Expression of miR-126 suppresses migration and invasion of colon cancer cells by targeting CXCR4

Molecular and Cellular Biochemistry

Volumn 381, Issue 1-2, 2013, Pages 233-242

  Li, Zeng ^a   Li, Nan ^b   Wu, Minghua ^b   Li, Xiayu ^b   Luo, Zhaohui ^c   Wang, Xiaoyan ^b  

^a Xiangtan Central Hospital   (China)

^b CENTRAL SOUTH UNIVERSITY   (China)

^c CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Colorectal cancer; CXCR4; MiR 126; Tumor cell migration and invasion

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; MICRORNA 126;

ARTICLE; BIOINFORMATICS; CANCER CELL; CELL INVASION; CELL MIGRATION; CELL VIABILITY; CLINICAL ARTICLE; COLON CANCER; CONTROLLED STUDY; GENE EXPRESSION; GENE FUNCTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; POLYMERASE CHAIN REACTION; PROTEIN TARGETING; WESTERN BLOTTING; WOUND HEALING;

BASE SEQUENCE; CELL LINE, TUMOR; CELL MOVEMENT; CELL SURVIVAL; COLONIC NEOPLASMS; COMPUTATIONAL BIOLOGY; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTESTINAL MUCOSA; MICRORNAS; MOLECULAR SEQUENCE DATA; NEOPLASM INVASIVENESS; RECEPTORS, CXCR4; TRANSFECTION; WOUND HEALING;

EID: 84882610048     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-013-1707-6     Document Type: Article

References (28)

