Interplay among subunit identity, subunit proportion, chain length, and stereochemistry in the activity profile of sequence-random peptide mixtures

Journal of the American Chemical Society

Volumn 135, Issue 32, 2013, Pages 11748-11751

  Hayouka, Zvi ^a   Chakraborty, Saswata ^a   Liu, Runhui ^a   Boersma, Melissa D ^a   Weisblum, Bernard ^b   Gellman, Samuel H ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVITY PROFILE; AMINO ACID RESIDUES; ANTI-BACTERIAL ACTIVITY; HOMOCHIRAL; HYDROPHOBIC RESIDUES; PEPTIDE MIXTURES; SOLID PHASE SYNTHESIS;

AMINO ACIDS; PEPTIDES;

BINARY MIXTURES;

CATION; MAGAININ 2; PEPTIDE; POLYPEPTIDE ANTIBIOTIC AGENT;

AMINO ACID SEQUENCE; ANTIBACTERIAL ACTIVITY; ARTICLE; BACILLUS SUBTILIS; CONTROLLED STUDY; ENTEROCOCCUS FAECIUM; ESCHERICHIA COLI; HEMOLYSIS; HYDROPHOBICITY; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PEPTIDE SYNTHESIS; SOLID PHASE SYNTHESIS; STEREOCHEMISTRY;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; BACTERIA; BACTERIAL INFECTIONS; CATIONS; HEMOLYSIS; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; PEPTIDES; SOLID-PHASE SYNTHESIS TECHNIQUES;

EID: 84882239766     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja406231b     Document Type: Article

References (35)

1. Diamond, G.; Beckloff, N.; Weinberg, A.; Kisich, K. O. Curr. Pharm. Des. 2009, 15, 2377
2. Zasloff, M. Nature 2002, 415, 389
3. Rathinakumar, R.; Walkenhorst, W. F.; Wimley, W. C. J. Am. Chem. Soc. 2009, 131, 7609
4. Boman, H. G. J. Intern. Med 2003, 254, 197
5. Hancock, R. E. Lancet Infect. Dis. 2001, 1, 156
6. Wimley, W. C. ACS Chem. Biol. 2010, 5, 905
7. Zasloff, M. J. Am. Soc. Nephrol. 2007, 18, 2810
8. Hilpert, K.; Elliott, M. R.; Volkmer-Engert, R.; Henklein, P.; Donini, O.; Zhou, Q.; Winkler, D. F.; Hancock, R. E. Chem. Biol. 2006, 13, 1101
9. Brogden, K. A. Nat. Rev. Microbiol. 2005, 3, 238
10. Yeaman, M. R.; Yount, N. Y. Pharmacol. Rev. 2003, 55, 27
11. Shai, Y. Biochim. Biophys. Acta 1999, 1462, 55
12. Tossi, A.; Sandri, L.; Giangaspero, A. Biopolymers 2000, 55, 4
13. Axelsen, P. H. Biophys. J. 2008, 94, 1549
14. Mowery, B. P.; Lee, S. E.; Kissounko, D. A.; Epand, R. F.; Epand, R. M.; Weisblum, B.; Stahl, S. S.; Gellman, S. H. J. Am. Chem. Soc. 2007, 129, 15474
15. Gelman, M. A.; Weisblum, B.; Lynn, D. M.; Gellman, S. H. Org. Lett. 2004, 6, 557
16. Kuroda, K.; DeGrado, W. F. J. Am. Chem. Soc. 2005, 127, 4128
17. Palermo, E. F.; Sovadinova, I.; Kuroda, K. Biomacromolecules 2009, 10, 3098
18. Paslay, L. C.; Abel, B. A.; Brown, T. D.; Koul, V.; Choudhary, V.; McCormick, C. L.; Morgan, S. E. Biomacromolecules 2012, 13, 2472
19. Mowery, B. P.; Lindner, A. H.; Weisblum, B.; Stahl, S. S.; Gellman, S. H. J. Am. Chem. Soc. 2009, 131, 9735
20. Liu, R.; Chen, X.; Hayouka, Z.; Chakraborty, S.; Falk, S. P.; Weisblum, B.; Masters, K. S.; Gellman, S. H. J. Am. Chem. Soc. 2013, 135, 5270
21. Ilker, M. F.; Nusslein, K.; Tew, G. N.; Coughlin, E. B. J. Am. Chem. Soc. 2004, 126, 15870
22. Gabriel, G. J.; Madkour, A. E.; Dabkowski, J. M.; Nelson, C. F.; Nusslein, K.; Tew, G. N Biomacromolecules 2008, 9, 2980
23. Lienkamp, K.; Madkour, A. E.; Musante, A.; Nelson, C. F.; Nusslein, K.; Tew, G. N. J. Am. Chem. Soc. 2008, 130, 9836
24. Zhou, C.; Qi, X.; Li, P.; Chen, W. N.; Chang, M. W.; Leong, S. S.; Chan-Park, M. B. Biomacromolecules 2010, 11, 60
25. Engler, A. C.; Shukla, A.; Puranam, S.; Buss, H. G.; Jreige, N.; Hammond, P. T. Biomacromolecules 2011, 12, 1666
26. Wang, Z.; Wang, G. Nucleic Acids Res. 2004, 32, D590
27. Mishra, B.; Wang, G. J. Am. Chem. Soc. 2012, 134, 12426
28. Yanisch-Perron, C.; Vieira, J.; Messing, J. Gene 1985, 33, 103
29. Young, F. E.; Smith, C.; Reilly, B. E. J. Bacteriol. 1969, 98, 1087
30. Weisblum, B.; Demohn, V. J. Bacteriol. 1969, 98, 447
31. Nicas, T. I.; Wu, C. Y.; Hobbs, J. N., Jr.; Preston, D. A.; Allen, N. E. Antimicrob. Agents Chemother. 1989, 33, 1121
32. Shai, Y.; Oren, Z. J. Biol. Chem. 1996, 271, 7305
33. Papo, N.; Oren, Z.; Pag, U.; Sahl, H. G.; Shai, Y. J. Biol. Chem. 2002, 277, 33913
34. Pag, U.; Oedenkoven, M.; Papo, N.; Oren, Z.; Shai, Y.; Sahl, H. G. J. Antimicrob. Chemother. 2004, 53, 230
35. Wade, D.; Boman, A.; Drain, C. M.; Andreu, D.; Boman, H. G.; Merrifield, R. B. Proc. Natl. Acad. Sci. U.S.A. 1990, 87, 4761