Aerobic exercise + weight loss decreases skeletal muscle myostatin expression and improves insulin sensitivity in older adults

Obesity

Volumn 21, Issue 7, 2013, Pages 1350-1356

  Ryan, A S ^a,b   Li, G ^a,b   Blumenthal, J B ^a,b   Ortmeyer, H K ^a,b  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN; MESSENGER RNA; MYOGENIC DIFFERENTIATION FACTOR; MYOGENIN; MYOSTATIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ADULT; AEROBIC EXERCISE; AGED; ARTICLE; ATTENUATION; BODY MASS; BODY WEIGHT; CLINICAL ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOWN REGULATION; FAT FREE MASS; FAT MASS; FEMALE; GENE EXPRESSION; GLUCOSE CLAMP TECHNIQUE; GLUCOSE UTILIZATION; HUMAN; HUMAN TISSUE; HYPERINSULINEMIA; INSULIN SENSITIVITY; LEG MUSCLE; LONGITUDINAL STUDY; MALE; OBESITY; OXYGEN CONSUMPTION; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEDENTARY LIFESTYLE; SKELETAL MUSCLE; THIGH; VASTUS LATERALIS MUSCLE; WEIGHT REDUCTION;

EID: 84881559411     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1002/oby.20216     Document Type: Article

References (35)

