The du2J mouse model of ataxia and absence epilepsy has deficient cannabinoid CB1 receptor-mediated signalling

Journal of Physiology

Volumn 591, Issue 16, 2013, Pages 3919-3933

  Wang, Xiaowei ^a   Whalley, Benjamin J ^a   Stephens, Gary J ^a  

^a UNIVERSITY OF READING   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHANNEL; CANNABINOID 1 RECEPTOR; G PROTEIN COUPLED RECEPTOR;

ABSENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CELL ACTIVITY; CEREBELLAR ATAXIA; CONTROLLED STUDY; GENE MUTATION; GRANULE CELL; INHIBITORY POSTSYNAPTIC POTENTIAL; INTERNEURON; INTERNEURON PURKINJE CELL SYNAPSE; MALE; MOUSE; NEUROMODULATION; NEUROTRANSMISSION; NONHUMAN; PATHOPHYSIOLOGY; PHENOTYPE; POSTSYNAPTIC INHIBITION; PRESYNAPTIC INHIBITION; PRIORITY JOURNAL; PURKINJE CELL; SIGNAL TRANSDUCTION; SYNAPSE;

EID: 84881616869     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2012.244947     Document Type: Article

References (57)

1. Alviña K & Khodakhah K (2010). KCa channels as therapeutic agents in episodic ataxia type-2. J Neurosci 30, 7249-7257
2. Barclay J, Balaguero N, Mione M, Ackerman SL, Letts VA, Brodbeck J, Canti C, Meir A, Page KM, Kusumi K, Perez-Reyes E, Lander ES, Frankel WN, Gardiner RM, Dolphin AC & Rees M (2001). Ducky mouse phenotype of epilepsy and ataxia is associated with mutations in the Cacna2d2 gene and decreased calcium channel current in cerebellar PCs. J Neurosci 21, 6095-6104.
3. Bauer CS, Tran-Van-Minh A, Kadurin I & Dolphin AC (2010). A new look at calcium channel α2δ subunits. Curr Opin Neurobiol 20, 563-571.
4. Brill J, Klocke R, Paul D, Boison D, Gouder N, Klugbauer N, Hofmann F, Becker CM & Becker K (2004). entla, a novel epileptic and ataxic Cacna2d2 mutant of the mouse. J Biol Chem 279, 7322-7330.
5. Brodbeck J, Davies A, Courtney JM, Meir A, Balaguero N, Canti C, Moss FJ, Page KM, Pratt WS, Hunt SP, Barclay J, Rees M & Dolphin AC (2002). The ducky mutation in Cacna2d2 results in altered Purkinje cell morphology and is associated with the expression of a truncated α2δ-2 protein with abnormal function. J Biol Chem 277, 7684-7693.
6. Cole RL, Lechner SM, Williams ME, Prodanovich P, Bleicher L, Varney MA & Gu G (2005). Differential distribution of voltage-gated calcium channel alpha-2 delta (α2δ) subunit mRNA-containing cells in the rat central nervous system and the dorsal root ganglia. J Comp Neurol 491, 246-269.
7. D'Angelo E & De Zeeuw CI (2009). Timing and plasticity in the cerebellum: focus on the granular layer. Trends Neurosci 32, 30-40.
8. DeSanty KP & Dar MS (2001). Cannabinoid-induced motor incoordination through the cerebellar CB1 receptor in mice. Pharmacol Biochem Behav 69, 251-259.
9. de Solages C, Szapiro G, Brunel N, Hakim V, Isope P, Buisseret P, Rousseau C, Barbour B & Léna C (2008). High-frequency organization and synchrony of activity in the Purkinje cell layer of the cerebellum. Neuron 58, 775-788.
10. De Zeeuw CI, Hoebeek FE, Bosman LW, Schonewille M, Witter L & Koekkoek SK (2011). Spatiotemporal firing patterns in the cerebellum. Nat Rev Neurosci 12, 327-344.
11. Dolphin AC (2012). Calcium channel auxiliary α2δ and β subunits: trafficking and one step beyond. Nat Rev Neurosci 13, 542-555.
12. 2J mutation in Cacna2d2 results in reduced spontaneous Purkinje cell activity and altered gene expression. J Neurosci 26, 12576-12586.
13. Egert U, Heck D & Aertsen A (2002). Two-dimensional monitoring of spiking networks in acute brain slices. Exp Brain Res 142, 268-274.
