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Volumn 1, Issue 5, 2012, Pages 649-658

Tumor-mediated inhibition of human dendritic cell differentiation and function is consistently counteracted by combined p38 MAPK and STAT3 inhibition

Author keywords

Dendritic cell; Differentiation; IL 6; Microenvironment; P38 MAPK; STAT3; Suppression; Tumor

Indexed keywords

CD14 ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 12P70; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; STAT3 PROTEIN; T6 ANTIGEN;

EID: 84882246825     PISSN: 21624011     EISSN: 2162402X     Source Type: Journal    
DOI: 10.4161/onci.20365     Document Type: Article
Times cited : (52)

References (47)
  • 1
    • 34948895988 scopus 로고    scopus 로고
    • Lasker Basic Medical Research Award Dendritic cells: versatile controllers of the immune system
    • PMID:17917664
    • Steinman RM. Lasker Basic Medical Research Award. Dendritic cells: versatile controllers of the immune system. Nat Med 2007; 13:1155-9; PMID:17917664; http://dx.doi.org/10.1038/nm1643.
    • (2007) Nat Med , vol.13 , pp. 1155-1159
    • Steinman, R.M.1
  • 2
    • 84862127053 scopus 로고    scopus 로고
    • Cross-talk between myeloid-derived suppressor cells (MDSC), macrophages and dendritic cells enhances tumor-induced immune suppression
    • PMID:22313874
    • Ostrand-Rosenberg S, Sinha P, Beury DW, Clements VK. Cross-talk between myeloid-derived suppressor cells (MDSC), macrophages and dendritic cells enhances tumor-induced immune suppression. Semin Cancer Biol 2012; PMID:22313874; http://dx.doi. org/10.1016/j.semcancer.2012.01.011.
    • (2012) Semin Cancer Biol
    • Ostrand-Rosenberg, S.1    Sinha, P.2    Beury, D.W.3    Clements, V.K.4
  • 3
    • 78650525665 scopus 로고    scopus 로고
    • Cross-talk between tumor and myeloid cells: how to tip the balance in favor of antitumor immunity
    • PMID:21174559
    • Lindenberg JJ, Fehres CM, van Cruijsen H, Oosterhoff D, de Gruijl TD. Cross-talk between tumor and myeloid cells: how to tip the balance in favor of antitumor immunity. Immunotherapy 2011; 3:77-96; PMID:21174559; http://dx.doi.org/10.2217/ imt.10.95.
    • (2011) Immunotherapy , vol.3 , pp. 77-96
    • Lindenberg, J.J.1    Fehres, C.M.2    van Cruijsen, H.3    Oosterhoff, D.4    de Gruijl, T.D.5
  • 4
    • 2442657786 scopus 로고    scopus 로고
    • IL-6 is required for glioma development in a mouse model
    • PMID:15064729
    • Weissenberger J, Loeffler S, Kappeler A, Kopf M, Lukes A, Afanasieva TA, et al. IL-6 is required for glioma development in a mouse model. Oncogene 2004; 23:3308-16; PMID:15064729; http://dx.doi. org/10.1038/sj.onc.1207455.
    • (2004) Oncogene , vol.23 , pp. 3308-3316
    • Weissenberger, J.1    Loeffler, S.2    Kappeler, A.3    Kopf, M.4    Lukes, A.5    Afanasieva, T.A.6
  • 5
    • 0034658698 scopus 로고    scopus 로고
    • STATs in oncogenesis
    • PMID:10851046
    • Bowman T, Garcia R, Turkson J, Jove R. STATs in oncogenesis. Oncogene 2000; 19:2474-88; PMID:10851046; http://dx.doi.org/10.1038/ sj.onc.1203527.
    • (2000) Oncogene , vol.19 , pp. 2474-2488
    • Bowman, T.1    Garcia, R.2    Turkson, J.3    Jove, R.4
  • 6
    • 85047695527 scopus 로고    scopus 로고
    • Constitutive Stat3 activity upregulates VEGF expression and tumor angiogenesis
    • PMID:11960372
    • Niu G, Wright KL, Huang M, Song L, Haura E, Turkson J, et al. Constitutive Stat3 activity upregulates VEGF expression and tumor angiogenesis. Oncogene 2002; 21:2000-8; PMID:11960372; http://dx.doi. org/10.1038/sj.onc.1205260.
