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Volumn 350, Issue 1, 2006, Pages 116-127

Viral load, organ distribution, histopathological lesions, and cytokine mRNA expression in goats infected with a molecular clone of the caprine arthritis encephalitis virus

Author keywords

Animal genetic; CAEV; Caprine arthritis encephalitis virus; Cytokine; Lentivirus; MVV; Real time PCR; Small ruminant lentiviruses; SRLV; Viral load

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAPRINE ARTHRITIS ENCEPHALITIS VIRUS; FEMALE; GENE EXPRESSION; GENETIC VARIABILITY; GENETICS; GOAT; HISTOPATHOLOGY; LENTIVIRINAE; LYMPH NODE; MALE; MAMMARY GLAND; MILK; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; ORGAN DISTRIBUTION; PRIMATE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VIRUS INFECTION; VIRUS LOAD; VIRUS REPLICATION;

EID: 33744933482     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2006.02.014     Document Type: Article
Times cited : (73)

References (60)
  • 1
    • 0028298084 scopus 로고
    • Primary stage of feline immunodeficiency virus infection: viral dissemination and cellular targets
    • Beebe A.M., Dua N., Faith T.G., Moore P.F., Pedersen N.C., and Dandekar S. Primary stage of feline immunodeficiency virus infection: viral dissemination and cellular targets. J. Virol. 68 (1994) 3080-3091
    • (1994) J. Virol. , vol.68 , pp. 3080-3091
    • Beebe, A.M.1    Dua, N.2    Faith, T.G.3    Moore, P.F.4    Pedersen, N.C.5    Dandekar, S.6
  • 2
    • 0027961025 scopus 로고
    • Antibody reactivity to the immunodominant epitopes of the caprine arthritis-encephalitis virus gp38 transmembrane protein associates with the development of arthritis
    • Bertoni G., Zahno M.-L., Zanoni R., Vogt H.R., Peterhans E., Ruff G., Cheevers W.P., Sonigo P., and Pancino G. Antibody reactivity to the immunodominant epitopes of the caprine arthritis-encephalitis virus gp38 transmembrane protein associates with the development of arthritis. J. Virol. 68 (1994) 7139-7147
    • (1994) J. Virol. , vol.68 , pp. 7139-7147
    • Bertoni, G.1    Zahno, M.-L.2    Zanoni, R.3    Vogt, H.R.4    Peterhans, E.5    Ruff, G.6    Cheevers, W.P.7    Sonigo, P.8    Pancino, G.9
  • 4
  • 5
    • 0027234620 scopus 로고
    • Early events in immune evasion by the lentivirus Maedi-Visna occurring within infected lymphoid tissue
    • Bird P., Blacklaws B.A., Reyburn H.T., Allen D., Hopkins J., Sargan D., and McConnell I. Early events in immune evasion by the lentivirus Maedi-Visna occurring within infected lymphoid tissue. J. Virol. 67 (1993) 5187-5197
    • (1993) J. Virol. , vol.67 , pp. 5187-5197
    • Bird, P.1    Blacklaws, B.A.2    Reyburn, H.T.3    Allen, D.4    Hopkins, J.5    Sargan, D.6    McConnell, I.7
  • 9
    • 0037292069 scopus 로고    scopus 로고
    • In situ PCR-associated immunohistochemistry identifies cell types harbouring the Maedi-Visna virus genome in tissue sections of sheep infected naturally
    • Carrozza M.L., Mazzei M., Bandecchi P., Arispici M., and Tolari F. In situ PCR-associated immunohistochemistry identifies cell types harbouring the Maedi-Visna virus genome in tissue sections of sheep infected naturally. J. Virol. Methods 107 (2003) 121-127
    • (2003) J. Virol. Methods , vol.107 , pp. 121-127
    • Carrozza, M.L.1    Mazzei, M.2    Bandecchi, P.3    Arispici, M.4    Tolari, F.5
  • 10
    • 0030806427 scopus 로고    scopus 로고
    • Type 1 and type 2 cytokine gene expression by viral gp135 surface protein-activated T lymphocytes in caprine arthritis-encephalitis lentivirus infection
