Mechanism of action of novel synthetic dodecapeptides against Candida albicans

Biochimica et Biophysica Acta - General Subjects

Volumn 1830, Issue 11, 2013, Pages 5193-5203

  Maurya, Indresh Kumar ^a   Thota, Chaitanya Kumar ^b   Sharma, Jyotsna ^b   Tupe, Santosh Genba ^c   Chaudhary, Preeti ^c   Singh, Manoj Kumar ^a   Thakur, Indu Shekhar ^a   Deshpande, Mukund ^c   Prasad, Rajendra ^a   Chauhan, Virander Singh ^b  

^a JAWAHARLAL NEHRU UNIVERSITY   (India)

^b INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Italy)

^c NATIONAL CHEMICAL LABORATORY   (India)

Author keywords

Antifungal peptide; Antimicrobial peptide (AMP); Apoptosis; Candida albicans; Oxygen; Reactive; Species (ROS)

Indexed keywords

AMPHOTERICIN B; CASPOFUNGIN; FLUCONAZOLE; IJ2 PEPTIDE; IJ3 PEPTIDE; IJ4 PEPTIDE; POLYPEPTIDE ANTIBIOTIC AGENT; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANTIFUNGAL ACTIVITY; APOPTOSIS; ARTICLE; CANDIDA ALBICANS; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG POTENTIATION; DRUG SCREENING; DRUG SYNTHESIS; FUNGAL CELL WALL; FUNGUS; HEMOLYSIS; HUMAN; HUMAN CELL; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; YEAST;

CANDIDA ALBICANS; FUNGI;

ABC; ANTIFUNGAL PEPTIDE; ANTIMICROBIAL PEPTIDE (AMP); APOPTOSIS; ATP-BINDING CASSETTE; CANDIDA ALBICANS; FICI; FRACTION INHIBITORY CONCENTRATION INDEX; MAJOR FACILITATOR SUPERFAMILY; MDR; MFS; MULTIDRUG RESISTANCE; REACTIVE OXYGEN SPECIES; REACTIVE OXYGEN SPECIES (ROS); ROS; SCANNING ELECTRON MICROSCOPY; SEM; TEM; TRANSMISSION ELECTRON MICROSCOPY;

ANTIFUNGAL AGENTS; APOPTOSIS; CANDIDA ALBICANS; CELL MEMBRANE PERMEABILITY; CELL WALL; DRUG SYNERGISM; ECHINOCANDINS; FLUCONAZOLE; HEMOLYSIS; NECROSIS; PEPTIDES; REACTIVE OXYGEN SPECIES;

EID: 84881524819     PISSN: 03044165     EISSN: 18728006     Source Type: Journal    
DOI: 10.1016/j.bbagen.2013.07.016     Document Type: Article

References (34)