    • (2002) Oncogene , vol.21 , pp. 2000-2008
    • Niu, G.1    Wright, K.L.2    Huang, M.3    Song, L.4    Haura, E.5    Turkson, J.6
  • 7
    • 33845865825 scopus 로고    scopus 로고
    • Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment
    • PMID:17186030
    • Yu H, Kortylewski M, Pardoll D. Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment. Nat Rev Immunol 2007; 7:41-51; PMID:17186030; http://dx.doi.org/10.1038/nri1995.
    • (2007) Nat Rev Immunol , vol.7 , pp. 41-51
    • Yu, H.1    Kortylewski, M.2    Pardoll, D.3
  • 8
    • 70350500225 scopus 로고    scopus 로고
    • STATs in cancer inflammation and immunity: a leading role for STAT3
    • PMID:19851315
    • Yu H, Pardoll D, Jove R. STATs in cancer inflammation and immunity: a leading role for STAT3. Nat Rev Cancer 2009; 9:798-809; PMID:19851315; http:// dx.doi.org/10.1038/nrc2734.
    • (2009) Nat Rev Cancer , vol.9 , pp. 798-809
    • Yu, H.1    Pardoll, D.2    Jove, R.3
  • 9
    • 25444444988 scopus 로고    scopus 로고
    • Activation of dendritic cells via inhibition of Jak2/STAT3 signaling
    • PMID:16177074
    • Nefedova Y, Cheng P, Gilkes D, Blaskovich M, Beg AA, Sebti SM, et al. Activation of dendritic cells via inhibition of Jak2/STAT3 signaling. J Immunol 2005; 175:4338-46; PMID:16177074.
    • (2005) J Immunol , vol.175 , pp. 4338-4346
    • Nefedova, Y.1    Cheng, P.2    Gilkes, D.3    Blaskovich, M.4    Beg, A.A.5    Sebti, S.M.6
  • 10
    • 11144357779 scopus 로고    scopus 로고
    • Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells
    • PMID:14702634
    • Wang T, Niu G, Kortylewski M, Burdelya L, Shain K, Zhang S, et al. Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells. Nat Med 2004; 10:48-54; PMID:14702634; http:// dx.doi.org/10.1038/nm976.
    • (2004) Nat Med , vol.10 , pp. 48-54
    • Wang, T.1    Niu, G.2    Kortylewski, M.3    Burdelya, L.4    Shain, K.5    Zhang, S.6
  • 11
    • 65549129226 scopus 로고    scopus 로고
    • Sunitinib inhibition of Stat3 induces renal cell carcinoma tumor cell apoptosis and reduces immunosuppressive cells
    • PMID:19244102
    • Xin H, Zhang C, Herrmann A, Du Y, Figlin R, Yu H. Sunitinib inhibition of Stat3 induces renal cell carcinoma tumor cell apoptosis and reduces immunosuppressive cells. Cancer Res 2009; 69:2506-13; PMID:19244102; http://dx.doi.org/10.1158/0008-5472.CAN-08-4323.
    • (2009) Cancer Res , vol.69 , pp. 2506-2513
    • Xin, H.1    Zhang, C.2    Herrmann, A.3    Du, Y.4    Figlin, R.5    Yu, H.6
  • 12
    • 35448979864 scopus 로고    scopus 로고
    • A novel small molecule inhibitor of signal transducers and activators of transcription 3 reverses immune tolerance in malignant glioma patients
    • PMID:17942891
    • Hussain SF, Kong LY, Jordan J, Conrad C, Madden T, Fokt I, et al. A novel small molecule inhibitor of signal transducers and activators of transcription 3 reverses immune tolerance in malignant glioma patients. Cancer Res 2007; 67:9630-6; PMID:17942891; http://dx.doi.org/10.1158/0008-5472.CAN-07-1243.
