Ventral tegmental area BDNF induces an opiate-dependent-like reward state in naïve rats

Science

Volumn 324, Issue 5935, 2009, Pages 1732-1734

  Vargas Perez, Hector ^a   Kee, Ryan Ting A ^a   Walton, Christine H ^b   Micah Hansen, D ^b   Razavi, Rozita ^a   Clarke, Laura ^a   Bufalino, Mary Rose ^a   Allison, David W ^b   Steffensen, Scott C ^b   Van Kooy, Derek Der ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b BRIGHAM YOUNG UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR; BRAIN DERIVED NEUROTROPHIC FACTOR; DOPAMINE; OPIATE; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; 4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; BICUCULLINE; DOPAMINE RECEPTOR BLOCKING AGENT; FLUPENTIXOL; MESSENGER RNA; MORPHINE; MUSCIMOL;

BEHAVIOR; DRUG; NERVOUS SYSTEM; RODENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASSOCIATION; CONTROLLED STUDY; DRUG EFFECT; DRUG EXPOSURE; DRUG WITHDRAWAL; NERVE CELL; NERVE EXCITABILITY; NONHUMAN; OPIATE ADDICTION; PRIORITY JOURNAL; PSYCHOMOTOR ACTIVITY; RAT; REWARD; SENSITIZATION; SIGNAL TRANSDUCTION; VENTRAL TEGMENTUM; ANIMAL; CONDITIONING; GENETICS; HEROIN DEPENDENCE; MALE; METABOLISM; PHYSIOLOGY; WISTAR RAT; WITHDRAWAL SYNDROME;

RATTUS;

ANIMALS; BICUCULLINE; BRAIN-DERIVED NEUROTROPHIC FACTOR; CONDITIONING (PSYCHOLOGY); DOPAMINE; DOPAMINE ANTAGONISTS; FLUPENTHIXOL; GABA AGONISTS; GABA ANTAGONISTS; HEROIN DEPENDENCE; MALE; MORPHINE; MUSCIMOL; OPIOID-RELATED DISORDERS; RATS; RATS, WISTAR; RECEPTORS, GABA-A; REWARD; RNA, MESSENGER; SIGNAL TRANSDUCTION; SUBSTANCE WITHDRAWAL SYNDROME; VENTRAL TEGMENTAL AREA;

EID: 67649970381     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1168501     Document Type: Article

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21. This work was funded by the Canadian Institutes of Health Research. S.C.S. received funding from NIH (grant AA13666).