Molecular biology and pathogenesis of animal lentivirus infections

Clinical Microbiology Reviews

Volumn 9, Issue 1, 1996, Pages 100-117

  Clements, Janice E ^a   Christine Zink, M ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS PROTEIN;

CENTRAL NERVOUS SYSTEM DISEASE; GENE EXPRESSION REGULATION; GOAT; HORSE; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNE RESPONSE; INCUBATION TIME; LENTIVIRINAE; MACROPHAGE; MOLECULAR BIOLOGY; NONHUMAN; PATHOGENESIS; RETROVIRUS INFECTION; REVIEW; SHEEP; SIMIAN IMMUNODEFICIENCY VIRUS; VIRUS REPLICATION;

ANIMALIA; CAPRA HIRCUS; EQUIDAE; EQUUS CABALLUS; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; LENTIVIRUS; OVINE LENTIVIRUS; OVIS ARIES; SIMIAE; SIMIAN IMMUNODEFICIENCY VIRUS; UNIDENTIFIED RETROVIRUS; VISNA VIRUS;

EID: 13344261388     PISSN: 08938512     EISSN: None     Source Type: Journal    
DOI: 10.1128/cmr.9.1.100     Document Type: Review

References (224)

1. Adams, D. S., R. E. Oliver, E. Ameghino, J. C. DeMartini, D. W. Verwoerd, D. J. Houwers, S. Waghela, J. R. Gorham, B. Hyllseth, and M. Dawson, 1984. Global survey of serological evidence of caprine arthritis-encephalitis virus infection. Vet. Rec. 115:493-495.
2. Agy, M. B., L. R. Frumkin, and L. Corey. 1992. Infection of Macaca nemestrina by human immunodeficiency virus type-1. Science 257:103-106.
3. Ahmed, Y. F., S. M. Hanly, M. H. Malim, B. R. Cullen, and W. C. Green. 1991. Structure function analysis of the HTLV-I rex and HIV-I rev RNA response elements: insights into the mechanisms of rev and rev functions. Genes Dev. 4:1014-1022.
4. Aiken, C., J. Konner, N. R. Landau, M. E. Lenburg, and D. Trono. 1994. Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain. Cell 76:553-864.
5. Anderson, L. W., P. K. Anderson, and H. D. Liggitt. 1983. Susceptibility of blood-derived monocytes and macrophages to caprine arthritis-encephalitis virus Infect. Immun. 41:837-840.
6. Anderson, M. G., D. Hauer, D. P. Sharma, S. V. Joag, O. Narayan, M. C. Zink, and J. E. Clements. 1993. Analysis of envelope changes acquired by SIVmac239 during neuroadaption in ihesus macaques. Virology 195:616-626.
7. Arrigo, S. J., and I. S. Y. Chen, 1991. Rev is necessary foi translation but not cytoplasmic accumulation of HIV-1, vif. vpr, and env/vpu 2 RNAs Genes Dev. 5:808-819.
8. Arya, S. K. 1988. Human and simian immunodeficiency retroviruses: activation and differential transactivation of gene expression. AIDS Res. Hum. Retroviruses 4:175-186.
9. Arya, S. K., and R. C. Gallo. 1988. Human immunodeficiency virus type 2: analysis of regulatory elements. Proc. Natl. Acad. Sci. USA 85:9753-9757.
10. Barre-Sinoussi, F., J. C. Chermann, F. Rey, M. T. Nugeyre, S. Chamaret, J. Gruest, C. Dauguet, C. Axler-Blin, F. Vezinet-Brun, C. Rnuzioux, W. Rosenbaum, and L. Montagnier. 1983. Isolation of a T-lymphocyte retrovirus from a patient at risk for acquired immunodeficiency syndrome (AIDS). Science 220:868-871.
11. Benson, R. E., A. Sanfridson, J. S. Ottinger, C. Doyle, and B. R. Cullen. 1993. Downregulation of cell-surface CD4 expression by simian immuno-deficiency virus Nef prevents viral super infection. J. Exp Med. 177:1561-1566.
12. Benveniste, R. E., L. O. Arthur, C. C. Tsai, R. Sowder, T. D. Copeland, L. E. Henderson, and S. Oroszlan. 1986. Isolation of a lentivirus from a macaque with lymphoma: comparison with HTLV-III/LAV and other lentiviruses. J. Virol. 60:483-490.
13. Berkower, I., G. E. Smith, C. Giri, and D. Murphy. 1989 Human immunodeficiency virus 1: predominance of a group-specific neutralizing epitope that persists m genetic variation. J. Exp. Med. 170:1681-1695.
14. Bhat, S., S. L. Spitalnik, F. Gonzalez-Scarann, and D. H. Silberberg. 1991. Galactosyl ceramide or a derivative is an essential component of the neural receptor for HIV-1 envelope glycoprotein gp120. Proc. Natl. Acad. Sci. USA 88:7131-7134.
15. Braun, M. J., J. E. Clements, and M. A. Gonda. 1987. The visna virus genome: evidence for a hypervariable site in the env gene and sequence homology among lentivirus envelope proteins. J. Virol. 61:4046-4054
16. Brodie, S. J., L. D. Pearson, M. C. Zink, H. M. Bickle, B. C. Anderson, K. A. Marcom, and J. C. DeMartmi. 1995. Ovine lentivirus expression and disease: virus replication, but not entry, is restricted to macrophages of specific tissues. Am. J Pathol 146:250-263.
17. Bukrinsky, M. I., S. Haggerty, M. P. Dempsey, N. Sharova, and M. Stevenson. 1993. A nuclear localization signal within HIV-1 matrix protein that governs infection of non-dividing cells. Nature (London) 365:666-669.
18. Bukrinsky, M. I., N. Sharova, M. P. Dempsey, T. L. Stanwick, A. G. Bukrinskaya, S. Haggerty, and M. Stevenson. 1992 Active nuclear import of human immunodeficiency virus type 1 preintegration complexes. Proc. Natl. Acad. Sci. USA 89:6580-6584.
19. Burns, D. P. W., and R. C. Desrosiers. 1991. Selection of genetic variants of simian immunodeficiency virus in persistently infected rhesus monkeys. J. Virol. 65:1843-1854
20. Calvert, I., Z. Q. Peng, and H. F. Kung. 1991. Cloning and characterization of a novel sequence specific DNA binding protein recognizing the negative regulatory element (NRE) region of the HIV-1 LTR Gene 101:171-176.
21. Carruth, L. M., J. M. Hardwick, B. Morse, and J. E. Clements. 1994. Visna virus Tat protein: a potent transcription factor with both activator and suppressor domains. J. Virol. 68:6137-6146.
22. Carvalho, M., and D. Derse. 1991. Mutational analysis of the equine infectious anemia virus tat-responsive element. J. Virol. 65:3468-3474.
23. Carvalho, M., and D. Derse. 1993. The PU.1/Spi-1 proto-oncogene is a transcriptional regulator of a lentivirus promoter. J. Virol. 67:3883-3890.