    • (2007) Cancer Res , vol.67 , pp. 9630-9636
    • Hussain, S.F.1    Kong, L.Y.2    Jordan, J.3    Conrad, C.4    Madden, T.5    Fokt, I.6
  • 13
    • 69149098253 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription-3, inflammation and cancer: how intimate is the relationship
    • PMID:19723038
    • Aggarwal BB, Kunnumakkara AB, Harikumar KB, Gupta SR, Tharakan ST, Koca C, et al. Signal transducer and activator of transcription-3, inflammation and cancer: how intimate is the relationship? Ann NY Acad Sci 2009; 1171:59-76; PMID:19723038; http:// dx.doi.org/10.1111/j.1749-6632.2009.04911.x.
    • (2009) Ann NY Acad Sci , vol.1171 , pp. 59-76
    • Aggarwal, B.B.1    Kunnumakkara, A.B.2    Harikumar, K.B.3    Gupta, S.R.4    Tharakan, S.T.5    Koca, C.6
  • 14
    • 17844375379 scopus 로고    scopus 로고
    • Critical roles of Raf/MEK/ERK and PI3K/AKT signaling and inactivation of p38 MAP kinase in the differentiation and survival of monocyte-derived immature dendritic cells
    • PMID:15850834
    • Xie J, Qian J, Yang J, Wang S, Freeman ME, 3rd, Yi Q. Critical roles of Raf/MEK/ERK and PI3K/AKT signaling and inactivation of p38 MAP kinase in the differentiation and survival of monocyte-derived immature dendritic cells. Exp Hematol 2005; 33:564-72; PMID:15850834; http://dx.doi.org/10.1016/j. exphem.2005.03.001.
    • (2005) Exp Hematol , vol.33 , pp. 564-572
    • Xie, J.1    Qian, J.2    Yang, J.3    Wang, S.4    Freeman, M.E.5    Yi, Q.6
  • 15
    • 33644757687 scopus 로고    scopus 로고
    • Tumor evasion of the immune system: inhibiting p38 MAPK signaling restores the function of dendritic cells in multiple myeloma
    • PMID:16291589
    • Wang S, Yang J, Qian J, Wezeman M, Kwak LW, Yi Q. Tumor evasion of the immune system: inhibiting p38 MAPK signaling restores the function of dendritic cells in multiple myeloma. Blood 2006; 107:2432-9; PMID:16291589; http://dx.doi.org/10.1182/blood- 2005-06-2486.
    • (2006) Blood , vol.107 , pp. 2432-2439
    • Wang, S.1    Yang, J.2    Qian, J.3    Wezeman, M.4    Kwak, L.W.5    Yi, Q.6
  • 16
    • 33845482670 scopus 로고    scopus 로고
    • Optimizing immunotherapy in multiple myeloma: Restoring the function of patients' monocyte-derived dendritic cells by inhibiting p38 or activating MEK/ ERK MAPK and neutralizing interleukin-6 in progenitor cells
    • PMID:16917008
    • Wang S, Hong S, Yang J, Qian J, Zhang X, Shpall E, et al. Optimizing immunotherapy in multiple myeloma: Restoring the function of patients' monocyte-derived dendritic cells by inhibiting p38 or activating MEK/ ERK MAPK and neutralizing interleukin-6 in progenitor cells. Blood 2006; 108:4071-7; PMID:16917008; http://dx.doi.org/10.1182/blood-2006-04-016980.
    • (2006) Blood , vol.108 , pp. 4071-4077
    • Wang, S.1    Hong, S.2    Yang, J.3    Qian, J.4    Zhang, X.5    Shpall, E.6
  • 17
    • 67650354587 scopus 로고    scopus 로고
    • Activation of p38 mitogen-activated protein kinase drives dendritic cells to become tolerogenic in ret transgenic mice spontaneously developing melanoma
    • PMID:19549770
    • Zhao F, Falk C, Osen W, Kato M, Schadendorf D, Umansky V. Activation of p38 mitogen-activated protein kinase drives dendritic cells to become tolerogenic in ret transgenic mice spontaneously developing melanoma. Clin Cancer Res 2009; 15:4382-90; PMID:19549770; http://dx.doi.org/10.1158/1078-0432.CCR-09-0399.
