Retroviral infections in sheep and goats: Small ruminant lentiviruses and host interaction

Viruses

Volumn 5, Issue 8, 2013, Pages 2043-2061

  Larruskain, Amaia ^a   Jugo, Begoña M ^a  

^a UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

Author keywords

Caprine arthritis encephalitis; Host genetics; Lentivirus; Small ruminants; Visna Maedi

Indexed keywords

CYTOKINE; CYTOKINE RECEPTOR;

CAPRINE ARTHRITIS ENCEPHALITIS VIRUS; CELLULAR IMMUNITY; DISEASE COURSE; DISEASE TRANSMISSION; ENVIRONMENTAL FACTOR; GENOTYPE; GOAT; HEREDITY; INFLAMMATORY DISEASE; INNATE IMMUNITY; LENTIVIRINAE; LENTIVIRUS INFECTION; MACROPHAGE; MAJOR HISTOCOMPATIBILITY COMPLEX; MONOCYTE; NONHUMAN; PATHOGENESIS; RETROVIRUS INFECTION; REVIEW; SHEEP; SMALL RUMINANT LENTIVIRUS; SMALL RUMINANT LENTIVIRUS INFECTION; T LYMPHOCYTE; VIRUS CELL INTERACTION; VISNA VIRUS;

ANIMALS; GOAT DISEASES; GOATS; HOST-PATHOGEN INTERACTIONS; LENTIVIRUS; LENTIVIRUS INFECTIONS; SHEEP; SHEEP DISEASES;

EID: 84882620501     PISSN: 19994915     EISSN: None     Source Type: Journal    
DOI: 10.3390/v5082043     Document Type: Review

References (135)

1. Patel, J.R.; Heldens, J.G.M.; Bakonyi, T.; Rusvai, M. Important mammalian veterinary viral immunodiseases and their control. Vaccine 2012, 30, 1767-1781.
2. Leroux, C.; Cruz, J.C.M.; Mornex, J.F. SRLVs: A genetic continuum of lentiviral species in sheep and goats with cumulative evidence of cross species transmission. Curr. HIV Res. 2010, 8, 94-100.
3. Leroux, C.; Vuillermoz, S.; Mornex, J.F.; Greenland, T. Genomic heterogeneity in the pol region of ovine lentiviruses obtained from bronchoalveolar cells of infected sheep from France. J. Gen. Virol. 1995, 76, 1533-1537.
4. Gorrell, M.D.; Brandon, M.R.; Sheffer, D.; Adams, R.J.; Narayan, O. Ovine lentivirus is macrophagetropic and does not replicate productively in T lymphocytes. J. Virol. 1992, 66, 2679-2688.
5. Ryan, S.; Tiley, L.; McConnell, I.; Blacklaws, B. Infection of dendritic cells by the Maedi-Visna lentivirus. J. Virol. 2000, 74, 10096-10103.
6. Christodoulopoulos, G. Maedi-Visna: Clinical review and short reference on the disease status in Mediterranean countries. Small Rumin. Res. 2006, 62, 47-53.
7. Blacklaws, B.A. Small ruminant lentiviruses: Immunopathogenesis of Visna-Maedi and caprine arthritis and encephalitis virus. Comp. Immunol. Microbiol. Infect.Dis. 2012, 35, 259-269.
8. Rowe, J.D.; East, N.E. Risk factors for transmission and methods for control of caprine arthritis-encephalitis virus infection. Vet. Clin. North Am. Food Anim. Pract. 1997, 13, 35-53.
9. Blacklaws, B.A.; Berriatúa, E.; Torsteinsdottir, S.; Watt, N.J.; De Andrés, D.; Klein, D.; Harkiss, G.D. Transmission of small ruminant lentiviruses. Vet. Microbiol. 2004, 101, 199-208.
10. Pépin, M.; Vitu, C.; Russo, P.; Mornex, J.F.; Peterhans, E. Maedi-Visna Virus infection in sheep: A review. Vet. Res. 1998, 29, 1-53.
11. Peterhans, E.; Greenland, T.; Badiola, J.; Harkiss, G.; Bertoni, G.; Amorena, B.; Eliaszewicz, M.; Juste, R.A.; Krassnig, R.; Lafont, J.P.; et al. Routes of transmission and consequences of small ruminant lentiviruses (SRLVs) infection and eradication schemes. Vet. Res. 2004 35, 257-274.
12. Leginagoikoa, I.; Daltabuit-Test, M.; Alvarez, V.; Arranz, J.; Juste, R.A.; Amorena, B.; de Andrés, D.; Luján, L.L.; Badiola, J.J.; Berriatúa, E. Horizontal Maedi-Visna Virus (MVV) infection in adult dairy-sheep raised under varying MVV-infection pressures investigated by ELISA and PCR. Res. Vet. Sci. 2006, 80, 235-241.