24. Cheevers, W. P., D. P. J. Knowles, and L. K. Norton. 1991. Neutralization-resistant antigenic variants of caprine arthritis-encephalitis lentivirus associated with progressive arthritis. J. Infect. Dis. 164:679-685.
25. Cheng-Mayer, C., C. Weiss, D. Seto, and J. A. Levy. 1989. Isolates of HIV-1 from brain may constitute a special group of AIDS viruses. Proc Natl. Acad. Sci. USA 86:8575-8579.
26. Cichutek, K., S. Norley, R. Linde, W. Kreuz, M. Gahr, J. Lower, G. von Wangenheim, and R. Kurth. 1991. Lack of HIV-1 V3 region sequence diversity in two haemophiliac patients infected with a putative biologic clone of HIV-1. AIDS 5:1185-1187.
27. Clavel, F., D. Greetard, F. Brun-Vezinet, S. Charmaret, M. A. Rey, M. O. Santos-Ferreria, A. G. Laurent, C. Dauguet, C. Katlama, and C. Rouzioux. 1986. Isolation of a new human retrovirus from West Africian patients with AIDS. Science 233:343-346.
28. Clements, J. E., S. L. Gdovin, H. C. Montelaro, and O. Narayan. 1988 Antigenic variation in lentiviral diseases Annu. Rev. Immunol. 6:139-159.
29. Clements, J. E., R. C. Montelaro, M. C. Zink, A. Martin-Amedee, S. Miller, A. M. Trichel, B. Jagerski, D. Hauer, L. N. Martin, R. P. Bohm, and M. Murphey-Corb. 1995. Cross-proteclive immune responses induced in rhesus macaques by immunization with attenuated macrophage-tropic simian immunodeficiency virus. J. Virol. 69:2737-2744.
30. Clements, J. E., O. Narayan, and L. C. Cork. 1980. Biochemical characterization of the virus causing leukoencephalitis and arthritis in goats. J Gen Virol 50:423-427.
31. Clements. J. E., and F. Wong-Staal. 1992. Molecular biology of lentiviruses. Scmin. Virol 3:137-146.
32. Cochrane, A. W., C. H. Chen, and C. A. Rosen. 1990. Specific interaction of the human immunodeficiency virus rev protein with a structured region in the env mRNA. Proc. Natl Acad. Sci. USA 87:1198-1202.
33. Cohen, E. A., G. Dehni, J. G. Sodroski, and W. A. Haseltine. 1990. Human immunodeficiency virus vpr product is vinon-associated regulatory protein. J. Virol. 64:3097-3099.
34. Cohen, E. A., E. F. Terwilliger, Y. Jalinoos, J. Proulx, J. G. Sodroski, and W. H. Haseltine. 1990. Identification of HIV-1 vpr product and function. J. Acquired Immune Defic. Syndr. 3:11-18.
35. Collman, R., N. F. Hassan, R. Walker, B. Godfrey, J. Cutilli, J. C. Hastings, H. Friedman, S. D. Douglas, and N. Nathanson. 1989. Infection of monocyte-derived macrophages with human immunodeficiency virus type 1 (HIV-1): monocyte-tropic and lymphocyte-tropic strains of HIV-1 show distinctive patterns of replication in a panel of cell types. J. Exp. Med 170:1149-1163.
36. Cork, L. C., W. J. Hadlow, T. B. Crawford, J. R. Gorham, and R. C. Piper. 1974 Infectious leukoencephalomyelitis of young goats. J. Infect. Dis. 129: 134-141.
37. Crane, S. E., J. Buzy, and J. E. Clements. 1991. Identification of cell membrane proteins that bind visna virus. J. Virol. 65:6137-6143.
38. Crawford, T. B., D. S. Adams, W. P. Cheevers, and L. C. Cork. 1980. Chronic arthritis in goats caused by a retrovirus. Science 207:997-999.
39. Cullen, B. R. 1992. Mechanism of action of regulatory proteins encoded by complex retroviruses. Microbiol Rev. 56:375-394.
40. Cullen, B. R., and W. C. Greene. 1990 Functions of the auxiliary gene products of the human immunodeficiency virus type 1. Virology 178:1-5.
41. Dalziel, K. G., J. Hopkins, N. J. Watt, B. M. Dutia, M. A. K. Clarke, and I. McConnell. 1991. Identification of a putative cellular receptor for the lentivirus visna virus. J. Gen. Virol. 72:1905-1911.
42. Daniel, M. D., F. Kirchhoff, C. Czajak, P. K. Sehgal, and R. C. Desrosiers. 1992. Protective effects of a live attenuated SIV vaccine with a deletion in the nef gene. Science 258:1938-1941
43. Daniel, M. D., N. L. Letvin, N. W. King, M. Kannagi, P. K. Sehgal, and R. D. Hunt. 1985. Isolation of T-cell tropic HTLV-III-like retrovirus from macaques. Science 228:1201-1204.
44. Desrosiers, R. C. 1990. The simian immunodeficiency viruses. Annu. Rev. Immunol. 8:557-578
45. Desrosiers, R. C., A. Hansen-Moosa, K. Mori, D. P. Bouvier, N. W. King, and D. J. Ringler, 1991. Macrophage-tropic variants of SIV are associated with specific AIDS-related lesions but arc not essential for the development of AIDS. Am. J. Pathol. 139:29-35
46. Duker, N. J., and C. L. Grant. 1980. Alterations in the levels of deoxyuridme triphosphatase, urac-DNA glycolsylase and AP endonuclease during the cell cycle. Exp. Cell Res. 125:493-497.
47. Elder, J. H., D. L. Lerner, C. S. Hasselkus-Light, D. J. Fontenot, E. Hunter, P. A. Luciw, R. C. Montelaro, and T. R. Phillips. 1992. Distinct subsets of retroviruses encode dUTPase. J. Virol. 66:1791-1794.
48. Fauci, A. S. 1993. Immunopathogenesis of HIV infection J. Acquired Immune Defic. Syndr. 6:655-662.
49. Fauci, A. S. 1993. New concepts in the iminunopathogenesis of HIV infection N. Engl. J Med. 328:327-335.
50. Feinberg, M. B., R. F. Jarrett, A. Aldovini, R. C. Gallo, and F. Wong-Staal. 1986. HTLV-III expression and production involve complex regulation at the levels of splicing and translation of viral RNA. Cell 46:807-817.
51. Fenouillet, E., J. C. Gluckman, and I. M. Jones. 1994 Functions of HIV envelope glycans. Trends Biochem. Sci. 19:65-70.
52. Franchini, G., C. Gurgo, H. G. Cuo, R. C. Gallo, E. Collalti, A. Fargnoli, L. F. Hall, F. Wong-Staal, and M. S. Reitz. 1987. Sequence of SIV and its relationship to the human immunodeficiency viruses. Nature (London) 328:539-543.
53. Franza, B., S. Joseph, M. Gilman, W. Ryan, and W. Clarkson. 1987. Characterization of cellular proteins recognizing the HIV enhancer using a microscale DNA-affinity precipitation assay. Nature (London) 330:391-395.
