Apoptotic and Autophagic Effects of Sesbania grandiflora Flowers in Human Leukemic Cells

PLoS ONE

Volumn 8, Issue 8, 2013, Pages

  Roy, Rajneeta ^a   Kumar, Deepak ^a   Chakraborty, Biswajit ^a   Chowdhury, Chinmay ^a   Das, Padma ^a  

^a INDIAN INSTITUTE OF CHEMICAL BIOLOGY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; APOPTOSIS INDUCING FACTOR; CASPASE; CYTOCHROME C; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHOSPHATIDYLSERINE; PLANT EXTRACT; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; SESBANIA GRANDIFLORA EXTRACT; TETRAZOLIUM; UNCLASSIFIED DRUG;

ANTIOXIDANT ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; AUTOFLUORESCENCE; AUTOPHAGY; BLOOD SAMPLING; CANCER CELL CULTURE; CANCER INHIBITION; CELL DEATH; CELL FRACTIONATION; CELL MEMBRANE DEPOLARIZATION; CELL ORGANELLE; CELL STRUCTURE; CELL VIABILITY; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG ISOLATION; ENZYME RELEASE; FLOW CYTOMETRY; FLOWER; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; LEUKEMIA CELL; MEDICINAL PLANT; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN PROCESSING; SESBANIA GRANDIFLORA; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; AUTOPHAGY; CASPASES; CELL LINE, TUMOR; CELL PROLIFERATION; CHEMICAL FRACTIONATION; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOWERS; HUMANS; LEUKEMIA; MICROTUBULE-ASSOCIATED PROTEINS; MITOCHONDRIA; OXYGEN CONSUMPTION; PLANT EXTRACTS; REACTIVE OXYGEN SPECIES; SESBANIA; U937 CELLS;

EID: 84881518969     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0071672     Document Type: Article

References (68)

