Gut Microbiota, Diet, Endotoxemia, and Diseases

Endogenous Toxins: Targets for Disease Treatment and Prevention

Volumn , Issue , 2010, Pages 511-524

  Cani, Patrice D ^a   Delzenne, Nathalie M ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

Endotoxemia; Gut microbiota; High fat diet; Low grade inflammation; NAFLD; NASH

Indexed keywords

EID: 84882657050     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9783527628100.ch20     Document Type: Chapter

References (83)

1. Ogden, C.L., Yanovski, S.Z., Carroll, M.D., and Flegal, K.M. (2007)The epidemiology of obesity. Gastroenterology,132, 2087-2102.
2. Eckel, R.H., Grundy, S.M., and Zimmet, P.Z. (2005)The metabolic syndrome. Lancet,365, 1415-1428.
3. Kahn, S.E., Hull, R.L., and Utzschneider, K.M. (2006)Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature,444, 840-846.
4. Alberti, K.G., Zimmet, P., and Shaw, J. (2005)The metabolic syndrome-a new worldwide definition. Lancet,366, 1059-1062.
5. Matarese, G., Mantzoros, C., and La, C.A. (2007)Leptin and adipocytokines: bridging the gap between immunity and atherosclerosis. Curr Pharm Des,13, 3676-3680.
6. Chaudhri, O.B., Salem, V., Murphy, K.G., and Bloom, S.R. (2008)Gastrointestinal satiety signals. Annu Rev Physiol,70, 239-255.
7. Levin, B.E. (2006) Central regulation of energy homeostasis intelligent design: how to build the perfect survivor. Obesity, 14 (Suppl 5), 192S-196S.
8. Wynne, K., Stanley, S., McGowan, B., and Bloom, S. (2005)Appetite control. J Clin Endocrinol Metab,184, 291-318.
9. Small, C.J. and Bloom, S.R. (2004)Gut hormones and the control of appetite. Trends Endocrinol Metab,15, 259-263.
10. Heilbronn, L.K. and Campbell, L.V. (2008)Adipose tissue macrophages, low grade inflammation and insulin resistance in human obesity. Curr Pharm Des,14, 1225-1230.
11. Hotamisligil, G.S. (2006)Inflammation and metabolic disorders. Nature,444, 860-867.
12. Wellen, K.E. and Hotamisligil, G.S. (2005)Inflammation, stress, and diabetes. J Clin Invest,115, 1111-1119.
13. Xu, J., Mahowald, M.A., Ley, R.E., Lozupone, C.A., Hamady, M., Martens, E.C. et al. (2007) Evolution of symbiotic bacteria in the distal human intestine. PLoS Biol, 5, e156.
14. Xu, J. and Gordon, J.I. (2003)Inaugural Article: Honor thy symbionts. Proc Natl Acad Sci U S A,100, 10452-10459.
15. Ley, R.E., Turnbaugh, P.J., Klein, S., and Gordon, J.I. (2006)Microbial ecology: human gut microbes associated with obesity. Nature,444, 1022-1023.
16. Turnbaugh, P.J., Ley, R.E., Mahowald, M.A., Magrini, V., Mardis, E.R., and Gordon, J.I. (2006)An obesity-associated gut microbiome with increased capacity for energy harvest. Nature,444, 1027-1031.
17. Backhed, F., Manchester, J.K., Semenkovich, C.F., and Gordon, J.I. (2007)Mechanisms underlying the resistance to diet-induced obesity in germ-free mice. Proc Natl Acad Sci U S A,104, 979-984.
18. Backhed, F., Ley, R.E., Sonnenburg, J.L., Peterson, D.A., and Gordon, J.I. (2005)Host-bacterial mutualism in the human intestine. Science,307, 1915-1920.
19. Backhed, F., Ding, H., Wang, T., Hooper, L.V., Koh, G.Y., Nagy, A. et al. (2004)The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci U S A,101, 15718-15723.
20. Ley, R.E., Backhed, F., Turnbaugh, P., Lozupone, C.A., Knight, R.D., and Gordon, J.I. (2005)Obesity alters gut microbial ecology. Proc Natl Acad Sci U S A,102, 11070-11075.
21. Jia, W., Li, H., Zhao, L., and Nicholson, J.K. (2008)Gut microbiota: a potential new territory for drug targeting. Nat Rev Drug Discov,7, 123-129.
22. Hill, J.O. (2006)Understanding and addressing the epidemic of obesity: an energy balance perspective. Endocr Rev,27, 750-761.
23. Turnbaugh, P.J., Backhed, F., Fulton, L., and Gordon, J.I. (2008)Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome. Cell Host Microbe,3, 213-223.
