Inhibition of HIV-1 enzymes, antioxidant and anti-inflammatory activities of Plectranthus barbatus

Journal of Ethnopharmacology

Volumn 149, Issue 1, 2013, Pages 184-190

  Kapewangolo, Petrina ^a   Hussein, Ahmed A ^b   Meyer, Debra ^a  

^a UNIVERSITY OF PRETORIA   (South Africa)

^b UNIVERSITY OF THE WESTERN CAPE   (South Africa)

Author keywords

Antioxidant; Cytokines; HIV 1 protease; HIV 1 reverse transcriptase; Plectranthus barbatus

Indexed keywords

HUMAN IMMUNODEFICIENCY VIRUS PROTEINASE; PLANT EXTRACT; PLECTRANTHUS BARBATUS EXTRACT; RNA DIRECTED DNA POLYMERASE; TETRAZOLIUM; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IC 50; PERIPHERAL BLOOD MONONUCLEAR CELL; PLANT LEAF; PLECTRANTHUS; PLECTRANTHUS BARBATUS;

HUMAN IMMUNODEFICIENCY VIRUS 1; PLECTRANTHUS BARBATUS;

ANTIOXIDANT; CYTOKINES; HIV-1 PROTEASE; HIV-1 REVERSE TRANSCRIPTASE; PLECTRANTHUS BARBATUS;

ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHNOPHARMACOLOGY; HIV PROTEASE; HIV PROTEASE INHIBITORS; HIV REVERSE TRANSCRIPTASE; HIV-1; HUMANS; LEUKOCYTES, MONONUCLEAR; MEDICINE, AFRICAN TRADITIONAL; PLANT EXTRACTS; PLANT LEAVES; PLECTRANTHUS;

EID: 84882237213     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2013.06.019     Document Type: Article

References (43)

