Interaction between the MTHFR C677T polymorphism and traumatic childhood events predicts depression

Translational Psychiatry

Volumn 3, Issue , 2013, Pages

  Lok, A ^a   Bockting, C L H ^b   Koeter, M W J ^a   Snieder, H ^c   Assies, J ^a   Mocking, R J T ^a   Vinkers, C H ^d   Kahn, R S ^d   Boks, M P ^d   Schene, A H ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b UNIVERSITY OF GRONINGEN   (Netherlands)

^c UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^d UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

childhood trauma; gene environment interaction; major depressive disorder; methylenetetrahydrofolate reductase gene; recurrence

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MTHFR PROTEIN, HUMAN;

ADULT; ARTICLE; CHILD ABUSE; CHILDHOOD INJURY; CONTROLLED STUDY; FEMALE; FOLLOW UP; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; PREDICTIVE VALUE; PSYCHOTRAUMA; RANDOMIZED CONTROLLED TRIAL; RECURRENT DISEASE; SINGLE NUCLEOTIDE POLYMORPHISM; SYMPTOMATOLOGY; TRAUMATIC CHILDHOOD EVENT; ADOLESCENT; ALLELE; CHILD; COMPLICATION; DEPRESSION; DEPRESSIVE DISORDER, MAJOR; GENETIC PREDISPOSITION; GENETICS; MENTAL STRESS; MIDDLE AGED; PROPORTIONAL HAZARDS MODEL; PSYCHOLOGICAL RATING SCALE; RISK FACTOR; YOUNG ADULT; CONTROLLED CLINICAL TRIAL;

ADOLESCENT; ADULT; ALLELES; CHILD; DEPRESSION; DEPRESSIVE DISORDER, MAJOR; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; PROPORTIONAL HAZARDS MODELS; PSYCHIATRIC STATUS RATING SCALES; RECURRENCE; RISK FACTORS; STRESS, PSYCHOLOGICAL; YOUNG ADULT;

EID: 84881531836     PISSN: None     EISSN: 21583188     Source Type: Journal    
DOI: 10.1038/tp.2013.60     Document Type: Article

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