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Volumn 140, Issue 3, 2012, Pages 614-623

Old formula, new Rx: The journey of PHY906 as cancer adjuvant therapy

Author keywords

Cancer adjuvant; Capecitabine; Colorectal cancer; CPT 11; Hepatocellular carcinoma; Mechanism of action; Pancreatic cancer; PHY906

Indexed keywords

7 ETHYL 10 HYDROXYCAMPTOTHECIN; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CAPECITABINE; CLEVUDINE; ETOPOFOS; ETOPOSIDE; FLUOROURACIL; FOLINIC ACID; GEMCITABINE; HERBACEOUS AGENT; IRINOTECAN; OXALIPLATIN; PACLITAXEL; PHY 906; REVOVIR; SORAFENIB; SUNITINIB; THALIDOMIDE; TROXACITABINE; UNCLASSIFIED DRUG;

EID: 84862777420     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2012.01.047     Document Type: Article
Times cited : (132)

References (61)
  • 1
    • 77955878152 scopus 로고    scopus 로고
    • A phase I study of PHY906 as a modulator of irinotecan (CPT-11) in patients with advanced solid tumors
    • abstr e13571
    • Alsamarai, S., Ravage-Mass, L., Kaley, K., et al., 2010. A phase I study of PHY906 as a modulator of irinotecan (CPT-11) in patients with advanced solid tumors. Journal of Clinical Oncology 28 (suppl; abstr e13571).
    • (2010) Journal of Clinical Oncology , vol.28 , Issue.SUPPL.
    • Alsamarai, S.1    Ravage-Mass, L.2    Kaley, K.3
  • 2
    • 0036165928 scopus 로고    scopus 로고
    • Review article: Non-surgical treatment of hepatocellular carcinoma
    • DOI 10.1046/j.1365-2036.2002.01149.x
    • Alsowmely, A.M., Hodgson, J.F., 2002. Review article: non-surgical treatment of hepatocellular carcinoma. Alimentary Pharmacology & Therapeutics 16, 1-15. (Pubitemid 34123859)
    • (2002) Alimentary Pharmacology and Therapeutics , vol.16 , Issue.1 , pp. 1-15
    • Alsowmely, A.M.1    Hodgson, H.J.F.2
  • 3
    • 84862809621 scopus 로고    scopus 로고
    • American Cancer Society, American Cancer Society, Atlanta, GA
    • American Cancer Society, 2011. Cancer Facts and Figures. American Cancer Society, Atlanta, GA.
    • (2011) Cancer Facts and Figures
  • 4
    • 49649122014 scopus 로고    scopus 로고
    • Use of complementary and alternative medical therapy by patients with primary brain tumors
    • Armstrong, T.S., Gilbert, M.R., 2008. Use of complementary and alternative medical therapy by patients with primary brain tumors. Current Neurology and Neuroscience Reports 8, 264-268.
    • (2008) Current Neurology and Neuroscience Reports , vol.8 , pp. 264-268
    • Armstrong, T.S.1    Gilbert, M.R.2
  • 5
    • 0036682041 scopus 로고    scopus 로고
    • Phase III study of gemcitabine in combination with fluorouracil versus gemcitabine alone in patients with advanced pancreatic carcinoma: Eastern Cooperative Oncology Group trial E2297
    • DOI 10.1200/JCO.2002.11.149
    • Berlin, J.D., Catalano, P., Thomas, J.P., et al., 2002. A 3rd. Phase III study of gemcitabine in combination with fluorouracil versus gemcitabine alone in patients with advanced pancreatic carcinoma: Eastern Cooperative Oncology Group Trial E2297. Journal of Clinical Oncology 20, 3270-3275. (Pubitemid 34831525)
    • (2002) Journal of Clinical Oncology , vol.20 , Issue.15 , pp. 3270-3275
    • Berlin, J.D.1    Catalano, P.2    Thomas, J.P.3    Kugler, J.W.4    Haller, D.G.5    Benson III, A.B.6
  • 6
    • 0029964873 scopus 로고    scopus 로고
    • Characterisation and clinical management of CPT-11 (irinotecan)-induced adverse events: The European perspective
    • Bleiberg, H., Cvitkovic, E., 1996. Characterisation and clinical management of CPT-11 (irinotecan)-induced adverse events: The European perspective. European Journal of Cancer Prevention 32A, S18-S23.