    • (2009) Clin Cancer Res , vol.15 , pp. 4382-4390
    • Zhao, F.1    Falk, C.2    Osen, W.3    Kato, M.4    Schadendorf, D.5    Umansky, V.6
  • 18
    • 0036569357 scopus 로고    scopus 로고
    • Prostanoids play a major role in the primary tumor-induced inhibition of dendritic cell differentiation
    • PMID:11970975
    • Sombroek CC, Stam AG, Masterson AJ, Lougheed SM, Schakel MJ, Meijer CJ, et al. Prostanoids play a major role in the primary tumor-induced inhibition of dendritic cell differentiation. J Immunol 2002; 168:4333-43; PMID:11970975.
    • (2002) J Immunol , vol.168 , pp. 4333-4343
    • Sombroek, C.C.1    Stam, A.G.2    Masterson, A.J.3    Lougheed, S.M.4    Schakel, M.J.5    Meijer, C.J.6
  • 19
    • 0032400862 scopus 로고    scopus 로고
    • Vascular endothelial growth factor inhibits the development of dendritic cells and dramatically affects the differentiation of multiple hematopoietic lineages in vivo
    • PMID:9834220
    • Gabrilovich D, Ishida T, Oyama T, Ran S, Kravtsov V, Nadaf S, et al. Vascular endothelial growth factor inhibits the development of dendritic cells and dramatically affects the differentiation of multiple hematopoietic lineages in vivo. Blood 1998; 92:4150-66; PMID:9834220.
    • (1998) Blood , vol.92 , pp. 4150-4166
    • Gabrilovich, D.1    Ishida, T.2    Oyama, T.3    Ran, S.4    Kravtsov, V.5    Nadaf, S.6
  • 20
    • 34249300128 scopus 로고    scopus 로고
    • Prostaglandin E2 promotes tumor progression by inducing myeloid-derived suppressor cells
    • PMID:17483367
    • Sinha P, Clements VK, Fulton AM, Ostrand-Rosenberg S. Prostaglandin E2 promotes tumor progression by inducing myeloid-derived suppressor cells. Cancer Res 2007; 67:4507-13; PMID:17483367; http://dx.doi. org/10.1158/0008-5472.CAN-06-4174.
    • (2007) Cancer Res , vol.67 , pp. 4507-4513
    • Sinha, P.1    Clements, V.K.2    Fulton, A.M.3    Ostrand-Rosenberg, S.4
  • 21
    • 9444287003 scopus 로고    scopus 로고
    • Novel immunosuppressive properties of interleukin-6 in dendritic cells: inhibition of NFkappaB binding activity and CCR7 expression
    • PMID:15247147
    • Hegde S, Pahne J, Smola-Hess S. Novel immunosuppressive properties of interleukin-6 in dendritic cells: inhibition of NFkappaB binding activity and CCR7 expression. FASEB J 2004; 18:1439-41; PMID:15247147.
    • (2004) FASEB J , vol.18 , pp. 1439-1441
    • Hegde, S.1    Pahne, J.2    Smola-Hess, S.3
  • 22
    • 0033561648 scopus 로고    scopus 로고
    • TGF-beta1 prevents the noncognate maturation of human dendritic Langerhans cells
    • PMID:10201996
    • Geissmann F, Revy P, Regnault A, Lepelletier Y, Dy M, Brousse N, et al. TGF-beta1 prevents the noncognate maturation of human dendritic Langerhans cells. J Immunol 1999; 162:4567-75; PMID:10201996.
    • (1999) J Immunol , vol.162 , pp. 4567-4575
    • Geissmann, F.1    Revy, P.2    Regnault, A.3    Lepelletier, Y.4    Dy, M.5    Brousse, N.6
  • 23
    • 4644249098 scopus 로고    scopus 로고
    • IL-6 regulates in vivo dendritic cell differentiation through STAT3 activation
    • PMID:15356132
    • Park SJ, Nakagawa T, Kitamura H, Atsumi T, Kamon H, Sawa S, et al. IL-6 regulates in vivo dendritic cell differentiation through STAT3 activation. J Immunol 2004; 173:3844-54; PMID:15356132.