1. Mondal S, Mandal C, Sangwan R, Chandra S, Mandal C, (2010) Withanolide D induces apoptosis in leukemia by targeting the activation of neutral sphingomyelinase-ceramide cascade mediated by synergistic activation of c-Jun N-terminal kinase and p38 mitogen-activated protein kinase. Mol Cancer 9: 239.
2. Bhattacharya K, Samanta SK, Tripathi R, Mallick A, Chandra S, et al. (2010) Apoptotic effects of mahanine on human leukemic cells are mediated through crosstalk between Apo-1/Fas signaling and the Bid protein and via mitochondrial pathways. Biochem Pharmacol 79: 361-372.
3. Mandal C, Dutta A, Mallick A, Chandra S, Misra L, et al. (2008) Withaferin A induces apoptosis by activating p38 mitogen-activated protein kinase signaling cascade in leukemic cells of lymphoid and myeloid origin through mitochondrial death cascade. Apoptosis 13: 1450-1464.
4. Ferantinos L (1990) Human consumption of Sesbania grandiflora. In: Macklin B, Evans DO, editors. Perennial Sesbania species in agroforestry systems. Hawaii: NFTA. 105.
5. Joshi SG (2000) Leguminoceae: text book of medicinal plants. New Delhi: Oxford Publishing. 130 p.
6. Tamboli S, (1996) Antiinflammatory activity of S. grandiflora. Indian Drugs 33: 504-506.
7. Tamboli SA, (2000) Analgesic and antipyretic activity of S. grandiflora. Indian Drugs 37: 95-98.
8. Kasture VS, Deshmukh VK, Chopde CT, (2002) Anxiolytic and anticonvulsive activity of Sesbania grandiflora leaves in experimental animals. Phytother Res 16: 455-460.
9. Pari L, Uma A, (2003) Protective effect of Sesbania grandiflora against erythromycin estolate-induced hepatotoxicity. Therapie 58: 439-443.
10. Ramesh T, Mahesh R, Sureka C, Begum VH, (2008) Cardioprotective effects of Sesbania grandiflora in cigarette smoke-exposed rats. J Cardiovasc Pharmacol 52: 338-343.
11. Doddola S, Pasupulati H, Koganti B, Prasad KV, (2008) Evaluation of Sesbania grandiflora for antiurolithiatic and antioxidant properties. J Nat Med 62: 300-307.
12. Laladhas KP, Cheriyan VT, Puliappadamba VT, Bava SV, Unnithan RG, et al. (2010) A novel protein fraction from Sesbania grandiflora shows potential anticancer andchemopreventive efficacy, in vitro and in vivo. J Cell Mol Med 14: 636-646.
13. Sreelatha S, Padma PR, Umasankari E, (2011) Evaluation of anticancer activity of ethanol extract of Sesbania grandiflora (Agati Sesban) against Ehrlich ascites carcinoma in Swiss albino mice. J Ethnopharmacol 134: 984-987.
14. Wang N, Feng Y, Zhu M, Tsang CM, Man K, et al. (2010) Berberine induces autophagic cell death and mitochondrial apoptosis in liver cancer cells: the cellular mechanism. J Cell Biochem 111: 1426-1436.
15. Chiu HW, Lin JH, Chen YA, Ho SY, Wang YJ, (2010) Combination treatment with arsenic trioxide and irradiation enhances cell-killing effects in humanfibrosarcoma cells in vitro and in vivo through induction of both autophagy and apoptosis. Autophagy 6: 353-365.
16. Jia YL, Li J, Qin ZH, Liang ZQ, (2009) Autophagic and apoptotic mechanisms of curcumin-induced death in K562 cells. J Asian Nat Prod Res 11: 918-928.
17. Al Omar SY, Marshall E, Middleton D, Christmas SE, (2012) Increased numbers but functional defects of CD56+CD3+ cells in lung cancer. Int Immunol 24: 409-415.
18. Price P, McMillan TJ, (1990) Use of the tetrazolium assay in measuring the response of human tumor cells to ionizing radiation. Cancer Res 50: 1392-1396.
19. Das B, Chowdhury C, Kumar D, Sen R, Roy R, et al. (2010) Synthesis, cytotoxicity, and structure-activity relationship (SAR) studies of andrographolide analogues as anti-cancer agent. Bioorg Med Chem Lett 20: 6947-6950.
20. Manna A, Saha P, Sarkar A, Mukhopadhyay D, Bauri AK, et al. (2012) Malabaricone-A induces a redox imbalance that mediates apoptosis in U937 cell line. PLoS One 7: e36938.