24. Xiong, Y., Miyamoto, N., Shibata, K., Valasek, M.A., Motoike, T., Kedzierski, R.M. et al. (2004)Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41. Proc Natl Acad Sci U S A,101, 1045-1050.
25. Brown, A.J., Goldsworthy, S.M., Barnes, A.A., Eilert, M.M., Tcheang, L., Daniels, D. et al. (2003)The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids. J Biochem Mol Biol Biophys,278, 11312-11319.
26. Le, P.E., Loison, C., Struyf, S., Springael, J.Y., Lannoy, V., Decobecq, M.E. et al. (2003)Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation. J Biochem Mol Biol Biophys,278, 25481-25489.
27. Denechaud, P.D., Dentin, R., Girard, J., and Postic, C. (2008)Role of ChREBP in hepatic steatosis and insulin resistance. FEBS Lett,582, 68-73.
28. Samuel, B.S., Shaito, A., Motoike, T., Rey, F.E., Backhed, F., Manchester, J.K. et al. (2008)Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41. Proc Natl Acad Sci U S A,105, 16767-16772.
29. Cani, P.D., Dewever, C., and Delzenne, N.M. (2004)Inulin-type fructans modulate gastrointestinal peptides involved in appetite regulation (glucagon-like peptide-1 and ghrelin) in rats. Br J Nutr,92, 521-526.
30. Cani, P.D., Neyrinck, A.M., Maton, N., and Delzenne, N.M. (2005)Oligofructose promotes satiety in rats fed a high-fat diet: involvement of glucagon-like Peptide-1. Obes Res,13, 1000-1007.
31. Cani, P.D., Daubioul, C.A., Reusens, B., Remacle, C., Catillon, G., and Delzenne, N.M. (2005)Involvement of endogenous glucagon-like peptide-1(7-36) amide on glycaemia-lowering effect of oligofructose in streptozotocin-treated rats. J Clin Endocrinol Metab,185, 457-465.
32. Cani, P.D., Knauf, C., Iglesias, M.A., Drucker, D.J., Delzenne, N.M., and Burcelin, R. (2006)Improvement of glucose tolerance and hepatic insulin sensitivity by oligofructose requires a functional glucagon-like peptide 1 receptor. Diabetes,55, 1484-1490.
33. Cani, P.D., Joly, E., Horsmans, Y., and Delzenne, N.M. (2006)Oligofructose promotes satiety in healthy human: a pilot study. Eur J Clin Nutr,60, 567-572.
34. Gibson, G.R. and Roberfroid, M.B. (1995)Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. J Anim Physiol Anim Nutr (Berl),125, 1401-1412.
35. Kleessen, B., Hartmann, L., and Blaut, M. (2001)Oligofructose and long-chain inulin: influence on the gut microbial ecology of rats associated with a human faecal flora. Br J Nutr,86, 291-300.
36. Kolida, S., Meyer, D., and Gibson, G.R. (2007)A double-blind placebo-controlled study to establish the bifidogenic dose of inulin in healthy humans. Eur J Clin Nutr,61, 1189-1195.
37. Kolida, S., Saulnier, D.M., and Gibson, G.R. (2006)Gastrointestinal microflora: probiotics. Adv Appl Microbiol,59, 187-219.
38. Duncan, S.H., Lobley, G.E., Holtrop, G., Ince, J., Johnstone, A.M., Louis, P. et al. (2008)Human colonic microbiota associated with diet, obesity and weight loss. Int J Obes,32, 1720-1724.
39. Hotamisligil, G.S., Shargill, N.S., and Spiegelman, B.M. (1993)Adipose expression of tumor necrosis factor-α: direct role in obesity-linked insulin resistance. Science,259, 87-91.
40. Weisberg, S.P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R.L., and Ferrante, A.W. Jr (2003) Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest, 112, 1796-1808.
41. Shi, H., Kokoeva, M.V., Inouye, K., Tzameli, I., Yin, H., and Flier, J.S. (2006)TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Invest,116, 3015-3025.
42. Suganami, T., Mieda, T., Itoh, M., Shimoda, Y., Kamei, Y., and Ogawa, Y. (2007)Attenuation of obesity-induced adipose tissue inflammation in C3H/HeJ mice carrying a Toll-like receptor 4 mutation. Biochem Biophys Res Commun,354, 45-49.
43. Suganami, T., Tanimoto-Koyama, K., Nishida, J., Itoh, M., Yuan, X., Mizuarai, S. et al. (2007)Role of the Toll-like receptor 4/NF-kappaB pathway in saturated fatty acid-induced inflammatory changes in the interaction between adipocytes and macrophages. Arterioscler Thromb Vasc Biol,27, 84-91.