14. Egertova M & Elphick MR (2000). Localization of cannabinoid receptors in the rat brain using antibodies to the intracellular C-terminal tail of CB1. J Comp Neurol 422, 159-171.
15. Fisyunov A, Tsintsadze V, Min R, Burnashev N & Lozovaya N (2006). Cannabinoids modulate the P-type high-voltage-activated calcium currents in Purkinje neurons. J Neurophysiol 96, 1267-1277.
16. 2+ signals and calcium channels in axons of developing rat cerebellar interneurones. J Physiol 527, 33-48.
17. Gao BN, Sekido Y, Maximov A, Saad M, Forgacs E, Latif F, Wei MH, Lerman M, Lee JH & Perez-Reyes E (2000). Functional properties of a new voltage-dependent calcium channel α2δ auxiliary subunit gene (CACNA2D2). J Biol Chem 275, 12237-12242.
18. Goldowitz D & Hamre K (1998). The cells and molecules that make a cerebellum. Trends Neurosci 21, 375-382.
19. Green MC (ed.) (1981). Genetic Variants and Strains of Laboratory Mouse, pp 1-7. Gustav Fischer Verlag, Stuttgart . ISBN: 0898741520.
20. Grüsser-Cornehls U & Baurle J (2001). Mutant mice as a model for cerebellar ataxia. Prog Neurobiol 63, 489-540.
21. Hausser M & Clark BA (1997). Tonic synaptic inhibition modulates neuronal output pattern and spatiotemporal synaptic integration. Neuron 19, 665-678.
22. Hobom M, Dai S, Marais E, Lacinova L, Hofmann F & Klugbauer N (2000). Neuronal distribution and functional characterization of the calcium channel α2δ-2 subunit. Eur J Neurosci 12, 1217-1226.
23. Hoebeek FE, Stahl JS, van Alphen AM, Schonewille M, Luo C, Rutteman M, van den Maagdenberg AM, Molenaar PC, Goossens HH, Frens MA & De Zeeuw CI (2005). Increased noise level of Purkinje cell activities minimizes impact of their modulation during sensorimotor control. Neuron 45, 953-965.
24. Hoppa MB, Lana B, Margas W, Dolphin AC & Ryan TA (2012). α2δ expression sets presynaptic calcium channel abundance and release probability. Nature 486, 122-125.
25. Inoue M, Oomura Y, Yakushiji T & Akaike N (1986). Intracellular calcium ions decrease the affinity of the GABA receptor. Nature 324, 156-158.
26. Ivanov SV, Ward JM, Tessarollo L, McAreavey D, Sachdev V, Fananapazir L, Banks MK, Morris N, Djurickovic D, Devor-Henneman DE, Wei MH, Alvord GW, Gao B, Richardson JA, Minna JD, Rogawski MA & Lerman MI (2004). Cerebellar ataxia, seizures, premature death, and cardiac abnormalities in mice with targeted disruption of the Cacna2d2 gene. Am J Pathol 165, 1007-1018.
27. Jones NA, Hill AJ, Smith I, Bevan SA, Williams CM, Whalley BJ & Stephens GJ (2010). Cannabidiol displays antiepileptiform and antiseizure properties in vitro and in vivo. J Pharmacol Exp Ther 332, 569-577.
28. Kano M, Ohno-Shosaku T, Hashimotodani Y, Uchigashima M & Watanabe M (2009). Endocannabinoid-mediated control of synaptic transmission. Physiol Rev 89, 309-380.
29. Kawamura Y, Fukaya M, Maejima T, Yoshida T, Miura E, Watanabe M, Ohno-Shosaku T & Kano M (2006). CB1 is the major cannabinoid receptor at excitatory presynaptic site in the hippocampus and cerebellum. J Neurosci 26, 2991-3001.
30. Klugbauer N, Marais E & Hofmann F (2003). Calcium channel α2δ subunits: differential expression, function, and drug binding. J Bioenerg Biomembr 35, 639-647.
31. 2+ channel mutation on excitatory synaptic transmission in cerebellar Purkinje cells. J Physiol 586, 4501-4515.
32. 2+-channels impairs synaptic GABA and glutamate release in the mouse cerebellar cortex in cultured slices. Eur J Neurosci 30, 2293-2307.