    • Cheevers W.P., Beyer J.C., and Knowles D.P. Type 1 and type 2 cytokine gene expression by viral gp135 surface protein-activated T lymphocytes in caprine arthritis-encephalitis lentivirus infection. J. Virol. 71 (1997) 6259-6263
    • (1997) J. Virol. , vol.71 , pp. 6259-6263
    • Cheevers, W.P.1    Beyer, J.C.2    Knowles, D.P.3
  • 11
    • 0033613070 scopus 로고    scopus 로고
    • Latent reservoirs of HIV: obstacles to the eradication of virus
    • Chun T.W., and Fauci A.S. Latent reservoirs of HIV: obstacles to the eradication of virus. Proc. Natl. Acad. Sci. U.S.A. 96 (1999) 10958-10961
    • (1999) Proc. Natl. Acad. Sci. U.S.A. , vol.96 , pp. 10958-10961
    • Chun, T.W.1    Fauci, A.S.2
  • 12
    • 0028471118 scopus 로고
    • A DNA fingerprinting band associated with the susceptibility to CAE virus-induced arthritis in goats
    • Dolf G., and Ruff G. A DNA fingerprinting band associated with the susceptibility to CAE virus-induced arthritis in goats. Br. Vet. J. 150 (1994) 349-353
    • (1994) Br. Vet. J. , vol.150 , pp. 349-353
    • Dolf, G.1    Ruff, G.2
  • 13
    • 0027516822 scopus 로고
    • Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS
    • Embretson J., Zupancic M., Ribas J.L., Burke A., Racz P., Tenner-Racz K., and Haase A.T. Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS. Nature 362 (1993) 359-362
    • (1993) Nature , vol.362 , pp. 359-362
    • Embretson, J.1    Zupancic, M.2    Ribas, J.L.3    Burke, A.4    Racz, P.5    Tenner-Racz, K.6    Haase, A.T.7
  • 14
    • 0022398502 scopus 로고
    • Slow, persistent replication of lentiviruses: role of tissue macrophages and macrophage precursors in bone marrow
    • Gendelman H.E., Narayan O., Molineaux S., Clements J.E., and Ghotbi Z. Slow, persistent replication of lentiviruses: role of tissue macrophages and macrophage precursors in bone marrow. Proc. Natl. Acad. Sci. U.S.A. 82 (1985) 7086-7090
    • (1985) Proc. Natl. Acad. Sci. U.S.A. , vol.82 , pp. 7086-7090
    • Gendelman, H.E.1    Narayan, O.2    Molineaux, S.3    Clements, J.E.4    Ghotbi, Z.5
  • 15
    • 0022517187 scopus 로고
    • Tropism of sheep lentiviruses for monocytes: susceptibility to infection and virus gene expression increase during maturation of monocytes to macrophages
    • Gendelman H.E., Narayan O., Kennedy-Stoskopf S., Kennedy P.G.E., Ghotbi Z., Clements J.E., Stanley J., and Pezeshkpour G. Tropism of sheep lentiviruses for monocytes: susceptibility to infection and virus gene expression increase during maturation of monocytes to macrophages. J. Virol. 58 (1986) 67-74
    • (1986) J. Virol. , vol.58 , pp. 67-74
    • Gendelman, H.E.1    Narayan, O.2    Kennedy-Stoskopf, S.3    Kennedy, P.G.E.4    Ghotbi, Z.5    Clements, J.E.6    Stanley, J.7    Pezeshkpour, G.8
  • 16
    • 0141428794 scopus 로고    scopus 로고
    • Controlling the angiogenic switch: a balance between two distinct TGF-b receptor signaling pathways
    • Goumans M.J., Lebrin F., and Valdimarsdottir G. Controlling the angiogenic switch: a balance between two distinct TGF-b receptor signaling pathways. Trends Cardiovasc. Med. 13 (2003) 301-307
    • (2003) Trends Cardiovasc. Med. , vol.13 , pp. 301-307
    • Goumans, M.J.1    Lebrin, F.2    Valdimarsdottir, G.3
  • 17
    • 23844530389 scopus 로고    scopus 로고
    • Immunohistochemical detection of the p27 capsid protein of caprine arthritis-encephalitis virus (CAEV) in bone-marrow cells of seropositive goats
