In vivo, in vitro, and in silico studies suggest a conserved immune module that regulates malaria parasite transmission from mammals to mosquitoes

Journal of Theoretical Biology

Volumn 334, Issue , 2013, Pages 173-186

  Price, Ian ^a   Ermentrout, Bard ^a   Zamora, Ruben ^a,b   Wang, Bo ^c   Azhar, Nabil ^a,b,d   Mi, Qi ^a   Constantine, Gregory ^a   Faeder, James R ^a,d   Luckhart, Shirley ^c   Vodovotz, Yoram ^a,b  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Malaria; Mathematical model; Mitogen activated protein kinase; Nitric oxide; Transforming growth Factor 1

Indexed keywords

ANOPHELES STEPHENSI NITRIC OXIDE SYNTHASE; AS60A PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INSECT PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; NITRIC OXIDE SYNTHASE; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ENZYME ACTIVITY; HOMEOSTASIS; IMMUNE RESPONSE; MALARIA; MAMMAL; MOSQUITO; NITRIC OXIDE; NUMERICAL MODEL; PARASITE TRANSMISSION;

ANOPHELES; ANOPHELES STEPHENSI; ARTICLE; COMPUTER MODEL; CROSS REACTION; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; GROWTH INHIBITION; IMMUNOREGULATION; INOS GENE; MAMMAL; MAMMAL CELL; MATHEMATICAL MODEL; MIDGUT; NONHUMAN; OSCILLATION; PARASITE DEVELOPMENT; PARASITE LOAD; PARASITE TRANSMISSION; PARASITE VECTOR; PLASMODIUM; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION;

ANOPHELES (GENUS); MAMMALIA; PLASMODIUM FALCIPARUM;

ANOPHELES STEPHENSI 60A; ANOPHELES STEPHENSI NOS; AS60A; ASNOS; ERK; ERK KINASE KINASE; EXTRACELLULAR SIGNAL-REGULATED KINASE; INOS; JNK; JUN N-TERMINAL KINASE; MALARIA; MAMMALIAN INDUCIBLE NOS; MAPK; MAPK OF 38 KILO DALTON MOLECULAR WEIGHT; MATHEMATICAL MODEL; MEK; MITOGEN-ACTIVATED PROTEIN KINASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NO; NOS; ODE; ORDINARY DIFFERENTIAL EQUATION; P38 MAPK; PBS; PHOSPHATE-BUFFERED SALINE; REACTIVE NITRIC OXIDE SPECIES; RNS; TGF-Β1; TRANSFORMING GROWTH FACTOR-Β1;

ANIMALS; ANOPHELES; COMPUTATIONAL BIOLOGY; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; HOST-PARASITE INTERACTIONS; HUMANS; INSECT PROTEINS; INSECT VECTORS; MALARIA, FALCIPARUM; MAP KINASE SIGNALING SYSTEM; MODELS, IMMUNOLOGICAL; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PLASMODIUM FALCIPARUM; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84882694160     PISSN: 00225193     EISSN: 10958541     Source Type: Journal    
DOI: 10.1016/j.jtbi.2013.05.028     Document Type: Article

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