54. Fultz, P. N., H. M. McClure, D. C. Anderson, R. B. Swenson, R. Anand, and A. Srinivasan. 1986. Isolation of a T-lymphoiropk: rctrovirus from naturally infected sooty manaabey monkeys (Cercocebui otys) Proc Natl Acad. Sci USA 83:5286-5290.
55. Gabuzda, D. H., J. L. Hess, J. A. Small, and J. E. Clements. 1989. Regulation of the visna virus long terminal repeat in macrophages involves cellular factors that bind sequences, containing AP-1 sites. Mol. Cell Biol. 9:2728-2733.
56. + T lymphocytes. J. Virol. 66:6489-6495.
57. Gallo, R. C., S. Z. Salahuddin, M. Popovic, G. M. Shearer, M. Kaplan, B. F. Haynes, T. J. Palker, R. Redfield, J. Oleske, B. Safai, G. White, P. Foster, and P. D. Markham. 1984 Frequent detection and isolation of cytopathic retronruses (HTLV-III) from patients with AIDS and at risk for AIDS. Science 224:500-503
58. Garcia, J. V., J. Alfano, and A. D. Miller. 1993. The negative effect of human immunodeficiency virus type 1 Nef on cell surface CD4 expression is not species specific and requires the cytoplasmic domain of CD4. J. Virol 67:1511-1516.
59. Garcia, J. V., and A. D. Miller. 1991. Serine phosphorylation-mdependent downregulation of cell-surface CD4 by Nef Nature (London) 350:508-511.
60. Garcia, J. A., F. K. Wu, R. Mitsuyasu, and R. B. Gaynor. 1987. Interactions of cellular proteins involved in the transcriptional regulation of the human immunodeficiency virus EMBO J. 6:3761-3770.
61. Garvey, K. J., M. S. Oberste, J. E. Elser, M. J. Braun, and M. A. Gonda. 1990. Nucleotide sequence and genome organization of biologically active proviruses of the bovine immunodeficiency like virus. Virology 175:391-409.
62. Gaynor, R. 1992. Cellular transcription factors involved in the regulation of HIV-1 gene expression. AIDS 6:347-363.
63. Gdovin, S. L., and J. E. Clements. 1992. Molecular mechanisms of visna virus tat: identification of the targets for transcriptional activation and evidence for a post-transcriptional effect. Virology 188:438-450.
64. Gendelman, H. E., L. M. Baca, H. Husayni, J. A. Turpin, D. Skillman, D. C. Kalter, J. M. Orenstein, D. L. Hoover, and M. S. Meltzer. 1990. Macrophage-HIV interaction: viral isolation and target cell tropism. AIDS 4:221-228
65. Gendelman, H. E., O. Narayan, S. Kennedy-Stoskopf, P. G. Kennedy, Z. Ghotbi, J. E. Clements, J. Stanley, and G. Pezeshkpour. 1986. Tropism of sheep lentiviruses for nioaocyles: susceptibility to infection and virus gene expression increase during maturation of monocytes to macrophages. J. Virol. 58:67-74.
66. Gendelman, H. E., O. Narayan, S. Molintaux, J. E. Clements, and Z. Ghotbi. 1985. Slow persistent replication of lentiviruses: role of tissue macrophages and macrophage precursors in bone marrow. Proc. Natl. Acad. Sci. USA 82:7086-7090
67. Georgsson, G., D. J. Houwers, P. A. Palsson, and G. Petursson. 1989. Expression of viral antigens in the central nervous system of visna-infected sheep: an immunohistochemical study on experimental visna induced by virus stiains of increased neurovirulence. Acta Neuropathol. 77:299-306.
68. Georgsson, G., N. Nathanson, P. A. Palsson, and G. Petursson. 1976. The pathology of visna and maedi in sheep. Front. Biol. 44:61-96.
69. Georgsson, G., and P. A. Palsson. 1971. The histopathology of maedi, a slow viral pneumonia of sheep. Vet. Pathol. 8:63-80
70. Geraghty, R. J., and A. T. Panganiban. 1993. Human immunodeficiency virus type 1 Vpu has a CD4- and an envelope glvcoprotem-mdependent function J. Virol. 67:4190-4194
71. Gislason, G. 1947. Thaettir umm innflutning bufjar og karakulsjukdoma, p. 235-254 Iceland Ministry of Agriculture Publication 1947.
72. Goncalves, J., P. Jallepalli, and D. H. Gabuzda. 1994. Subcellular localization of the Vif protein of human immunodeficiency virus type 1. J. Virol 68:704-712.
73. Gonda, M. A., M. J. Braun, S. G. Carter, T. A. Kost, J. W. Bess, Jr., L. O. Arthur, and M. J. Van der Maaten. 1987. Characterization and molecular cloning of a bovine lentivirus related to human immunodeficiency virus. Nature (London) 330:388-391.
74. Gonda, M. A., M. J. Braun, J. E. Clements, J. M. Pyper, J. W. Casey, F. Wong-Staal, R. C. Gallo, and R. V. Gilden. 1986. HTLV-III shares sequence homology with a family of pathogenic lentiviruses. Proc. Natl. Acad Sci. USA 83:4007-4011.
75. Gonda, M. A., D. G. Luther, S. E. Fong, and G. J. Tobin. 1994. Bovine immunodeficiency virus: molecular biology and virus-host interactions. Virus Res. 32:155-181.
76. Gonda, M. A., F. Wong-Staal, R. C. Gallo, J. E. Clements, O. Narayan, and R. V. Gilden. 1985. Sequence homology and morphologic similarity of HTLV-III and visna virus, a pathogenic lentivirus. Science 227:173-177
77. Gorelick, R. J., S. M. Nigida, J. W. Bess, L. O. Arthur, L. E. Henderson, and A. Rein. 1990 Noninfectious human immunodeficiency virus type 1 mutants deficient in genomic RNA. J Virol. 64:3207-3211.
78. Gorrell, M. D., M. R. Brandon, D. Sheffer, R. J. Adams, and O. Narayan. 1992. Ovine lentivirus is macrophage tropic and does not productively infect T lymphocytes. J. Virol. 66:2679-2688.
79. Green, L. M., and J. M. Berg. 1989 A retroviral Cys-Xaa2-Cys-Xaa4-HisXaa4-Cys peptide binds metal ions: spectroscopic studies and a proposed three-dimensional structure. Proc Natl. Acad. Sci. USA 86:4047-4051.
80. Gulizia, J., M. P. Dempsey, N. Sharova, M. I. Bukrinsky, L. Spitz, D. Goldfarb, and M. Stevenson. 1994 Reduced nuclear import of human immunodeficiency virus type 1 preintegration complexes in the presence of a prototypic nuclear targeting signal. J. Virol. 68:2021-2025.
81. Hahn, B. H., M. A. Gonda, G. M. Shaw, M. Popovic, J. A. Hoxie, R. C. Gallo, and F. Wong-Staal. 1985 Genomic diversity of the acquired immune deficiency syndrome virus HTLV-III: different viruses exhibit greatest divergence in their envelope genes. Proc. Natl. Acad. Sci. USA 82:4813-4817.