    • (2004) J Immunol , vol.173 , pp. 3844-3854
    • Park, S.J.1    Nakagawa, T.2    Kitamura, H.3    Atsumi, T.4    Kamon, H.5    Sawa, S.6
  • 24
    • 0038094524 scopus 로고    scopus 로고
    • B7-H4, a molecule of the B7 family, negatively regulates T cell immunity
    • PMID:12818165
    • Sica GL, Choi IH, Zhu G, Tamada K, Wang SD, Tamura H, et al. B7-H4, a molecule of the B7 family, negatively regulates T cell immunity. Immunity 2003; 18:849-61; PMID:12818165; http://dx.doi. org/10.1016/S1074-7613(03)00152-3.
    • (2003) Immunity , vol.18 , pp. 849-861
    • Sica, G.L.1    Choi, I.H.2    Zhu, G.3    Tamada, K.4    Wang, S.D.5    Tamura, H.6
  • 25
    • 34347230533 scopus 로고    scopus 로고
    • Elevated interleukin-6 and G-CSF in human pancreatic cancer cell conditioned medium suppress dendritic cell differentiation and activation
    • PMID:17545630
    • Bharadwaj U, Li M, Zhang R, Chen C, Yao Q. Elevated interleukin-6 and G-CSF in human pancreatic cancer cell conditioned medium suppress dendritic cell differentiation and activation. Cancer Res 2007; 67:5479-88; PMID:17545630; http://dx.doi. org/10.1158/0008-5472.CAN-06-3963.
    • (2007) Cancer Res , vol.67 , pp. 5479-5488
    • Bharadwaj, U.1    Li, M.2    Zhang, R.3    Chen, C.4    Yao, Q.5
  • 26
    • 80053046377 scopus 로고    scopus 로고
    • Glioblastoma-induced inhibition of Langerhans cell differentiation from CD34(+) precursors is mediated by IL-6 but unaffected by JAK2/STAT3 inhibition
    • PMID:21913828
    • van Cruijsen H, Oosterhoff D, Lindenberg JJ, Lougheed SM, Fehres C, Weijers K, et al. Glioblastoma-induced inhibition of Langerhans cell differentiation from CD34(+) precursors is mediated by IL-6 but unaffected by JAK2/STAT3 inhibition. Immunotherapy 2011; 3:1051-61; PMID:21913828; http://dx.doi. org/10.2217/imt.11.107.
    • (2011) Immunotherapy , vol.3 , pp. 1051-1061
    • van Cruijsen, H.1    Oosterhoff, D.2    Lindenberg, J.J.3    Lougheed, S.M.4    Fehres, C.5    Weijers, K.6
  • 27
    • 34548800403 scopus 로고    scopus 로고
    • p38 pathway kinases as anti-inflammatory drug targets
    • PMID:17720847
    • Schindler JF, Monahan JB, Smith WG. p38 pathway kinases as anti-inflammatory drug targets. J Dent Res 2007; 86:800-11; PMID:17720847; http://dx.doi. org/10.1177/154405910708600902.
    • (2007) J Dent Res , vol.86 , pp. 800-811
    • Schindler, J.F.1    Monahan, J.B.2    Smith, W.G.3
  • 28
    • 81155161000 scopus 로고    scopus 로고
    • The aromatic volatile organic compounds toluene, benzene and styrene induce COX-2 and prostaglandins in human lung epithelial cells via oxidative stress and p38 MAPK activation
    • PMID:21801798
    • Mögel I, Baumann S, Böhme A, Kohajda T, von Bergen M, Simon JC, et al. The aromatic volatile organic compounds toluene, benzene and styrene induce COX-2 and prostaglandins in human lung epithelial cells via oxidative stress and p38 MAPK activation. Toxicology 2011; 289:28-37; PMID:21801798; http://dx.doi.org/10.1016/j.tox.2011.07.006.
    • (2011) Toxicology , vol.289 , pp. 28-37
    • Mögel, I.1    Baumann, S.2    Böhme, A.3    Kohajda, T.4    von Bergen, M.5    Simon, J.C.6
  • 29
    • 84858142404 scopus 로고    scopus 로고
    • Nanostructured, self-assembling peptide K5 blocks TNFa and PGE2 production by suppression of the AP-1/p38 pathway
    • Epub ahead of press; PMID:22315508
    • Yang WS, Park YC, Kim JH, Kim HR, Yu T, Byeon SE, et al. Nanostructured, self-assembling peptide K5 blocks TNFa and PGE2 production by suppression of the AP-1/p38 pathway. Mediators Inflamm 2012; Epub ahead of press; PMID:22315508; http://dx.doi.org/10.1155/2012/489810.
