Rationale-based, de novo design of dehydrophenylalanine-containing antibiotic peptides and systematic modification in sequence for enhanced potency

Antimicrobial Agents and Chemotherapy

Volumn 55, Issue 5, 2011, Pages 2178-2188

  Pathak, Sarika ^a   Singh Chauhan, Virander ^a  

^a INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

DEHYDROPHENYLALANINE; POLYPEPTIDE ANTIBIOTIC AGENT; TYROSINE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL CELL WALL; BACTERIAL MEMBRANE; CONTROLLED STUDY; COST EFFECTIVENESS ANALYSIS; DEPOLARIZATION; DRUG DESIGN; DRUG POTENCY; ESCHERICHIA COLI; HEMOLYSIS; LYSIS; MEMBRANE PERMEABILITY; NONHUMAN; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS; TRANSMISSION ELECTRON MICROSCOPY;

ANTI-BACTERIAL AGENTS; FLOW CYTOMETRY; MASS SPECTROMETRY; MICROBIAL SENSITIVITY TESTS; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON, TRANSMISSION; PEPTIDES; PHENYLALANINE;

EID: 79955542011     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.01493-10     Document Type: Article

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