Differences in the order of potency for agonists but not antagonists at human and rat adenosine A(2A) receptors

Biochemical Pharmacology

Volumn 57, Issue 1, 1999, Pages 65-75

  Kull, Björn ^a   Arslan, Guilia ^a   Nilsson, Christer ^b   Owman, Christer ^b   Lorenzen, Anna ^c   Schwabe, Ulrich ^c   Fredholm, Bertil B ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b LUND UNIVERSITY   (Sweden)

^c Im Neuenheimer Feld 366   (Germany)

Author keywords

Adenosine receptors; Cloned receptor; Cyclic AMP; PC12 cells; Receptor binding; Species differences

Indexed keywords

2 (4 METHOXYPHENYL)ADENOSINE; 2 ANILINOADENOSINE; 2 CHLOROADENOSINE; 2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); 5 AMINO 2 (2 FURYL) 7 (2 PHENYLETHYL)PYRAZOLO[4,3 E][1,2,4]TRIAZOLO[1,5 C]PYRIMIDINE; ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE A2 RECEPTOR AGONIST; ADENOSINE A2 RECEPTOR ANTAGONIST; CAFFEINE; CYCLIC AMP; DIPYRIDAMOLE; FORSKOLIN; METRIFUDIL; PARAXANTHINE; ROLIPRAM; THEOPHYLLINE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CHO CELL; CONTROLLED STUDY; DISSOCIATION CONSTANT; DOSE RESPONSE; DRUG RECEPTOR BINDING; HUMAN; HUMAN CELL; HUMAN TISSUE; NONHUMAN; PHEOCHROMOCYTOMA; PREDICTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

EID: 0032901196     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(98)00298-6     Document Type: Article

References (38)

1. 2A receptors. Pharmacol Toxicol. 76:(Suppl II):1995;P1.26.
2. Fredholm B.B., Abbracchio M.P., Burnstock G., Daly J.W., Harden T.K., Jacobsen K.A., Leff P., Williams M. Nomenclature and classification of purinoceptors. Pharmacol Rev. 46:1994;143-156.
3. Palmer T.M., Stiles G.M. Adenosine receptors. Neuropharmacology. 34:1995;683-694.
4. Londos C., Cooper D.M.F., Wolff J. Subclasses of external adenosine receptors. Proc Natl Acad Sci USA. 77:1980;2551-2554.
5. van Calker D., Muller M., Hamprecht B. Adenosine regulates via two different types of receptors, the accumulation of cyclic AMP in cultured brain cells. J Neurochem. 33:1979;999-1005.
6. 3H]-NECA in rat striatal membranes. Mol Pharmocol. 29:1986;331-346.
7. Bruns F.R., Davis R.E., Ninteman F.W., Poschel B.P.H., Wiley J.N., Heffner T.G. Adenosine antagonists as pharmacological tools. Paton D.M., Adenosine and Adenine nucleotides. Physiology and Pharmacology. 1988;39-49 Taylor & Francis, Basingstoke.
8. 2 receptor with physiological constitutive activity. Biochem Biophys Res Commun. 173:1990;1169-1178.
9. 2 dopamine receptors in rat striatum . Mol Brain Res. 14:1992;186-195.
10. 2 receptor. Brain Res Mol Brain Res. 15:1992;62-66.
11. 2-adenosine receptor subtype. Mol Endocrinol. 6:1992;384-393.
12. 2b receptors from human brain. Biochem Biophys Res Commun. 187:1992;86-93.
13. 2A receptors. Trends Pharmacol Sci. 17:1996;364-372.
14. 1 receptor cDNA. FEBS Lett. 297:1992;107-111.
15. Greene L.A. Nerve growth factor prevents death and stimulates neuronal differentiation of clonal PC12 pheochromocytoma cells in serum-free medium. J Cell Biol. 78:1978;747-755.
16. Guroff G., Dickens G., End D., Londos C. The action of adenosine analogues on PC 12 cells. J Neurochem. 37:1981;1431-1439.
17. 2A adenosine receptors from rat striatum and rat pheochromocytoma PC12 cells Characterization with radioligand binding and by activation of adenylate cyclase . Mol Pharmacol. 41:1992;352-359.
18. Bonner T.I., Affolter H.U., Young A.C., Young W.S. III. A cDNA encoding the precursor of the rat neuropeptide, neurokinin B. Mol Brain Res. 2:1987;243-249.
19. Libert F., Parmentier M., Lefort A., Dinsart C., Van Sande J., Maenhaut C., Simons M.-J., Dumont J.E., Vassart G. Selective amplification and cloning of four new members of the G protein-coupled receptor family. Science. 244:1989;569-572.
20. Chen C., Okayama H. High-efficiency transformation of mammalian cells by plasmid DNA. Mol Cell Biol. 7:1987;2745-2752.
21. Clementi E., Racchetti G., Zacchetti D., Panzeri M.C., Meldolesi J. Differential expression of markers and activities in a group of PC12 nerve cell clones. Eur J Neurosci. 4:1992;944-953.
22. 2A receptors. Naunyn-Schmiedeberg's Arch Pharmacol. 353:1996;261-271.
23. 3H]CGS 21680 to rat cortex differs from its binding to rat striatum. Eur J Pharmacol, Mol Pharmacol Sect. 247:1993;103-110.
24. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 72:1976;248-294.
25. Nordstedt C., Fredholm B.B. A modification of a protein-binding method for rapid quantification of cAMP in cell-culture supernatants and body fluid. Anal Biochem. 189:1990;231-234.
26. 3H]SCH58261 to coronary artery membranes. Circ Res. 79:1996;1153-1160.
27. 3H]-SCH 58261. J Pharmacol. 121:1997;353-360.
28. 2A adenosine receptor antagonist, to rat striatal membranes. Br J Pharmacol. 117:1996;1381-1386.
29. Klotz K.-N., Hessling J., Hegler J., Owman C., Kull B., Fredholm B.B., Lohse M.J. Comparative pharmacology of human adenosine receptor subtypes - Characterization of stably transfected receptors in CHO cells. Naunyn-Schmiedeberg's Arch Pharmacol. 357:1998;1-9.
30. 2 receptors in Jurkat cells and PC12 cells using adenosine receptor agonists. Naunyn-Schmiedeberg's Arch Pharmacol. 353:1996;250-260.
31. 2b adenosine receptor in NIH 3T3 fibroblasts. Biochem Pharmacol. 47:1994;801-814.
32. Kenakin T. Differences between natural and recombinant G protein-coupled receptor systems with varying receptor/G protein stoichiometry. Trends Pharmacol Sci. 18:1997;456-464.
33. Gurden M.F., Coates J., Ellis F., Evans B., Foster M., Hornby E., Kennedy I., Martin D.P., Strong P., Vardey C.J. Functional characterization of three adenosine receptor types. Br J Pharmacol. 109:1993;693-698.
34. 2 receptors mediate the inhibitory effect of adenosine on fMLP-stimulated respiratory burst in neutrophil leukocytes. Naunyn-Schmiedeberg's Arch Pharmacol. 354:1996;262-267.
35. 2 selective adenosine receptor agonist with preferential hypotensive activity. J Pharmacol Exp Ther. 251:1989;47-55.
36. 2A adenosine receptors are required for ligand recognition. Mol Pharmacol. 50:1996;512-521.
37. 2a adenosine receptor. J Biol Chem. 270:1995;13987-13997.
38. 2A receptor. Eur J Pharmacol, Mol Pharmacol Sect. 268:1994;95-104.