Sp1 acetylation is associated with loss of DNA binding at promoters associated with cell cycle arrest and cell death in a colon cell line

Molecular Cancer

Volumn 9, Issue , 2010, Pages

  Waby, Jennifer S ^a,e   Chirakkal, Haridasan ^a,d   Yu, ChenWei ^a   Griffiths, Gareth J ^c   Benson, Roderick S P ^c   Bingle, Colin D ^b   Corfe, Bernard M ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b UNIVERSITY OF SHEFFIELD   (United Kingdom)

^c Imagen Biotech Ltd   (United Kingdom)

^d Kemin Industries Inc   (United States)

^e UNIVERSITY OF HULL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BUTYRIC ACID; DNA; HISTONE DEACETYLASE INHIBITOR; PREGNANCY SPECIFIC BETA1 GLYCOPROTEIN; PROTEIN BAK; PROTEIN P21; PROTEIN P53; SMALL INTERFERING RNA; BUTYRIC ACID DERIVATIVE; CYCLIN DEPENDENT KINASE INHIBITOR 1A; TRANSCRIPTION FACTOR SP1;

ACETYLATION; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL CYCLE ARREST; CELL DEATH; COLON CANCER; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA BINDING; DRUG MECHANISM; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULAR MODEL; PROMOTER REGION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; BIOLOGY; CELL CYCLE; CELL STRAIN HCT116; COLON; CYTOLOGY; DNA MICROARRAY; DRUG EFFECT; GENETICS; METABOLISM; POLYMERASE CHAIN REACTION; PROTEIN BINDING; WESTERN BLOTTING;

ACETYLATION; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BLOTTING, WESTERN; BUTYRATES; CELL CYCLE; CELL DEATH; COLON; COMPUTATIONAL BIOLOGY; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DNA; HCT116 CELLS; HISTONE DEACETYLASE INHIBITORS; HUMANS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POLYMERASE CHAIN REACTION; PROTEIN BINDING; RNA, SMALL INTERFERING; SP1 TRANSCRIPTION FACTOR;

EID: 77957917520     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-9-275     Document Type: Article

References (41)

