Immunological Characteristics Associated with the Protective Efficacy of Antibodies to Ricin

Journal of Immunology

Volumn 172, Issue 10, 2004, Pages 6221-6228

  Maddaloni, Massimo ^a   Cooke, Corrie ^a   Wilkinson, Royce ^a   Stout, Audrey V ^a   Eng, Leta ^a   Pincus, Seth H ^a,b,c  

^a MONTANA STATE UNIVERSITY   (United States)

^b LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^c The Research Institute for Children at Children's Hospital New Orleans   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

A CHAIN ANTIBODY; EPITOPE; MONOCLONAL ANTIBODY; RICIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY AFFINITY; ANTIBODY RESPONSE; ARTICLE; BACTERIUM; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFICACY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNIZATION; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PLANT; PRIORITY JOURNAL;

EID: 2442626550     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.172.10.6221     Document Type: Article

References (39)

1. von Behring, E., and S. Kitasato. 1890. On the mechanism of immunity in animals to diphtheria and tetanus. Deutsche Med. Wochenschr. [Translated and reprinted in Milestones in Microbiology. T. D. Brock, ed. and translator. ASM Press, 1999] 16:1113.
2. von Behring, E., and S. Kitasato. 1890. On the mechanism of immunity in animals to diphtheria and tetanus. Deutsche Med. Wochenschr. [Translated and reprinted in Milestones in Microbiology. T. D. Brock, ed. and translator. ASM Press, 1999] 16:1113.
3. Pappenheimer, A. M., T. Uchida, and A. A. Harper. 1972. An immunological study of the diphtheria toxin molecule. Immunochemistry 9:891.
4. Janeway, C. A., P. Travers, M. Walport, and M. Shlomchik. 2001. Immunobiology. The Immune System in Health and Disease, 5th Ed. Garland, New York, p. 365.
5. Parham, P. 2000. The Immune System, 1st Ed. Garland, New York, p. 175.
6. Tizard, I. R. 1995. Immunology: An Introduction, 4th Ed. Harcourt Brace, Philadelphia, p. 380.
7. Goldsby, R. A., T. J. Kindt, and B. A. Osborne. 2000. Kuby: Immunology, 4th Ed. W. H. Freeman, New York, p. 436.
8. Olsnes, S., A. M. Pappenheimer, and R. Meren. 1974. Lectins from Abrus precatorius and Ricinus communis. II. Hybrid toxins and their interactions with chain-specific antibodies. J. Immunol. 113:842.
9. Foxwell, B. M., S. I. Detre, T. A. Donovan, and P. E. Thorpe. 1985. The use of anti-ricin antibodies to protect mice intoxicated with ricin. Toxicology 34:79.
10. Zucker, D. R., and J. R. Murphy. 1984. Monoclonal antibody analysis of diphtheria toxin. I. Localization of epitopes and neutralization of cytotoxicity. Mol. Immunol. 21:785.
11. Lemley, P. V., and D. C. Wright. 1992. Mice are actively immunized after passive monoclonal antibody prophylaxis and ricin toxin challenge. Immunology 76:511.
12. Lemley, P. V., P. Amanatides, and D. C. Wright. 1994. Identification and characterization of a monoclonal antibody that neutralizes ricin toxicity in vitro and in vivo. Hybridoma 13:417.
13. Barbieri, J. T., D. Armellini, J. Molkentin, and R. Rappuoli. 1992. Construction of a diphtheria toxin A fragment-C180 peptide fusion protein which elicits a neutralizing antibody response against diphtheria toxin and pertussis toxin. Infect. Immun. 60:5071.
14. Matsuda, M., M. Kamei, N. Sugimoto, Y. Ma, and S. Hashizume. 1992. Characteristics of toxin-neutralization by anti-tetanus human monoclonal antibodies directed against the three functional domains [A], [B] and [C] of the tetanus toxin molecule and a reliable method for evaluating the protective effects of monoclonal antibodies. Eur. J. Epidemiol. 8:1.
15. Pastan, I., V. Chaudhary, and D. J. FitzGerald. 1992. Recombinant toxins as novel therapeutic agents. Annu. Rev. Biochem. 61:331.
16. Robertus, J. 1991. The structure and action of ricin, a cytotoxic N-glycosidase. Semin. Cell Biol. 1991:23.
17. Vitetta, E. S., and P. E. Thorpe. 1991. Immunotoxins containing ricin or its A chain. Semin. Cell. Biol. 2:47.
