Optimization of pyrimidinyl- and triazinyl-amines as non-nucleoside inhibitors of HIV-1 reverse transcriptase

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 21, 2006, Pages 5664-5667

  Thakur, Vinay V ^a   Kim, Joseph T ^a   Hamilton, Andrew D ^a   Bailey, Christopher M ^b   Domaoal, Robert A ^b   Wang, Ligong ^a,b   Anderson, Karen S ^b   Jorgensen, William L ^a  

^a YALE UNIVERSITY   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

2 Pyrimidinylamine; Anti HIV; Free energy perturbation; NNRTI; Structure based drug design; Triazinylamine

Indexed keywords

EFAVIRENZ; NEVIRAPINE; PYRIMIDINE DERIVATIVE; RNA DIRECTED DNA POLYMERASE INHIBITOR; TRIAZINE DERIVATIVE;

ANTIVIRAL ACTIVITY; ARTICLE; CYTOTOXICITY; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; STRUCTURE ANALYSIS;

AMINES; HIV REVERSE TRANSCRIPTASE; HIV-1; HIV-1 REVERSE TRANSCRIPTASE; PYRIMIDINES; TRIAZINES;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 33748788858     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.08.037     Document Type: Article

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