ST101 induces a novel 17kDa APP cleavage that precludes Aβ generation in vivo

Annals of Neurology

Volumn 69, Issue 5, 2011, Pages 831-844

  Green, Kim N ^a   Khashwji, Hasan ^a   Estrada, Tatiana ^a   Laferla, Frank M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SECRETASE; AMINO ACID; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; CENTRAL NERVOUS SYSTEM AGENTS; ST 101; TUBULIN; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN HOMOGENATE; CONTROLLED STUDY; DRUG EFFICACY; EXPERIMENTAL MONKEY; HISTOPATHOLOGY; IN VIVO STUDY; MEMORY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; TREATMENT OUTCOME;

AGE FACTORS; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOIDOGENIC PROTEINS; ANIMALS; BRAIN; CATHEPSIN D; CELL LINE, TUMOR; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; INDANS; MACACA FASCICULARIS; MAZE LEARNING; MEMORY; MICE; MICE, TRANSGENIC; MOLECULAR WEIGHT; NEUROBLASTOMA; PEPTIDE FRAGMENTS; PROTEOMICS; REACTION TIME; SCHIZOPHRENIA; SPIRO COMPOUNDS; SUBCELLULAR FRACTIONS; TAU PROTEINS; TRANSFECTION; TUBULIN;

EID: 79955413534     PISSN: 03645134     EISSN: 15318249     Source Type: Journal    
DOI: 10.1002/ana.22325     Document Type: Article

References (24)

1. Querfurth HW, LaFerla FM., Alzheimer's disease. N Engl J Med 2010; 362: 329-344.
2. Barten DM, Meredith JE Jr, Zaczek R, et al. Gamma-secretase inhibitors for Alzheimer's disease: balancing efficacy and toxicity. Drugs R D 2006; 7: 87-97.
3. Ghosh AK, Gemma S, Tang J., beta-Secretase as a therapeutic target for Alzheimer's disease. Neurotherapeutics 2008; 5: 399-408. (Pubitemid 351952491)
4. Ito Y, Takuma K, Mizoguchi H, et al. A novel azaindolizinone derivative ZSET1446 (spiro[imidazo[1,2-a]pyridine-3,2-indan]-2(3H)-one) improves methamphetamine-induced impairment of recognition memory in mice by activating extracellular signal-regulated kinase 1/2. J Pharmacol Exp Ther 2007; 320: 819-827. (Pubitemid 46147964)
5. Yamaguchi Y, Miyashita H, Tsunekawa H, et al. Effects of a novel cognitive enhancer, spiro[imidazo-[1,2-a]pyridine-3,2-indan]-2(3H)-one (ZSET1446), on learning impairments induced by amyloid-beta1-40 in the rat. J Pharmacol Exp Ther 2006; 317: 1079-1087. (Pubitemid 43764111)
6. Han F, Shioda N, Moriguchi S, et al. Spiro[imidazo[1,2-a]pyridine-3,2- indan]-2(3H)-one (ZSET1446/ST101) treatment rescues olfactory bulbectomy-induced memory impairment by activating Ca2+/calmodulin kinase II and protein kinase C in mouse hippocampus. J Pharmacol Exp Ther 2008; 326: 127-134. (Pubitemid 351872142)
7. Shioda N, Yamamoto Y, Han F, et al. A novel cognitive enhancer, ZSET1446/ST101, promotes hippocampal neurogenesis and ameliorates depressive behavior in olfactory bulbectomized mice. J Pharmacol Exp Ther 2010; 333: 43-50.
8. Oddo S, Caccamo A, Kitazawa M, et al. Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease. Neurobiol Aging 2003; 24: 1063-1070. (Pubitemid 37487883)
9. Billings LM, Oddo S, Green KN, et al. Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice. Neuron 2005; 45: 675-688. (Pubitemid 40320703)
10. Poon WW, Blurton-Jones M, Tu CH, et al. beta-Amyloid impairs axonal BDNF retrograde trafficking. Neurobiol Aging (2009 Jun 18).
11. Chen F, Tandon A, Sanjo N, et al. Presenilin 1 and presenilin 2 have differential effects on the stability and maturation of nicastrin in mammalian brain. J Biol Chem 2003; 278: 19974-19979. (Pubitemid 36799189)
12. Lee MS, Kao SC, Lemere CA, et al. APP processing is regulated by cytoplasmic phosphorylation. J Cell Biol 2003; 163: 83-95. (Pubitemid 37271436)
13. Green KN, Steffan JS, Martinez-Coria H, et al. Nicotinamide restores cognition in Alzheimer's disease transgenic mice via a mechanism involving sirtuin inhibition and selective reduction of Thr231-phosphotau. J Neurosci 2008; 28: 11500-11510.
14. Jager S, Leuchtenberger S, Martin A, et al. alpha-secretase mediated conversion of the amyloid precursor protein derived membrane stub C99 to C83 limits Abeta generation. J Neurochem 2009; 111: 1369-1382.
15. Caccamo A, Oddo S, Billings LM, et al. M1 receptors play a central role in modulating AD-like pathology in transgenic mice. Neuron 2006; 49: 671-682. (Pubitemid 43290127)
16. Yang AJ, Knauer M, Burdick DA, Glabe C., Intracellular A beta 1-42 aggregates stimulate the accumulation of stable, insoluble amyloidogenic fragments of the amyloid precursor protein in transfected cells. J Biol Chem 1995; 270: 14786-14792.
17. Li QX, Evin G, Small DH, et al. Proteolytic processing of Alzheimer's disease beta A4 amyloid precursor protein in human platelets. J Biol Chem 1995; 270: 14140-14147.
18. Chong YH, Jung JM, Choi W, et al. Bacterial expression, purification of full length and carboxyl terminal fragment of Alzheimer amyloid precursor protein and their proteolytic processing by thrombin. Life Sci 1994; 54: 1259-1268. (Pubitemid 24107408)
19. Bronfman FC, Fernandez HL, Inestrosa NC., Amyloid precursor protein fragment and acetylcholinesterase increase with cell confluence and differentiation in a neuronal cell line. Exp Cell Res 1996; 229: 93-99. (Pubitemid 26423938)
20. Siman R, Card JP, Davis LG., Proteolytic processing of beta-amyloid precursor by calpain I. J Neurosci 1990; 10: 2400-2411.
21. Chong YH, Suh YH., Amyloidogenic processing of Alzheimer's amyloid precursor protein in vitro and its modulation by metal ions and tacrine. Life Sci 1996; 59: 545-557.
22. Matsumoto A, Matsumoto R, Baba H, Fujiwara Y., A serine protease in Alzheimer's disease cells cleaves a 16K-peptide with flanking residues upstream to beta-amyloid-N-terminus as natural substrate. Neuroscience Lett 1995; 195: 171-174.
23. Nordstedt C, Gandy SE, Alafuzoff I, et al. Alzheimer beta/A4 amyloid precursor protein in human brain: aging-associated increases in holoprotein and in a proteolytic fragment. Proc Natl Acad Sci U S A 1991; 88: 8910-8914. (Pubitemid 21915539)
24. Buxbaum JD, Gandy SE, Cicchetti P, et al. Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation. Proc Natl Acad Sci U S A 1990; 87: 6003-6006.