1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D (2011) Global cancer statistics. CA Cancer J Clin 61(2):69-90
2. Kudo-SaitoC, ShirakoH, TakeuchiT, KawakamiY(2009) Cancer metastasis is accelerated through immunosuppression during Snail-induced EMT of cancer cells. Cancer Cell 15(3):195-206
3. Pancione M, Forte N, Fucci A, Sabatino L, Febbraro A, Di Blasi A, Daniele B, Parente D, Colantuoni V (2010) Prognostic role of beta-catenin and p53 expression in the metastatic progression of sporadic colorectal cancer. Hum Pathol 41(6):867-876
4. Roger L, Jullien L, Gire V, Roux P (2010) Gain of oncogenic function of p53 mutants regulates E-cadherin expression uncoupled from cell invasion in colon cancer cells. J Cell Sci 123(Pt 8): 1295-1305
5. Fang YJ, LuZH, Wang GQ, Pan ZZ, Zhou ZW, Yun JP, Zhang MF, Wan DS (2009) Elevated expressions of MMP7, TROP2, and survival are associated with survival, disease recurrence, and liver metastasis of colon cancer. Int J Colorectal Dis 24(8):875-884
6. Wang SC, Lin JK, Wang HS, Yang SH, Li AF, Chang SC (2010) Nuclear expression of CXCR4 is associated with advanced colorectal cancer. Int J Colorectal Dis 25(10):1185-1191
7. Li XH, Zheng HC, Takahashi H, Masuda S, Yang XH, Takano Y (2009) PTEN expression and mutation in colorectal carcinomas. Oncol Rep 22(4):757-764
8. Jiang Y, Liu XQ, Rajput A, Geng L, Ongchin M, Zeng Q, Taylor GS, Wang J (2011) Phosphatase PRL-3 is a direct regulatory target of TGF-beta in colon cancer metastasis. Cancer Res 71(1): 234-244
9. Suzuki H, Masuda N, Shimura T, Araki K, Kobayashi T, Tsutsumi S, AsaoT, KuwanoH (2008) Nuclear beta-catenin expression atthe invasive front and in the vessels predicts liver metastasis in colo-rectal carcinoma. Anticancer Res 28(3B):1821-1830
10. Wang Xiaoyan, Wu Minghua, Liu Fen, Li Yu, Li Nan, Li Guiyuan, Shen Shourong (2010) Differential miRNA expression and their target genes between NGX6-positive and negative colon cancer cells. Mol Cell Biochem 345(1-2):283-290
11. Guo C, Sah JF, Beard L, Willson JK, Markowitz SD, Guda K (2008) The noncoding RNA, miR-126, suppresses the growth of neoplastic cells by targeting phosphatidylinositol 3-kinase signaling and is frequently lost in colon cancers. Genes Chromosom Cancer 47(11):939-946
12. Li XM, Wang AM, Zhang J, Yi H (2011) Down-regulation of miR-126 expression in colorectal cancer and its clinical significance. Med Oncol 28(4):1054-1057
13. Tavazoie SF, Alarcón C, Oskarsson T, Padua D, Wang Q, Bos PD, Gerald WL, Massagué J (2008) Endogenous human microRNAs that suppress breast cancer metastasis. Nature 451(7175):147-152
14. Png KJ, Halberg N, Yoshida M, Tavazoie SF (2011) A micr-oRNA regulon that mediates endothelial recruitment and metastasis by cancer cells. Nature 481(7380):190-194
15. Crawford M, Brawner E, Batte K, Yu L, Hunter MG, Otterson GA, Nuovo G, Marsh CB, Nana-Sinkam SP (2008) MicroRNA-126 inhibits invasion in non-small cell lung carcinoma cell lines. Biochem Biophys Res Commun 373(4):607-612
16. Feng RH, Chen XH et al (2010) miR-126 functions as a tumour suppressor in human gastric cancer. Cancer Lett 298(1):50-63
17. Fish Jason E, Santoro Massimo M et al (2008) miR-126 regulates angiogenic signaling and vascular integrity. Dev Cell 15:272-284
18. Lagos-Quintana M, Rauhut R, Yalcin A et al (2002) Identification of tissue-specific microRNAs from mouse. Curr Biol 12(9): 735-739
19. Landgraf P, Rusu M, Sheridan R et al (2007) A mammalian microRNA expression atlas based on small RNA library sequencing. Cell 129(7):1401-1414
20. Majka M, Janowska-Wieczorek A, Ratajczak J et al (2000) Stromal-derived factor 1 and thrombopoietin regulate distinct aspects of human megakaryopoiesis. Blood 96(13):4142-4151
21. Kijowski J, Baj-Krzyworzeka M, Majka M et al (2001) The SDF-1-CXCR4 axis stimulates VEGF secretion and activates integrins but does not affect proliferation and survival in lymphohemato-poietic cells. Stem Cells 19:453-466
22. Yasuoka H, Tsujimoto M, Yoshidome K et al (2008) Cytoplasmic CXCR4 expression in breast cancer: induction by nitric oxide and correlation with lymph node metastasis and poor prognosis. BMC Cancer 8:340
23. Burger M, Glodek A, Hartmann T et al (2003) Functional expression of CXCR4 (CD184) on small-cell lung cancer cells mediates migration, integrin activation, and adhesion to stromal cells. Oncogene 22(50):8093-8101
24. Singh S, Singh UP et al (2004) CXCL12-CXCR4 interactions modulate prostate cancer cell migration, metalloproteinase expression and invasion. Lab Invest 84(12):1666-1676
25. Wang L, Li CL, Wang L et al (2011) Influence of CXCR4/SDF-1 axis on E-cadherin/b-catenin complex expression in HT29 colon cancer cells. World J Gastroenterol 17(5):625-632
26. Saur D, Seidler B et al (2005) CXCR4 expression increases liver and lung metastasis in a mouse model of pancreatic cancer. Gastroenterology 129(4):1237-1250
27. Kollmar O, Rupertus K, Scheuer C et al (2007) Stromal cell-derived factor-1 promotes cell migration and tumor growth of colorectal metastasis. Neoplasia 9(10):862-870
28. Heckmann D, Laufs S, Maier P, Zucknick M, Giordano FA, Veldwijk MR, Eckstein V, Wenz F, Zeller WJ, Fruehauf S, Allgayer H (2011) Lentiviral CXCR4 overexpression and knockdown model in colorectal cancer cell lines reveals pler-ixafor-dependent suppression of SDF-1a-induced migration and invasion. Onkologie 34(10):502-508