    • (1996) European Journal of Cancer Prevention , vol.32 A
    • Bleiberg, H.1    Cvitkovic, E.2
  • 9
    • 50849115450 scopus 로고    scopus 로고
    • Phase III trial comparing intensive induction chemoradiotherapy (60 Gy, infusional 5-FU and intermittent cisplatin) followed by maintenance gemcitabine with gemcitabine alone for locally advanced unresectable pancreatic cancer
    • Chauffert, B., Mornex, F., Bonnetain, F., et al., 2008. Phase III trial comparing intensive induction chemoradiotherapy (60 Gy, infusional 5-FU and intermittent cisplatin) followed by maintenance gemcitabine with gemcitabine alone for locally advanced unresectable pancreatic cancer. Annals of Oncology 19, 1592-1599.
    • (2008) Annals of Oncology , vol.19 , pp. 1592-1599
    • Chauffert, B.1    Mornex, F.2    Bonnetain, F.3
  • 10
    • 84984559474 scopus 로고    scopus 로고
    • Sorafenib overcomes TRAIL resistance of hepatocellular carcinoma cells through the inhibition of STAT3
    • Chen, K.F., Tai, W.T., Liu, T.H., et al., 2010. Sorafenib overcomes TRAIL resistance of hepatocellular carcinoma cells through the inhibition of STAT3. Clinical Cancer Research 16, 5189-5199.
    • (2010) Clinical Cancer Research , vol.16 , pp. 5189-5199
    • Chen, K.F.1    Tai, W.T.2    Liu, T.H.3
  • 11
    • 53649089738 scopus 로고    scopus 로고
    • New therapies from old medicines
    • Chen, S.T., Dou, J., Temple, R., et al., 2008. New therapies from old medicines. Nature Biotechnology 26, 1077-1083.
    • (2008) Nature Biotechnology , vol.26 , pp. 1077-1083
    • Chen, S.T.1    Dou, J.2    Temple, R.3
  • 12
    • 79151477730 scopus 로고    scopus 로고
    • Regulation of research: Is it a drug trial or a supplement trial?
    • Chen, S.T., 2011. Regulation of research: is it a drug trial or a supplement trial? Fitoterapia 82, 14-16.
    • (2011) Fitoterapia , vol.82 , pp. 14-16
    • Chen, S.T.1
  • 13
    • 57749189578 scopus 로고    scopus 로고
    • Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: A phase III randomised, double-blind, placebo-controlled trial
    • Cheng, A.L., Kang, Y.K., Chen, Z., et al., 2009. Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial. Lancet Oncology 10, 25-34.
    • (2009) Lancet Oncology , vol.10 , pp. 25-34
    • Cheng, A.L.1    Kang, Y.K.2    Chen, Z.3
  • 14
    • 79955931455 scopus 로고    scopus 로고
    • When it takes two to tango, FDA suggests a new regulatory dance
    • Dolgin, E., 2011. When it takes two to tango, FDA suggests a new regulatory dance. Nature Medicine 17, 270.