13. Gufler, H.; Gasteiner, J.; Lombardo, D.; Stifter, E.; Krassnig, R. Serological study of small ruminant lentivirus in goats in Italy. Small Rumin. Res. 2007, 73, 169-173.
14. Herrmann-Hoesing, L.M.; Palmer, G.G.H.; Knowles, D.P.D. Evidence of proviral clearance following postpartum transmission of an ovine lentivirus. Virology 2007, 362, 226-234.
15. Broughton-neiswanger, L.E.; White, S.N.; Knowles, D.P.; Mousel, M.R.; Lewis, G.S.; Herndon, D.R.; Herrmann-Hoesing, L.M. Non-maternal transmission is the major mode of ovine lentivirus transmission in a ewe flock: A molecular epidemiology study. Infect. Genet. Evol. 2010, 10, 998-1007.
16. Álvarez, V.; Arranz, J.; Daltabuit-Test, M.; Leginagoikoa, I.; Juste, R.A.; Amorena, B.; de Andrés, D.; Luján, L.L.; Badiola, J.J.; Berriatúa, E. Relative contribution of colostrum from Maedi-Visna Virus (MVV) infected ewes to MVV-seroprevalence in lambs. Res. Vet. Sci. 2005, 78, 237-243.
17. Thormar, H. Maedi-Visna Virus and its relationship to human immunodeficiency virus. AIDS Rev. 2005, 7, 233-245.
18. Leroux, C.; Mornex, J.F. Retroviral infections in sheep and the associated diseases. Small Rumin. Res. 2008, 76, 68-76.
19. Cheevers, W.P.; Beyer, J.C.; Knowles, D.P. Type 1 and type 2 cytokine gene expression by viral gp135 surface protein-activated T lymphocytes in caprine arthritis-encephalitis lentivirus infection. J. Virol. 1997, 71, 6259-6263.
20. Lechner, F.; Machado, J.; Bertoni, G.; Seow, H.F.; Dobbelaere, D.A.E.; Peterhans, E. Caprine arthritis encephalitis virus dysregulates the expression of cytokines in macrophages. J. Virol. 1997, 71, 7488-7497.
21. Ravazzolo, A.P.; Nenci, C.; Vogt, H.R.; Waldvogel, A.; Obexer-Ruff, G.; Peterhans, E.; Bertoni, G. Viral load, organ distribution, histopathological lesions, and cytokine mRNA expression in goats infected with a molecular clone of the caprine arthritis encephalitis virus. Virology 2006, 350, 116-127.
22. Benavides, J.; García-Pariente, C.; Fuertes, M.; Ferreras, M.C.; García-Marín, J.F.; Juste, R.A. Maedi-Visna: The meningoencephalitis in naturally occurring cases. J. Comp. Pathol. 2009, 141, 1-11.
23. Heaton, M.P.M.; Clawson, M.L.M.; Chitko-Mckown, C.G.; Leymaster, K.A.; Smith, T.P.L.; Harhay, G.P.; White, S.N.; Herrmann-Hoesing, L.M.; Mousel, M.R.; Lewis, G.S.; et al. Reduced lentivirus susceptibility in sheep with TMEM154 mutations. PLoS Genet. 2012, 8, e1002467.
24. Cheevers, W.P.; Ho, I.; Beyer, J.C. Immune response to caprine arthritis/encephalitis virus surface protein induced by coimmunization with recombinant vaccinia viruses expressing the caprine arthritis/encephalitis virus envelope gene and caprine interleukin-12. Vaccine 2000, 18, 2494-2503.
25. Torsteinsdóttir, S.; Carlsdóttir, H.M.; Svansson, V.; Matthíasdóttir, S.; Pétursson, G. Vaccination of sheep with Maedi-Visna Virus gag gene and protein, beneficial or harmful? Vaccine 2007, 25, 6713-6720.
26. Brodie, S.J.; Marcom, K.A.; Pearson, L.D.; Anderson, B.C.; de la Concha-Bermejillo A.; Ellis, J.A.; DeMartini, J.C. Effects of virus load in the pathogenesis of lentivirus-induced lymphoid interstitial pneumonia. J. Infect. Dis. 1992, 166, 531-541.
27. Pétursson, G.; Matthíasdóttir, S.; Svansson, V.; Andrésdóttir, V.; Georgsson, G.; Martin, A.H.; Agnarsdóttir, G.; Gísladóttir, E.; Arnadóttir, S.; Högnadóttir, S.; et al. Mucosal vaccination with an attenuated Maedi-Visna Virus clone. Vaccine 2005, 23, 3223-3228.