82. Harouse, J. M., C. Kunsch, H. T. Hartle, M. A. Lauglilin, J. A. Hoxie, B. Wigdahl, and F. Gonzalez-Scarano. 1989 CD4-indepcndent infection of human neural cells by human immunodeficiency virus type 1. J. Virol 63:2527-2533.
83. Hattori, N., F. Michaels, K. Fargnoli, L. Marcon, R. C. Gallo, and G. Franchini. 1990. The human immunodeficiency virus type 2 vpr gene is essential for productive infection of human macrophages. Proc. Natl. Acad. Sci. USA 87:8080-8084.
84. Hauber, J., and B. R. Cullen. 1988. Mutational analysis of the transactivation response region of the human immunodeficiency virus type 1 long terminal repeat. J. Virol. 62:673-679.
85. Heinzinger, N. K., M. I. Bukrinsky, S. A. Haggerty, A. M. Ragland, V. Kewalramani, M. Lee, H. Gendelman, L. Ratner, M. Stevenson, and M. Emerman. 1994. The vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing cells. Proc. Natl. Acad. Sci. USA 91:7311-7315.
86. Hess, J. L., J. A. Small, and J. E. Clements. 1989. Sequences in the visna virus long terminal repeat that control transcriptional activity and respond to viral transactivation: involvement of AP-I sites in basal activity and transactivation. J. Virol. 63:3001-3015.
87. Hirsch, V. M., G. A. Dapolito, S. Goldstein, H. McClure, P. Emau, P. N. Fultz, M. Isahakia, R. Lenroot, G. Myers, and P. R, Johnson. 1993. A distinct African lentivirus from Sykes: monkeys. J. Virol 67:1517-1528.
88. Hirsch, V. M., and P. R. Johnson. 1994. Pathogenic diversity of simian immunodeficiency viruses. Virus Res. 32:183-203.
89. Hoffman, P. M., E. F. Cimino, D. S. Robbins, R. D. Broadwell, J. M. Powers, and S. K. Ruscetti. 1992 Cellular tropism and localization in the rodent nervous system of a neuropathogenic variant of Friend murine leukemia virus. Lab Invest. 67:314.
90. Horikoshi, N., K. Maguire, A. Kralli, E. Maldonado, D. Reinberg, and R. Weinmann. 1991. Direct interaction between adenovirus E1A protein and the TATA box binding transcription factor IID. Proc. Natl. Acad. Sci. USA 88:5124-5128.
91. Houwers, D. J., C. D. Konig, G. F. DeBoer, and J. Schaake. 1983. Maedivisna control in sheep. I. Artificial rearing of colostrum-deprived lambs. Vet. Microbiol. 8:179-185.
92. Huet, T., R. Cheynier, A. Meyerhans, G. Roelants, and S. Wain Hobson. 1990. Genetic organization of a chimpanzee lentivirus related to HIV-1. Nature (London) 345:356-359.
93. Hunt, R. D., B. J. Blake, L. V. Chalifoux, P. K. Sehgal, N. W. King, and N. L. Letvin. 1983. Transmission of naturally occurring iymphoma in macaque monkeys. Proc. Natl. Acad. Sci. USA 80:5085-5089
94. Ingles, C. J., M. Shales, W. D. Cress, S. J. Triezenberg, and J. Greenblatt, 1991. Reduced binding of TFIID to transcriptionally compromised mutants of VP16. Nature (London) 88:588-590.
95. Jamieson, B. D., G. M. Aldrovandi, V. Planelles, J. B. M. Jowett, L. Gao, L. M. Bloch, I. S. Y. Chen, and J. A. Zack. 1994. Requirement of human immunodeficiency virus type 1 nef for in vivo replication and pathogenicity. J Virol. 68:3478-3485.
96. Joag, S. V., M. G. Anderson, J. E. Clements, M. F. McEntee, D. P. Sharma, R. J. Adams, and O. Narayan. 1993. Antigenic variation of molecularly cloned SIVmac239 during persistent infection in a rhesus macaque. Virology 195:406-412.
97. Jones, K. A., J. J. Kadonaga, P. A. Luciw, and R. Tjian. 1986. Activation of AIDS retrovirus promoter by the cellular transcription factor, SpI. Science 232:755-758.
98. Kan, N. C., G. Franchini, F. Wong-Staal, G. C. DuBois, W. G. Robey, J. A. Lautenberger, and T. S. Papas. 1986. Identification of HTLV-III/LAV or gene product and detection of antibodies in human sera. Science 231:1553-1555.
99. Kanki, P. J., J. Alroy, and M. Essex. 1985. Isolation of a T-lymphotropic retrovirus related to HTLV-II/LAV from wild-caught African green monkeys. Science 230:951-954.
100. Kappes, J. C., J. A. Conway, S. W. Lee, G. M. Shaw, and B. H. Hahn. 1991. Human immunodeficiency virus type 2 vpx protein augments viral infectivity. Virology 184:197-209.
101. Kawakami, T., L. Sherman, J. E. Dahlberg, A. Gazit, A. Yaniv, S. R. Tronick, and S. A. Aaronson. 1987. Nucleotide sequence analysis of the integrated form of the genome of equine infectious anemia virus. Virology 158:300-312.
102. Kennedy, P. G., O. Narayan, Z. Ghotbi, J. Hopkins, H. E. Gendelman, and J. E. Clements. 1985 Persistent expression of Ia antigen and viral genome in visna-madei virus-induced inflammatory cells. Possible role of lentivirus-induced interferon J Exp. Med. 162:1970-1982
103. Kestler, H. W., D. J. Ringler, K. Mon, D. L. Panicali, P. D. Sehgal, M. D. Daniel, and R. C. Desrosiers. 1991. Importance of the nef gene for maintenance of high virus loads and for development of AIDS. Cell 65:651-662.
104. Khan, A. S., T. A. Galvin, L. J. Luwenstine, M. B. Jennings, M. B. Gardner, and C. E. Buckler. 1991. A highly divergent simian immunodeficiency virus (SIVstm) recovered from stored stump-tailed macaque tissues. J. Virol. 65:7061-7065.
105. Klimkait, T., K. Strebel, M. D. Hoggan, M. A. Martin, and J. M. Orenstein. 1990. The human immunodeficiency virus type 1-specific protein Vpu is required for efficient virus maturation and release. J. Virol. 64:621-629
106. Kono, Y., K. Kobayaski, and Y. Fukunaga. 1973. Antigenic drift of equine infectious anemia virus in chronically infected horses. Arch. Virusforch 41:1-10.
107. Kure, K., W. D. Lyman, K. M. Weidenheim, and D. W. Dickson. 1990. Cellular localization of an HIV-1 antigen in subacute AIDS encephalitis using an improved double-labeling immunohistochemical method. Am. J Pathol 136:1085-1092
108. Lairmore, M. D., G. Y. Akita, II. I. Russell, and J. C. DeMartini. 1987 Replication and cytopathic effects of ovine lentivirus strains in alveolar macrophages correlate with in vivo pathogeniciry. J. Virol. 61:4038-4042.
