Gastrointestinal pain: Unraveling a novel endogenous pathway through uroguanylin/guanylate cyclase-C/cGMP activation

Pain

Volumn 154, Issue 9, 2013, Pages 1820-1830

  Silos Santiago, Inmaculada ^a   Hannig, Gerhard ^a   Eutamene, Helene ^b   Ustinova, Elena E ^c   Bernier, Sylvie G ^a   Ge, Pei ^a   Graul, Christopher ^a   Jacobson, Sarah ^a   Jin, Hong ^a   Liong, Elaine ^a   Kessler, Marco M ^a   Reza, Tammi ^a   Rivers, Samuel ^a   Shea, Courtney ^a   Tchernychev, Boris ^a   Bryant, Alexander P ^a   Kurtz, Caroline B ^a   Bueno, Lionel ^b   Pezzone, Michael A ^c   Currie, Mark G ^a  

^a IRONWOOD PHARMACEUTICALS INC   (United States)

^b CNRS   (France)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Cyclic guanosine monophosphate; Gastrointestinal pain; Guanylate cyclase C; Linaclotide; Uroguanylin

Indexed keywords

CYCLIC GMP; GUANYLATE CYCLASE; MALONALDEHYDE; MORPHINE; MULTIDRUG RESISTANCE PROTEIN 4; MULTIDRUG RESISTANCE PROTEIN 5; ORGANIC ANION TRANSPORTER 2; PROBENECID; UROGUANYLIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BASOLATERAL MEMBRANE; COLON MUCOSA; CONTROLLED STUDY; DEGRANULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; EX VIVO STUDY; FEMALE; GASTROINTESTINAL PAIN; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; INTESTINE DISTENSION; MALE; MOUSE; NONHUMAN; PAIN THRESHOLD; PERITONEUM MAST CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENSORY NERVE; SIGNAL TRANSDUCTION; STRESS; VISCERAL PAIN;

CYCLIC GUANOSINE MONOPHOSPHATE; GASTROINTESTINAL PAIN; GUANYLATE CYCLASE-C; LINACLOTIDE; UROGUANYLIN;

ACETYLCHOLINE; ACETYLGLUCOSAMINE; ADENOCARCINOMA; ANIMALS; CELL DIFFERENTIATION; CELL LINE, TUMOR; COLITIS; COLON; COLORECTAL NEOPLASMS; CYCLIC GMP; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ELECTRIC STIMULATION; FEMALE; GASTROINTESTINAL DISEASES; GENE EXPRESSION REGULATION, NEOPLASTIC; GUANYLATE CYCLASE; HUMANS; HYPERALGESIA; INTESTINAL MUCOSA; INTESTINES; MALE; MAST CELLS; MORPHINE; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; NATRIURETIC PEPTIDES; ORGANIC ANION TRANSPORTERS, SODIUM-INDEPENDENT; PEROXIDASE; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; RESTRAINT, PHYSICAL; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRINITROBENZENESULFONIC ACID; VISCERAL PAIN;

EID: 84881667700     PISSN: 03043959     EISSN: 18726623     Source Type: Journal    
DOI: 10.1016/j.pain.2013.05.044     Document Type: Article

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