    • (2011) Nature Medicine , vol.17 , pp. 270
    • Dolgin, E.1
  • 17
    • 0033545541 scopus 로고    scopus 로고
    • Rising incidence of hepatocellular carcinoma in the United States
    • DOI 10.1056/NEJM199903113401001
    • El-Serag, H.B., Mason, A.C., 1999. Rising incidence of hepatocellular carcinoma in the United States. New England Journal of Medicine 340, 745-750. (Pubitemid 29114292)
    • (1999) New England Journal of Medicine , vol.340 , Issue.10 , pp. 745-750
    • El-Serag, H.B.1    Mason, A.C.2
  • 18
    • 0037302385 scopus 로고    scopus 로고
    • Phase I/IIA randomized study of PHY906, a novel herbal agent, as a modulator of chemotherapy in patients with advanced colorectal cancer
    • Farrell, M.P., Kummar, S., 2003. Phase I/IIA randomized study of PHY906, a novel herbal agent, as a modulator of chemotherapy in patients with advanced colorectal cancer. Clinical Colorectal Cancer 2, 253-256. (Pubitemid 36367315)
    • (2003) Clinical Colorectal Cancer , vol.2 , Issue.4 , pp. 253-256
    • Farrell, M.P.1    Kummar, S.2
  • 19
    • 79959596596 scopus 로고    scopus 로고
    • Guidance for Industry
    • FDA. FDA, DC, June
    • FDA. Guidance for Industry. Botanical Drug Products (FDA, DC, June 2004). http://www.fda.gov/cder/guidance/4592fnl.pdf.
    • (2004) Botanical Drug Products
  • 20
    • 0028068850 scopus 로고
    • The role of chemotherapy and adjuvant therapy in the management of colorectal cancer
    • Forman, W.B., 1994. The role of chemotherapy and adjuvant therapy in the management of colorectal cancer. Cancer 74, 2151-2153. (Pubitemid 24304387)
    • (1994) Cancer , vol.74 , Issue.7 SUPPL. , pp. 2151-2153
    • Forman, W.B.1
  • 21
    • 0031793675 scopus 로고
    • Irinotecan plus FU and leucovorin in advanced colorectal cancer: North American trials
    • Goldber, R.M., Erlichman, C., 1988. Irinotecan plus FU and leucovorin in advanced colorectal cancer: North American trials. Oncology 12, 59-63.
    • (1988) Oncology , vol.12 , pp. 59-63
    • Goldber, R.M.1    Erlichman, C.2
  • 22
    • 71949127923 scopus 로고    scopus 로고
    • A phase I/II study of PHY906 plus capecitabine (CAP) in patients (pts) with advanced pancreatic cancer
    • May 20 abstr 15538
    • Hoimes, C.J., Lamb, L., Ruta, S., et al., 2008. A phase I/II study of PHY906 plus capecitabine (CAP) in patients (pts) with advanced pancreatic cancer. Journal of Clinical Oncology 26 (May 20 suppl abstr 15538).
    • (2008) Journal of Clinical Oncology , vol.26 , Issue.SUPPL.
    • Hoimes, C.J.1    Lamb, L.2    Ruta, S.3
  • 24
    • 39149109582 scopus 로고    scopus 로고
    • Evidence-based Chinese medicine for cancer therapy
    • Konkimalla, V.B., Efferth, T., 2008. Evidence-based Chinese medicine for cancer therapy. Journal of Ethnopharmacology 116, 207-210.
    • (2008) Journal of Ethnopharmacology , vol.116 , pp. 207-210
    • Konkimalla, V.B.1    Efferth, T.2
  • 25
    • 79959336608 scopus 로고    scopus 로고
    • A phase I study of the Chinese herbal medicine PHY906 as a modulator of irinotecan-based chemotherapy in patients with advanced colorectal cancer
    • Kummar, S., Copur, M.S., Rose, M., et al., 2011. A phase I study of the Chinese herbal medicine PHY906 as a modulator of irinotecan-based chemotherapy in patients with advanced colorectal cancer. Clinical Colorectal Cancer 10, 85-96.