109. Lairmore, M. D., S. T. Butera, G. N. Callahan, and J. C. DeMartini. 1988 Spontaneous interferon production by pulmonary leukocytes is associated with lentivirus-induced lymphoid interstitial pneumonia. J Immunol. 140: 779-785.
110. Lairmore, M. D., J. M. Poulson, T. A. Adducci, and J. C. DeMartini. 1988. Lentivirus-induced lymphoprohferative disease. Comparative pathogenicity of phenotypically distinct ovine lentivirus strains Am. J Pathol 130:80-90.
111. Lang, S. M., M. Weeger, C. Stahl-Hennig, C. Coulibaly, G. Hunsmann, J. Muller, H. Muller-Hermelink, D. Fuchs, H. Wachter, M. M. Daniel, R. C. Desrosiers, and B. Fleckenstein. 1993. Importance of vpr for infection of rhesus monkeys with simian immunodeficiency virus. J. Virol. 67:902-912.
112. Lee, T. H., J. E. Coligan, J. S. Allan, M. F. McLane, J. E. Groopman, and M. Essex. 1986. A new HTLV-III/LAV protein encoded by a gene found in cytopathic retroviruses. Science 231:1546-1549.
113. Lenburg, M. E., and N. R. Landau. 1993. Vpu-induced degradation of CD4: requirement for specific amino acid residues in the cytoplasmic domain of CD4 J. Virol. 67:7238-7245.
114. Levy, D. N., L. S. Fernandes, W. V. Williams, and D. B. Weiner. 1993. Induction of cell differentiation by human immunodeficiency virus 1 vpr Cell 72:541-550.
115. Levy, J., C. Cheng-Mayer, D. Dina, and P. A. Lueiw. 1986 AIDS retrovirus (AR-2) clone replicates in transfected human and animal fibroblasts Science 232:998-1001.
116. Lignee, M. 1843. Memoire el observations sur une maladie de sang, connue sous Ie nom d'anhemie hydrohemie cachexie aqueuse du cheval. Rec. Med. Vet. 20:30.
117. Lindenmann, D., R. Wilhelm, P. Renard, A. Althage, R. Zinkernagel, and J. Mous. 1994. Severe immunodeficiency associated with a human immunodeficiency virus 1 Nef/3′ long terminal repeat transgene. J. Exp. Med. 179:797-807.
118. Locardi, C., C. Petrini, G. Boccoli, U. Testa, C. Dieffenbach, S. Butto, and F. Belardelli. 1990. Increased human immunodeficiency virus (HIV) expression in chronically infected U937 cells upon in vitro differentiation by hydroxyvitamme D3: role of Interferon and tumor necrosis factor in regulation of HIV production. J. Virol. 64:5874-5882.
119. Lohman, B. L., M. B. McChesney, C. J. Miller, E. McGowan, S. M. Joye, K. K. A. Van Rompay, E. Reay, L. Antipa, N. C. Pedersen, and M. L. Marthas. 1994. A partially attenuated simian immunodeficiency virus induces host immunity that correlates with resistance to pathogenic virus challenge. J. Virol. 68:7021-7029.
120. Lowenstein, L. J., N. C. Pedersen, J. Higgins, K. C. Pallis, A. Uyeda, P. Marx, N. W. Lerche, R. J. Munn, and M. B. Gardner. 1986. Seroepidemiologic survey of captive Old-World primates for antibodies to human and simian retroviruses and isolation of a lentivirus from sooty mangabeys (Cercocebus atys) Int J. Cancer 38:563-574.
121. Lu, Y., M. Stenzel, J. Sodroski, and W. A. Haseltine. 1989. Effects of long terminal repeat mutations on human immunodeficiency virus type 1 replication. J Virol 63:4115-4119.
122. Lujan, L., J. F. Garcia Martin, D. Fernandex de Luco, A. Vargas, and J. J. Badiola. 1991 Pathological changes in the lungs and mammary glands of sheep and their relationship with maedi-visna infection. Vet. Rec. 129:51-54
123. Maddon, P. J., A. G. Dalgleish, J. S. McDougal, P. R. Clapham, R. A. Weiss, and R. Axel. 1986. The T-4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain. Cell 47:333-348
124. Maddon, P. J., J. S. McDougal, and P. R. Clapham. 1988. HIV infection does not require endocytosis of its receptor. Cell 54:865-874.
125. Maldarelli, F., M. Y. Chen, R. L. Willey, and K. Strebel. 1993 Human immunodeficiency virus type 1 Vpu protein is an oligomeric type 1 integral membrane protein. J. Virol. 67:5056-5061
126. Malim, M., J. Hauber, S. Y. Le, J. Maizel, and B. Cullen. 1989. The HIV-1 rev trans-activator acts through a structured target sequence to activate nuclear export of unspliced viral mRNA Nature (London) 338:254-257
127. Malim, M., L. Tiley, D. McCarn, J. Rusche, J. Hauber, and B. R. Cullen. 1990. HIV-1 structural gene expression requires binding of the rev transactivator to its RNA target sequence Cell 60:675-683.
128. Mankowski, J. L., J. P. Spelman, H. G. Ressetar, J. D. Strandberg, J. Laterra, J. E. Clements, and M. C. Zink. 1994. Neurovirulent simian im munodeficiency virus (SIVmac) replicates productively in central nervous system endothelial cells, in vivo and m vitro. J. Virol. 68:8202-8208
129. Marsh, H. 1923. Progressive pneumonia in sheep. J. Am Vet. Med. Assoc 62:458-473.
130. Marthas, M. L., R. A. Ramos, B. L. Luhman, K. K. A. Van Rompay, R. E. Unger, C. J. Miller, B. Banapour, N. C. Pedersen, and P. A. Luciw. 1993 Viral determinants of simian immunodeficiency virus (SIV) virulence in rhesus macaques assessed by using attenuated and pathogenic molecular clones of SIVmac. J. Virol. 67:6047-6055.
131. Matthews, T. J., C. Wild, C. H. Chen, D. P. Bolognesi, and M. L. Greenberg. 1994. Structural rearrangements in the transmembrane glycoprotein after receptor binding. Immunol. Rev. 140:93-104.
132. McCune, J. M., R. Namikawa, H. Kaneshima, L. D. Shultz, M. Lieberman, and I. L. Weissman. 1988. The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and function Science 241:1632-1639
133. McGeoch, D. J. 1990. Protein sequence comparisons show that the pseudoproteases encoded by poxviruses and certain retroviruses belong to the deoxyuridme triphosphatase family. Nucleic Acids Res. 18:4105-4110.
134. McGuire, T. C., L. K. Norton, K. I. O'Rourke, and W. P. Cheevers. 1988. Antigenic variation of neutralization-sensitive epitopes of caprine arthritisencephalitis lentivirus during persistent arthritis. J. Virol. 62:3488-3492.
