A Neutral envelope-type nanoparticle containing pH-responsive and ss-cleavable lipid-like material as a carrier for plasmid DNA

Advanced Healthcare Materials

Volumn 2, Issue 8, 2013, Pages 1120-1125

  Akita, Hidetaka ^a   Ishiba, Ryohei ^a   Hatakeyama, Hiroto ^a   Tanaka, Hiroki ^a   Sato, Yusuke ^a   Tange, Kota ^b   Arai, Masaya ^b   Kubo, Kazuhiro ^b   Harashima, Hideyoshi ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b NOF Corporation   (Japan)

Author keywords

Cleavable material; Gene delivery; Lipid like materials; Neutralized particle; Non viral vector

Indexed keywords

AMINES; GENE TRANSFER; SULFUR COMPOUNDS;

ACIDIC ENVIRONMENT; DISULFIDE BONDING; GENE DELIVERY; LIPID NANOPARTICLES; NONVIRAL VECTORS; PH-RESPONSIVE; REDUCING ENVIRONMENT; TERTIARY AMINE;

NANOPARTICLES;

1,2 DIOLEOYL 3 DIMETHYLAMMONIOPROPANE; 1,2 DIOLEOYL 3 TRIMETHYLAMMONIOPROPANE; CC CLEAVABLE PROTON ACTIVATED LIPID LIKE MATERIAL; DITHIOTHREITOL; LIPID; MESSENGER RNA; NANOMATERIAL; NANOPARTICLE; PLASMID DNA; PROTEOHEPARAN SULFATE; SS CLEAVABLE PROTON ACTIVATED LIPID LIKE MATERIAL; UNCLASSIFIED DRUG;

ARTICLE; CELLULAR DISTRIBUTION; CONCENTRATION (PARAMETERS); CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DEGRADATION KINETICS; DISULFIDE BOND; DNA TRANSFECTION; GENE EXPRESSION; HYDROPHOBICITY; LIPID BILAYER; MATERIAL COATING; MOLECULAR MODEL; NANODEVICE; NANOENCAPSULATION; NONVIRAL GENE DELIVERY SYSTEM; PARTICLE SIZE; PH MEASUREMENT; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SIGNAL TRANSDUCTION; STATIC ELECTRICITY; ULTRAFILTRATION;

CLEAVABLE MATERIAL; GENE DELIVERY; LIPID-LIKE MATERIALS; NEUTRALIZED PARTICLE; NON-VIRAL VECTOR;

CELL LINE, TUMOR; DISULFIDES; DNA; FLUORESCENT DYES; HUMANS; HYDROGEN-ION CONCENTRATION; LIPID BILAYERS; NANOPARTICLES; PLASMIDS; PROTONS; RHODAMINES; TRANSFECTION;

EID: 84881561983     PISSN: 21922640     EISSN: 21922659     Source Type: Journal    
DOI: 10.1002/adhm.201200431     Document Type: Article

References (23)

1. H. Akita, H. Harashima, Expert Opin. Drug Delivery 2008, 5, 847
2. H. Kamiya, H. Akita, H. Harashima, Drug Discovery Today 2003, 8, 990.
3. C. Marty, C. Meylan, H. Schott, K. Ballmer-Hofer, R. A. Schwendener, Cell Mol Life Sci. 2004, 61, 1785;
4. K.A. Mislick, J. D. Baldeschwieler, Proc. Natl. Acad. Sci. USA 1996, 93, 12349;
5. L. C. Mounkes, W. Zhong, G. Cipres-Palacin, T. D. Heath, R. J. Debs, J. Biol. Chem. 1998, 273, 26164.
6. S. Hama, H. Akita, R. Ito, H. Mizuguchi, T. Hayakawa, H. Harashima, Mol. Ther. 2006, 13, 786;
7. C. M. Varga, N. C. Tedford, M. Thomas, A. M. Klibanov, L. G. Griffith, D. A. Lauffenburger, Gene Ther. 2005, 12, 1023.
8. S. Hama, H. Akita, S. Iida, H. Mizuguchi, H. Harashima, Nucleic Acids Res. 2007, 35, 1533.
9. K. Kogure, H. Akita, H. Harashima, J. Controlled Release 2007, 122, 246;
10. K. Kogure, H. Akita, Y. Yamada, H. Harashima, Adv. Drug Delivery Rev. 2008, 60, 559.
11. E. P. Feener, W. C. Shen, H. J. Ryser, J Biol Chem 1990, 265, 18780
12. R. Mandel, H. J. Ryser, F. Ghani, M. Wu, D. Peak, Proc. Natl. Acad. Sci. USA 1993, 90, 4112;
13. D. J. Morre, D. M. Morre, Free Radical Res. 2003, 37, 795.
14. L. B. Jeffs, L. R. Palmer, E. G. Ambegia, C. Giesbrecht, S. Ewanick, I. MacLachlan, Pharm Res. 2005, 22, 362.
15. H. Hatakeyama, H. Akita, K. Kogure, M. Oishi, Y. Nagasaki, Y. Kihira, M. Ueno, H. Kobayashi, H. Kikuchi, H. Harashima, Gene Ther. 2007, 14, 68.
16. M. A. Gosselin, W. Guo, R. J. Lee, Bioconjug. Chem. 2001, 12, 989.
17. J.P. Behr, Chimia 1997, 51, 34;
18. A. E. Nel, L. Madler, D. Velegol, T. Xia, E. M. Hoek, P. Somasundaran, F. Klaessig, V. Castranova, M. Thompson, Nat. Mater. 2009, 8, 543.
19. R. Leventis, J. R. Silvius, Biochim. Biophys. Acta 1990, 1023, 124.
20. J. S. Choi, E. J. Lee, H. S. Jang, J. S. Park, Bioconjug. Chem. 2001, 12, 108.
21. M. Breunig, U. Lungwitz, R. Liebl, A. Goepferich, Proc. Natl. Acad. Sci. USA 2007, 104, 14454.
22. S. Fumoto, S. Kawakami, K. Shigeta, Y. Higuchi, F. Yamashita, M. Hashida, J. Pharmacol. Exp. Ther. 2005, 315, 484.
23. S. C. Semple, S. K. Klimuk, T. O. Harasym, N. Dos Santos, S. M. Ansell, K. F. Wong, N. Maurer, H. Stark, P. R. Cullis, M. J. Hope, P. Scherrer, Biochim. Biophys. Acta 2001, 1510, 152.