    • Grossi P., Giudice C., Bertoletti I., Cioccarelli G., Brocchi E., Cammarata G., and Gelmetti D. Immunohistochemical detection of the p27 capsid protein of caprine arthritis-encephalitis virus (CAEV) in bone-marrow cells of seropositive goats. J. Comp. Pathol. 133 (2005) 197-200
    • (2005) J. Comp. Pathol. , vol.133 , pp. 197-200
    • Grossi, P.1    Giudice, C.2    Bertoletti, I.3    Cioccarelli, G.4    Brocchi, E.5    Cammarata, G.6    Gelmetti, D.7
  • 20
    • 0017577407 scopus 로고
    • Slow persistent infection caused by visna virus: role of host restriction
    • Haase A.T., Stowring L., Narayan P., Griffin D., and Price D. Slow persistent infection caused by visna virus: role of host restriction. Science 195 (1977) 175-177
    • (1977) Science , vol.195 , pp. 175-177
    • Haase, A.T.1    Stowring, L.2    Narayan, P.3    Griffin, D.4    Price, D.5
  • 23
    • 0025303688 scopus 로고
    • Severity of arthritis is predicted by antibody response to Gp135 in chronic infection with caprine arthritis-encephalitis virus
    • Knowles D.P., Cheevers W.P., McGuire T.C., Stem T.A., and Gorham J.R. Severity of arthritis is predicted by antibody response to Gp135 in chronic infection with caprine arthritis-encephalitis virus. J. Virol. 64 (1990) 2396-2398
    • (1990) J. Virol. , vol.64 , pp. 2396-2398
    • Knowles, D.P.1    Cheevers, W.P.2    McGuire, T.C.3    Stem, T.A.4    Gorham, J.R.5
  • 24
    • 0029742706 scopus 로고    scopus 로고
    • Transforming growth factor-beta: a general review
    • Lawrence D.A. Transforming growth factor-beta: a general review. Eur. Cytokine Netw. 7 (1996) 363-374
    • (1996) Eur. Cytokine Netw. , vol.7 , pp. 363-374
    • Lawrence, D.A.1
  • 25
    • 0030819359 scopus 로고    scopus 로고
    • Caprine arthritis encephalitis virus dysregulates the expression of cytokines in macrophages
    • Lechner F., Machado J., Bertoni G., Seow H.F., Dobbelaere D.A., and Peterhans E. Caprine arthritis encephalitis virus dysregulates the expression of cytokines in macrophages. J. Virol. 71 (1997) 7488-7497
    • (1997) J. Virol. , vol.71 , pp. 7488-7497
    • Lechner, F.1    Machado, J.2    Bertoni, G.3    Seow, H.F.4    Dobbelaere, D.A.5    Peterhans, E.6
  • 28
    • 0031008309 scopus 로고    scopus 로고
    • Genomic heterogeneity of small ruminant lentiviruses: existence of heterogeneous populations in sheep and of the same lentiviral genotypes in sheep and goats
    • Leroux C., Chastang J., Greenland T., and Mornex J.F. Genomic heterogeneity of small ruminant lentiviruses: existence of heterogeneous populations in sheep and of the same lentiviral genotypes in sheep and goats. Arch. Virol. 142 (1997) 1125-1137
    • (1997) Arch. Virol. , vol.142 , pp. 1125-1137
    • Leroux, C.1    Chastang, J.2    Greenland, T.3    Mornex, J.F.4
  • 29
    • 0033031005 scopus 로고    scopus 로고
    • Use of real-time PCR and molecular beacons to detect virus replication in human immunodeficiency virus type 1-infected individuals on prolonged effective antiretroviral therapy
    • Lewin S.R., Vesanen M., Kostrikis L., Hurley A., Duran M., Zhang L., Ho D.D., and Markowitz M. Use of real-time PCR and molecular beacons to detect virus replication in human immunodeficiency virus type 1-infected individuals on prolonged effective antiretroviral therapy. J. Virol. 73 (1999) 6099-6103
    • (1999) J. Virol. , vol.73 , pp. 6099-6103
    • Lewin, S.R.1    Vesanen, M.2    Kostrikis, L.3    Hurley, A.4    Duran, M.5    Zhang, L.6    Ho, D.D.7    Markowitz, M.8