135. McGuire, T. C., K. I. O'Rourke, D. P. Knowles, and W. P. Cheevers. 1990. Caprine arthritis encephalitis lentivirus transmission and disease. Curr. Top. Microbiol. 160:61-75
136. McIntosh, E. M., D. D. Ager, M. H. Gadsden, and R. H. Haynes. 1992. Human dUTP prophosphatase: cDNA sequence and potential biological importance of the enzyme. Proc. Natl. Acad. Sci. USA 89:8020-8024.
137. McKeating, J. A., J. Gow, J. Goudsmit, L. H. Pearl, C. Mulder, and R. A. Weiss. 1989. Characterization of HIV-1 neutralization escape mutants. AIDS 3:777-784.
138. McNearney. T., Z. Hornickova, R. Markham, A. Birdwell, M. Arens, A. Saah, and L. Ratner. 1992 Relationship of human immunodeficiency virus type 1 sequence heterogeneity to stage of disease. Proc. Natl. Acad. Sci. USA 89:10247-10251.
139. Merigan, T. C., and S. K. Kundu. 1994. Human immunodeficiency virus envelope glycoproteins. J. Acquired Immune Defic. Syndr. 1:S14-S20.
140. Michaels, F. H., N. Hattori, R. C. Gallo, and G. Franchini. 1993. The human immunodeficiency virus type 1 Vif protein is located in the cytoplasm of infected cells and its effect on viral replication is equivalent in HIV-2 AIDS Res. Hum Retroviruses 9:1025-1030.
141. Michaels, J., R. W. Price, and M. K. Rosenblum. 1988 Microgha in the giant cell encephalitis of acquired immunodeficiency syndrome: proliferation, infection and fusion Acta Neuropathol. 76:373-379.
142. Moore, J. P., B. A. Jameson, Q. J. Sattentau, R. Willey, and J. Sodroski. 1993. Towards a structure of the HIV-1 envelope glycoprotein gp120: an immunochemical approach Philos. Trans. R Soc. London Ser B Biol. Sci. 342:83-88.
143. Moses, A. V., F. E. Bloom, C. D. Pauza, and J. A. Nelson. 1993. Human immunodeficiency virus infection of human brain capillary endothelial cells occurs via a CD4/galactosylceramide-independent mechanism. Proc Natl Acad. Sci. USA 90:10474-10478.
144. Mosier, D. E., R. J. Gulizia, P. D. MacIsaac, B. E. Torbett, and J. A. Levy. 1993 Rapid loss of CD4+ T cells in human-PBL-SCID mice by noncytopathic HIV isolates. Science 260:689-692.
145. Muesing, M., D. Smith, and D. Capon. 1987. Regulation of mRNA accumulation by a human immunodeficiency virus trans-activator protein. Cell 48:691-701.
146. Murphey-Corb, M., L. N. Martin, and S. R. S. Rangan. 1986. Isolation of an HTLV-III related retrovirus from macaques with simian AIDS and its possible origin in asymptomatic mangabeys. Nature (London) 321:435-437.
147. Myers, G., and G. Pavlakis. 1991. Evolutionary potential of complex retroviruses. Retroviridae 1:1-37.
148. Nabel, G., and D. Baltimore. 1987. An inducible transcription factor activates expression of human immunodeficiency virus in T cells. Nature (London) 326:711-713
149. Narayan, O., and J. E. Clements. 1989 Biology and pathogenesis of lentiviruses. J. Gen Virol. 70:1617-1639
150. Narayan, O., J. E. Clements, J. D. Strandberg, L. C. Cork, and D. E. Griffin. 1980. Biological characterization of the virus causing leukoencephalitis and arthritis in goats. J Gen Virol. 50:69-79.
151. Narayan, O., D. E. Griffin, and J. Chase. 1977. Antigenic drift of visna virus in persistently infected sheep Science 197:376-378.
152. Narayan, O., S. Kennedy-Stoskopf, D. Sheffer, D. E. Griffin, and J. E. Clements. 1983 Activation of caprine arthritis-encephalitis virus expression during maturation of monocytes to macrophages. Infect Immun. 41:67-73
153. Narayan, O., D. Sheffer, J. E. Clements, and G. Tennekoon. 1985. Restricted replication ot lentiviruses. Visna viruses induce a unique interferon during interaction between lymphocytes and infected macrophages J Exp. Med 162:1954-1969.
154. Narayan, O., J. S. Wolinsky, J. E. Clements, J. D. Strandberg, D. E. Griffin, and L. C. Cork. 1982. Slow virus replication: the role of macrophages in the persistence and expression of visna viruses of sheep and goats. J Gen. Virol. 59:345-356.
155. Oberste, M. S., and M. A, Gonda. 1992 Conservation of armno-acid sequence motifs in lentivirus Vif proteins. Virus Genes 6:95-102.
156. Ohta, Y., T. Masuda, H. Tsujimoto, K. I. Ishikawa, T. Kodama, S. Morikawa, M. Nakai, S. Honjo, and M. Hayami. 1988. Isolation of simian immunodeficiency virus from African green monkeys and seroepiderniologic survey of the virus in various non-human primates. Int. J. Cancer 41:115-122.
157. Oliver, R. E., J. R. Gorham, S. F. Parish, W. J. Hadlow, and O. Narayan. 1981. Ovine progressive pneumonia: pathologic and virologic studies on the naturally occurring disease Am. J. Vet. Res. 42:1554-1559.
158. Olsen, H., A. W. Cuchrane, P. J. Dillon, C. M. Nalin, and C. A. Rosen. 1990. Interaction of the human immunodeficiency virus type 1 rev protein with a structured region in env mRNA is dependent on m30. Genes Dev. 4:1357-1364
159. Palsson, P. A. 1976. Maedi and visna in sheep, p. 17-43. In R. H. Kimberlin (ed.), Slow virus diseases of animals and man. North-Holland Publishing, Amsterdam.
160. Pang, S., Y. Schlesinger, E. S. Daar, T. Moudgil, D. D. Ho, and I. S. Chen. 1992. Rapid generation of sequence variation during primary HIV-1 infection. AIDS 6:453-460
161. Park, B. H., E. Lavi, K. J. Blank, and G. N. Gaulton. 1993. Intracerebral hemorrhages and syncytium formation induced by endothehal cell infection with a murine leukemia virus J. Virol. 67:6015-6024.
162. Pavne, S. Unpublished data.
163. Pedersen, N. C., E. Ho, and M. L. Brown. 1987. Isolation of a T-lymphotropic virus from domestic cats with an immunodeficiency-like syndrome. Science 235:790-793.
164. Peeters, M., K. Fransen, and E. Delaporte. 1992. Isolation and characterization of a new chimpanzee lentivirus (simian immunodeficiency virus isolate cpz-ant) frum a wild-captured chimpanzee. AIDS 6:447-451.
165. Peluso, R., A. Haase, L. Stowring, M. Edwards, and P. Ventura. 1985 A Trojan Horse mechanism for the spiead of visna virus in monocytes. Virology 147:231-236
166. Petursson, G., V. Andresdottir, O. Andresson, S. Torsteinsdottir, G. Georgsson, and P. A. Palsson. 1991. Human and ovine lentiviral infections compared. Comp. Immunol. Microbiol. Infect Dis. 14:277-287.