28. Cheevers, W.P.; Snekvik, K.R.; Trujillo, J.D.; Kumpula-McWhirter, N.M.; Pretty O T K.J.; Knowles, D.P. Prime-boost vaccination with plasmid DNA encoding caprine-arthritis encephalitis lentivirus env and viral SU suppresses challenge virus and development of arthritis. Virology 2003, 306, 116-125.
29. Nenci, C.; Zahno, M.L.; Vogt, H.R.; Obexer-Ruff, G.; Doherr, M.G.; Zanoni, R.; Bertoni, G. Vaccination with a T-cell-priming Gag peptide of caprine arthritis encephalitis virus enhances virus replication transiently in vivo. J. Gen. Virol. 2007, 88, 1589-1593.
30. Blacklaws, B.; Bird, P.; McConnell, I. Early events in infection of lymphoid tissue by a lentivirus, Maedi-Visna. Trends Microbiol. 1995, 3, 434-440.
31. Berriatúa, E.; Álvarez, V.; Extramiana, B.; González, L.; Daltabuit, M.; Juste, R. Transmission and control implications of seroconversion to Maedi-Visna Virus in Basque dairy-sheep flocks. Prev. Vet. Med. 2003, 60, 265-279.
32. DeMartini, J.; Concha-Bermejillo, de la A.; Carlson, J.; Bowen, R. Diseases caused by Maedi-Visna and other ovine lentiviruses. In Breeding for Disease Resistance in Farm Animals; Axford, R.F.E., Bishop, S.C., Nicholas, F.W., Owen, J.B., Eds.; CAB International: Oxon, UK, 2000; pp. 301-324.
33. Bishop, S.; Morris, C. Genetics of disease resistance in sheep and goats. Small Rumin. Res. 2007, 70, 48-59.
34. Torsteinsdottir, S.; Andresdottir, V.; Arnarson, H.; Petursson, G. Immune response to Maedi-Visna Virus. Front Biosci. 2007, 12, 1532-1543.
35. Lawson-Handley, L.; Byrne, K.; Santucci, F.; Townsend, S.; Taylor, M.; Bruford, M.W.; Hewitt, G.M. Genetic structure of European sheep breeds. Heredity 2007, 99, 620-631.
36. Kijas, J.W.; Townley, D.; Dalrymple, B.P.; Heaton, M.P.; Maddox, J.F.; Wilson, P.; Ingersoll, R.G.; Mcculloch, R.; Mcwilliam, S.; Tang, D.; et al. A Genome wide survey of SNP variation reveals the genetic structure of sheep breeds. PLoS One 2009, 4, e4668.
37. The International Sheep Genomics Consortium; Archibald, A.; Cockett, N.; Dalrymple, B.P.; Faraut, T.; Kijas, J.W.; Maddox, J.F.; Mcewan, J.C.; Oddy, V.H.; Raadsma, H.W.; et al. The sheep genome reference sequence: A work in progress. Anim. Genet. 2010, 2009, 449-453.
38. Ibeagha-Awemu, E.M.; Kgwatalala, E.M.I.P.; Ibeagha, A.E.; Zhao, X. A critical analysis of disease-associated DNA polymorphisms in the genes of cattle, goat, sheep, and pig. Mamm. Genome 2008, 19, 226-245.
39. Becker, D.; Tetens, J.; Brunner, A.; Bürstel, D.; Ganter, M.; Kijas, J.; International Sheep Genomics Consortium; Drögemüller, C. Microphthalmia in Texel sheep is associated with a missense mutation in the paired-like homeodomain 3 (PITX3) gene. PLoS One 2010, 5, e8689.
40. Purdie, A.C.; Plain, K.M.; Begg, D.J.; de Silva, K.; Whittington, R.J.; de Silva, K. Candidate gene and genome-wide association studies of Mycobacterium avium subsp. paratuberculosis infection in cattle and sheep: A review. Comp. Immunol. Microbiol. Infect. Dis. 2011, 34, 197-208.
41. Silverman, E.K.; Palmer, L.J. Case-control association studies for the genetics of complex respiratory diseases. Am. J. Respir. Cell Mol. Biol. 2000, 22, 645-648.
42. Daly, A.K.; Day, C.P. Candidate gene case-control association studies: Advantages and potential pitfalls. Br. J. Clin. Pharmacol. 2001, 52, 489-499.
43. Campbell, H.; Rudan, I. Interpretation of genetic association studies in complex disease. Pharmacogenomics J. 2002, 2, 349-360.
44. Hirschhorn, J.N.; Lohmueller, K.; Byrne, E.; Hirschhorn, K. A comprehensive review of genetic association studies. Genet. Med. 2002, 4, 45-61.
45. Cardon, L.R.; Palmer, L.J. Population stratification and spurious allelic association. Lancet 2003, 361, 598-604.
46. Colhoun, H.M.; McKeigue, P.M.; Smith, G.D. Problems of reporting genetic associations with complex outcomes. Lancet 2003, 361, 865-872.