1. Y.A. Abassi, B. Xi, W. Zhang, P. Ye, S.L. Kirstein, M.R. Gaylord, S.C. Feinstein, X. Wang, and X. Xu Kinetic cell-based morphological screening: prediction of mechanism of compound action and off-target effects Chemistry and Biology 16 2009 712 723
2. M. Abdel-Mogib, H.A. Albar, and S.M. Batterjee Chemistry of the genus Plectranthus Molecules 7 2002 271 301
3. K. Abel, M.J. Alegria-hartman, M. Marthas, and C.J. Miller The relationship between simian immunodeficiency virus RNA levels and the mRNA levels of alpha/beta interferons (IFN-α/β) and IFN-α/β- inducible Mx in lymphoid tissues of Rhesus Macaques during acute and chronic infection Journal of Virology 76 2002 8433 8445
4. R.H. Alasbahi, and M.F. Melzig Plectranthus barbatus: a review of phytochemistry, ethnobotanical uses and pharmacology - part 1 Planta Medica 76 2010 653 661
5. R.H. Alasbahi, and M.F. Melzig Plectranthus barbatus: A review of phytochemistry, ethnobotanical uses and pharmacology - part 2 Planta Medica 76 2010 753 765
6. J.P. Allard, E. Aghdassi, J. Chau, C. Tam, C.M. Kovacs, I.E. Salit, and S.L. Walmsley Effects of vitamin E and C supplementation on oxidative stress and viral load in HIV-infected subjects AIDS 12 1998 1653 1659
7. F.B.S. Almeida Antispasmodic effect of the essential oil of Plectranthus barbatus and some major constituents on the guinea-pig ileum Planta Medica 69 2003 1080 1085
8. F.A. Atienzar, K. Tilmant, H.H. Gerets, G. Toussaint, S. Speeckaert, E. Hanon, O. Depelchin, and S. Dhalluin The use of real-time cell analyzer technology in drug discovery: Defining optimal cell culture conditions and assay reproducibility with different adherent cellular models Journal of Biomolecular Screening 16 2011 575 587
9. P. Biswas, G. Poli, A.L. Kinter, J.S. Justement, S.K. Stanley, W.J. Maury, P. Bressler, J.M. Orenstein, and A.S. Fauci Interferonɣ induces the expression of human immunodeficiency virus in persistently infected promonocytic cells (U1) and redirects the production of virions to intracytoplasmic vacuoles in phorbol myristate acetate-differentiated U1 cells The Journal of Experimental Medicine 176 1992 739 750
10. E.C. Breen Pro- and anti-inflammatory cytokines in human immunodeficiency virus infection and acquired immunodeficiency syndrome Pharmacology and Therapeutics 95 2002 295 304
11. K.C. Chinsembu, and M. Hedimbi An ethnobotanical survey of plants used to manage HIV/AIDS opportunistic infections in Katima Mulilo, Caprivi region Namibia. Journal of Ethnobiology and Ethnomedicine 6 2010 1 9
12. N.L. Figueiredo, S. Raquel, M.M. De Aguiar, P. Luis, L. Ascensão, M. Luisa, M. Serralheiro, A. Rosa, and L. Lino The inhibitory effect of Plectranthus barbatus and Plectranthus ecklonii leaves on the viability, glucosyltransferase activity and biofilm formation of Streptococcus sobrinus and Streptococcus mutans Food Chemistry 119 2010 664 668
13. P.N. Fonteh, F.K. Keter, and D. Meyer New bis(thiosemicarbazonate) gold(III) complexes inhibit HIV replication at cytostatic concentrations: potential for incorporation into virostatic cocktails Journal of Inorganic Biochemistry 105 2011 1173 1180
14. P.N. Fonteh, F.K. Keter, D. Meyer, I.A. Guzei, and J. Darkwa Tetra-chloro-(bis-(3,5-dimethylpyrazolyl)methane)gold(III) chloride: An HIV-1 reverse transcriptase and protease inhibitor Journal of Inorganic Biochemistry 103 2009 190 194
15. M.L. Francis, M.S. Meltzer, and G.E. Howard Interferons in the persistence, pathogenesis, and treatment of HIV infection AIDS Research and Human Retroviruses 8 1992 199 207
16. D. Fulcher, and S. Wong Carboxyfluorescein succinimidyl ester-based proliferative assays for assessment of T cell function in the diagnostic laboratory Immunology and Cell Biology 77 1999 559 564
17. L. Gil del Valle, R.G. Hernández, and J.P. Ávila Oxidative stress associated to disease progression and toxicity during antiretroviral therapy in human immunodeficiency virus infection Journal of Virology and Microbiology 2013 2013
18. L. Gil, G. Mart, I. González, A. Tarinas, A. Álvarez, A. Giuliani, R. Molina, R. Tápanes, J. Pérez, and O. Sonia Contribution to characterization of oxidative stress in HIV/AIDS patients Pharmacological Research 47 2003 217 224
19. S.M. Keating, E.T. Golub, M. Nowicki, M. Young, K. Anastos, H. Crystal, M.H. Cohen, J. Zhang, R.M. Greenblatt, S. Desai, S. Wu, A.L. Landay, S.J. Gange, and P.J. Norris The effect of HIV infection and HAART on inflammatory biomarkers in a population-based cohort of women AIDS 25 2011 1823 1832
20. D.P. Kisangau, T.M. Herrmann, V.M. Lyaruu, K.M. Hosea, C.C. Joseph, Z.H. Mbwambo, and P.J. Masimba Traditional knowledge, use practices and conservation of medicinal plants for HIV/AIDS care in rural Tanzania Ethnobotany Research and Applications 9 2011 43 57
