Rationally designed transmembrane peptide mimics of the multidrug transporter protein Cdr1 act as antagonists to selectively block drug efflux and chemosensitize azole-resistant clinical isolates of Candida albicans

Journal of Biological Chemistry

Volumn 288, Issue 23, 2013, Pages 16775-16787

  Maurya, Indresh Kumar ^a   Thota, Chaitanya Kumar ^b   Verma, Sachin Dev ^a   Sharma, Jyotsna ^b   Rawal, Manpreet Kaur ^a   Ravikumar, Balaguru ^a   Sen, Sobhan ^a   Chauhan, Neeraj ^c   Lynn, Andrew M ^a   Chauhan, Virander Singh ^b   Prasad, Rajendra ^a  

^a JAWAHARLAL NEHRU UNIVERSITY   (India)

^b INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Italy)

^c PUBLIC HEALTH RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLUORESCENCE MEASUREMENTS; MULTIDRUG TRANSPORTERS; SINGLE PHOTON COUNTING; SPECIFIC INTERACTION; STRUCTURAL INFORMATION; THERAPEUTIC POTENTIALS; TRANS-MEMBRANE DOMAINS; TRANSMEMBRANE HELICES;

ACTIVATION ANALYSIS; CANDIDA; FLUORESCENCE; PEPTIDES; YEAST;

BIOSYNTHESIS;

ANTIINFECTIVE AGENT; CANDIDA DRUG RESISTANCE 1 PROTEIN; CANDIDA DRUG RESISTANCE 2 PROTEIN; CELL PROTEIN; FLUCONAZOLE; FLUORESCEIN ISOTHIOCYANATE; FUNGAL PROTEIN; MEMBRANE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 1; PYRROLE; TRANSMEMBRANE PEPTIDE MIMIC; TRANSMEMBRANE PEPTIDE MIMIC 8; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIFUNGAL ACTIVITY; ARTICLE; BINDING SITE; CANDIDA ALBICANS; CANDIDIASIS; CARBOXY TERMINAL SEQUENCE; CHEMOSENSITIZATION; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENTIATION; DRUG SCREENING; DRUG SYNTHESIS; FEMALE; FUNGUS ISOLATION; HYDROPHOBICITY; MOUSE; NONHUMAN; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; STRUCTURE ANALYSIS; YEAST CELL;

ABC TRANSPORTER; ANTAGONIST; CANDIDA ALBICANS; CDR1 PROTEIN; DRUG DESIGN; EFFLUX PUMP; MEMBRANE PROTEINS; MULTIDRUG TRANSPORTERS; TIME CORRELATION SINGLE PHOTON COUNTING (TCSPC); TRANSMEMBRANE PEPTIDE MIMICS;

ANTIFUNGAL AGENTS; AZOLES; BIOMIMETIC MATERIALS; CANDIDA ALBICANS; DRUG RESISTANCE, FUNGAL; FUNGAL PROTEINS; HUMANS; MEMBRANE TRANSPORT PROTEINS; PEPTIDES; PROTEIN STRUCTURE, SECONDARY;

CANDIDA; CANDIDA ALBICANS; FUNGI;

EID: 84878765907     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.467159     Document Type: Article

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