47. Cordell, H.J.; Clayton, D.G. Genetic association studies. Lancet 2005, 366, 1121-1131.
48. Balding, D.J. A tutorial on statistical methods for population association studies. Nat. Rev. Genet. 2006, 7, 781-791.
49. Narum, S.R. Beyond bonferroni: Less conservative analyses for conservation genetics. Conserv. Genet. 2006, 7, 783-787.
50. Bochud, P.Y.; Bochud, M.; Telenti, A.; Calandra, T. Innate immunogenetics: A tool for exploring new frontiers of host defence. Lancet Infect. Dis. 2007, 7, 531-542.
51. Abbas, A.K.; Lichtman, A.H. Basic Immunology, Updated Edition; Saunders Elsevier: Philadelphia, PA, USA, 2006.
52. Maclachlan, N.; Dubovi, E.J. Fenner's Veterinary Virology, 4th ed.; Elsevier: London, UK, 2011.
53. Miyazawa, M.; Tsuji-kawahara, S.; Kanari, Y. Host genetic factors that control immune responses to retrovirus infections. Vaccine 2010, 26, 2981-2996.
54. Kaur, G.; Mehra, N. Genetic determinants of HIV-1 infection and progression to AIDS: Immune response genes. Tissue Antigens 2009, 74, 373-385.
55. Brodie, S. Current concepts in the epizootiology, diagnosis, and economic importance of ovine progressive pneumonia in North America: A review. Small Rumin. Res. 1998, 27, 1-17.
56. Blacklaws, B.A.; Harkiss, G.D. Small ruminant lentiviruses and human immunodeficiency virus: Cousins that take a long view. Curr. HIV Res. 2010, 8, 26-52.
57. Stump, D.S.; VandeWoude, S. Animal models for HIV AIDS: A comparative review. Comp. Med. 2007, 57, 33-43.
58. Angelopoulou, K.; Brellou, G.D.; Vlemmas, I.; Greenland, T. A novel deletion in the LTR region of a Greek small ruminant lentivirus may be associated with low pathogenicity. Virus Res. 2006, 118, 178-184.
59. Oskarsson, T.; Hreggvidsdóttir, H.S.; Agnarsdóttir, G.; Matthíasdóttir, S.; Ogmundsdóttir, M.H.; Jónsson, S.R.; Georgsson, G.; Ingvarsson, S.; Andrésson, O.S.; Andrésdóttir, V. Duplicated sequence motif in the long terminal repeat of Maedi-Visna Virus extends cell tropism and is associated. J. Virol. 2007, 81, 4052-4057.
60. Leginagoikoa, I.; Minguijón, E.; Juste, R.A.; Barandika, J.; Amorena, B.; de Andrés, D.; Badiola, J.J.; Luján, L.; Berriatua, E.; de Andrés, D. Effects of housing on the incidence of Visna/Maedi virus infection in sheep flocks. Res. Vet. Sci. 2010, 88, 415-421.
61. González, L.; Juste, R.A.; Cuervo, L.A.; Idigoras, I.; Saez de Ocariz, C. Pathological and epidemiological aspects of the coexistence of Maedi-Visna and sheep pulmonary adenomatosis. Res. Vet. Sci. 1993, 54, 140-146.
62. Andrésdóttir, V.; Tang, X.; Agnarsdóttir, G.; Andrésson, O.S.; Georgsson, G.; Skraban, R.; Torsteinsdóttir, S.; Rafnar, B.; Benediktsdóttir, E.; Matthíasdóttir, S.; Arnadóttir, S.; et al. Biological and genetic differences between lung-and brain-derived isolates of Maedi-Visna Virus. Virus Genes 1998, 16, 281-293.
63. Reina, R.; Grego, E.; Bertolotti, L.; de Meneghi, D.; Rosati, S. Genome analysis of small-ruminant lentivirus genotype E: A caprine lentivirus with natural deletions of the dUTPase subunit, vpr-like accessory gene, and 70-base-pair repeat of the U3 region. J. Virol. 2009, 83, 1152-1155.
64. Herrmann-Hoesing, L.M.; White, S.N.; Mousel, M.R.; Lewis, G.S.; Knowles, D.P. Ovine progressive pneumonia provirus levels associate with breed and Ovar-DRB1. Immunogenetics 2008, 60, 749-758.
65. Palsson, P. Maedi and visna in sheep. In Slow Virus Diseases of Animals and Man; Kimberlin, R.H., Ed.; North-Holland: Amsterdam, The Netherland, 1976; pp. 17-43.
66. Straub, O.C. Maedi-Visna Virus infection in sheep. History and present knowledge. Comp. Immunol. Microbiol. Infect. Dis. 2004, 27, 1-5.