1. Kouzarides T. Acetylation: a regulatory modification to rival phosphorylation?. EMBO J 2000, 15:1176-9117.
2. Braun H, Koop R, Ertmer A, Nacht S, Suske G. Transcription factor Sp3 is regulated by acetylation. Nucl Acids Res 2001, 29:4994-5000. 10.1093/nar/29.24.4994, 97549, 11812829.
3. Hung JJ, Wang YT, Chang WC. Sp1 deacetylation induced by phorbol ester recruits p300 to activate 12(S)-lipoxygenase gene transcription. Mol Cell Biol 2006, 26:1770-85. 10.1128/MCB.26.5.1770-1785.2006, 1430254, 16478997.
4. Torigoe T, Izumi H, Wakasugi T, Niina I, Igarashi T, Yoshida T, Shibuya I, Chijiwa K, Matsuo K, Itoh H, Kohno K. DNA topoisomerase II poison TAS-103 transactivates GC-box-dependent transcription via acetylation of Sp1. J Biol Chem 2005, 280:1179-85. 10.1074/jbc.M410499200, 15533934.
5. Tong X, Yin L, Giardina C. Butyrate suppresses Cox-2 activation in colon cancer cells through HDAC inhibition. Biochem Biophys Res Comm 2004, 317:463-71. 10.1016/j.bbrc.2004.03.066, 15063780.
6. White NR, Mulligan P, King PJ, Sanderson IR. Sodium butyrate-mediated Sp3 acetylation represses human insulin-like growth factor binding protein-3 expression in intestinal epithelial cells. J Ped Gastroenterol Nutr 2006, 42:134-41.
7. Dennig J, Beato M, Suske G. An inhibitor domain in Sp3 regulates its glutamine-rich activation domains. EMBO J 1996, 15:5659-67. 452310, 8896459.
8. Steiner E, Holzmann K, Pirker C, Elbling L, Micksche M, Berger W. SP-transcription factors are involved in basal MVP promoter activity and its stimulation by HDAC inhibitors. Biochem Biophys Res Comm 2004, 317:235-43. 10.1016/j.bbrc.2004.03.029, 15047174.
9. Chirakkal H, Leech SH, Brookes KE, Prais AL, Waby JS, Corfe BM. Upregulation of BAK by butyrate in the colon is associated with increased Sp3 binding. Oncogene 2006, 25:7192-200. 10.1038/sj.onc.1209702, 16732318.
10. Doetzlhofer A, Rotheneder H, Lagger G, Koranda M, Kurtev V, Brosch G, Wintersberger E, Seiser C. Histone deacetylase 1 can repress transcription by binding to Sp1. Mol Cell Biol 1991, 19:5504-11.
11. Davie JR. Inhibition of histone deacetylase activity by butyrate. J Nutr 2003, 133:2485S-2493S.
12. Choi HS, Lee JH, Park JG, Lee YI. Trichostatin A, a histone deacetylase inhibitor, activates the IGFBP-3 promoter by upregulating Sp1 activity in hepatoma cells: alteration of the Sp1/Sp3/HDAC1 multiprotein complex. Biochem Biophys Res Comm 2002, 296:1005-12. 10.1016/S0006-291X(02)02001-6, 12200149.
13. Kang JE, Kim MH, Lee JA, Park H, Min-Nyung L, Auh CK, Hur MW. Histone deacetylase-1 represses transcription by interacting with zinc-fingers and interfering with the DNA binding activity of Sp1. Cell Physiol Biochem 2005, 16:23-30. 10.1159/000087728, 16121030.
14. Song J, Noh JH, Lee JH, Eun JW, Ahn YM, Kim SY, Lee SH, Park WS, Yoo NJ, Lee JY, Nam SW. Increased expression of histone deacetylase 2 is found in human gastric cancer. APMIS 2005, 113(4):264-8. 10.1111/j.1600-0463.2005.apm_04.x, 15865607.
15. Bartling B, Hofmann HS, Boettger T, Hansen G, Burdach S, Silber RE, Simm A. Comparative application of antibody and gene array for expression profiling in human squamous cell lung carcinoma. Lung Cancer 2005, 49(2):145-54. 10.1016/j.lungcan.2005.02.006, 16022908.
16. Saji S, Kawakami M, Hayashi S, Yoshida N, Hirose M, Horiguchi S, Itoh A, Funata N, Schreiber SL, Yoshida M, Toi M. Significance of HDAC6 regulation via estrogen signaling for cell motility and prognosis in estrogen receptor-positive breast cancer. Oncogene 2005, 24(28):4531-9. 10.1038/sj.onc.1208646, 15806142.
17. Ishihama K, Yamakawa M, Semba S, Takeda H, Kawata S, Kimura S, Kimura W. Expression of HDAC1 and CBP/p300 in human colorectal carcinomas. J Clin Pathol 2007, 60(11):1205-10. Epub 2007 Aug 24, 10.1136/jcp.2005.029165, 17720775.
18. Khabele D, Son DS, Parl AK, Goldberg GL, Augenlicht LH, Mariadason JM, Rice VM. Drug-induced inactivation or gene silencing of class I histone deacetylases suppresses ovarian cancer cell growth: implications for therapy. Cancer Biol Ther 2007, 6(5):795-801. Epub 2007 Feb 14, 10.4161/cbt.6.5.4007, 17387270.
19. Riggs MG, Whittaker RG, Neumann JR, Ingram VM. n-Butyrate causes histone modification in HeLa and Friend erythroleukaemia cells. Nature 1977, 268(5619):462-4. 10.1038/268462a0, 268489.
20. Grant S, Easley C, Kirkpatrick P. Vorinostat. Nat Rev Drug Discov 2007, 6(1):21-2. 10.1038/nrd2227, 17269160.
21. Ma X, Ezzeldin HH, Diasio RB. Histone deacetylase inhibitors: current status and overview of recent clinical trials. J Clin Oncol 2009, 27(32):5459-68. Epub 2009 Oct 13, 10.1200/JCO.2009.22.1291, 19826124.
22. Lane AA, Chabner BA. Histone deacetylase inhibitors in cancer therapy. J Clin Oncol 2009, 27(32):5459-68. Epub 2009 Oct 13, 10.1200/JCO.2009.22.1291, 19826124.