  • 30
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
    • Livak K.J., and Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25 (2001) 402-408
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 31
    • 0026572388 scopus 로고
    • Transmembrane protein oligomers of caprine arthritis-encephalitis lentivirus are immunodominant in goats with progressive arthritis
    • McGuire T.C., Knowles Jr. D.P., Davis W.C., Brassfield A.L., Stem T.A., and Cheevers W.P. Transmembrane protein oligomers of caprine arthritis-encephalitis lentivirus are immunodominant in goats with progressive arthritis. J. Virol. 66 (1992) 3247-3250
    • (1992) J. Virol. , vol.66 , pp. 3247-3250
    • McGuire, T.C.1    Knowles Jr., D.P.2    Davis, W.C.3    Brassfield, A.L.4    Stem, T.A.5    Cheevers, W.P.6
  • 32
    • 3142778353 scopus 로고    scopus 로고
    • Separate isolation of genomic DNA and total RNA from single samples using the SV Total RNA Isolation System
    • Otto P., Kephart D., Bitner R., Huber S., and Volkerding K. Separate isolation of genomic DNA and total RNA from single samples using the SV Total RNA Isolation System. Promega Notes 69 (1998) 19-23
    • (1998) Promega Notes , vol.69 , pp. 19-23
    • Otto, P.1    Kephart, D.2    Bitner, R.3    Huber, S.4    Volkerding, K.5
  • 34
    • 0028889960 scopus 로고
    • + T lymphocyte proliferative response and enhanced antibody response to viral antigen in chronic lentivirus-induced arthritis
    • + T lymphocyte proliferative response and enhanced antibody response to viral antigen in chronic lentivirus-induced arthritis. J. Infect. Dis. 171 (1995) 328-334
    • (1995) J. Infect. Dis. , vol.171 , pp. 328-334
    • Perry, L.L.1    Wilkerson, M.J.2    Hullinger, G.A.3    Cheevers, W.P.4
  • 36
    • 0034040118 scopus 로고    scopus 로고
    • Reservoirs for HIV-1: mechanisms for viral persistence in the presence of antiviral immune responses and antiretroviral therapy
    • Pierson T., McArthur J., and Siliciano R.F. Reservoirs for HIV-1: mechanisms for viral persistence in the presence of antiviral immune responses and antiretroviral therapy. Annu. Rev. Immunol. 18 (2000) 665-708
    • (2000) Annu. Rev. Immunol. , vol.18 , pp. 665-708
    • Pierson, T.1    McArthur, J.2    Siliciano, R.F.3
  • 37
    • 23844535509 scopus 로고    scopus 로고
    • Phylogenetic analysis of small-ruminant lentivirus subtype B1 in mixed flocks: evidence for natural transmission from goats to sheep
    • Pisoni G., Quasso A., and Moroni P. Phylogenetic analysis of small-ruminant lentivirus subtype B1 in mixed flocks: evidence for natural transmission from goats to sheep. Virology 339 (2005) 147-152
    • (2005) Virology , vol.339 , pp. 147-152
    • Pisoni, G.1    Quasso, A.2    Moroni, P.3
  • 38
    • 0022542548 scopus 로고
    • Sequence homology between cloned caprine arthritis encephalitis virus and visna virus, two neurotropic lentiviruses
    • Pyper J.M., Clements J.E., Gonda M.A., and Narayan O. Sequence homology between cloned caprine arthritis encephalitis virus and visna virus, two neurotropic lentiviruses. J. Virol. 58 (1986) 665-700
    • (1986) J. Virol. , vol.58 , pp. 665-700
    • Pyper, J.M.1    Clements, J.E.2    Gonda, M.A.3    Narayan, O.4
  • 39
    • 33744899297 scopus 로고    scopus 로고
    • Ravazzolo, A.-P., 1993. Régulation temporelle de la transcription du virus de l'arthrite et de l'encéphalite de la chèvre au cours de son cycle lytique. PhD thesis, Université Claude-Bernard.