67. Cutlip, R.C.; Lehmkuhl, H.D.; Brogden, K.A.; Sacks, J.M. Breed susceptibility to ovine progressive pneumonia (Maedi/Visna) virus. Vet. Microbiol. 1986, 12, 283-288.
68. Houwers, D.J.; VIsscher, A.H.; Defise, P.R. Importance of ewe/lamb relationship and breed in the epidemiology of Maedi-Visna VIRUS infections. Res. Vet. Sci. 1989, 46, 5-8.
69. Zink, M.C.; Johnson, L.K. Pathobiology of lentivirus infections of sheep and goats. Virus Res. 1994, 32, 139-154.
70. Concha-Bermejillo, De la A.; Brodie, S.J.; Magnus-Corral, S.; Bowen, R.A.; DeMartini, J.C. Pathologic and serologic responses of isogeneic twin lambs to phenotypically disinct lentiviruses. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 1995, 8, 116-123.
71. Gates, N.L.; Winward, L.D.; Gorham, J.R.; Shen, D.T. Serologic survey of prevalence of ovine progressive pneumonia in Idaho range sheep. J. Am. Vet. Med. Assoc. 1978, 173, 1575-1577.
72. Keen, J.E.; Hungerford, L.L.; Wittum, T.E.; Kwang, J.; Littledike, E.T. Risk factors for seroprevalence of ovine lentivirus in breeding ewe flocks in Nebraska, USA. Prev. Vet. Med. 1997, 30, 81-94.
73. Rowe, J.D.; East, N.E.; Franti, C.E.; Thurmond, M.C.; Pedersen, N.C.; Theilen, G.H. Risk factors associated with the incidence of seroconversion to caprine arthritis-encephalitis virus in goats on California dairies. Am. J. Vet. Res. 1992, 53, 2396-2403.
74. Perk, K. Characteristics of ovine and caprine lentivirus infections. Leukemia 1995, 9, 98-100.
75. Zhang, Z.; Watt, N.J.; Hopkins, J.; Harkiss, G.; Woodall, C.J. Quantitative analysis of Maedi-Visna Virus DNA load in peripheral blood monocytes and alveolar macrophages. J. Virol. Methods 2000, 86, 13-20.
76. Singh, I.; McConnell, I.; Blacklaws, B. Immune response to individual Maedi-Visna Virus gag antigens. J. Virol. 2006, 80, 912-919.
77. Fluri, A.; Nenci, C.; Zahno, M.-L.; Vogt, H.; Charan, S.; Busato, A.; Pancino, G.; Peterhans, E.; Obexer-Ruff, G.; Bertoni, G. The MHC-haplotype influences primary, but not memory, immune responses to an immunodominant peptide containing T-and B-cell epitopes of the caprine arthritis encephalitis virus Gag protein. Vaccine 2006, 24, 597-606.
78. Clements, J.E.; Zink, M.C. Molecular biology and pathogenesis of animal lentivirus infections. Clin. Microbiol. Rev. 1996, 9, 100-117.
79. Staskus, K.A.; Couch, L.; Bitterman, P.; Retzel, E.F.; Zupancic, M.; List, J.; Haase, A.T. In situ amplification of visna virus DNA in tissue sections reveals a reservoir of latently infected cells. Microb. Pathog. 1991, 11, 67-76.
80. Reina, R.; Glaria, I.; Benavides, J.; de Andrés, X.; Crespo, H.; Solano, C.; Pérez, V.; Luján, L.; Pérez, M.M.; Pérez de la Lastra J.M.; et al. Association of CD80 and CD86 expression levels with disease status of Visna/Maedi virus infected sheep. Viral Immunol. 2007, 20, 609-622.
81. Gudnadóttir, M.; Demosthenous, A.; Hadjisavvas, T. Vaccination delays Maedi-Visna lentivirus infection in a naturally-infected sheep flock. BMC Vet. Res. 2013, 9, e16.
82. Benavides, J.; García-Pariente, C.; Ferreras, M.C.; Fuertes, M.; García-Marín, J.F.; Pérez, V. Diagnosis of clinical cases of the nervous form of Maedi-Visna in 4-and 6-month-old lambs. Vet. J. 2007, 174, 255-258.
83. Brodie, S.J.; Pearson, L.D.; Zink, M.C.; Bickle, H.M.; Anderson, B.C.; Marcom, K.A.; Demartinit, J.C.; DeMartini, J.C. Ovine lentivirus expression and disease. Virus replication, but not entry, is restricted to macrophages of specific tissues. Am. J. Pathol. 1995, 146, 250-263.
84. Agnarsdóttir, G.; Thorsteinsdóttir, H.; Oskarsson, T.; Matthíasdóttir, S.; Haflidadóttir, B.S.; Andrésson, O.S.; Andrésdóttir, V. The long terminal repeat is a determinant of cell tropism of Maedi-Visna Virus. J. Gen. Virol. 2000, 81, 1901-1905.