    • (2012) Mediators Inflamm
    • Yang, W.S.1    Park, Y.C.2    Kim, J.H.3    Kim, H.R.4    Yu, T.5    Byeon, S.E.6
  • 30
    • 80053412980 scopus 로고    scopus 로고
    • The role of p38 mitogen-activated protein kinase in the pathogenesis of inflammatory bowel disease
    • PMID:21955425
    • Feng YJ, Li YY. The role of p38 mitogen-activated protein kinase in the pathogenesis of inflammatory bowel disease. J Dig Dis 2011; 12:327-32; PMID:21955425; http://dx.doi.org/10.1111/j.1751-2980.2011.00525.x.
    • (2011) J Dig Dis , vol.12 , pp. 327-332
    • Feng, Y.J.1    Li, Y.Y.2
  • 31
    • 80051706186 scopus 로고    scopus 로고
    • TLR4 engagement during TLR3-induced proinflammatory signaling in dendritic cells promotes IL-10-mediated suppression of antitumor immunity
    • PMID:21730023
    • Bogunovic D, Manches O, Godefroy E, Yewdall A, Gallois A, Salazar AM, et al. TLR4 engagement during TLR3-induced proinflammatory signaling in dendritic cells promotes IL-10-mediated suppression of antitumor immunity. Cancer Res 2011; 71:5467-76; PMID:21730023; http://dx.doi.org/10.1158/0008-5472.CAN-10-3988.
    • (2011) Cancer Res , vol.71 , pp. 5467-5476
    • Bogunovic, D.1    Manches, O.2    Godefroy, E.3    Yewdall, A.4    Gallois, A.5    Salazar, A.M.6
  • 33
    • 0142148330 scopus 로고    scopus 로고
    • Novel and detrimental effects of lipopolysaccharide on in vitro generation of immature dendritic cells: involvement of mitogen-activated protein kinase p38
    • PMID:14568957
    • Xie J, Qian J, Wang S, Freeman ME, 3rd, Epstein J, Yi Q. Novel and detrimental effects of lipopolysaccharide on in vitro generation of immature dendritic cells: involvement of mitogen-activated protein kinase p38. J Immunol 2003; 171:4792-800; PMID:14568957.
    • (2003) J Immunol , vol.171 , pp. 4792-4800
    • Xie, J.1    Qian, J.2    Wang, S.3    Freeman, M.E.4    Epstein, J.5    Yi, Q.6
  • 34
    • 79951959153 scopus 로고    scopus 로고
    • CD40 engagement on dendritic cells induces cyclooxygenase-2 and EP2 receptor via p38 and ERK MAPKs
    • PMID:20697426
    • Harizi H, Limem I, Gualde N. CD40 engagement on dendritic cells induces cyclooxygenase-2 and EP2 receptor via p38 and ERK MAPKs. Immunol Cell Biol 2011; 89:275-82; PMID:20697426; http://dx.doi.org/10.1038/icb.2010.94.
    • (2011) Immunol Cell Biol , vol.89 , pp. 275-282
    • Harizi, H.1    Limem, I.2    Gualde, N.3
  • 35
    • 78650656137 scopus 로고    scopus 로고
    • The regulation of Th1 responses by the p38 MAPK
    • PMID:20937847
    • Yang Z, Zhang X, Darrah PA, Mosser DM. The regulation of Th1 responses by the p38 MAPK. J Immunol 2010; 185:6205-13; PMID:20937847; http://dx.doi. org/10.4049/jimmunol.1000243.
    • (2010) J Immunol , vol.185 , pp. 6205-6213
    • Yang, Z.1    Zhang, X.2    Darrah, P.A.3    Mosser, D.M.4
  • 36
    • 27744522930 scopus 로고    scopus 로고
    • Potential adverse effects associated with inhibition of p38alpha/beta MAP kinases
    • PMID:16178738
    • Dambach DM. Potential adverse effects associated with inhibition of p38alpha/beta MAP kinases. Curr Top Med Chem 2005; 5:929-39; PMID:16178738; http:// dx.doi.org/10.2174/1568026054985911.