167. Petursson, G., N. Nathanson, G. Georgsson, H. Panitch, and P. A. Palsson. 1976. Pathogenesis of visna. I. Sequential virologic, serologic and pathologic studies. Lab. Invest. 35:402-412.
168. Pifat, D. Y., W. H. Ennis, J. M. Ward, M. S. Oberste, and M. A. Gonda. 1992. Persistent infection of rabbits with the bovine immunodeficiency-like virus. J. Virol. 66:4518-4524.
169. Poland, S. D., G. P. A. Rice, and G. A. Dekaban. 1995. HIV-1 infection of human brain-derived microvascular endothelial cells in vitro. J. Acquired Immune Defie. Syndr. 8:437-445
170. Poli, G., and A. S. Fauci. 1992. Role of monocyte/macrophages and cytokines in the pathogenesis of HIV infection. Pathobiology 60:246-251.
171. Ringler, D. J., M. S. Wyand, D. G. Walsh, J. J. MacKey, L. V. Chalifoux, M. Popovic, A. A. Minassian, P. K. Sehgal, M. D. Daniel, R. C. Desrosiers, and N. W. King. 1989. Cellular localization of simian immunodeficiency virus in lymphoid tissues. I. Immunochemistry and electron microscopy. Am. J. Pathol. 134:373-383.
172. Robert-Guroff, M., M. Brown, and R. C. Gallo. 1985. HTLV-III-neutralizing antibodies in patients with AIDS and AIDS related complex. Nature (London) 316:72-74.
173. Roberts, S. G. E., I. Ha, E. Maldonado, D. Reinberg, and M. R. Green. 1993. Interaction between an acidic activator and transcription factor TFIIB is required for transcriptional activation Nature (London) 363:741
174. Rosen, C. A., J. Sodroski, and W. A. Haseltine. 1985. The location of cis-acting regulatory sequences in the human T cell lymphotropic virus type III (HTLV-III/LAV) long terminal repeat. Cell 41:813-823.
175. Rowe, J. D., N. E. East, M. C. Thurmond, C. E. Franti, and N. C. Pedersen. 1992. Cohort study of natural transmission and two methods for control of caprine arthritis-encephalitis virus infection in goats on a California dairy. Am. J Vet. Res. 53:2386-2395.
176. Rushlow, K., K. Olsen, G. Steigler, S. L. Payne, R. C. Montelaro, and C. J. Issel. 1986. Lentivirus, genomic organization, the complete nucleotide sequence of the env region of equine infectious anemia virus. Virology 155: 309-321
177. Rwambo, P. M., C. J. Issel, W. V. J. Adams, K. A. Hussain, M. Miller, and R. C. Montelaro. 1990. Equine infectious anemia virus (EIAV) humoral responses of recipient ponies and antigenic variation during persistent infection. Arch. Virol 111:199-212
178. Rwambo, P. M., C. J. Issel, K. A. Hussain, and R. C. Mantelaro. 1990. In vitro isolation of a neutralization escape mutant of equine infectious anemia virus (EIAV). Arch. Virol. 111:275-280.
179. Saltarelli, M., G. Querat, D. A. M. Konings, R. Vigne, and J. E. Clements. 1990. Nucleotide sequence and transcriptional analysis of molecular clones of CAEV which generate infectious virus. Virology 179:347-364.
180. Sanfridson, A., B. R. Cullen, and C. Doyle. 1994. The simian immunodeficiency virus NEF protein promotes degradation of CD4 in human T-cells. J. Biol. Chem. 269:3917-3920.
181. Schoborg, R., and J. E. Clements. 1994. The Rev protein of visna virus is localized to the nucleus of infected cells. Virology 202:485-490.
182. Schwartz, S., B. K. Felber, D. M. Benko, E. M. Fenyo, and G. N. Pavlakis. 1990. Cloning and functional analysis of multiply spliced mRNA species of human immunodeficiency virus type 1. J. Virol. 64:2519-2529.
183. Sellon, D. C., S, T. Perry, L. Coggins, and F. J. Fuller. 1992. Wild-type equine infection anemia virus replicates in vivo predominantly in tissue macrophages, not in peripheral blood monocytes. J. Virol. 66:5906-5913.
184. Sharma, D. P., M. C. Zink, M. G. Anderson, R. Adams, J. E. Clements, S. V. Joag, and O. Narayan. 1992. Derivation of neurotropic simian immunodeficiency virus from exclusively lymphocyte-tropic parental virus: pathogenesis of infection in macaques. J. Virol 66:3550-3556.
185. Sherman, L., A. Gazit, A. Yaniv, T. Kawakami, J. E. Dahlberg, and S. R. Tronick. 1988. Localization of sequences responsible for transactivation of the equine infectious anemia virus long terminal repeat J. Virol. 62:120-126.
186. Shih, D. S., L. M. Carruth, M. Anderson, and J. E. Clements. 1992. Involvement of FOS and JUN in the activation of visna virus gene expression in macrophages through an AP-1 site in the viral LTR Virology 190:84-91.
187. Siekevitz, M., S. Josephs, M. Dukovich, N. Peffer, F. Wong-Staal, and W. C. Greene. 1987. Activation of the HIV-1 LTR by T-cell mitogens and the trans-activator protein of HTLV-1. Science 238:1575-1578.
188. Sigurdsson, B. 1954. Maedi, a slow progressive pneumonia of sheep: an epizootiological and pathologic study. Br. Vet. J. 110:255-270
189. Simon, M. A., L. V. Chalifoux, and D. J. Ringler. 1992. Pathologic features of SIV-induced disease and the association of macrophage infection with disease evolution AIDS Res. Hum. Retroviruses 8:327-337
190. Skowronski, J., D. Parks, and R. Mariani. 1993. Altered T-cell activation and development in transgenic mice expressing the HIV-1 nef gene. EMBO J. 12:703-713.
191. Smith, M. R., and W. C. Greene. 1990. Identification of HTLV-1 tax trans-activator mutants exhibiting novel transcriptional phenotypes. Genes Dev. 4:1875-1885.
192. Sodroski, J., W. C. Goh, C. Rosen, A. Tartar, D. Portetelle, A. Burny, and W. Haseltine. 1986. Replicative and cytopathic potential of HTLV-III/LAV with or gene deletions. Science 231:1549-1553.
193. Sonigo, P., M. Alizon, K. Staskus, D. Klatzman, S. Cole, O. Danos, E. Retzel, P. Tiollais, A. Haase, and S. Wain-Hobson. 1985. Nucleotide sequence of the visna lentivirus: relationship to the AIDS virus. Cell 42:369-382
194. Sova, P., and D. J. Volsky. 1993. Efficiency of viral DNA synthesis during infection of permissive and nonpermissive cells with Vif-negative human immunodeficiency virus type 1 J. Virol. 67:6322-6326.
195. Stein, B., D. Gowda, R. Lifson, R. Penhallon, K. Beusch, and E. Engelman. 1987. pH independant HIV entry into CD4-positive T-cells via virus envelope fusion to the plasma membrane. Cell 49:659-668.