33. Lossi L, Mioletti S & Merighi A (2002). Synapse-independent and synapse-dependent apoptosis of cerebellar granule cells in postnatal rabbits occur at two subsequent but partly overlapping developmental stages. Neuroscience 112, 509-523.
34. Lowry OH, Rosebrough NJ, Farr AL & Randall RJ (1951). Protein measurement with the Folin phenol reagent. J Biol Chem 193, 265-275.
35. Lozovaya N, Min R, Tsintsadze V & Burnashev N (2009). Dual modulation of CNS voltage-gated calcium channels by cannabinoids: Focus on CB1 receptor-independent effects. Cell Calcium 46, 154-162.
36. 9-tetrahydrocannabivarin modulates inhibitory neurotransmission in the cerebellum. Br J Pharmacol 154, 204-215.
37. Mapelli J & D'Angelo E. (2007). The spatial organization of long-term synaptic plasticity at the input stage of cerebellum. J Neurosci 27, 1285-1296.
38. 2+ on GABA-activated currents in cerebella granule cells in culture. J Membr Biol 142, 209-216.
39. 2+ channel mutant mice. J Neurosci 22, 4388-4398.
40. 2+ channel mutant mice. Cerebellum 11, 666-680.
41. Patel S & Hillard CJ (2001). Cannabinoid CB1 receptor agonists produce cerebellar dysfunction in mice. J Pharmacol Exp Ther 297, 629-637.
42. Person AL & Raman IM (2011). Purkinje neuron synchrony elicits time-locked spiking in the cerebellar nuclei. Nature 481, 502-505.
43. Shin SL, Hoebeek FE, Schonewille M, De Zeeuw CI, Aertsen A & De Schutter E (2007). Regular patterns in cerebellar Purkinje cell simple spike trains. PLoS One 2, e485.
44. 9-THC ataxia: role of the α4β2 subtype. Brain Res 1115, 16-25.
45. Stephens GJ (2009). G-protein-coupled-receptor-mediated presynaptic inhibition in the cerebellum. Trends Pharmacol Sci 30, 421-430.
46. v2.1/α1A (P/Q-type) voltage-dependent calcium channel mediates inhibitory neurotransmission onto mouse cerebellar Purkinje cells. Eur J Neurosci 13, 1902-1912.
47. Szabo B, Than M, Thorn D & Wallmichrath I (2004). Analysis of the effects of cannabinoids on synaptic transmission between basket and Purkinje cells in the cerebellar cortex of the rat. J Pharmacol Exp Ther 310, 915-925.
48. Takahashi KA & Linden DJ (2000). Cannabinoid receptor modulation of synapses received by cerebellar Purkinje cells. J Neurophysiol 83, 1167-1180.
49. V2.1 channels is sufficient to cause cerebellar ataxia in mice. Cerebellum 11, 246-258.
50. Tsou K, Brown S, Sañudo-Peña MC, Mackie K & Walker JM (1997). Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous system. Neuroscience 83, 393-411.
51. Twitchell W, Brown S & Mackie K (1997). Cannabinoids inhibit N- and P/Q-type calcium channels in cultured rat hippocampal neurons. J Neurophysiol 78, 43-50.
52. Walter JT, Alviña K, Womack MD, Chevez C & Khodakhah K (2006). Decreases in the precision of Purkinje cell pacemaking cause cerebellar dysfunction and ataxia. Nat Neurosci 9, 389-397.
53. Wang X, Horswill JG, Whalley BJ & Stephens GJ (2011). Effects of the allosteric antagonist PSNCBAM-1 on CB1 receptor modulation in the cerebellum. Mol Pharm 79, 758-767.
54. Wetts R & Herrup K (1982). Interaction of granule, Purkinje and inferior olivary neurons in lurcher chimeric mice. II. Granule cell death. Brain Res 250, 358-362.
55. Womack MD & Khodakhah K (2002). Active contribution of dendrites to the tonic and trimodal patterns of activity in cerebellar Purkinje neurons. J Neurosci 22, 10603-10612.
56. 2+ rise are selectively suppressed by cannabinoid receptor activation in cerebellar Purkinje cells. J Neurosci 26, 86-95.
57. 2+ channel-mutant mouse, tottering. J Physiol 547, 497-507.