Kamolonol suppresses angiotensin II-induced stress fiber formation and cellular hypertrophy through inhibition of Rho-associated kinase 2 activity

Biochemical and Biophysical Research Communications

Volumn 438, Issue 2, 2013, Pages 318-323

  Kim, Mun Sun ^a,b   Oh, Kwang Seok ^a   Lee, Jeong Hyun ^a   Ryu, Shi Yong ^a   Mun, Jihye ^a   Lee, Byung Ho ^a,b  

^a Korea Research Institute of Chemical Technology   (South Korea)

^b Chungnam National University   (South Korea)

Author keywords

Actin stress fiber; Angiotensin II; Cellular hypertrophy; Kamolonol; Rho associated kinase

Indexed keywords

ANGIOTENSIN II; F ACTIN; KAMOLONOL; MYOSIN I; MYOSIN LIGHT CHAIN 2; MYOSIN PHOSPHATASE 1; RHO ASSOCIATED KINASE 2; RHO KINASE; SESQUITERPENE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; FLUORESCENCE RESONANCE ENERGY TRANSFER; HYPERTROPHY; IMMUNOFLUORESCENCE TEST; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; STRESS FIBER;

ACTIN STRESS FIBER; ANG II; ANGIOTENSIN II; CELLULAR HYPERTROPHY; DMEM; DULBECCO'S MODIFIED EAGLE'S MEDIUM; IMAP; IMMOBILIZED METAL AFFINITY FOR PHOSPHOCHEMICALS; KAMOLONOL; MLC; MYOSIN LIGHT CHAIN; MYOSIN PHOSPHATASE; MYPT; RHO-ASSOCIATED KINASE; ROCK; TIME-RESOLVED FLUORESCENCE RESONANCE ENERGY TRANSFER; TR-FRET;

ANGIOTENSIN II; ANIMALS; CELL LINE; COUMARINS; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; HYPERTROPHY; INHIBITORY CONCENTRATION 50; PHOSPHORYLATION; RATS; RHO-ASSOCIATED KINASES; SESQUITERPENES; STRESS FIBERS;

FERULA ASSA-FOETIDA; RATTUS;

EID: 84882688176     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.07.069     Document Type: Article

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