85. Hötzel, I.; Cheevers, W.P. A maedi-visna virus strain K1514 receptor gene is located in sheep chromosome 3p and the syntenic region of human chromosome 2. J. Gen. Virol. 2002, 83, 1759-1764.
86. Hötzel, I.; Cheevers, W.P. Host range of small-ruminant lentivirus cytopathic variants determined with a selectable caprine arthritis-encephalitis virus pseudotype system. J. Virol. 2001, 75, 7384-7391.
87. Crespo, H.; Jauregui, P.; Glaria, I.; José, I.S.; Polledo, L.; García-Marín, J.F.; Luján, L.; de Andrés, D.; Amorena, B.; Reina, R. Mannose receptor may be involved in small ruminant lentivirus pathogenesis. Vet. Res. 2012, 43, e43.
88. Amills, M.; Ramiya, V.; Norimine, J.; Lewin, H.A. The major histocompatibility complex of ruminants. Rev. Sci. Tech. 1998, 17, 108-120.
89. Dukkipati, V.S.R.; Blair, H.T.; Garrick, D.J.; Murray, A. "Ovar-Mhc"-Ovine major histocompatibility complex: Structure and gene polymorphisms. Genet. Mol. Res. 2006, 5, 581-608.
90. Sayers, G.; Sweeney, T. Gastrointestinal nematode infection in sheep-A review of the alternatives to anthelmintics in parasite control. Anim. Health Res. Rev. 2005, 6, 159-172.
91. Lee, W.C.; Bird, P.; McConnell, I.; Watt, N.J.; Blacklaws, B. The phenotype and phagocytic activity of macrophages during Maedi-Visna Virus infection. Vet. Immunol. Immunopathol. 1996, 51, 113-126.
92. Bergsteinsdóttir, K.; Arnadóttir, S.; Torsteinsdóttir, S.; Agnarsdóttir, G.; Andrésdóttir, V.; Péttursson, G.; Georgsson, G. Constitutive and visna virus induced expression of class I and II major histocompatibility complex antigens in the central nervous system of sheep and their role in the pathogenesis of visna lesions. Neuropathol. Appl. Neurobiol. 1998, 24, 224-232.
93. Harkiss, G.D.; Watt, N.J.; King, T.J. Williams, J.; Hopkins, J. Retroviral arthritis: Phenotypic analysis of cells in the synovial fluid of sheep with inflammatory synovitis associated with visna virus infection. Clin. Immunol. Immunopathol. 1991, 60, 106-117.
94. Anderson, A.A.; Harkiss, G.D.; Watt, N.J. Quantitative analysis of immunohistological changes in the synovial membrane of sheep infected with Maedi-Visna Virus. Clin. Immunol. Immunopathol. 1994, 72, 21-29.
95. Larruskain, A.; Minguijón, E.; García-etxebarria, K.; Moreno, B.; Arostegui, I.; Juste, R.A; Jugo, B.M. MHC class II DRB1 gene polymorphism in the pathogenesis of Maedi-Visna and pulmonary adenocarcinoma viral diseases in sheep. Immunogenetics 2010, 62, 75-83.
96. Larruskain, A.; Minguijón, E.; Arostegui, I.; Moreno, B.; Juste, R.A.; Jugo, B.M. Microsatellites in immune-relevant regions and their associations with Maedi-Visna and ovine pulmonary adenocarcinoma viral diseases. Vet. Immunol. Immunopathol. 2012, 145, 438-446.
97. Ruff, G.; Regli, J.G.; Lazary, S. Occurrence of caprine leucocyte class I and II antigens in Saanen goats affected by caprine arthritis (CAE). Eur. J. Immunogenet. 1993, 20, 285-288.
98. Batalia, M.A.; Collins, E.J.; Carolina, N. Peptide binding by class I and class II MHC molecules. Biopolymers 1997, 43, 281-302.
99. Konnai, S.; Takeshima, S.; Tajima, S.; Yin, S.A.; Okada, K.; Onuma, M.; Aida, Y. The influence of ovine MHC class II DRB1 alleles on immune response in bovine leukemia virus infection. Microbiol. Immunol. 2003, 47, 223-232.
100. De Andrés, D.; Klein, D.; Watt, N.J.; Berriatua, E.; Torsteinsdottir, S.; Blacklaws, B.A.; Harkiss, G.D. Diagnostic tests for small ruminant lentiviruses. Vet. Microbiol. 2005, 107, 49-62.
101. Singh, D.K.; Chebloune, Y.; Mselli-Lakhal, L.; Karr, B.M.; Narayan, O. Ovine lentivirus-infected macrophages mediate productive infection in cell types that are not susceptible to infection with cell-free virus. J. Gen. Virol. 1999, 80, 1437-1444.