    • (2005) Curr Top Med Chem , vol.5 , pp. 929-939
    • Dambach, D.M.1
  • 37
    • 80052867880 scopus 로고    scopus 로고
    • ERK1/2 and p38α/β signaling in tumor cell quiescence: opportunities to control dormant residual disease
    • PMID:21673068
    • Sosa MS, Avivar-Valderas A, Bragado P, Wen HC, Aguirre-Ghiso JA. ERK1/2 and p38α/β signaling in tumor cell quiescence: opportunities to control dormant residual disease. Clin Cancer Res 2011; 17:5850-7; PMID:21673068; http://dx.doi.org/10.1158/1078-0432.CCR-10-2574.
    • (2011) Clin Cancer Res , vol.17 , pp. 5850-5857
    • Sosa, M.S.1    Avivar-Valderas, A.2    Bragado, P.3    Wen, H.C.4    Aguirre-Ghiso, J.A.5
  • 38
    • 42449157639 scopus 로고    scopus 로고
    • Targeting dendritic cell signaling to regulate the response to immunization
    • PMID:18180378
    • Escors D, Lopes L, Lin R, Hiscott J, Akira S, Davis RJ, et al. Targeting dendritic cell signaling to regulate the response to immunization. Blood 2008; 111:3050-61; PMID:18180378; http://dx.doi.org/10.1182/blood- 2007-11-122408.
    • (2008) Blood , vol.111 , pp. 3050-3061
    • Escors, D.1    Lopes, L.2    Lin, R.3    Hiscott, J.4    Akira, S.5    Davis, R.J.6
  • 39
    • 9644260767 scopus 로고    scopus 로고
    • Metastatic melanoma secreted IL-10 downregulates CD1 molecules on dendritic cells in metastatic tumor lesions
    • PMID:15579430
    • Gerlini G, Tun-Kyi A, Dudli C, Burg G, Pimpinelli N, Nestle FO. Metastatic melanoma secreted IL-10 downregulates CD1 molecules on dendritic cells in metastatic tumor lesions. Am J Pathol 2004; 165:1853-63; PMID:15579430; http://dx.doi.org/10.1016/S0002-9440(10)63238-5.
    • (2004) Am J Pathol , vol.165 , pp. 1853-1863
    • Gerlini, G.1    Tun-Kyi, A.2    Dudli, C.3    Burg, G.4    Pimpinelli, N.5    Nestle, F.O.6
  • 40
    • 80053224991 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 3 (Stat3C) promotes myeloid-derived suppressor cell expansion and immune suppression during lung tumorigenesis
    • PMID:21864492
    • Wu L, Du H, Li Y, Qu P, Yan C. Signal transducer and activator of transcription 3 (Stat3C) promotes myeloid-derived suppressor cell expansion and immune suppression during lung tumorigenesis. Am J Pathol 2011; 179:2131-41; PMID:21864492; http://dx.doi.org/10.1016/j.ajpath.2011.06.028.
    • (2011) Am J Pathol , vol.179 , pp. 2131-2141
    • Wu, L.1    Du, H.2    Li, Y.3    Qu, P.4    Yan, C.5
  • 41
    • 77953025421 scopus 로고    scopus 로고
    • MAPK/ERK1/2 signaling mediates endothelial-like differentiation of immature DCs in the microenvironment of esophageal squamous cell carcinoma
    • PMID:20221785
    • Lu J, Zhao J, Liu K, Zhao J, Yang H, Huang Y, et al. MAPK/ERK1/2 signaling mediates endothelial-like differentiation of immature DCs in the microenvironment of esophageal squamous cell carcinoma. Cell Mol Life Sci 2010; 67:2091-106; PMID:20221785; http:// dx.doi.org/10.1007/s00018-010-0316-8.
    • (2010) Cell Mol Life Sci , vol.67 , pp. 2091-2106
    • Lu, J.1    Zhao, J.2    Liu, K.3    Zhao, J.4    Yang, H.5    Huang, Y.6
  • 42
    • 40549097355 scopus 로고    scopus 로고
    • MAP kinase p38 and its relation to T cell anergy and suppressor function of regulatory T cells
    • PMID:18212528
    • Adler HS, Steinbrink K. MAP kinase p38 and its relation to T cell anergy and suppressor function of regulatory T cells. Cell Cycle 2008; 7:169-70; PMID:18212528; http://dx.doi.org/10.4161/ cc.7.2.5312.
