Using poly(lactic-co-glycolic acid) microspheres to encapsulate plasmid of bone morphogenetic protein 2/polyethylenimine nanoparticles to promote bone formation in vitro and in vivo

International Journal of Nanomedicine

Volumn 8, Issue , 2013, Pages 2985-2995

  Qiao, Chunyan ^a   Zhang, Kai ^b   Jin, Han ^a   Miao, Leiying ^c   Shi, Ce ^a   Liu, Xia ^a   Yuan, Anliang ^a   Liu, Jinzhong ^a   Li, Daowei ^a   Zheng, Changyu ^d   Zhang, Guirong ^a   Li, Xiangwei ^a   Yang, Bai ^b   Sun, Hongchen ^a  

^a JILIN UNIVERSITY   (China)

^b Jilin University   (China)

^c MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

^d NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

Author keywords

Biodegradable polymer; Bone regeneration; Gene therapy; Human BMP 2

Indexed keywords

ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEIN 2; CALCIUM; COLLAGEN TYPE 1; MICROSPHERE; NANOPARTICLE; PLASMID DNA; POLYETHYLENEIMINE; POLYGLACTIN; TRANSCRIPTION FACTOR OSTERIX; TRANSCRIPTION FACTOR RUNX2;

ALP GENE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE DEFECT; COLL I GENE; CONTROLLED STUDY; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MALE; MICRO-COMPUTED TOMOGRAPHY; MICROENCAPSULATION; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; OSSIFICATION; OSTEOBLAST; PARTICLE SIZE; PROTEIN SECRETION; RAT; RUNX2 GENE; SLOW RELEASE FORMULATION; SP7 GENE;

BIODEGRADABLE POLYMER; BONE REGENERATION; GENE THERAPY; HUMAN BMP-2;

ANIMALS; BONE MORPHOGENETIC PROTEIN 2; CELL LINE; DRUG DELIVERY SYSTEMS; GENE EXPRESSION; GENETIC THERAPY; IMMUNOHISTOCHEMISTRY; LACTIC ACID; MALE; MICE; MICROSPHERES; NANOPARTICLES; OSTEOGENESIS; PARTICLE SIZE; PLASMIDS; POLYETHYLENEIMINE; POLYGLYCOLIC ACID; RATS; RATS, WISTAR; SKULL; TRANSFECTION;

EID: 84881606188     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S45184     Document Type: Article

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