44. Wright, S.D., Ramos, R.A., Tobias, P.S., Ulevitch, R.J., and Mathison, J.C. (1990)CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science,249, 1431-1433.
45. Neal, M.D., Leaphart, C., Levy, R., Prince, J., Billiar, T.R., Watkins, S. et al. (2006)Enterocyte TLR4 mediates phagocytosis and translocation of bacteria across the intestinal barrier. J Clin Lab Immunol,176, 3070-3079.
46. Tomita, M., Ohkubo, R., and Hayashi, M. (2004)Lipopolysaccharide transport system across colonic epithelial cells in normal and infective rat. Drug Metab Pharmacokinet,19, 33-40.
47. Moore, F.A., Moore, E.E., Poggetti, R., McAnena, O.J., Peterson, V.M., Abernathy, C.M. et al. (1991)Gut bacterial translocation via the portal vein: a clinical perspective with major torso trauma. J Neurotrauma,31, 629-636.
48. Vreugdenhil, A.C., Rousseau, C.H., Hartung, T., Greve, J.W., van't Veer, V., and Buurman, W.A. (2003)Lipopolysaccharide (LPS)-binding protein mediates LPS detoxification by chylomicrons. J Clin Lab Immunol,170, 1399-1405.
49. Black, D.D., Tso, P., Weidman, S., and Sabesin, S.M. (1983)Intestinal lipoproteins in the rat with D-(+)-galactosamine hepatitis. J Lipid Res,24, 977-992.
50. Ghoshal, S., Witta, J., Zhong, J., de Villiers, W., and Eckhardt, E. Chylomicrons promote intestinal absorption of lipopolysaccharides. (2008) J Lipid Res, 50, 1-2.
51. Cani, P.D., Amar, J., Iglesias, M.A., Poggi, M., Knauf, C., Bastelica, D. et al. (2007)Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes,56, 1761-1772.
52. Cani, P.D. and Delzenne, N.M. (2007)Gut microflora as a target for energy and metabolic homeostasis. Curr Opin Clin Nutr Metab Care,10, 729-734.
53. Cani, P.D., Bibiloni, R., Knauf, C., Waget, A., Neyrinck, A.M., Delzenne, N.M. et al. (2008)Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice. Diabetes,57, 1470-1481.
54. Brun, P., Castagliuolo, I., Leo, V.D., Buda, A., Pinzani, M., Palu, G. et al. (2007) Increased intestinal permeability in obese mice: new evidence in the pathogenesis of nonalcoholic steatohepatitis. Am J Physiol Gastrointest Liver Physiol, 292, G518-G525.
55. Pappo, I., Becovier, H., Berry, E.M. and Freund, H.R. (1991)Polymyxin B reduces cecal flora, TNF production and hepatic steatosis during total parenteral nutrition in the rat. J Invest Surg,51, 106-112.
56. Hord, N.G. (2008)Eukaryotic-microbiota crosstalk: potential mechanisms for health benefits of prebiotics and probiotics. Annu Rev Nutr,28, 215-231.
57. Griffiths, E.A., Duffy, L.C., Schanbacher, F.L., Qiao, H., Dryja, D., Leavens, A. et al. (2004)In vivo effects of bifidobacteria and lactoferrin on gut endotoxin concentration and mucosal immunity in Balb/c mice. Dig Dis Sci,49, 579-589.
58. Wang, Z., Xiao, G., Yao, Y., Guo, S., Lu, K., and Sheng, Z. (2006)The role of bifidobacteria in gut barrier function after thermal injury in rats. J Neurotrauma,61, 650-657.
59. Wang, Z.T., Yao, Y.M., Xiao, G.X., and Sheng, Z.Y. (2004)Risk factors of development of gut-derived bacterial translocation in thermally injured rats. World J Gastroenterol,10, 1619-1624.
60. Tuohy, K.M., Rouzaud, G.C., Bruck, W.M., and Gibson, G.R. (2005)Modulation of the human gut microflora towards improved health using prebiotics-assessment of efficacy. Curr Pharm Des,11, 75-90.
61. Cani, P.D., Neyrinck, A.M., Fava, F., Knauf, K., Burcelin, R.G., Tuohy, K.M. et al. (2007) Selective increases of bifidobacteria in gut microflora improves high-fat diet-induced diabetes in mice through a mechanism associated with endotoxemia Diabetologia, 50 ( 11), 2374-2383.
62. Ma, X., Hua, J., and Li, Z. (2008)Probiotics improve high fat diet-induced hepatic steatosis and insulin resistance by increasing hepatic NKT cells. J Hepatol,49, 821-830.
63. Nolan, J.P. (1975)The role of endotoxin in liver injury. Gastroenterology,69, 1346-1356.