1. R.E. Lewis Current concepts in antifungal pharmacology Mayo Clin. Proc. 86 2011 805 817
2. A.C. Pasqualotto, and D.W. Denning New and emerging treatment for infections J. Antimicrob. Chemother. 61 2008 119 130
3. A. Giuliani, G. Pirri, and S.F. Nicoletto Antimicrobial peptides: an overview of a promising class of therapeutics Cent. Eur. J. Biol. 2 2007 1 33 (Pubitemid 46450753)
4. A.J. De Luca, and T.J. Walsh Antifungal peptides: origin, activity, and therapeutic potential Rev. Iberoam. Micol. 17 2000 116 120 (Pubitemid 32230078)
5. K.L. Brown, and R.E. Hancock Cationic host defense (antimicrobial) peptides Curr. Opin. Immunol. 18 2006 24 30 (Pubitemid 43049644)
6. C.D. Fjell, J.A. Hiss, R. Hancock, and G. Schneider Designing antimicrobial peptides: form follows function Nature 11 2012 37 51
7. R.M. Epand, and H.J. Vogel Diversity of antimicrobial peptides and their mechanisms of action Biochim. Biophys. Acta 1462 1999 11 28
8. K.A. Brogden Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria? Nat. Rev. Microbiol. 3 2005 238 250 (Pubitemid 40298223)
9. J.F. Marcos, and M. Gandia Antimicrobial peptides: to membranes and beyond Expert Opin. Drug Discovery 4 2009 659 671
10. P. Mathur, S. Ramakumar, and V.S. Chauhan Peptide design using α,β-dehydro amino acids: from β-turns to helical hairpins Biopolymers 76 2004 150 161 (Pubitemid 38529430)
11. U.A. Ramagopal, S. Ramakumar, D. Sahal, and V.S. Chauhan De novo design and characterization of an apolar helical hairpin peptide at atomic resolution: compaction mediated by weak interactions Proc. Natl. Acad. Sci. U. S. A. 30 2001 870 874 (Pubitemid 32121154)
12. I.K. Maurya, S. Pathak, M. Sharma, H. Sanwal, P. Chaudhary, S. Tupe, M. Deshpande, V.S. Chauhan, and R. Prasad Antifungal activity of novel synthetic peptides by accumulation of reactive oxygen species (ROS) and disruption of cell wall against Candida albicans Peptides 32 2011 1732 1740
13. S. Pathak, and V.S. Chauhan Rationale-based, de novo design of dehydrophenylalanine-containing antibiotic peptides and systematic modification in sequence for enhanced potency Antimicrob. Agents Chemother. 55 2011 2178 2188
14. E. Kaiser, R.L. Colescott, C.D. Bossinger, and P.I. Cook Color test for detection of free terminal amino groups in the solid-phase synthesis of peptides Anal. Biochem. 34 1970 595 598
15. Clinical and Laboratory Standards Institute. A) M27-A3, Reference method for broth dilution antifungal susceptibility testing of yeasts: approved standard, 3rd ed., 2008. B) M38-A2, Reference method for broth dilution antifungal susceptibility testing of filamentous fungi. Approved Standard, edn 2; Clinical and Laboratory Standards Institute, Wayne, PA.
16. Y. Rukayadi, K. Lee, M.S. Lee, D. Yong, and J.K. Hwang Synergistic anticandidal activity of xanthorrhizol in combination with ketoconazole or amphotericin B FEMS Yeast Res. 9 2009 1302 1311
17. N. Guo, X. Wu, L. Yu, J. Liu, R. Meng, J. Jin, H. Liu, X. Wang, S. Yan, and X. Deng In vitro and in vivo interactions between fluconazole and allicin against clinical isolates of fluconazole-resistant Candida albicans determined by alternative methods FEMS Immunol. Med. Microbiol. 58 2009 193 201
18. F.C. Odds Synergy, antagonism, and what the chequerboard puts between them J. Antimicrob. Chemother. 52 2003 1 (Pubitemid 36850074)
19. S. Huang, Y.Y. Cao, B.D. Dai, X.R. Sun, Z.Y. Zhu, Y.B. Cao, Y. Wang, P. Gao, and Y.Y. Jiang In vitro synergism of fluconazole and baicalein against clinical isolates of Candida albicans resistant to fluconazole Biol. Pharm. Bull. 31 2008 2234 2236
20. M.E. Klepser, E.J. Ernet, R.E. Lewis, and M.A. Pfaller Influence of test conditions on antifungal time-kill curve results: proposal for standardized methods Antimicrob. Agents Chemother. 5 1998 1207 1212 (Pubitemid 28227921)
21. D.H. Kim, D.G. Lee, K.L. Kim, and Y. Lee Internalization of tenecin-3 by a fungal cellular process is essential for its fungicidal effect on Candida albicans Eur. J. Biochem. 268 2001 4449 4458 (Pubitemid 32862854)
22. I.K. Maurya, C.K. Thota, S.D. Verma, J. Sharma, M.K. Rawal, B. Ravikumar, S. Sen, N. Chauhan, A.M. Lynn, V.S. Chauhan, and R. Prasad Rationally designed transmembrane peptide mimics of the multidrug transporter protein Cdr1 act as antagonists to selectively block drug efflux and chemosensitize azole-resistant clinical isolates of Candida albicans J. Biol. Chem. 288 2013 16775 16787
23. D. Kobayashi, K. Kondo, N. Uehara, O. Tokozawa, N. Tszoleuji, and A. Yagihashi Endogenous reactive oxygen species is an important mediator of miconazole antifungal effect Antimicrob. Agents Chemother. 46 2002 3113 3117
24. C. Park, and D.G. Lee Melittin induces apoptotic features in Candida albicans Biochem. Biophys. Res. Commun. 394 2010 170 172
25. A.J. Philips, I. Sudbery, and M. Ramsdale Apoptosis induced by environmental stresses and amphotericin B in Candida albicans Proc. Natl. Acad. Sci. U. S. A. 100 2003 14327 14332 (Pubitemid 37499236)
26. D. Mares Electron microscopy of Microsporum cookie after in vitro treatment with protoanemonin: a combined SEM and TEM study Mycopathologia 108 1989 37 46 (Pubitemid 19286767)
27. M. Borgers, M.A. Van de Ven, and J. Van Cutsen Structural degeneration of Aspergillus fumigatus after exposure to saperconazole J. Med. Vet. Mycol. 27 1989 381 389 (Pubitemid 20131644)
28. S. Kaneshima, S. Koga, and K. Tanaka A simple method for cellular identification of free cell by light microscopy and scanning electron microscopy J. Electron Microsc. 26 1977 355 358 (Pubitemid 8272923)
29. S.Y. Shin, J.H. Kang, and K.S. Hahm Structure-antibacterial, antitumor and hemolytic activity relationships of cecropin A-magainin 2 and cecropin A-melittin hybrid peptides J. Pept. Res. 53 1999 82 90 (Pubitemid 29128183)
30. T. Mosmann Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays J. Immunol. Methods 65 1983 33 55
31. E.E. Hodgkin, J.D. Clark, K.R. Miller, and G.R. Marshall Conformational analysis and helical preferences of normal and α, α-dialkyl amino acids Biopolymers 30 1990 533 546 (Pubitemid 20363996)
32. P. Mathur, N.R. Jagannathan, and V.S. Chauhan α,β- Dehydrophenylalanine containing cecropin-melittin hybrid peptides: conformation and activity J. Pept. Sci. 13 2007 253 262 (Pubitemid 46638196)
33. E.J. Helmerhorst, R.F. Troxler, and F.G. Oppenheim The human salivary peptide histatin 5 exerts its antifungal activity through the formation of reactive oxygen species Proc. Natl. Acad. Sci. U. S. A. 98 2011 14637 14642
34. Y. Park, D.G. Lee, and K.S. Hahm HP (2-9)-magainin 2(1-12), a synthetic hybrid peptide, exerts its antifungal effect on Candida albicans by damaging the plasma membrane J. Pept. Sci. 10 2004 204 209 (Pubitemid 38515003)