The uptake characteristics of flavonoids in the Caco-2 model system

Chinese Journal of Natural Medicines

Volumn 4, Issue 4, 2006, Pages 299-302

  Chen, Bing Luan ^a   Li, Song Lin ^a   Li, Ping ^a   Zhang, Lu Yong ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Caco 2; Flavonoids; Uptake

Indexed keywords

APIGENIN; BAICALIN; DAIDZEIN; FLAVONOID; FLAVONOID GLYCOSIDE; GENISTEIN; LONICERIN; LUTEOLIN; LUTEOLIN 7 O BETA DEXTRO GALACTOSIDE; QUERCETIN; RUTOSIDE; UNCLASSIFIED DRUG;

ACIDITY; ARTICLE; CELL CULTURE; CELL STRAIN CACO 2; CELL TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; DIFFUSION; DRUG ABSORPTION; DRUG STRUCTURE; DRUG UPTAKE; HUMAN; HUMAN CELL;

EID: 33746641680     PISSN: 20956975     EISSN: 18755364     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Xie BX, Zhang MH. Chinese source. Acta Zoonutri Sin, 2003, 15 (2): 11-15.
2. Crepy V, Morand C, Besson C, et al. Quercetin, butnotits glycosides, is absorbed from the rats tomach [J]. J Agric Food Chem, 2002, 50 (3): 618-621.
3. Walgren RA. Transport of quercetin and its glucosides across human intestinal epithelial Caco-2 cells [J]. Biochem Pharmacol, 1998, 55: 1721-1727.
4. Murota K, Shimizu S, Chujo H, et al. Efficiency of absorption and metabolic conversion of quercetin and its glucosides in human intestinal cell line Caco-2 [J]. Arch Biochem Biophys, 2000, 384 (2): 391-397.
5. Chen J, Lin H, Hu M. Absorption and metabolism of genistein and its five isoflavone analogs in the human intestinal Caco-2 model[J]. Cancer Chemother Pharmacol, 2005, 55(2):159-169.
6. Liu Y, Hu M. Absorption and metabolism of flavonoids in the Caco-2 cell culture model and a perused rat intestinal model [J]. Drug Metab Dispos, 2002, 30 (4): 370-377.
7. Gugler R, et al. Disposition of quercetin in man after single oral and intravenous doses [J]. Eur J Clin Pharmacol, 1975, 9: 229-234.
8. Nieder M. Phrmakokinetik der ginkgo-flavanole in plasma. Munch Med Wochenschr, 1991, 133: S61-S62 (Suppl.).
9. Hu M, Chen J, Tran D, et al. The Caco-2 cell monolayers as an intestinal metabolism model: metabolism of dipeptide Phe-Pro [J]. J Drug Target, 1994, 2(1): 79-89.
10. Satio H, Inui KI. Dipeptide transporters in apical and basolateral membranes of the human intestinal cell line Caco-2 [J]. Am J Physiol, 1993, 265(2): G289-G294.
11. Chen JY, Xu ZY, Li YQ. Chinese source. Acta Pharm Sin, 1998, 33 (3): 222-225.
12. Su JF, Guo CJ, Wei JY, Chinese source. J Hyg Res, 2002,31(1):55-57.
13. Crespy V, Morand C, Manach C, et al. Part of quercetin absorbed in the small intestine is conjugated and further secreted in intestinal lumen [J]. Am J Physiol, 1999, 277 (1 Pt 1): G120-126.
14. Hidalgo IJ, Raub TJ, Borchardt RT. Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability [J]. Gastroenterology, 1989, 96 (3): 736-749.
15. Gan LL, Dhiren RT. Applications of the Caco-2 model in the design and development of orally active drug: elucidation of biochemical and physical barriers posed by the intestinal epithelium [J]. Adv Drug Deliv Rev, 1997, 23 (1): 77.