102. Torsteinsdóttir, S.; Georgsson, G.; Gísladóttir, E.; Rafnar, B.; Pálsson, P.A.; Pétursson, G. Pathogenesis of central nervous system lesions in visna: Cell-mediated immunity and lymphocyte subsets in blood, brain and cerebrospinal fluid. J. Neuroimmunol. 1992, 41, 149-158.
103. Perry, L.L.; Wilkerson, M.J.; Hullinger, G.A.; Cheevers, W.P. Depressed CD4T lymphocyte proliferative response and enhanced antibody response to viral antigen in chronic lentivirus-induced arthritis. J. Infect. Dis. 1995, 171, 328-334.
104. Trujillo, J.D.; Hotzel, K.J.; Snekvik, K.R.; Cheevers, W.P. Antibody response to the surface envelope of caprine arthritis-encephalitis lentivirus: Disease status is predicted by SU antibody isotype. Virology 2004, 325, 129-136.
105. Bird, P.; Reyburn, H.T.; Blacklaws, B.A.; Allen, D.; Nettleton, P.; Yirrell, D.L.; Watt, N.; Sargan, D.; McConnell, I. The restricted IgG1 antibody response to maedi visna virus is seen following infection but not following immunization with recombinant gag protein. Clin. Exp. Immunol. 1995, 102, 274-280.
106. Watt, N.J.; MacIntyre, N.; Collie, D.; Sargan, D.; McConnell, I. Phenotypic analysis of lymphocyte populations in the lungs and regional lymphoid tissue of sheep naturally infected with Maedi-Visna Virus. Clin. Exp. Immunol. 1992, 90, 204-208.
107. Luján, L.; Begara, I.; Collie, D.D.; Watt, N.J. CD8+ lymphocytes in bronchoalveolar lavage and blood: In vivo indicators of lung pathology caused by Maedi-Visna Virus. Vet. Immunol. Immunopathol. 1995, 49, 89-100.
108. Jolly, P.E.; Gangopadhyay, A.; Chen, S.; Reddy, P.G.; Weiss, H.L. Changes in the leukocyte phenotype profile of goats infected with the caprine arthritis encephalitis virus. Vet. Immunol. Immunopathol. 1997, 56, 97-106.
109. Blacklaws, B.A; Bird, P.; Allen, D.; McConnell, I. Circulating cytotoxic T lymphocyte precursors in Maedi-Visna Virus-infected sheep. J. Gen. Virol. 1994, 75, 1589-1596.
110. Lee, W.C.; McConnell, I.; Blacklaws, B.A. Cytotoxic activity against Maedi-Visna Virus-infected macrophages. J. Virol. 1994, 68, 8331-8338.
111. Estes, D.M.; Brown, W.C. Type 1 and type 2 responses in regulation of Ig isotype expression in cattle. Vet. Immunol. Immunopathol. 2002, 90, 1-10.
112. Snekvik, K.R.; Beyer, J.C.; Bertoni, G.; von Beust, B.R.; Baszler, T.V; Palmer, G.H.; McElwain, T.F.; Cheevers, W.P. Characterization of caprine interleukin-4. Vet. Immunol. Immunopathol. 2001, 78, 219-229.
113. Lechner, F.; Vogt, H.R.; Seow, H.F.; Bertoni, G.; Cheevers, W.P.; von Bodungen, U.; Zurbriggen, A; Peterhans, E. Expression of cytokine mRNA in lentivirus-induced arthritis. Am. J. Pathol. 1997, 151, 1053-1065.
114. Woodall, C.J.; Maclaren, L.J.; Watt, N.J. Differential levels of mRNAs for cytokines, the interleukin-2 receptor and Class II DR/DQ genes in ovine interstitial pneumonia induced by Maedi visna virus infection. Vet. Pathol. 1997, 34, 204-211.
115. Legastelois, I.; Cottin, V.; Mornex, J.F.; Cordier, G. Alveolar macrophages from sheep naturally infected by Visna-Maedi virus contribute to IL-8 production in the lung. Vet. Immunol. Immunopathol. 1997, 59, 131-139.
116. Zhang, Z.; Harkiss, G.D.; Hopkins, J. Granulocyte macrophage colony stimulating factor is elevated in alveolar macrophages from sheep naturally infected with Maedi-Visna Virus and stimulates Maedi-Visna Virus replication in macrophages in vitro. Clin. Exp. Immunol. 2002, 129, 240-246.
117. Legastelois, I.; Cordier, O.; Cozon, G.; Cador, J. Visna-Maedi virus-induced expression of interleukin-8 gene in sheep alveolar cells following experimental in vitro and in vivo infection. Res. Virol. 1996, 147, 191-197.
