Natural capsaicinoids improve swallow response in older patients with oropharyngeal dysphagia

Gut

Volumn 62, Issue 9, 2013, Pages 1280-1287

  Rofes, Laia ^a   Arreola, Viridiana ^b   Martin, Alberto ^b   Clavé, Pere ^a,b  

^a INSTITUTO DE SALUD CARLOS III   (Spain)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CAPSAICINOID; NATURAL PRODUCT; THICKENING AGENT; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1; VANILLOID RECEPTOR AGONIST;

AGED; ARTICLE; CEREBROVASCULAR ACCIDENT; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIGESTIVE TRACT PARAMETERS; DYSPHAGIA; FEMALE; FLUOROSCOPY; FOOD TEXTURE; HUMAN; HYOID DISPLACEMENT; LARYNGEAL VESTIBULE CLOSURE TIME; LARYNX DISPLACEMENT; LIQUID; MAJOR CLINICAL STUDY; MALE; NECTAR; PRIORITY JOURNAL; SWALLOWING; UPPER ESOPHAGEAL SPHINCTER OPENING TIME; VIDEOFLUOROSCOPY; VISCOSITY;

DEGLUTITION; DYSPHAGIA; GASTRO-OESOPHAGEAL REFLUX DISEASE; GASTROINTESTINAL PHYSIOLOGY; MOTILITY DISORDERS; NERVE-GUT INTERACTIONS; NEUROGENIC DYSPHAGIA; OROPHARYNGEAL DYSPHAGIA; SENSORY INPUT; SWALLOWING CENTER; TRPV1;

AGED; CAPSAICIN; CHROMATOGRAPHY, LIQUID; DEGLUTITION; DEGLUTITION DISORDERS; DRUG MONITORING; FEMALE; FLUOROSCOPY; FOOD ADDITIVES; GERIATRIC ASSESSMENT; HUMANS; MALE; OROPHARYNX; SENSORY SYSTEM AGENTS; STARCH; TREATMENT OUTCOME; TRPV CATION CHANNELS; VIDEO RECORDING;

EID: 84881541595     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gutjnl-2011-300753     Document Type: Article

References (39)