196. Stephens, R. M., D. Derse, and N. R. Rice. 1990. Cloning and characterization of cDNAs encoding equine infectious anemia virus Tat and putative Rev proteins. J. Virol. 64:3716-3725
197. Strebel, K., T. Klimkait, F. Maldarelli, and M. A. Martin. 1989. Molecular and biochemical analysis of human immunodeficiency virus type 1 Vpu protein. J Virol. 63:3784-3791.
198. Talbott, R. L., E. E. Sparger, K. M. Lovelace, W. M. Fitch, N. C. Pederson, P. A. Luciw. and J. H. Elder. 1989. Nuelcotide sequence and genomic organization of feline immunodeficiency virus. Proc. Natl. Acad. Sci. USA 86:5743-5447.
199. Threadgill, D. S., W. K. Steagall, M. T. Flaherty, F. J. Fuller, S. T. Perry, K. E. Rushlow, S. F. J. LeGrice, and S. L. Payne. 1993. Characterization of equine infectious anemia virus dUTPase: growth properties of a dUTPascdeficient mutant. J. Virol. 67:2592-2600.
200. Tiley, L. S., P. H. Brown, S. Y. Le, J. V. Maizel, J. E. Clements, and B. R. Cullen. 1990. Visna virus encodes a post-transcriptional regulator of viral structural gene expression Proc. Natl. Acad Sci. USA 87:7497-7501.
201. Tristem, M., C. Marshall, A. Karpas, J. Petrik, and F. Hill. 1990. Origin of vpx in lentiviruses Nature (London) 347:341-342.
202. Tsujimoto, H., R. W. Cooper, T. Kodama, M. Fukasawa, M. Tomoyuki, Y. Ohta, K. I. Ishikawa, M. Nakai, E. Frost, G. E. Roelants, J. Roffi, and M. Hayami. 1988. Isolation and characterization of simian immunodeficiency virus from mandrills in Africa and its relationship to other human and simian immunodeficiency viruses J. Virol. 62:4044-4050.
203. Vallee, H., and H. Carre. 1904. Nature infectieuse de l'anemie du cheval C R. Acad. Sci. 139:331-333.
204. Van Der Maaten, M. J., A. D. Boothe, and C. L. Seger. 1972. Isolation of a virus from cattle with persistent lymphocytosis J Natl Cancer Inst. 49: 1649-1657.
205. von Schwedler, U., J. Song, C. Aiken, and D. Trono. 1993 Vif is crucial for human immunodeficiency virus type 1 proviral DNA synthesis in infected cells. J. Virol. 67:4945-4955
206. Watkins, B. A., H. H. Dorn, W. B. Kelly, R. C. Armstrong, B. Poots, F. Michaels, C. V. Kufta, and M. Dubois-Dalcq. 1990. Specific tropism of HIV-1 for microglial cells in primary human brain cultures. Science 249: 549-553.
207. Willey, R. L., F. Matdarelli, M. A. Martin, and K. Strebel. 1992. Human immunodeficiency virus type 1 Vpu protein regulates the formation of mtracellular gp160-CD4 complexes. J Virol. 66:226-234.
208. Wolfs, T. F. W., G. Zwart, M. Bakker, and J. Goudsmit. 1992. HIV-1 genomic RNA diversification following sexual and pareriteral virus transmission. Virology 189:103-110.
209. Wolinsky, S. M., C. N. Wike, B. T. M. Korber, C. Hutto, W. P. Parks, L. A. Rosenblum, K. J. Kunstman, M. R. Furtado, and J. L. Munoz. 1992. Selective transmission of human immunodeficiency virus type-1 variants from mothers to infants. Science 255:1134-1137.
210. Wu, F. K., J. A. Garcia, D. Harrich, and R. B. Gaynor. 1988. Purification of the human immunodeficiency virus type 1 enhancer and TAR binding proteins EBP-1 and UBP-1 EMBO J 7:2117-2129.
211. Yao, X., H. Goettlinger, W. A. Haseltine, and E. Cohen. 1992. Envelope glycoprotein and CD4 independence of Vpu-facilitated human immunodeficiency virus type 1 capsid export. J. Virol. 66:5119-5126.
212. Yao, X. J., S. Garzon, F. Boisvert, W. A. Haseltine, and E. A. Cohen. 1993. The effect of Vpu on HIV-1 induced syncytia formation. J. Acquired Immune Defic Syndr. 6:135-141.
213. Yu, X., Z. Matsuda, Q. C. Yu, T. H. Lee, and M. Essex. 1993. Vpx of simian immunodeficiency virus is localized primarily outside the virus core in mature virions. J Virol. 67:4386-4390.
214. Yu, X. F., M. Matsuda, M. Essex, and T. H. Lee. 1990. Open reading frame Vpr of simian immunodeficiency virus encodes a virion-associated protein. J. Virol. 64:5688-5693.
215. Yuan, X., Z. Matsuda, M. Matsuda, M. Essex, and T. H. Lee. 1990. Human immunodeficiency virus vpr gene encodes a virion-associated protein. AIDS Res. Hum. Retroviruses 6:1265-1271.
216. Zack, J., S. Arrigo, S. Weltsman, A. Go, A. Haislip, and I. Chen. 1990. HIV-1 entry into quiescent primary lymphocytes; molecular analysis reveals a labile, latent viral structure. Cell 61:213-222.
217. Zeichner, S. L., J. Y. H. Kim, and J. C. Alwine. 1991. Linker-scanning mutational analysis of the transcriptional activity of human immunodeficiency virus type 1 long terminal repeat J. Virol. 65:2436-2444.
218. Zhang, L. Q., P. MacKenzie, A. Cleland, E. C. Holmes, A. J. L. Brown, and P. Simmonds. 1993. Selection of specific sequences in the external envelope protein of human immunodeficiency virus type 1 upon primary infection. J. Virol. 67:3345-3356.
219. Zhu, T., H. Mo, N. Wang, D. S. Nam, Y. Cao, R. A. Koup, and D. D. Ho. 1993. Genotypic and pheuolypic characterization of HIV-1 in patients with primary infection Science 261:1179-1181.
220. Zink, M. C, M. D. Gorrell, and O. Narayan. 1991. The neuropathogenesis of visna virus infection in sheep. Semin. Ncurosci. 3:125-130.
221. Zink, M. C., M. D. Gorrell, and O. Narayan. 1991. The neuropathogenesis of visna virus infection in sheep Semin. Neurosci. 3:125-130.
222. Zink, M. C., and L. K. Johnson. 1994. Pathobiology of lentivirus infections of sheep and goats. Virus Res. 32:139-154.
223. Zink, M. C., and O. Narayan. 1989. Lentivirus-induced interferon inhibits maturation and proliferation of monocytes and restrict the replication of caprine arthritis-encephalitis virus. J Virol. 63:2578-2584.
224. Zink, M. C., J. A. Yager, and J. D. Myers. 1990. Pathogenesis of caprine arthritis encephalitis virus. Cellular localization of viral transcripts in tissues of infected goats. Am. J. Pathol. 136:843-854.