21. Pelicano H, Feng L, Zhou Y, Carew JS, Hileman EO, et al. (2003) Inhibition of mitochondrial respiration: a novel strategy to enhance drug-induced apoptosis in human leukemia cells by a reactive oxygen species-mediated mechanism. J Biol Chem 278: 37832-37839.
22. Deeb D, Gao X, Jiang H, Janic B, Arbab AS, et al. (2010) Oleanane triterpenoid CDDO-Me inhibits growth and induces apoptosis in prostate cancer cells through a ROS-dependent mechanism. Biochem Pharmacol 79: 350-360.
23. Leist M, Jäättelä M, (2001) Four deaths and a funeral: from caspases to alternative mechanisms. Nat Rev Mol Cell Biol 2: 589-598.
24. Kaczanowski S, Sajid M, Reece SE, (2011) Evolution of apoptosis-like programmed cell death in unicellular protozoan parasites. Parasit Vectors 4: 44.
25. Kabeya Y, Mizushima N, Ueno T, Yamamoto A, Kirisako T, et al. (2000) LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J 19: 5720-5728.
26. Daido S, Kanzawa T, Yamamoto A, Takeuchi H, Kondo Y, et al. (2004) Pivotal role of the cell death factor BNIP3 in ceramide-induced autophagic cell death in malignant glioma cells. Cancer Res 64: 4286-4293.
27. Chen YJ, Huang WP, Yang YC, Lin CP, Chen SH, et al. (2009) Platonin induces autophagy-associated cell death in human leukemia cells. Autophagy 5: 173-183.
28. Nag TC, Wadhwa S, (2009) Observations on the synaptic ribbon morphology in retinas of two human subjects at autopsy. Ann Anat 191: 556-562.
29. Gibellini L, Pinti M, Nasi M, Biasi SD, Roat E, et al. (2010) Interfering with ROS Metabolism in Cancer Cells: The Potential Role of Quercetin. Cancers 2: 1288-1311.
30. Bieda R, Kitanovic I, Alborzinia H, Meyer A, Ott I, et al. (2011) Antileukemic activity and cellular effects of rhodium(III) crown thiaether complexes. Biometals 24: 645-661.
31. Hail N Jr, Lotan R, (2001) Mitochondrial respiration is uniquely associated with the prooxidant and apoptotic effects of N-(4-hydroxyphenyl)retinamide. J Biol Chem 276: 45614-45621.
32. Hail N Jr, Chen P, Bushman LR, (2010) Teriflunomide (leflunomide) promotes cytostatic, antioxidant, and apoptotic effects in transformed prostate epithelial cells: evidence supporting a role for teriflunomide in prostate cancer chemoprevention. Neoplasia 12: 464-475.
33. Harris MH, Thompson CB, (2000) The role of the Bcl-2 family in the regulation of outer mitochondrial membrane permeability. Cell Death Differ 7: 1182-1191.
34. Daugas E, Nochy D, Ravagnan L, Loeffler M, Susin SA, et al. (2000) Apoptosis-inducing factor (AIF): a ubiquitous mitochondrial oxidoreductase involved in apoptosis. FEBS Lett 476: 118-123.
35. Thayyullathil F, Chathoth S, Hago A, Patel M, Galadari S, (2008) Rapid reactive oxygen species (ROS) generation induced by curcumin leads to caspase-dependent and-independent apoptosis in L929 cells. Free Radic Biol Med 45: 1403-1412.
36. Pattingre S, Levine B, (2006) Bcl-2 inhibition of autophagy: a new route to cancer? Cancer Res 66: 2885-2888.
37. Levine B, Ranganathan R, (2010) Autophagy: Snapshot of the network. Nature 466: 38-40.
38. Liang C, Feng P, Ku B, Dotan I, Canaani D, et al. (2006) Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG. Nat Cell Biol 8: 688-699.
39. Paglin S, Hollister T, Delohery T, Hackett N, McMahill M, et al. (2001) A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles. Cancer Res 61: 439-444.
40. Kondo Y, Kondo S, (2006) Autophagy and cancer therapy. Autophagy 2: 85-90.
41. Fong MY, Jin S, Rane M, Singh RK, Gupta R, et al. (2012) Withaferin A synergizes the therapeutic effect of doxorubicin through ROS-mediated autophagy in ovarian cancer. PLoS One 7: e42265.
42. Chiu HW, Ho YS, Wang YJ, (2011) Arsenic trioxide induces autophagy and apoptosis in human glioma cells in vitro and in vivo through downregulation of survivin. J Mol Med (Berl) 89: 927-941.