    • (2011) Clinical Colorectal Cancer , vol.10 , pp. 85-96
    • Kummar, S.1    Copur, M.S.2    Rose, M.3
  • 27
    • 84862797207 scopus 로고    scopus 로고
    • Exploration of the mechanisms of PHY906 in reducing the intestinal toxicity caused by irinotecan
    • # 4584
    • Lam, W., Bussom, S., Guan, F., et al., 2009. Exploration of the mechanisms of PHY906 in reducing the intestinal toxicity caused by irinotecan. In: Proceedings of American Association for Cancer Research. # 4584.
    • (2009) Proceedings of American Association for Cancer Research
    • Lam, W.1    Bussom, S.2    Guan, F.3
  • 28
    • 77955898834 scopus 로고    scopus 로고
    • PHY906, a four-herb Chinese medicine formula first described 1800 years ago, reduces irinotecan-induced intestinal damage through anti-inflammatory effects and by promotion of the repopulation of intestinal progenitor cells
    • Lam, W., Bussom, S., Guan, F., et al., 2010. PHY906, a four-herb Chinese medicine formula first described 1800 years ago, reduces irinotecan-induced intestinal damage through anti-inflammatory effects and by promotion of the repopulation of intestinal progenitor cells. Science Translational Medicine 2, 45ra59.
    • (2010) Science Translational Medicine , vol.2
    • Lam, W.1    Bussom, S.2    Guan, F.3
  • 29
    • 77749245776 scopus 로고    scopus 로고
    • Any second-line therapy for advanced pancreatic cancer? Highlights from the 2010 ASCO Gastrointestinal Cancers Symposium
    • Li, J., Merl, M.Y., Saif, M.W., 2010. Any second-line therapy for advanced pancreatic cancer? Highlights from the 2010 ASCO Gastrointestinal Cancers Symposium. Journal of Oncology Practice 11, 151-153.
    • (2010) Journal of Oncology Practice , vol.11 , pp. 151-153
    • Li, J.1    Merl, M.Y.2    Saif, M.W.3
  • 31
    • 0012734882 scopus 로고    scopus 로고
    • A Chinese medicine formulation, PHY-906, can enhance the therapeutic index of CPT-11 and other anticancer drugs against cancer in mice
    • # 458
    • Liu, S.H., Jiang, Z., Cheng, Y.C., 2001. A Chinese medicine formulation, PHY-906, can enhance the therapeutic index of CPT-11 and other anticancer drugs against cancer in mice. In: Proceedings of American Association for Cancer Research. # 458.
    • (2001) Proceedings of American Association for Cancer Research
    • Liu, S.H.1    Jiang, Z.2    Cheng, Y.C.3
  • 32
    • 0012738146 scopus 로고    scopus 로고
    • Botanical activity relationship in traditional Chinese medicine: Studies of PHY906 as an adjuvant therapy with cancer chemotherapeutic agents
    • #4758
    • Liu, S.H., Jiang, Z., Cheng, Y.C., 2002. Botanical activity relationship in traditional Chinese medicine: studies of PHY906 as an adjuvant therapy with cancer chemotherapeutic agents. In: Proceedings of American Association for Cancer Research, vol. 43, #4758.
    • (2002) Proceedings of American Association for Cancer Research , vol.43
    • Liu, S.H.1    Jiang, Z.2    Cheng, Y.C.3
  • 33
    • 71949100830 scopus 로고    scopus 로고
    • PHY906, a Chinese herbal formulation enhances the therapeutic effect of cancer chemotherapy in human colorectal and liver cancer
    • #864
    • Liu, S.H., Jiang, Z., Gao, W., et al., 2003. PHY906, a Chinese herbal formulation enhances the therapeutic effect of cancer chemotherapy in human colorectal and liver cancer. In: Proceedings of American Society of Clinical Oncology, #864.