  • 40
    • 0027689996 scopus 로고
    • Delayed seroconversion following naturally acquired caprine arthritis-encephalitis virus infection in goats
    • Rimstad E., East N.E., Torten M., Higgins J., DeRock E., and Pedersen N.C. Delayed seroconversion following naturally acquired caprine arthritis-encephalitis virus infection in goats. Am. J. Vet. Res. 54 (1993) 1858-1862
    • (1993) Am. J. Vet. Res. , vol.54 , pp. 1858-1862
    • Rimstad, E.1    East, N.E.2    Torten, M.3    Higgins, J.4    DeRock, E.5    Pedersen, N.C.6
  • 43
    • 0023786008 scopus 로고
    • Evidence for linkage between the caprine leucocyte antigen (CLA) system and susceptibility to CAE virus-induced arthritis in goats
    • Ruff G., and Lazary S. Evidence for linkage between the caprine leucocyte antigen (CLA) system and susceptibility to CAE virus-induced arthritis in goats. Immunogenetics 28 (1988) 303-309
    • (1988) Immunogenetics , vol.28 , pp. 303-309
    • Ruff, G.1    Lazary, S.2
  • 44
    • 0027199295 scopus 로고
    • Occurrence of caprine leucocyte class I and II antigens in Saanen goats affected by caprine arthritis (CAE)
    • Ruff G., Regli J.G., and Lazary S. Occurrence of caprine leucocyte class I and II antigens in Saanen goats affected by caprine arthritis (CAE). Eur. J. Immunogenet. 20 (1993) 285-288
    • (1993) Eur. J. Immunogenet. , vol.20 , pp. 285-288
    • Ruff, G.1    Regli, J.G.2    Lazary, S.3
  • 45
    • 0033779919 scopus 로고    scopus 로고
    • Infection of dendritic cells by the Maedi-Visna lentivirus
    • Ryan S., Tiley L., McConnell I., and Blacklaws B.A. Infection of dendritic cells by the Maedi-Visna lentivirus. J. Virol. 74 (2000) 10096-10103
    • (2000) J. Virol. , vol.74 , pp. 10096-10103
    • Ryan, S.1    Tiley, L.2    McConnell, I.3    Blacklaws, B.A.4
  • 47
    • 0025036273 scopus 로고
    • Nucleotide sequence and transcriptional analysis of molecular clones of CAEV which generate infectious virus
    • Saltarelli M., Querat G., Konings D.AM., Vigne R., and Clements J.E. Nucleotide sequence and transcriptional analysis of molecular clones of CAEV which generate infectious virus. Virology 179 (1990) 347-364
    • (1990) Virology , vol.179 , pp. 347-364
    • Saltarelli, M.1    Querat, G.2    Konings, D.AM.3    Vigne, R.4    Clements, J.E.5
  • 48
    • 0036891622 scopus 로고    scopus 로고
    • Analysis of caprine arthritis encephalitis virus (CAEV) temporal gene expression in infected cells
    • Schoborg R.V. Analysis of caprine arthritis encephalitis virus (CAEV) temporal gene expression in infected cells. Virus Res. 90 (2002) 37-46
    • (2002) Virus Res. , vol.90 , pp. 37-46
    • Schoborg, R.V.1
  • 49
    • 3142722030 scopus 로고    scopus 로고
    • Direct evidence for natural transmission of small-ruminant lentiviruses of subtype A4 from goats to sheep and vice versa
    • Shah C., Huder J.B., Boni J., Schonmann M., Muhlherr J., Lutz H., and Schupbach J. Direct evidence for natural transmission of small-ruminant lentiviruses of subtype A4 from goats to sheep and vice versa. J. Virol. 78 (2004) 7518-7522
    • (2004) J. Virol. , vol.78 , pp. 7518-7522
    • Shah, C.1    Huder, J.B.2    Boni, J.3    Schonmann, M.4    Muhlherr, J.5    Lutz, H.6    Schupbach, J.7
  • 51
    • 0031132768 scopus 로고    scopus 로고
    • Immunohistochemical identification of caprine arthritis-encephalitis virus in paraffin-embedded specimens from naturally infected goats
