2010. Regulation of ovine and porcine stearoyl coenzyme A desaturase gene promoters by fatty acids and sterols. J. Anim. Sci. 88:2565-2575.