    • (2008) Cell Cycle , vol.7 , pp. 169-170
    • Adler, H.S.1    Steinbrink, K.2
  • 43
    • 0030603986 scopus 로고    scopus 로고
    • Improved methods for the generation of dendritic cells from nonproliferating progenitors in human blood
    • PMID:8841451
    • Bender A, Sapp M, Schuler G, Steinman RM, Bhardwaj N. Improved methods for the generation of dendritic cells from nonproliferating progenitors in human blood. J Immunol Methods 1996; 196:121-35; PMID:8841451; http://dx.doi.org/10.1016/0022-1759(96)00079-8.
    • (1996) J Immunol Methods , vol.196 , pp. 121-135
    • Bender, A.1    Sapp, M.2    Schuler, G.3    Steinman, R.M.4    Bhardwaj, N.5
  • 44
    • 33645977500 scopus 로고    scopus 로고
    • Dendritic cells require multidrug resistance protein 1 (ABCC1) transporter activity for differentiation
    • PMID:16621983
    • van de Ven R, de Jong MC, Reurs AW, Schoonderwoerd AJ, Jansen G, Hooijberg JH, et al. Dendritic cells require multidrug resistance protein 1 (ABCC1) transporter activity for differentiation. J Immunol 2006; 176:5191-8; PMID:16621983.
    • (2006) J Immunol , vol.176 , pp. 5191-5198
    • van de Ven, R.1    de Jong, M.C.2    Reurs, A.W.3    Schoonderwoerd, A.J.4    Jansen, G.5    Hooijberg, J.H.6
  • 45
    • 0037109013 scopus 로고    scopus 로고
    • Potential of the conditionally replicative adenovirus Ad5-Delta24RGD in the treatment of malignant gliomas and its enhanced effect with radiotherapy
    • PMID:12384532
    • Lamfers ML, Grill J, Dirven CM, Van Beusechem VW, Geoerger B, Van Den Berg J, et al. Potential of the conditionally replicative adenovirus Ad5-Delta24RGD in the treatment of malignant gliomas and its enhanced effect with radiotherapy. Cancer Res 2002; 62:5736-42; PMID:12384532.
    • (2002) Cancer Res , vol.62 , pp. 5736-5742
    • Lamfers, M.L.1    Grill, J.2    Dirven, C.M.3    Van Beusechem, V.W.4    Geoerger, B.5    van den Berg, J.6
  • 46
    • 0033798213 scopus 로고    scopus 로고
    • Skin tests predict survival after autologous tumor cell vaccination in metastatic melanoma: experience in 81 patients
    • PMID:11038032
    • Baars A, Claessen AM, van den Eertwegh AJ, Gall HE, Stam AG, Meijer S, et al. Skin tests predict survival after autologous tumor cell vaccination in metastatic melanoma: experience in 81 patients. Ann Oncol 2000; 11:965-70; PMID:11038032; http://dx.doi. org/10.1023/A:1008363601515.
    • (2000) Ann Oncol , vol.11 , pp. 965-970
    • Baars, A.1    Claessen, A.M.2    van den Eertwegh, A.J.3    Gall, H.E.4    Stam, A.G.5    Meijer, S.6
  • 47
    • 0033616482 scopus 로고    scopus 로고
    • Active specific immunotherapy for stage II and stage III human colon cancer: a randomised trial
    • PMID:9950438
    • Vermorken JB, Claessen AM, van Tinteren H, Gall HE, Ezinga R, Meijer S, et al. Active specific immunotherapy for stage II and stage III human colon cancer: a randomised trial. Lancet 1999; 353:345-50; PMID:9950438; http://dx.doi.org/10.1016/S0140-6736(98)07186-4.
    • (1999) Lancet , vol.353 , pp. 345-350
    • Vermorken, J.B.1    Claessen, A.M.2    van Tinteren, H.3    Gall, H.E.4    Ezinga, R.5    Meijer, S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.