    • (2003) Proceedings of American Society of Clinical Oncology
    • Liu, S.H.1    Jiang, Z.2    Gao, W.3
  • 34
  • 35
    • 71949103478 scopus 로고    scopus 로고
    • PHY906 as a broad-spectrum enhancer in cancer therapy: Clinical and preclinical results in hepatocellular carcinoma
    • # 2145
    • Liu, S.H., Foo, A., Jiang, Z., et al., 2006. PHY906 as a broad-spectrum enhancer in cancer therapy: clinical and preclinical results in hepatocellular carcinoma. Proceedings of American Association for Cancer Research, # 2145.
    • (2006) Proceedings of American Association for Cancer Research
    • Liu, S.H.1    Foo, A.2    Jiang, Z.3
  • 37
    • 84862804392 scopus 로고    scopus 로고
    • Controlling chemotherapy-related side effects with Chinese medicine
    • Springer Science, Netherlands, Chapter 7
    • Liu, S.H., Cheng, Y.C., Saif, M.W., 2010. Controlling chemotherapy-related side effects with Chinese medicine. In: Supportive Cancer Care with Chinese Medicine. Springer Science, Netherlands, Chapter 7, pp. 141-167.
    • (2010) Supportive Cancer Care with Chinese Medicine , pp. 141-167
    • Liu, S.H.1    Cheng, Y.C.2    Saif, M.W.3
  • 40
    • 0037137578 scopus 로고    scopus 로고
    • Botanical medicines - The need for new regulations
    • DOI 10.1056/NEJMsb022858
    • Marcus, D.M., Grollman, A.P., 2002. Botanical medicines - the need for new regulations. New England Journal of Medicine 347, 2073-2076. (Pubitemid 35461667)
    • (2002) New England Journal of Medicine , vol.347 , Issue.25 , pp. 2073-2076
    • Marcus, D.M.1    Grollman, A.P.2
  • 41
    • 33845607687 scopus 로고    scopus 로고
    • The use of herbal therapies in pediatric oncology patients: Treating symptoms of cancer and side effects of standard therapies
    • DOI 10.1177/1043454206296027
    • Quimby, E.L., 2007. The use of herbal therapies in pediatric oncology patients: treating symptoms of cancer and side effects of standard therapies. Journal of Pediatric Oncology Nursing 24, 35-40. (Pubitemid 44954360)
    • (2007) Journal of Pediatric Oncology Nursing , vol.24 , Issue.1 , pp. 35-40
    • Quimby, E.L.1
  • 44
    • 0033558004 scopus 로고    scopus 로고
    • A multicenter, phase II trial of weekly irinotecan (CPT-11) in patients with previously treated colorectal carcinoma
    • Rothenberg, M.L., Cox, J.V., DeVore, R.F., 1999. A multicenter, phase II trial of weekly irinotecan (CPT-11) in patients with previously treated colorectal carcinoma. Cancer 85, 786-795.
    • (1999) Cancer , vol.85 , pp. 786-795
    • Rothenberg, M.L.1    Cox, J.V.2    DeVore, R.F.3
  • 46
    • 42949130589 scopus 로고    scopus 로고
    • Is there a standard of care for the management of advanced pancreatic cancer?. Highlights from the Gastrointestinal Cancers Symposium. Orlando, FL, USA. January 25-27, 2008
    • Saif, M.W., 2008a. Is there a standard of care for the management of advanced pancreatic cancer? Highlights from the Gastrointestinal Cancers Symposium, January 25-27, Orlando, FL, USA. Journal of the Pancreas 9 (2), 91-98. (Pubitemid 351611724)
    • (2008) Journal of the Pancreas , vol.9 , Issue.2 , pp. 91-98
    • Saif, M.W.1
  • 47
    • 48949099568 scopus 로고    scopus 로고
    • Is there a role for herbal medicine in the treatment of pancreatic cancer? Highlights from the 44th ASCO Annual Meeting
    • Saif, M.W., 2008b. Is there a role for herbal medicine in the treatment of pancreatic cancer? Highlights from the 44th ASCO Annual Meeting. Journal of the Pancreas 9 (4), 403-407.