    • Storset A.K., Evensen O., and Rimstad E. Immunohistochemical identification of caprine arthritis-encephalitis virus in paraffin-embedded specimens from naturally infected goats. Vet. Pathol. 34 (1997) 180-188
    • (1997) Vet. Pathol. , vol.34 , pp. 180-188
    • Storset, A.K.1    Evensen, O.2    Rimstad, E.3
  • 52
    • 0029126486 scopus 로고
    • Temporal patterns of feline immunodeficiency virus transcripts in peripheral blood cells during the latent stage of infection
    • Tomonaga K., Inoshima Y., Ikeda Y., and Mikami T. Temporal patterns of feline immunodeficiency virus transcripts in peripheral blood cells during the latent stage of infection. J. Gen. Virol. 76 (1995) 2193-2204
    • (1995) J. Gen. Virol. , vol.76 , pp. 2193-2204
    • Tomonaga, K.1    Inoshima, Y.2    Ikeda, Y.3    Mikami, T.4
  • 53
    • 0023446038 scopus 로고
    • Transcription of visna virus during its lytic cycle: evidence for a sequential early and late gene expression
    • Vigne R., Barban V., Querat G., Mazarin V., Gourdou I., and Sauze N. Transcription of visna virus during its lytic cycle: evidence for a sequential early and late gene expression. Virology 161 (1987) 218-227
    • (1987) Virology , vol.161 , pp. 218-227
    • Vigne, R.1    Barban, V.2    Querat, G.3    Mazarin, V.4    Gourdou, I.5    Sauze, N.6
  • 54
    • 33744943501 scopus 로고    scopus 로고
    • Vogt, H.R., 2000. Caprine arthritis encephalitis: analysis of an outbreak associated with a goat and sheep market. Thesis. University of Bern, Faculty of Veterinary Medicine
  • 56
    • 0026474528 scopus 로고
    • Phenotypic analysis of lymphocyte populations in the lungs and regional lymphoid tissue of sheep naturally infected with Maedi Visna virus
    • Watt N.J., MacIntyre N., Collie D., Sargan D., and McConnell I. Phenotypic analysis of lymphocyte populations in the lungs and regional lymphoid tissue of sheep naturally infected with Maedi Visna virus. Clin. Exp. Immunol. 90 (1992) 204-208
    • (1992) Clin. Exp. Immunol. , vol.90 , pp. 204-208
    • Watt, N.J.1    MacIntyre, N.2    Collie, D.3    Sargan, D.4    McConnell, I.5
  • 57
    • 0028797823 scopus 로고
    • Peripheral blood and synovial fluid mononuclear cell phenotypes in lentivirus induced arthritis
    • Wilkerson M.J., Davis W.C., and Cheevers W.P. Peripheral blood and synovial fluid mononuclear cell phenotypes in lentivirus induced arthritis. J. Rheumatol. 22 (1995) 8-15
    • (1995) J. Rheumatol. , vol.22 , pp. 8-15
    • Wilkerson, M.J.1    Davis, W.C.2    Cheevers, W.P.3
  • 58
    • 0034010375 scopus 로고    scopus 로고
    • Quantitative analysis of Maedi-Visna virus DNA load in peripheral blood monocytes and alveolar macrophages
    • Zhang Z., Watt N.J., Hopkins J., Harkiss G., and Woodall C.J. Quantitative analysis of Maedi-Visna virus DNA load in peripheral blood monocytes and alveolar macrophages. J. Virol. Methods 86 (2000) 13-20
    • (2000) J. Virol. Methods , vol.86 , pp. 13-20
    • Zhang, Z.1    Watt, N.J.2    Hopkins, J.3    Harkiss, G.4    Woodall, C.J.5
  • 59
    • 0025327150 scopus 로고
    • Pathogenesis of caprine arthritis encephalitis virus-cellular localization of viral transcripts in tissues of infected goats
    • Zink M.C., Yager J.A., and Myers J.D. Pathogenesis of caprine arthritis encephalitis virus-cellular localization of viral transcripts in tissues of infected goats. Am. J. Pathol. 136 (1990) 843-854
    • (1990) Am. J. Pathol. , vol.136 , pp. 843-854
    • Zink, M.C.1    Yager, J.A.2    Myers, J.D.3


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