23. Bingham SA, Day NE, Luben R, Ferrari P, Slimani N, Norat T, Clavel-Chapelon F, Kesse E, Nieters A, Boeing H, Tjønneland A, Overvad K, Martinez C, Dorronsoro M, Gonzalez CA, Key TJ, Trichopoulou A, Naska A, Vineis P, Tumino R, Krogh V, Bueno-de-Mesquita HB, Peeters PH, Berglund G, Hallmans G, Lund E, Skeie G, Kaaks R, Riboli E. European Prospective Investigation into Cancer and Nutrition, Dietary fibre in food and protection against colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC): an observational study. Lancet 2003, 361:1496-501. 10.1016/S0140-6736(03)13174-1, 12737858.
24. Peters P, Sinha R, Chatterjee N, Subar AF, Ziegler RG, Kulldorff M, Bresalier R, Weissfeld JL, Flood A, Schatzkin A, Hayes RB. Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial Project Team. Dietary fibre and colorectal adenoma in a colorectal cancer early detection programme. Lancet 2003, 361:1491-5. 10.1016/S0140-6736(03)13173-X, 12737857.
25. Blottière HM, Buecher B, Galmiche JP, Cherbut C. Molecular analysis of the effect of short-chain fatty acids on intestinal cell proliferation. Proc Nutr Soc 2003, 62(1):101-6. 10.1079/PNS2002215, 12740064.
26. Hague A, Diaz GD, Hicks DJ, Krajewski S, Reed JC, Paraskeva C. Bcl-2 and bak may play a pivotal role in sodium butyrate-induced apoptosis in colonic epithelial cells; however overexpression of bcl-2 does not protect against bak-mediated apoptosis. Int J Cancer 1997, 72(5):898-905. 10.1002/(SICI)1097-0215(19970904)72:5<898::AID-IJC30>3.0.CO;2-2, 9311611.
27. Ruemmele FM, Schwartz S, Seidman EG, Dionne S, Levy E, Lentze MJ. Butyrate induced Caco-2 cell apoptosis is mediated via the mitochondrial pathway. Gut 2003, 52(1):94-100. 10.1136/gut.52.1.94, 1773532, 12477768.
28. Chou CW, Chen CC. HDAC inhibition upregulates the expression of angiostatic ADAMTS1. FEBS Lett 2008, 582(29):4059-65. Epub 2008 Nov 11, 10.1016/j.febslet.2008.10.048, 19007777.
29. Siavoshian S, Segain JP, Kornprobst M, Bonnet C, Cherbut C, Galmiche JP, Blottière HM. Butyrate and trichostatin A effects on the proliferation/differentiation of human intestinal epithelial cells: induction of cyclin D3 and p21 expression. Gut 2000, 46:507-14. 10.1136/gut.46.4.507, 1727889, 10716680.
30. Siavoshian S, Blottiere HM, Cherbut C, Garmiche JP. Butyrate stimulates cyclin D and p21 and inhibits cyclin-dependent kinase 2 expression in HT-29 colonic epithelial cells. Biochem Biophys Res Comm 1997, 232:169-172. 10.1006/bbrc.1997.6255, 9125124.
31. Abramova MV, Pospelova TV, Nikulenkov FP, Hollander CM, Fornace AJ, Pospelov VA. G1/S arrest induced by histone deacetylase inhibitor sodium butyrate in E1A + Ras-transformed cells is mediated through down-regulation of E2F activity and stabilization of beta-catenin. J Biol Chem 2006, 281(30):21040-51. Epub 2006 May 22, 10.1074/jbc.M511059200, 16717102.
32. Koutsodontis G, Moustakas A, Kardassis D. The role of Sp1 family members, the proximal GC-rich motifs, and the upstream enhancer region in the regulation of the human cell cycle inhibitor p21WAF-1/Cip1 gene promoter. Biochemistry 2002, 41:12771-84. 10.1021/bi026141q, 12379120.
33. Li L, Zhang G, Zhang Y, Tan J, Huang H, Huang B, Lu J. Sodium butyrate-induced upregulation of p18(INK4C) gene affects K562 cell G (0)/G (1) arrest and differentiation. Mol Cell Biochem 2008, 319(1-2):9-15. Epub 2008 Jul 19, 10.1007/s11010-008-9870-x, 18642058.
34. Prais AL, Dive C, Corfe BC. Butyrate-mediated cell cycle arrest of HCT116 colon carcinoma cells is accompanied by hyperploidy. Gums and stabilisers for the food industry 12 535-538. Williams PA, Philips GO.
35. Barnard JA, Warwick G. Butyrate rapidly induces growth inhibition and differentiation in HT-29 cells. Cell Growth Differ 2003, 4:495-501.
36. Archer SY, Meng S, Shei A, Hodin RA. p21(WAF1) is required for butyrate-mediated growth inhibition of human colon cancer cells. Proc Natl Acad Sci USA 1998, 95:6791-6. 10.1073/pnas.95.12.6791, 22637, 9618491.
37. Harper JW, Adami GR, Wei N, Keyomarsi K, Elledge SJ. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 1993, 19:805-16.
38. Liberman E, Naumov I, Kazanov D, Dvory-Sobol H, Sagiv E, Birkenfeld S, Deutsch V, Trakhtenbrot L, Moshkowitz M, Arber N. Malignant transformation of normal enterocytes following downregulation of Bak expression. Digestion 2008, 77:48-56. 10.1159/000121411, 18349538.
39. Huang DW, Sherman BT, Lempicki RA. Systematic and integrative analysis of large gene lists using DAVID Bioinformatics Resources. Nature Protoc 2009, 4:44-57.
40. Dennis G, Sherman BT, Hosack DA, Yang J, Gao W, Lane HC, Lempicki RA. DAVID: Database for Annotation, Visualization, and Integrated Discovery. Genome Biol 2003, 4:3.
41. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001, 25:402-8. 10.1006/meth.2001.1262, 11846609.