118. Ellis, J.A.; DeMartini, J.C. Ovine interleukin-2: Partial purification and assay in normal sheep and sheep with ovine progressive pneumonia. Vet. Immunol. Immunopathol. 1985, 8, 15-25.
119. Legastelois, I.; Levrey, H.; Greenland, T.; Mornex, J.F.; Cordier, G. Visna-Maedi virus induces interleukin-8 in sheep alveolar macrophages through a tyrosine-kinase signaling pathway. Am. J. Respir. Cell Mol. Biol. 1998, 18, 532-537.
120. Larruskain, A.; Bernales, I.; Luján, L.; de Andrés, D.; Amorena, B.; Jugo, B.M. Expression analysis of 13 ovine immune response candidate genes in Visna/Maedi disease progression. Comp. Immunol. Microbiol. Infect. Dis. 2013, 36, 405-413.
121. White, S.N.; Mousel, M.R.; Reynolds, J.O.; Lewis, G.S.; Herrmann-Hoesing, L.M. Common promoter deletion is associated with 3.9-fold differential transcription of ovine CCR5 and reduced proviral level of ovine progressive pneumonia virus. Anim. Genet. 2009, 40, 583-589.
122. Shirakawa, I.; Deichmann, K.A.; Izuhara, I.; Mao, I.; Adra, C.N.; Hopkin, J.M. Atopy and asthma: Genetic variants of IL-4 and IL-13 signalling. Immunol. Today 2000, 21, 60-64.
123. Locati, M.; Otero, K.; Schioppa, T.; Signorelli, P.; Perrier, P.; Baviera, S.; Sozzani, S.; Mantovani, A. The chemokine system: Tuning and shaping by regulation of receptor expression and coupling in polarized responses. Allergy 2002, 57, 972-982.
124. Medzhitov, R. Recognition of microorganisms and activation of the immune response. Nature 2007, 449, 819-826.
125. Werling, D.; Jann, O.; Offord, V.; Glass, E.; Coffey, T. Variation matters: TLR structure and species-specific pathogen recognition. Trends mmunol. 2009, 30, 124-130.
126. Takeda, K.; Kaisho, T.; Akira, S. Toll-like receptors. Annu. Rev. Immunol. 2003, 21, 335-376.
127. Mikula, I.; Bhide, M.; Pastorekova, S. Characterization of ovine TLR7 and TLR8 protein coding regions, detection of mutations and Maedi-Visna Virus infection. Vet. Immunol. Immunopathol. 2010, 138, 51-59.
128. Bell, J.K.; Mullen, G.E.; Leifer, C.A.; Mazzoni, A.; Davies, D.R.; Segal, D.M. Leucine-rich repeats and pathogen recognition in Toll-like receptors. Trends Immunol. 2003, 24, 528-533.
129. Zheng, Y.H.; Peterlin, B.B. Intracellular immunity to HIV-1: Newly defined retroviral battles inside infected cells. Retrovirology 2005, 2, e25.
130. Huthoff, H.; Towers, G.J. Restriction of retroviral replication by APOBEC3G/F and TRIM5alpha. Trends Microbiol. 2008, 16, 612-619.
131. Jáuregui, P.; Crespo, H.; Glaria, I.; Luján, L.; Contreras, A.; Rosati, S.; de Andrés, D.; Amorena, B.; Towers, G.J.; Reina, R. Ovine TRIM5α can restrict Visna/Maedi virus. J. Virol. 2012, 86, 9504-9509.
132. Van Manen, D.; Rits, M.A.; Beugeling, C.; van Dort, K.; Schuitemaker, H.; Kootstra, N.A. The effect of Trim5 polymorphisms on the clinical course of HIV-1 infection. PLoS Pathog. 2008, 4, e18.
133. LaRue, R.S.; Jónsson, S.R.; Silverstein, K.A.T.; Lajoie, M.; Bertrand, D.; El-Mabrouk, N.; Hötzel, I.; Andrésdóttir, V.; Smith, T.P.L.; Harris, R.S. The artiodactyl APOBEC3 innate immune repertoire shows evidence for a multi-functional domain organization that existed in the ancestor of placental mammals. BMC Mol. Biol. 2008, 9, doi:10.1186/1471-2199-9-104.
134. LaRue, R.S.; Lengyel, J.; Jonsson, S.R.; Andresdottir, V.; Harris, R.S. Lentiviral Vif degrades the APOBEC3Z3/APOBEC3H protein of its mammalian host and is capable of cross-species activity. J. Virol. 2010, 84, 8193-8201.
135. Jónsson, S.R.; Haché, G.; Stenglein, M.D.; Fahrenkrug, S.C.; Andrésdóttir, V.; Harris, R.S. Evolutionarily conserved and non-conserved retrovirus restriction activities of artiodactyl APOBEC3F proteins. Nucleic Acids Res. 2006, 34, 5683-5694.