Phylogenetic and phenotypic characterisation of the 3-ketoacyl-CoA thiolase gene family from the opportunistic human pathogenic fungus Candida albicans

FEMS Yeast Research

Volumn 13, Issue 6, 2013, Pages 553-564

  Otzen, Christian ^a   Müller, Sebastian ^a,c   Jacobsen, Ilse D ^a   Brock, Matthias ^a,b  

^a HANS KNÖLL INSTITUTE   (Germany)

^b FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Beta oxidation; Embryonated chicken eggs; Fatty acids; Gene duplication; Virulence

Indexed keywords

ACETYL COENZYME A ACYLTRANSFERASE;

AMINO ACID SEQUENCE; ARTICLE; CANDIDA ALBICANS; CELL COUNT; COLONY FORMATION; CONTROLLED STUDY; DELETION MUTANT; DNA FLANKING REGION; EMBRYO; FUNGAL GENETICS; FUNGAL VIRULENCE; FUNGUS CULTURE; FUNGUS GROWTH; GENE DELETION; MULTIGENE FAMILY; MYCELIAL GROWTH; NONHUMAN; OPEN READING FRAME; PHENOTYPE; PHYLOGENY; SACCHAROMYCES CEREVISIAE;

CANDIDA ALBICANS; FUNGI; SACCHAROMYCES CEREVISIAE; SACCHAROMYCETALES;

EID: 84881542871     PISSN: 15671356     EISSN: 15671364     Source Type: Journal    
DOI: 10.1111/1567-1364.12057     Document Type: Article

References (35)

