A randomized trial of olfactory stimulation using black pepper oil in older people with swallowing dysfunction

Journal of the American Geriatrics Society

Volumn 54, Issue 9, 2006, Pages 1401-1406

  Ebihara, Takae ^a   Ebihara, Satoru ^a   Maruyama, Masahiro ^a   Kobayashi, Mitsuru ^b   Itou, Azusa ^b   Arai, Hiroyuki ^a   Sasaki, Hidetada ^a  

^a TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b Tohoku Welfare University   (Japan)

Author keywords

Anterior insular cortex; Elderly pneumonia; Olfactory stimulation; Swallowing movement; Swallowing reflex

Indexed keywords

BLACK PEPPER OIL; UNCLASSIFIED DRUG; VEGETABLE OIL;

AGED; ARTICLE; BLACK PEPPER; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEMOGRAPHY; DYSPHAGIA; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; NURSING HOME; PNEUMONIA; RANDOMIZED CONTROLLED TRIAL; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; STIMULATION; STROKE;

AGED; AGED, 80 AND OVER; BLACK PEPPER; CEREBROVASCULAR CIRCULATION; DEGLUTITION DISORDERS; FEMALE; HUMANS; MALE; OILS, VOLATILE; PHYSICAL STIMULATION; PROSPECTIVE STUDIES; REFLEX; SMELL; SUBSTANCE P;

EID: 33748415567     PISSN: 00028614     EISSN: 15325415     Source Type: Journal    
DOI: 10.1111/j.1532-5415.2006.00840.x     Document Type: Article

References (29)

1. Yamaya M, Yanai M, Ohrui T et al. Interventions to prevent pneumonia among older adults. J Am Geriatr Soc 2001;49:85-90.
2. Daniels SK, Foundas AL, Iglesia GC et al. Lesion site in unilateral stroke patients with dysphagia. J Stroke Cerebrovasc Dis 1996;6:30-34.
3. Daniels SK, Foundas AL. The role of the insular cortex in dysphagia. Dysphagia 1997;12:146-156.
4. Zald DH, Pardo JV. The functional neuroanatomy of voluntary swallowing. Ann Neurol 1999;46:281-286.
5. Okamura N, Maruyama M, Ebihara T et al. Aspiration pneumonia and insular hypoperfusion in patients with cerebrovascular disease. J Am Geriatr Soc 2004;52:645-646.
6. Tataranni PA, Gautier JF, Chen K et al. Neuroanatomical correlates of hunger and satiation in human using positron emission tomography. Proc Natl Acad Sci U S A 1999;96:4569-4574.
7. Allen KV, McGregor IS, Hunt GE et al. Regional differences in naloxone modulation of Delta(9)-THC induced Fos expression in rat brain. Neuropharmacology 2003;44:264-274.
8. Gordon CM, Dougherty DD, Rauch SL et al. Neuroanatomy of human appetitive function: A positron emission tomography investigation. Int J Eat Disord 2000;27:163-171.
9. Vijayan KK, Ajithan-Thampuran RVA. Pharmacology, toxicology and clinical application of black pepper. In: Ravindran PN, ed. Black Pepper. Amsterdam: Harwood Academic Publishers, 2000, pp 455-466.
10. Matsubayashi K, Okumiya K, Osaki Y et al. Frailty in elderly Japanese. Lancet 1999;353:1445.
11. Folstein MF, Folstein SE, McHugh PR. 'Mini-mental state'. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12:189-198.
12. Doty RL, Shaman P, Dann M. Development of the University of Pennsylvania Smell Identification Test: A standardized microencapsulated test of olfactory function. Physiol Behav 1984;32:489-502.
13. Yoshino A, Ebihara T, Ebihara S et al. Daily oral care and risk factors for pneumonia among elderly nursing home patients. JAMA 2001;286:2235-2236.
14. Sekizawa K, Ujiie Y, Itabashi S et al. Lack of cough reflex in aspiration pneumonia. Lancet 1990;335:1228-1229.
15. Joyce TJ, Yood RA, Caraway RE. Quantification of substance-P and its metabolites in plasma and synovial fluid from patients with arthritis. J Clin Endocrinol Metab 1993;77:632-637.
16. 123I] Iodoamphetamine SPECT in mild cognitive impairment: Implications for a novel predictor of Alzheimer's disease. Am J Psychiatry 2002;159:474-476.
17. Nakajoh K, Nakagawa K, Sekizawa K et al. Relation between incidence of pneumonia and protective reflexes in post-stroke patients with oral or tube feeding. J Intern Med 2000;247:39-42.
18. Szallasi A. Vanilloid (capsaicin) receptors in health and disease. Am J Clin Pathol 2002;118:110-121.
19. Ebihara T, Sekizawa K, Nakazawa H et al. Capsaicin and swallowing reflex. Lancet 1993;341:432.
20. Ebihara T, Takahashi H, Ebihara S et al. Capsaicin troche for swallowing dysfunction in older people. J Am Geriatr Soc 2005;53:824-828.
21. Watando A, Ebihara S, Ebihara T et al. Effects of temperature on swallowing reflex in elderly patients with aspiration pneumonia. J Am Geriatr Soc 2004;54:2143-2144.
22. Fraser C, Power M, Hamdy S et al. Driving plasticity in human adult motor cortex is associated with improved motor function after brain injury. Neuron 2002;34:831-840.
23. Lai J-P, Douglas SD, Ho W-Z. Human lymphocytes express substance P and its receptor. J Neuroimmunol 1998;86:80-86.
24. Arai T, Yoshimi N, Fujiwara H et al. Serum substance P concentrations and silent aspiration in elderly patientswith stroke. Neurology 2003;61:1625-1626.
25. Zald DH, Pardo JV. Cortical activation induced by intraoral stimulation with water in humans. Chem Senses 2000;25:267-275.
26. Savic I, Gulyas B. PET shows that odors are processed both ipsilaterally and contralaterally to the stimulated nostril. Neuroreport 2000;11:2861-2866.
27. Murphy C, Schubert CR, Cruickshanks KJ et al. Prevalence of olfactory impairment in older adults. JAMA 2002;288:2307-2312.
28. Berendse HW, Booji J, Francot CM et al. Subclinical dopaminergic dysfunction in asymptomatic Parkinson's disease patients' relatives with a decreased sense of smell. Ann Neurol 2001;50:34-41.
29. Hu XS, Okamura N, Arai H et al. Neuroanatomical correlates of low body weight in Alzheimer's disease: A PET study. Prog Neuropsychopharmacol Biol Psychiatry 2002;26:1285-1289.