Targeting Rac1 Signaling Inhibits Streptococcal M1 Protein-Induced CXC Chemokine Formation, Neutrophil Infiltration and Lung Injury

PLoS ONE

Volumn 8, Issue 8, 2013, Pages

  Zhang, Songen ^a   Rahman, Milladur ^a   Zhang, Su ^a   Song, Lei ^a   Herwald, Heiko ^a   Thorlacius, Henrik ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINO 6 [2 [[4 (DIETHYLAMINO) 1 METHYLBUTYL]AMINO] 6 METHYL 4 PYRIMIDINYL] 2 METHYLQUINOLINE; ALPHA CHEMOKINE; BACTERIAL PROTEIN; CD11B ANTIGEN; PROTEIN M1; RAC1 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FLOW CYTOMETRY; GENE EXPRESSION; GROUP A STREPTOCOCCAL INFECTION; LUNG ALVEOLUS MACROPHAGE; LUNG EDEMA; LUNG INJURY; LUNG LAVAGE; LUNG PARENCHYMA; MALE; MOUSE; NEUTROPHIL CHEMOTAXIS; NEUTROPHIL COUNT; NONHUMAN; PATHOPHYSIOLOGY; PROTEIN EXPRESSION; PROTEIN TARGETING; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STREPTOCOCCUS PYOGENES;

AMINOQUINOLINES; ANIMALS; ANTIGENS, BACTERIAL; CELL LINE; CHEMOKINES, CXC; DISEASE MODELS, ANIMAL; GENE EXPRESSION; LUNG; LUNG INJURY; MACROPHAGES, ALVEOLAR; MALE; MICE; NEUTROPHIL INFILTRATION; NEUTROPHILS; PULMONARY EDEMA; PYRIMIDINES; RAC1 GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION; STREPTOCOCCUS PYOGENES;

EID: 84881520819     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0071080     Document Type: Article

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