1. Serra-Prat M, Hinojosa G, Lopez D, et al. Prevalence of oropharyngeal dysphagia and impaired safety and efficacy of swallow in independently living older persons. J Am Geriatr Soc 2011;59:186-7.
2. Clave P, Verdaguer A, Arreola V. [Oral-pharyngeal dysphagia in the elderly] (In Spanish). Med Clin (Barc) 2005;124:742-8.
3. Rofes L, Arreola V, Romea M, et al. Pathophysiology of oropharyngeal dysphagia in the frail elderly. Neurogastroenterol Motil 2010;22:851-8, e230.
4. Cabre M, Serra-Prat M, Palomera E, et al. Prevalence and prognostic implications of dysphagia in elderly patients with pneumonia. Age Ageing 2010;39:39-45.
5. Serra-Prat M, Palomera M, Gomez C, et al. Oropharyngeal dysphagia as a risk factor for malnutrition and lower respiratory tract infection in independently living older persons: a population-based prospective study. Age Aging 2012;41:376-81.
6. Aviv JE, Martin JH, Jones ME, et al. Age-related changes in pharyngeal and supraglottic sensation. Ann Otol Rhinol Laryngol 1994;103:749-52. (Pubitemid 24324770)
7. Aviv JE. Effects of aging on sensitivity of the pharyngeal and supraglottic areas. Am J Med 1997;103:74S-6S. (Pubitemid 28020889)
8. Aviv JE, Martin JH, Sacco RL, et al. Supraglottic and pharyngeal sensory abnormalities in stroke patients with dysphagia. Ann Otol Rhinol Laryngol 1996;105:92-7. (Pubitemid 26065220)
9. Mortelliti AJ, Malmgren LT, Gacek RR. Ultrastructural changes with age in the human superior laryngeal nerve. Arch Otolaryngol Head Neck Surg 1990;116:1062-9. (Pubitemid 20277079)
10. Tiago R, Pontes P, do Brasil OC. Age-related changes in human laryngeal nerves. Otolaryngol Head Neck Surg 2007;136:747-51. (Pubitemid 46660236)
11. Teismann IK, Steinstraeter O, Stoeckigt K, et al. Functional oropharyngeal sensory disruption interferes with the cortical control of swallowing. BMC Neurosci 2007;8:62.
12. Hamdy S, Aziz Q, Rothwell JC, et al. Cranial nerve modulation of human cortical swallowing motor pathways. Am J Physiol 1997;272:G802-8.
13. Teismann IK, Steinstrater O, Warnecke T, et al. Tactile thermal oral stimulation increases the cortical representation of swallowing. BMC Neurosci 2009;10:71.
14. Ebihara T, Ebihara S, Maruyama M, et al. A randomized trial of olfactory stimulation using black pepper oil in older people with swallowing dysfunction. J Am Geriatr Soc 2006;54:1401-6. (Pubitemid 44342891)
15. Jean A. Brain stem control of swallowing: neuronal network and cellular mechanisms. Physiol Rev 2001;81:929-69. (Pubitemid 32267080)
16. Hamamoto T, Takumida M, Hirakawa A, et al. Localization of transient receptor potential vanilloid (TRPV) in the human larynx. Acta Otolaryngol 2009;129:560-8.
17. Ebihara T, Sekizawa K, Nakazawa H, et al. Capsaicin and swallowing reflex. Lancet 1993;341:432.
18. Ebihara T, Takahashi H, Ebihara S, et al. Capsaicin troche for swallowing dysfunction in older people. J Am Geriatr Soc 2005;53:824-8. (Pubitemid 41662119)
19. Ebihara T, Ebihara S, Yamazaki M, et al. Intensive stepwise method for oral intake using a combination of transient receptor potential stimulation and olfactory stimulation inhibits the incidence of pneumonia in dysphagic older adults. J Am Geriatr Soc 2010;58:196-8.
20. Logemann JA, Pauloski BR, Colangelo L, et al. Effects of a sour bolus on oropharyngeal swallowing measures in patients with neurogenic dysphagia. J Speech Hear Res 1995;38:556-63.
21. Watando A, Ebihara S, Ebihara T, et al. Effect of temperature on swallowing reflex in elderly patients with aspiration pneumonia. J Am Geriatr Soc 2004;52:2143-4.
22. Gonzalez R, Dunkel R, Koletzko B, et al. Effect of capsaicin-containing red pepper sauce suspension on upper gastrointestinal motility in healthy volunteers. Dig Dis Sci 1998;43:1165-71. (Pubitemid 28272546)
23. Clave P, de Kraa M, Arreola V, et al. The effect of bolus viscosity on swallowing function in neurogenic dysphagia. Aliment Pharmacol Ther 2006;24:1385-94. (Pubitemid 44571569)
24. Clave P, Arreola V, Romea M, et al. Accuracy of the volume-viscosity swallow test for clinical screening of oropharyngeal dysphagia and aspiration. Clin Nutr 2008;27:806-15.
25. Wallace KL, Middleton S, Cook IJ. Development and validation of a self-report symptom inventory to assess the severity of oral-pharyngeal dysphagia. Gastroenterology 2000;118:678-87. (Pubitemid 30171617)
26. Kahrilas PJ, Lin S, Rademaker AW, et al. Impaired deglutitive airway protection: a videofluoroscopic analysis of severity and mechanism. Gastroenterology 1997;113:1457-64. (Pubitemid 27461231)
27. Logemann JA, Rademaker AW, Pauloski BR, et al. A randomized study comparing the Shaker exercise with traditional therapy: a preliminary study. Dysphagia 2009;24:403-11.
28. Rofes L, Arreola V, Almirall J, et al. Diagnosis and management of oropharyngeal Dysphagia and its nutritional and respiratory complications in the elderly. Gastroenterol Res Pract 2011;2011:818979. http://dx.doi.org/10.1155/ 2011/818979
29. Speyer R, Baijens L, Heijnen M, et al. Effects of therapy in oropharyngeal dysphagia by speech and language therapists: a systematic review. Dysphagia 2010;25:40-65.
30. Caterina MJ, Schumacher MA, Tominaga M, et al. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 1997;389:816-24. (Pubitemid 27462969)
31. Hamdy S, Aziz Q, Rothwell JC, et al. Explaining oropharyngeal dysphagia after unilateral hemispheric stroke. Lancet 1997;350:686-92. (Pubitemid 27371166)
32. Spiro J, Rendell JK, Gay T. Activation and coordination patterns of the suprahyoid muscles during swallowing. Laryngoscope 1994;104:1376-82. (Pubitemid 24346966)
33. Leonard RJ, Kendall KA, McKenzie S, et al. Structural displacements in normal swallowing: a videofluoroscopic study. Dysphagia 2000;15:146-52. (Pubitemid 30411772)
34. Kajii Y, Shingai T, Kitagawa J, et al. Sour taste stimulation facilitates reflex swallowing from the pharynx and larynx in the rat. Physiol Behav 2002;77:321-5. (Pubitemid 35373887)
35. Bryant B, Silver WL. Chemesthesis: the common chemical sense. In: Finger TE, Silver WL, et al, eds. Neurobiology of Taste and Smell. Wiley-Liss, Inc, 2000:73-100.
36. Pelletier CA, Lawless HT. Effect of citric acid and citric acid-sucrose mixtures on swallowing in neurogenic oropharyngeal dysphagia. Dysphagia 2003;18:231-41. (Pubitemid 37221641)
37. Tominaga M, Caterina MJ, Malmberg AB, et al. The cloned capsaicin receptor integrates multiple pain-producing stimuli. Neuron 1998;21:531-43. (Pubitemid 28475505)
38. Pelletier CA, Dhanaraj GE. The effect of taste and palatability on lingual swallowing pressure. Dysphagia 2006;21:121-8. (Pubitemid 44078545)
39. Sculptoreanu A, Aura KF, de Groat WC. Neurokinin 2 receptor-mediated activation of protein kinase C modulates capsaicin responses in DRG neurons from adult rats. Eur J Neurosci 2008;27:3171-81. (Pubitemid 351863592)