18. Melton-Celsa, A., and A. D. O'Brien. 2003. Plant and bacterial toxins as RNA N-glycosidases. In Bacterial Protein Toxins. D. L. Burns, J. T. Barbieri B. H. Iglewski, and R. Rappuoli, eds. Am. Soc. Microbiol., Washington, DC, p. 245.
19. Vitetta, E. S., P. E. Thorpe, and J. W. Uhr. 1993. Immunotoxins: magic bullets or misguided missiles? Immunol. Today. 14:252.
20. Pincus, S. H. 1994. Immunotoxins. In Pharmacology of Monoclonal Antibodies, Vol. 113. M. Rosenberg, and G. Moore, eds. Springer-Verlag, Berlin, p. 149.
21. Pincus, S. H., A. O. Shigeoka, A. A. Moe, L. P. Ewing, and H. R. Hill. 1988. Protective efficacy of IgM monoclonal antibodies in experimental group B streptococcal infection is a function of antibody avidity. J. Immunol. 140:2779.
22. Pincus, S. H., C. J. Stocks, Jr., and L. P. Ewing. 1982. Monoclonal anti-(T,G)-A-L antibodies: characterization of fine specificity and idiotype expression. Mol. Immunol. 19:1551.
23. Pincus, S. H., W. R. Watson, L. R. Ewing, C. J. Stocks, S. B. Harris, and D. R. Rollins. 1984. Monoclonal anti-digoxin antibodies: genotypic and phenotypic characterization. Life Sci. 35:433.
24. Furukawa-Stoffer, T. L., D. C. W. Mah, J. W. Cherwonogrodzky, and R. J. Weselake. 1999. A novel biological-based assay for the screening of neutralizing antibodies to ricin. Hybridoma 18:505.
25. Pincus, S. H., M. J. Smith, J. B. Burritt, and P. M. Glee. 1998. Peptides that mimic the protective antigen of group B streptococcal type III capsular polysaccharide. J. Immunol. 160:293.
26. Glee, P. E., S. H. Pincus, M. J. Smith, D. K. McNamer, J. B. Burritt, and J. E. Cutler. 1999. Peptide ligands that bind IgM antibodies and block interaction with antigen. J. Immunol. 163:826.
27. Burritt, J. B., M. T. Quinn, M. A. Jutila, C. W. Bond, and A. J. Jesaitis. 1995. Topological mapping of neutrophil cytochrome B epitopes with phage-display libraries. J. Biol. Chem. 270:16974.
28. Burritt, J. B., C. W. Bond, K. W. Doss, and A. J. Jesaitis. 1996. Filamentous phage display of oligopeptide libraries. Anal. Biochem. 338:1.
29. Pincus, S. H., L. Eng, C. L. Cooke, and M. Maddaloni. 2002. Identification of hypoglycemia in mice as a surrogate marker of ricin toxicosis. Comp. Med. 52:530.
30. Smith, G. P., and J. K. Scott. 1992. Peptide-display phage libaries. Methods Enzymol. 217:228.
31. Montfort, W., J. E. Villafranca, A. F. Monzingo, S. Ernst, B. Katzin, E. Rutenber, N. H. Xuong, R. Hamlin, and J. D. Robertus. 1987. The three-dimensional structure of ricin at 2.8A. J. Biol. Chem 262:5398.
32. Katzin, B. J., E. J. Collins, and J. D. Robertus. 1991. Structure of ricin A-chain at 2.5 A. Proteins 10:251.
33. Gould, J. H., M. R. Hartley, P. C. Welsh, D. K. Hoshizaki, A. Frankel, L. M. Roberts, and J. M. Lord. 1991. Alteration of an amino acid residue outside the active site of the ricin A chain reduces its toxicity towards yeast ribosomes. Mol. Gen. Genet. 230:81.
34. Youle, R. J., and M. Colombatti. 1987. Hybridoma cells containing intracellular anti-ricin antibodies show ricin meets secretory antibody before entering the cytosol. J. Biol. Chem. 262:4676.
35. Pappenheimer, A. M. 1980-1981. Diphtheria: studies on the biology of an infectious disease. Harvey Lect. 76:45.
36. Yamaizumi, M., T. Uchida, Y. Okada, and M. Furusawa. 1978. Neutralization of diphtheria toxin in living cells by microinjection of antifragment A contained within resealed erythrocyte ghosts. Cell 13:227.
37. Hagenaars, A. M., R. W. van Delft, and J. Nagel. 1984. Comparison of ELISA and toxin neutralization for the determination of tetanus antibodies. J. Immunoassay 5:1.
38. Dokmetjian, J., C. Della Valle, V. Lavigne, C. M. de Lujan, and M. A. Manghi. 2000. A possible explanation for the discrepancy between ELISA and neutralising antibodies to tetanus toxin. Vaccine 18:2698.
39. Maynard, J., C. B. M. Maassen, S. H. Leppla, K. Brasky, J. L. Patterson, B. L. Iverson, and G. Georgiou. 2002. Protection against anthrax toxin by recombinant antibody fragments correlates with antigen affinity. Nat. Biotechnol. 20:597.