1. McPherron AC, Lawler AM, Lee SJ,. Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member. Nature 1997; 387: 83-90.
2. Zammit PS, Partridge TA, Yablonka-Reuveni Z,. The skeletal muscle satellite cell: the stem cell that came in from the cold. J Histochem Cytochem 2006; 54: 1177-1191.
3. Grobet L, Martin LJ, Poncelet D, et al. A deletion in the bovine myostatin gene causes the double-muscled phenotype in cattle. Nat Genet 1997; 17: 71-74.
4. McPherron AC, Lee SJ,. Double muscling in cattle due to mutations in the myostatin gene. Proc Natl Acad Sci USA 1997; 94: 12457-12461.
5. Schuelke M, Wagner KR, Stolz LE, et al. Myostatin mutation associated with gross muscle hypertrophy in a child. N Engl J Med 2004; 350: 2682-2688.
6. Hulmi JJ, Tannerstedt J, Selanne H, Kainulainen H, Kovanen V, Mero AA,. Resistance exercise with whey protein ingestion affects mTOR signaling pathway and myostatin in men. J Appl Physiol 2009; 106: 1720-1729.
7. Dennis RA, Przybyla B, Gurley C, et al. Aging alters gene expression of growth and remodeling factors in human skeletal muscle both at rest and in response to acute resistance exercise. Physiol Genomics 2008; 32: 393-400.
8. Deldicque L, Atherton P, Patel R, et al. Effects of resistance exercise with and without creatine supplementation on gene expression and cell signaling in human skeletal muscle. J Appl Physiol 2008; 104: 371-378.
9. Kim JS, Cross JM, Bamman MM,. Impact of resistance loading on myostatin expression and cell cycle regulation in young and older men and women. Am J Physiol Endocrinol Metab 2005; 288: E1110-E1119.
10. Mascher H, Tannerstedt J, Brink-Elfegoun T, Ekblom B, Gustafsson T, Blomstrand E,. Repeated resistance exercise training induces different changes in mRNA expression of MAFbx and MuRF-1 in human skeletal muscle. Am J Physiol Endocrinol Metab 2008; 294: E43-E51.
11. Roth SM, Martel GF, Ferrell RE, Metter EJ, Hurley BF, Rogers MA,. Myostatin gene expression is reduced in humans with heavy-resistance strength training: a brief communication. Exp Biol Med 2003; 228: 706-709.
12. Ryan AS, Ivey FM, Prior S, Li G, Hafer-Macko C,. Skeletal muscle hypertrophy and muscle myostatin reduction after resistive training in stroke survivors. Stroke 2011; 42: 416-420.
13. Hittel DS, Axelson M, Sarna N, Shearer J, Huffman KM, Kraus WE,. Myostatin decreases with aerobic exercise and associates with insulin resistance. Med Sci Sports Exerc 2010; 42: 2023-2029.
14. Milan G, Dalla Nora E, Pilon C, et al. Changes in muscle myostatin expression in obese subjects after weight loss. J Clin Endocrinol Metab 2004; 89: 2724-2727.
15. Park JJ, Berggren JR, Hulver MW, Houmard JA, Hoffman EP,. GRB14, GPD1, and GDF8 as potential network collaborators in weight loss-induced improvements in insulin action in human skeletal muscle. Physiol Genomics 2006; 27: 114-121.
16. McPherron AC, Lee SJ,. Suppression of body fat accumulation in myostatin-deficient mice. J Clin Invest 2002; 109: 595-601.
17. Guo T, Jou W, Chanturiya T, Portas J, Gavrilova O, McPherron AC,. Myostatin inhibition in muscle, but not adipose tissue, decreases fat mass and improves insulin sensitivity. PLoS One 2009; 4: e4937, p. 1-11.
18. Wilkes JJ, Lloyd DJ, Gekakis N,. Loss-of-function mutation in myostatin reduces tumor necrosis factor alpha production and protects liver against obesity-induced insulin resistance. Diabetes 2009; 58: 1133-1143.
19. Zhang C, McFarlane C, Lokireddy S, et al. Myostatin-deficient mice exhibit reduced insulin resistance through activating the AMP-activated protein kinase signalling pathway. Diabetologia 2011; 54: 1491-1501.
20. Storgaard H, Song XM, Jensen CB, et al. Insulin signal transduction in skeletal muscle from glucose-intolerant relatives of type 2 diabetic patients [corrected]. Diabetes 2001; 50: 2770-2778.
21. Lichtenstein AH, Appel LJ, Brands M, et al. Summary of american heart association diet and lifestyle recommendations revision 2006. Arterioscler Thromb Vasc Biol 2006; 26: 2186-2191.
22. Ryan AS, Nicklas BJ, Berman DM,. Aerobic exercise is necessary to improve glucose utilization with moderate weight loss in women. Obesity 2006; 14: 1064-1072.
23. DeFronzo RA, Tobin JD, Andres R,. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 1979; 237: E214-E223.
24. McGuire EA, Helderman JH, Tobin JD, Andres R, Berman M,. Effects of arterial versus venous sampling on analysis of glucose kinetics in man. J Appl Physiol 1976; 41: 565-573.
25. American Diabetes A. Diagnosis and classification of diabetes mellitus. Diabetes 2009; 32: S62-S67.
26. Durieux AC, Amirouche A, Banzet S, et al. Ectopic expression of myostatin induces atrophy of adult skeletal muscle by decreasing muscle gene expression. Endocrinology 2007; 148: 3140-3147.
27. Smith IJ, Aversa Z, Alamdari N, Petkova V, Hasselgren PO,. Sepsis downregulates myostatin mRNA levels without altering myostatin protein levels in skeletal muscle. J Cell Biochem 2010; 111: 1059-1073.
28. Coffey VG, Zhong Z, Shield A, et al. Early signaling responses to divergent exercise stimuli in skeletal muscle from well-trained humans. FASEB J 2006; 20: 190-192.
29. Willoughby DS,. Effects of heavy resistance training on myostatin mRNA and protein expression. Med Sci Sports Exerc 2004; 36: 574-582.
30. Coffey VG, Shield A, Canny BJ, Carey KA, Cameron-Smith D, Hawley JA,. Interaction of contractile activity and training history on mRNA abundance in skeletal muscle from trained athletes. Am J Physiol Endocrinol Metab 2006; 290: E849-E855.
31. Drummond MJ, Fujita S, Abe T, Dreyer HC, Volpi E, Rasmussen BB,. Human muscle gene expression following resistance exercise and blood flow restriction. Med Sci Sports Exerc 2008; 40: 691-698.
32. Liu Y, Heinichen M, Wirth K, Schmidtbleicher D, Steinacker JM,. Response of growth and myogenic factors in human skeletal muscle to strength training. Br J Sports Med 2008; 42: 989-993.
33. Akpan I, Goncalves MD, Dhir R, et al. The effects of a soluble activin type IIB receptor on obesity and insulin sensitivity. Int J Obes 2009; 33: 1265-1273.
34. Trendelenburg AU, Meyer A, Rohner D, Boyle J, Hatakeyama S, Glass DJ,. Myostatin reduces Akt/TORC1/p70S6K signaling, inhibiting myoblast differentiation and myotube size. Am J Physiol Cell Physiol 2009; 296: C1258-C1270.
35. Kelley DE, Mandarino LJ,. Fuel selection in human skeletal muscle in insulin resistance: a reexamination. Diabetes 2000; 49: 677-683.