    • (2008) Journal of the Pancreas , vol.9 , Issue.4 , pp. 403-407
    • Saif, M.W.1
  • 49
    • 84862831520 scopus 로고    scopus 로고
    • A phase II study of capecitabine (CAP) plus PHY906 in Pts with advanced pancreatic cancer (APC)
    • # e15508
    • Saif, M.W., Li, J., Lamb, L., et al., 2009. A phase II study of capecitabine (CAP) plus PHY906 in Pts with advanced pancreatic cancer (APC). In: Proceedings of American Society of Clinical Oncology, # e15508.
    • (2009) Proceedings of American Society of Clinical Oncology
    • Saif, M.W.1    Li, J.2    Lamb, L.3
  • 50
    • 84862813508 scopus 로고    scopus 로고
    • Phase II study of PHY906 plus capecitabine (CAP) in pts with gemcitabine-refractory pancreatic cancer (PC) and measurement of cytokines
    • abstr e14540
    • Saif, M., Li, J., Lamb, L., et al., 2010a. Phase II study of PHY906 plus capecitabine (CAP) in pts with gemcitabine-refractory pancreatic cancer (PC) and measurement of cytokines. Journal of Clinical Oncology 28 (suppl; abstr e14540).
    • (2010) Journal of Clinical Oncology , vol.28 , Issue.SUPPL.
    • Saif, M.1    Li, J.2    Lamb, L.3
  • 51
    • 75249102511 scopus 로고    scopus 로고
    • Phase I study of the botanical formulation PHY906 with capecitabine in advanced pancreatic and other gastrointestinal malignancies?
    • Saif, M.W., Lansigan, F., Ruta, S., et al., 2010b. Phase I study of the botanical formulation PHY906 with capecitabine in advanced pancreatic and other gastrointestinal malignancies? Phytomedicine 17 (3-4), 161-169.
    • (2010) Phytomedicine , vol.17 , Issue.3-4 , pp. 161-169
    • Saif, M.W.1    Lansigan, F.2    Ruta, S.3
  • 52
    • 0034727063 scopus 로고    scopus 로고
    • Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer
    • Saltz, L.B., Cox, J.V., Blanke, C., et al., 2000. Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. New England Journal of Medicine 343, 905-914.
    • (2000) New England Journal of Medicine , vol.343 , pp. 905-914
    • Saltz, L.B.1    Cox, J.V.2    Blanke, C.3
  • 53
    • 34548160680 scopus 로고    scopus 로고
    • Irinotecan fluorouracil plus leucovorin is not superior to fluorouracil plus leucovorin alone as adjuvant treatment for stage III colon cancer: Results of CALGB 89803
    • DOI 10.1200/JCO.2007.11.2144
    • Saltz, L.B., Niedzwiecki, D., Hollis, D., et al., 2007. Irinotecan fluorouracil plus leucovorin is not superior to fluorouracil plus leucovorin alone as adjuvant treatment for stage III colon cancer: results of CALGB 89803. Journal of Clinical Oncology 25 (23), 3456-3461. (Pubitemid 47310883)
    • (2007) Journal of Clinical Oncology , vol.25 , Issue.23 , pp. 3456-3461
    • Saltz, L.B.1    Niedzwiecki, D.2    Hollis, D.3    Goldberg, R.M.4    Hantel, A.5    Thomas, J.P.6    Fields, A.L.A.7    Mayer, R.J.8
  • 55
    • 77955684821 scopus 로고    scopus 로고
    • A comprehensive platform for quality control of botanical drugs (PhytomicsQC): A case study of Huangqin Tang (HQT) and PHY906
    • Tilton, R., Paiva, A.A., Guan, J.Q., et al., 2010. A comprehensive platform for quality control of botanical drugs (PhytomicsQC): a case study of Huangqin Tang (HQT) and PHY906. Chinese Medicine 5, 30.