1. Abascal F, Zardoya R & Posada D (2005) ProtTest: selection of best-fit models of protein evolution. Bioinformatics 21: 2104-2105.
2. Bergsson G, Arnfinnsson J, Steingrímsson O & Thormar H (2001) In vitro killing of Candida albicans by fatty acids and monoglycerides. Antimicrob Agents Chemother 45: 3209-3212.
3. Black PN & DiRusso CC (2007) Yeast acyl-CoA synthetases at the crossroads of fatty acid metabolism and regulation. Biochim Biophys Acta 1771: 286-298.
4. Brock M (2009) Fungal metabolism in host niches. Curr Opin Microbiol 12: 371-376.
5. Cheng SC, Joosten LA, Kullberg BJ & Netea MG (2012) Interplay between Candida albicans and the mammalian innate host defense. Infect Immun 80: 1304-1313.
6. Clément M, Tremblay J, Lange M, Thibodeau J & Belhumeur P (2007) Whey-derived free fatty acids suppress the germination of Candida albicans in vitro. FEMS Yeast Res 7: 276-285.
7. Dujon B, Sherman D, Fischer G et al. (2004) Genome evolution in yeasts. Nature 430: 35-44.
8. Dumitru R, Hornby JM & Nickerson KW (2004) Defined anaerobic growth medium for studying Candida albicans basic biology and resistance to eight antifungal drugs. Antimicrob Agents Chemother 48: 2350-2354.
9. Dunn MF, Ramírez-Trujillo JA & Hernández-Lucas I (2009) Major roles of isocitrate lyase and malate synthase in bacterial and fungal pathogenesis. Microbiology 155: 3166-3175.
10. Fazius F, Shelest E, Gebhardt P & Brock M (2012) The fungal alpha-aminoadipate pathway for lysine biosynthesis requires two enzymes of the aconitase family for the isomerization of homocitrate to homoisocitrate. Mol Microbiol 86: 1508-1530.
11. Felsenstein J (1989) PHYLIP - Phylogeny Inference Package (Version 3.2). Cladistics 5: 164-166.
12. Fleck CB & Brock M (2008) Characterization of an acyl-CoA: carboxylate CoA-transferase from Aspergillus nidulans involved in propionyl-CoA detoxification. Mol Microbiol 68: 642-656.
13. Fleck CB & Brock M (2009) Re-characterisation of Saccharomyces cerevisiae Ach1p: fungal CoA-transferases are involved in acetic acid detoxification. Fungal Genet Biol 46: 473-485.
14. Fleck CB, Schöbel F & Brock M (2011) Nutrient acquisition by pathogenic fungi: nutrient availability, pathway regulation, and differences in substrate utilization. Int J Med Microbiol 301: 400-407.
15. Funato M, Shimozawa N, Nagase T et al. (2006) Aberrant peroxisome morphology in peroxisomal beta-oxidation enzyme deficiencies. Brain Dev 28: 287-292.
16. Ghosh S, Navarathna DH, Roberts DD, Cooper JT, Atkin AL, Petro TM & Nickerson KW (2009) Arginine-induced germ tube formation in Candida albicans is essential for escape from murine macrophage line RAW 264.7. Infect Immun 77: 1596-1605.
17. Griebel T, Brinkmeyer M & Böcker S (2008) EPoS: a modular software framework for phylogenetic analysis. Bioinformatics 24: 2399-2400.
18. Gow NA & Hube B (2012) Importance of the Candida albicans cell wall during commensalism and infection. Curr Opin Microbiol 15: 406-412.
19. Hynes MJ, Murray SL, Khew GS & Davis MA (2008) Genetic analysis of the role of peroxisomes in the utilization of acetate and fatty acids in Aspergillus nidulans. Genetics 178: 1355-1369.
20. Jacobsen ID, Grosse K, Berndt A & Hube B (2011) Pathogenesis of Candida albicans infections in the alternative chorio-allantoic membrane chicken embryo model resembles systemic murine infections. PLoS ONE 6: e19741.
21. Kim J & Sudbery P (2011) Candida albicans, a major human fungal pathogen. J Microbiol 49: 171-177.
22. Legras JL, Erny C, Le Jeune C et al. (2010) Activation of two different resistance mechanisms in Saccharomyces cerevisiae upon exposure to octanoic and decanoic acids. Appl Environ Microbiol 76: 7526-7535.
23. Lorenz MC & Fink GR (2001) The glyoxylate cycle is required for fungal virulence. Nature 412: 83-86.
24. Lorenz MC & Fink GR (2002) Life and death in a macrophage: role of the glyoxylate cycle in virulence. Eukaryot Cell 1: 657-662.
25. Lorenz MC, Bender JA & Fink GR (2004) Transcriptional response of Candida albicans upon internalization by macrophages. Eukaryot Cell 3: 1076-1087.
26. Müller S, Fleck CB, Wilson D, Hummert C, Hube B & Brock M (2011) Gene acquisition, duplication and metabolic specification: the evolution of fungal methylisocitrate lyases. Environ Microbiol 13: 1534-1548.
27. Pfaller MA & Diekema DJ (2007) Epidemiology of invasive candidiasis: a persistent public health problem. Clin Microbiol Rev 20: 133-163.
28. Piekarska K, Mol E, Van Den Berg M et al. (2006) Peroxisomal fatty acid beta-oxidation is not essential for virulence of Candida albicans. Eukaryot Cell 5: 1847-1856.
29. Piekarska K, Hardy G, Mol E et al. (2008) The activity of the glyoxylate cycle in peroxisomes of Candida albicans depends on a functional beta-oxidation pathway: evidence for reduced metabolite transport across the peroxisomal membrane. Microbiology 154: 3061-3072.
30. Poirier Y, Antonenkov VD, Glumoff T & Hiltunen JK (2006) Peroxisomal beta-oxidation-a metabolic pathway with multiple functions. Biochim Biophys Acta 1763: 1413-1426.
31. Reuss O, Vik A, Kolter R & Morschhäuser J (2004) The SAT1 flipper, an optimized tool for gene disruption in Candida albicans. Gene 341: 119-127.
32. Shareck J & Belhumeur P (2011) Modulation of morphogenesis in Candida albicans by various small molecules. Eukaryot Cell 10: 1004-1012.
33. Shen YQ & Burger G (2009) Plasticity of a key metabolic pathway in fungi. Funct Integr Genomics 9: 145-151.
34. Stevens S & Hofmeyr J-HS (1993) Effects of ethanol, octanoic and decanoic acids on fermentation and the passive influx of protons through the plasma membrane of Saccharomyces cerevisiae. Appl Microbiol Biotechnol 38: 656-663.
35. Sudbery PE (2011) Growth of Candida albicans hyphae. Nat Rev Microbiol 9: 737-748.