43. Okada H, Mak TW, (2004) Pathways of apoptotic and non-apoptotic death in tumour cells. Nat Rev Cancer 4: 592-603.
44. Vander Heiden MG, (2011) Targeting cancer metabolism: a therapeutic window opens. Nat Rev Drug Discov 10: 671-684.
45. Brodská B, Holoubek A, (2011) Generation of reactive oxygen species during apoptosis induced by DNA-damaging agents and/or histone deacetylase inhibitors. Oxid Med Cell Longev 2011: 253529.
46. Rodriguez-Enriquez S, He L, Lemasters JJ, (2004) Role of mitochondrial permeability transition pores in mitochondrial autophagy. Int J Biochem Cell Biol 36: 2463-2472.
47. Trachootham D, Alexandre J, Huang P, (2009) Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? Nat Rev Drug Discov 8: 579-591.
48. Turrens JF, (1997) Superoxide production by the mitochondrial respiratory chain. Biosci Rep 17: 3-8.
49. Ballot C, Kluza J, Lancel S, Martoriati A, Hassoun SM, et al. (2010) Inhibition of mitochondrial respiration mediates apoptosis induced by the anti-tumoral alkaloid lamellarin D. Apoptosis. 15: 769-81.
50. Green DR, Reed JC, (1998) Mitochondria and apoptosis. Science 281: 1309-1312.
51. Galluzzi L, Morselli E, Kepp O, Vitale I, Rigoni A, et al. (2010) Mitochondrial gateways to cancer. Mol Aspects Med 31: 1-20.
52. Krishna S, Low IC, Pervaiz S, (2011) Regulation of mitochondrial metabolism: yet another facet in the biology of the oncoprotein Bcl-2. Biochem J 435: 545-551.
53. McDonnell TJ, Beham A, Sarkiss M, Andersen MM, Lo P, (1996) Importance of the Bcl-2 family in cell death regulation. Experientia 52: 1008-1017.
54. Wuillème-Toumi S, Robillard N, Gomez P, Moreau P, Le Gouill S, et al. (2005) Mcl-1 is overexpressed in multiple myeloma and associated with relapse and shorter survival. Leukemia 19: 1248-1452.
55. Zou H, Yang R, Hao J, Wang J, Sun C, et al. (2003) Regulation of the Apaf-1/caspase-9 apoptosome by caspase-3 and XIAP. J Biol Chem 278: 8091-8098.
56. Wei Y, Sinha S, Levine B, (2008) Dual role of JNK1-mediated phosphorylation of Bcl-2 in autophagy and apoptosis regulation. Autophagy 4: 949-951.
57. He C, Klionsky DJ, (2009) Regulation mechanisms and signaling pathways of autophagy. Annu Rev Genet 43: 67-93.
58. Ohsumi Y, Mizushima N, (2004) Two ubiquitin-like conjugation systems essential for autophagy. Semin Cell Dev Biol 15: 231-236.
59. Mizushima N, Ohsumi Y, Yoshimori T, (2002) Autophagosome formation in mammalian cells. Cell Struct Funct 27: 421-429.
60. Sun Q, Fan W, Zhong Q, (2009) Regulation of Beclin 1 in autophagy. Autophagy 5: 713-716.
61. Yue Z, Jin S, Yang C, Levine AJ, Heintz N, (2003) Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci U S A 100: 15077-15082.
62. Liang XH, Jackson S, Seaman M, Brown K, Kempkes B, et al. (1999) Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature 402: 672-676.
63. Qu X, Yu J, Bhagat G, Furuya N, Hibshoosh H, et al. (2003) Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Invest 112: 1809-1820.
64. Sinha S, Levine B, (2008) The autophagy effector Beclin 1: a novel BH3-only protein. Oncogene 27: S137-S148.
65. Maiuri MC, Zalckvar E, Kimchi A, Kroemer G, (2007) Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat Rev Mol Cell Biol 8: 741-752.
66. Kondo Y, Kanzawa T, Sawaya R, Kondo S, (2005) The role of autophagy in cancer development and response to therapy. Nat Rev Cancer 5: 726-734.
67. Bursch W, Hochegger K, Torok L, Marian B, Ellinger A, et al. (2000) Autophagic and apoptotic types of programmed cell death exhibit different fates of cytoskeletal filaments. J Cell Sci 113: 1189-98.
68. Lavieu G, Scarlatti F, Sala G, Carpentier S, Levade T, et al. (2006) Regulation of autophagy by sphingosine kinase 1 and its role in cell survival during nutrient starvation. J Biol Chem 281: 8518-8527.