    • (2010) Chinese Medicine , vol.5 , pp. 30
    • Tilton, R.1    Paiva, A.A.2    Guan, J.Q.3
  • 56
    • 79955755861 scopus 로고    scopus 로고
    • Interaction of a traditional Chinese Medicine (PHY906) and CPT-11 on the inflammatory process in the tumor microenvironment
    • Wang, E., Bussom, S., Gen, J., et al., 2011. Interaction of a traditional Chinese Medicine (PHY906) and CPT-11 on the inflammatory process in the tumor microenvironment. BMC Medical Genomics 4, 38.
    • (2011) BMC Medical Genomics , vol.4 , pp. 38
    • Wang, E.1    Bussom, S.2    Gen, J.3
  • 57
    • 0034847219 scopus 로고    scopus 로고
    • Integration of Chinese medicine into supportive cancer care: A modern role for an ancient tradition
    • DOI 10.1053/ctrv.2001.0227
    • Wong, R., Sagar, C.M., Sagar, S.M., 2001. Integration of Chinese medicine into supportive cancer care: A modern role for an ancient tradition. Cancer Treatment Reviews 27, 235-246. (Pubitemid 32851176)
    • (2001) Cancer Treatment Reviews , vol.27 , Issue.4 , pp. 235-246
    • Wong, R.1    Sagar, C.M.2    Sagar, S.M.3
  • 58
    • 3843133110 scopus 로고    scopus 로고
    • Regulatory toxicology perspectives on the development of botanical drug products in the United Sates
    • Wu, K.M., Farrelly, J., Birnkrant, D., et al., 2004. Regulatory toxicology perspectives on the development of botanical drug products in the United Sates. American Journal of Therapeutics 11, 213-217.
    • (2004) American Journal of Therapeutics , vol.11 , pp. 213-217
    • Wu, K.M.1    Farrelly, J.2    Birnkrant, D.3
  • 59
    • 36249012384 scopus 로고    scopus 로고
    • Liquid chromatography/mass spectrometry analysis of PHY906, a Chinese medicine formulation for cancer therapy
    • DOI 10.1002/rcm.2832
    • Ye, M., Liu, S.H., Jiang, Z., et al., 2007. Liquid chromatography/mass spectrometry analysis of PHY906, a Chinese medicine formulation for cancer therapy. Rapid Communications in Mass Spectrometry 21, 3593-3607. (Pubitemid 350124627)
    • (2007) Rapid Communications in Mass Spectrometry , vol.21 , Issue.22 , pp. 3593-3607
    • Ye, M.1    Liu, S.-H.2    Jiang, Z.3    Lee, Y.4    Tilton, R.5    Cheng, Y.-C.6
  • 60
    • 71949107671 scopus 로고    scopus 로고
    • Phase I/II study of capecitabine and PHY906 in hepatocellular carcinoma
    • Yen, Y., So, S., Rose, M., et al., 2009. Phase I/II study of capecitabine and PHY906 in hepatocellular carcinoma. Anticancer Research 29, 4083-4092.
    • (2009) Anticancer Research , vol.29 , pp. 4083-4092
    • Yen, Y.1    So, S.2    Rose, M.3
  • 61
    • 77955925853 scopus 로고    scopus 로고
    • Identification of chemicals and their metabolites from PHY906, a Chinese medicine formulation, in the plasma of a patient treated with irinotecan and PHY906 using liquid chromatography/tandem mass spectrometry (LC/MS/MS)
    • Zhang, W., Saif, M.W., Dutschman, G.E., et al., 2010. Identification of chemicals and their metabolites from PHY906, a Chinese medicine formulation, in the plasma of a patient treated with irinotecan and PHY906 using liquid chromatography/tandem mass spectrometry (LC/MS/MS). Journal of Chromatography A 1217, 5785-5793.
    • (2010) Journal of Chromatography A , vol.1217 , pp. 5785-5793
    • Zhang, W.1    Saif, M.W.2    Dutschman, G.E.3


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