64. Nolan, J.P. and Ali, M.V. (1975) Letter: Kupffer cells and cirrhosis. Lancet, 1, 449.
65. Nolan, J.P., Hare, D.K., McDevitt, J.J., and Ali, M.V. (1977)In vitro studies of intestinal endotoxin absorption. I. Kinetics of absorption in the isolated everted gut sac. Gastroenterology,72, 434-439.
66. Nolan, J.P. and Leibowitz, A.I. (1978)Endotoxin and the liver. III. Modification of acute carbon tetrachloride injury by polymyxin b-an antiendotoxin. Gastroenterology,75, 445-449.
67. Nolan, J.P. and Leibowitz, A.I. (1978)Endotoxins in liver disease. Gastroenterology,75, 765-766.
68. Nolan, J.P. (1979)The contribution of gut-derived endotoxins to liver injury. Yale J Biol Med,52, 127-133.
69. Adachi, Y., Moore, L.E., Bradford, B.U., Gao, W., and Thurman, R.G. (1995)Antibiotics prevent liver injury in rats following long-term exposure to ethanol. Gastroenterology,108, 218-224.
70. Li, S., Wu, W.C., He, C.Y., Han, Z., Jin, D.Y., and Wang, L. (2008)Change of intestinal mucosa barrier function in the progress of non-alcoholic steatohepatitis in rats. World J Gastroenterol,14, 3254-3258.
71. Daubioul, C., Rousseau, N., Demeure, R., Gallez, B., Taper, H., Declerck, B. et al. (2002)Dietary fructans, but not cellulose, decrease triglyceride accumulation in the liver of obese Zucker fa/fa rats. J Anim Physiol Anim Nutr (Berl),132, 967-973.
72. Daubioul, C.A., Taper, H.S., De Wispelaere, L.D., and Delzenne, N.M. (2000)Dietary oligofructose lessens hepatic steatosis, but does not prevent hypertriglyceridemia in obese zucker rats. J Anim Physiol Anim Nutr (Berl),130, 1314-1319.
73. Daubioul, C.A., Horsmans, Y., Lambert, P., Danse, E., and Delzenne, N.M. (2005)Effects of oligofructose on glucose and lipid metabolism in patients with nonalcoholic steatohepatitis: results of a pilot study. Eur J Clin Nutr,59, 723-726.
74. Delzenne, N.M., Daubioul, C., Neyrinck, A., Lasa, M., and Taper, H.S. (2002) Inulin and oligofructose modulate lipid metabolism in animals: review of biochemical events and future prospects. Br J Nutr, 87, S255-S259.
75. Membrez, M., Blancher, F., Jaquet, M., Bibiloni, R., Cani, P.D., Burcelin, R.G. et al. (2008) Gut microbiota modulation with norfloxacin and ampicillin enhances glucose tolerance in mice FASEB J, 22 ( 7), 2416-2426.
76. Nanji, A.A., Khettry, U., and Sadrzadeh, S.M. (1994)Lactobacillus feeding reduces endotoxemia and severity of experimental alcoholic liver (disease). Proc Soc Exp Biol Med,205, 243-247.
77. Li, Z., Yang, S., Lin, H., Huang, J., Watkins, P.A., Moser, A.B. et al. (2003)Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease. Hepatology,37, 343-350.
78. O'Sullivan, D.J. (2008)Genomics can advance the potential for probiotic cultures to improve liver and overall health. Curr Pharm Des,14, 1376-1381.
79. Erridge, C., Attina, T., Spickett, C.M., and Webb, D.J. (2007)A high-fat meal induces low-grade endotoxemia: evidence of a novel mechanism of postprandial inflammation. Am J Clin Nutr,86, 1286-1292.
80. Creely, S.J., McTernan, P.G., Kusminski, C.M., Fisher, M., da Silva, N.F., Khanolkar, M. et al. (2007) Lipopolysaccharide activates an innate immune system response in human adipose tissue in obesity and type 2 diabetes. Am J Physiol Endocrinol Metab, 292, E740-E747.
81. Amar, J., Burcelin, R., Ruidavets, J.B., Cani, P.D., Fauvel, J., Alessi, M.C. et al. (2008)Energy intake is associated with endotoxemia in apparently healthy men. Am J Clin Nutr,87, 1219-1223.
82. Anderson, P.D., Mehta, N.N., Wolfe, M.L., Hinkle, C.C., Pruscino, L., Comiskey, L.L. et al. (2007)Innate immunity modulates adipokines in humans. J Clin Endocrinol Metab,92, 2272-2279.
83. Dixon, A.N., Valsamakis, G., Hanif, M.W., Field, A., Boutsiadis, A., Harte, A. et al. (2008)Effect of the orlistat on serum endotoxin lipopolysaccharide and adipocytokines in South Asian individuals with impaired glucose tolerance. Int J Clin Pract,62, 1124-1129.