21. D.P. Kisangau, H.V.M. Lyaruu, K.M. Hosea, and C.C. Joseph Use of traditional medicines in the management of HIV/AIDS opportunistic infections in Tanzania: a case in the Bukoba rural district Journal of Ethnobiology and Ethnomedicine 8 2007 1 8
22. V. Kuete, R. Metuno, P.L. Keilah, E.T. Tshikalange, and B.T. Ngadjui Evaluation of the genus Treculia for antimycobacterial, anti-reverse transcriptase, radical scavenging and antitumor activities South African Journal of Botany 76 2010 530 535
23. V. Kuete, B. Ngameni, A.T. Mbaveng, B. Ngadjui, J.J.M. Meyer, and N. Lall Evaluation of flavonoids from Dorstenia barteri for their antimycobacterial, antigonorrheal and anti-reverse transcriptase activities Acta Tropica 116 2010 100 104
24. T.L. Lam, M.L. Lam, T.K. Au, D.T.M. Ip, T.B. Ng, W.P. Fong, and D.C.C. Wan A comparison of human immunodeficiency virus type-1 protease inhibition activities by the aqueous and methanol extracts of Chinese medicinal herbs Life Sciences 67 2000 2889 2896
25. M. Lamorde, J.R.S. Tabuti, C. Obua, C. Kukunda-byobona, H. Lanyero, P. Byakika-kibwika, G.S. Bbosa, A. Lubega, J. Ogwal-okeng, M. Ryan, P.J. Waako, and C. Merry Medicinal plants used by traditional medicine practitioners for the treatment of HIV/AIDS and related conditions in Uganda Journal of Ethnopharmacology 130 2010 43 53
26. C.W. Lukhoba, M.S.J. Simmonds, and A.J. Paton Plectranthus: a review of ethnobotanical uses Journal of Ethnopharmacology 103 2006 1 24
27. A.B. Lyons Analysing cell division in vivo and in vitro using flow cytometric measurement of CFSE dye dilution Journal of Immunological Methods 243 2000 147 154
28. X.H. Ma, C.J. Zheng, L.Y. Han, B. Xie, J. Jia, Z.W. Cao, Y.X. Li, and Y.Z. Chen Synergistic therapeutic actions of herbal ingredients and their mechanisms from molecular interaction and network perspectives Drug Discovery Today 14 2009 579 588
29. M.A. Maioli, L.C. Alves, A.L. Campanini, M.C. Lima, D.J. Dorta, M. Groppo, A.J. Cavalheiro, C. Curti, and F.E. Mingatto Iron chelating-mediated antioxidant activity of Plectranthus barbatus extract on mitochondria Food Chemistry 122 2010 203 208
30. K. Marxen, K.H. Vanselow, S. Lippemeier, R. Hintze, A. Ruser, and U. Hansen Determination of DPPH radical oxidation caused by methanolic extracts of some microalgal species by linear regression analysis of spectrophotometric measurements Sensors 7 2007 2080 2095
31. E.N. Matu, and J.Van Staden Antibacterial and anti-inflammatory activities of some plants used for medicinal purposes in Kenya Journal of Ethnopharmacology 87 2003 35 41
32. A.T. Mbaveng, V. Kuete, B.M. Mapunya, V.P. Beng, A.E. Nkengfack, J.J.M. Meyer, and N. Lall Evaluation of four Cameroonian medicinal plants for anticancer, antigonorrheal and antireverse transcriptase activities Environmental Toxicology and Pharmacology 32 2011 162 167
33. C.K. Mirabelli, R.K. Johnson, C.M. Sung, C. Sung, L. Faucette, K. Muirhead, and S.T. Crooke Evaluation of the in vivo antitumor activity and in vitro cytotoxic properties of auranofin, a coordinated gold compound, in murine tumor models Cancer Research 45 1985 32 39
34. T. Mosmann Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays Journal of Immunological Methods 65 1983 55 63
35. J.M. Nguta, J.M. Mbaria, D.W. Gakuya, P.K. Gathumbi, and S.G. Kiama Antimalarial herbal remedies of Msambweni, Kenya Journal of Ethnopharmacology 128 2010 424 432
36. J.M. Nguta, J.M. Mbaria, D.W. Gakuya, P.K. Gathumbi, and S.G. Kiama Traditional antimalarial phytotherapy remedies used by the South Coast community, Kenya Journal of Ethnopharmacology 131 2010 256 267
37. D.E. Nixon, and A.L. Landay Biomarkers of immune dysfunction in HIV Current Opinion in HIV and AIDS 5 2010 498 503
38. L.J. Rice, G.J. Brits, C.J. Potgieter, and J.Van Staden Plectranthus: a plant for the future? South African Journal of Botany 77 2011 947 959
39. D.K.B. Runyoro, M.I.N. Matee, O.D. Ngassapa, C.C. Joseph, and Z.H. Mbwambo Screening of Tanzanian medicinal plants for anti-Candida activity BMC Complementary and Alternative Medicine 10 2006 1 10
40. D. Vaira, J. Pincemail, and A.V.A.N. De Activation of human immunodeficiency virus type 1 by oxidative stress AIDS Research and Human Retroviruses 6 1990 1389 1397
41. A. Williams, F. Steffens, C. Reinecke, and D. Meyer The Th1/Th2/Th17 cytokine profile of HIV-infected individuals: A multivariate cytokinomics approach Cytokine 61 2013 521 526
42. C.M. Worsley, M.S. Suchard, W.S. Stevens, A. Van Rie, and D.M. Murdoch Multi-analyte profiling of ten cytokines in South African HIV-infected patients with Immune Reconstitution Inflammatory Syndrome (IRIS) AIDS Research and Therapy 7 2010 36
43. F.Y. Yue, A. Merchant, C.M. Kovacs, M. Loutfy, D. Persad, and M.A. Ostrowski Virus-specific interleukin-17-producing CD4+ T cells are detectable in early human immunodeficiency virus type 1 infection Journal of Virology 82 2008 6767 6771