Molecular mechanisms of LKB1 induced cell cycle arrest

Thoracic Cancer

Volumn 4, Issue 3, 2013, Pages 229-233

  Zhong, Dian Sheng ^a   Sun, Lin Lin ^a   Dong, Li Xia ^a  

^a TIANJIN MEDICAL UNIVERSITY   (China)

Author keywords

Cell cycle; LKB1; Lung cancer; P21 WAF1; P53

Indexed keywords

CELL PROTEIN; P21 ACTIVATED KINASE; PROTEIN KINASE LKB1; PROTEIN P53; TUMOR SUPPRESSOR PROTEIN;

ALLELE; CANCER INHIBITION; CELL CYCLE ARREST; CYTOPLASM; HUMAN; LUNG CANCER; NONHUMAN; PRIORITY JOURNAL; REVIEW; TUMOR GROWTH; UPREGULATION;

EID: 84881489925     PISSN: 17597706     EISSN: 17597714     Source Type: Journal    
DOI: 10.1111/1759-7714.12003     Document Type: Review

References (50)

1. Jenne DE, Reimann H, Nezu J etal. Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase. Nat Genet 1998; 18: 38-43.
2. Hemminki A, Markie D, Tomlinson I etal. A serine/threonine kinase gene defective in Peutz-Jeghers syndrome. Nature 1998; 391: 184-187.
3. Giardiello FM, Brensinger JD, Tersmette AC etal. Very high risk of cancer in familial Peutz-Jeghers syndrome. Gastroenterology 2000; 119: 1447-1453.
4. Lim W, Hearle N, Shah B etal. Further observations on LKB1/STK11 status and cancer risk in Peutz-Jeghers syndrome. Br J Cancer 2003; 89: 308-313.
5. Hearle N, Schumacher V, Menko FH etal. Frequency and spectrum of cancers in the Peutz-Jeghers syndrome. Clin Cancer Res 2006; 12: 3209-3215.
6. Dong SM, Kim KM, Kim SY etal. Frequent somatic mutations in serine/threonine kinase 11/Peutz-Jeghers syndrome gene in left-sided colon cancer. Cancer Res 1998; 58: 3787-3790.
7. Bardeesy N, Sinha M, Hezel AF etal. Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation. Nature 2002; 419: 162-167.
8. Jishage K, Nezu J, Kawase Y etal. Role of Lkb1, the causative gene of Peutz-Jegher's syndrome, in embryogenesis and polyposis. Proc Natl Acad Sci USA 2002; 99: 8903-8908.
9. Miyoshi H, Nakau M, Ishikawa TO, Seldin MF, Oshima M, Taketo MM. Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice. Cancer Res 2002; 62: 2261-2266.
10. Nakau M, Miyoshi H, Seldin MF, Imamura M, Oshima M, Taketo MM. Hepatocellular carcinoma caused by loss of heterozygosity in Lkb1 gene knockout mice. Cancer Res 2002; 62: 4549-4553.
11. Rossi DJ, Ylikorkala A, Korsisaari N etal. Induction of cyclooxygenase-2 in a mouse model of Peutz-Jeghers polyposis. Proc Natl Acad Sci USA 2002; 99: 12327-12332.
12. Ikediobi ON, Davies H, Bignell G etal. Mutation analysis of 24 known cancer genes in the NCI-60 cell line set. Mol Cancer Ther 2006; 5: 2606-2612.
13. Wang ZJ, Churchman M, Campbell IG etal. Allele loss and mutation screen at the Peutz-Jeghers (LKB1) locus (19p13.3) in sporadic ovarian tumours. Br J Cancer 1999; 80: 70-72.
14. Sanchez-Cespedes M, Parrella P, Esteller M etal. Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung. Cancer Res 2002; 62: 3659-3662.
15. Matsumoto S, Iwakawa R, Takahash K etal. Prevalence and specificity of LKB1 genetic alterations in lung cancers. Oncogene 2007; 26: 5911-5918.
16. Zhong D, Guo L, de Aguirre I etal. LKB1 mutation in large cell carcinoma of the lung. Lung Cancer 2006; 53: 285-294.
17. Carretero J, Medina PP, Pio R, Montuenga LM, Sanchez-Cespedes M. Novel and natural knockout lung cancer cell lines for the LKB1/STK11 tumor suppressor gene. Oncogene 2004; 23: 4037-4040.
18. Fernandez P, Carretero J, Medina PP etal. Distinctive gene expression of human lung adenocarcinomas carrying LKB1 mutations. Oncogene 2004; 23: 5084-5091.
19. Alessi DR, Sakamoto K, Bayascas JR. LKB1-dependent signaling pathways. Annu Rev Biochem 2006; 75: 137-163.
20. Boudeau J, Baas AF, Deak M etal. MO25α/β interact with STRADα/β enhancing their ability to bind, activate and localize LKB1 in the cytoplasm. EMBO J 2003; 22: 5102-5114.
21. Baas AF, Boudeau J, Sapkota GP etal. Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD. EMBO J 2003; 22: 3062-3072.
22. Boudeau J, Scott JW, Resta N etal. Analysis of the LKB1-STRAD-MO25 complex. J Cell Sci 2004; 117: 6365-6375.
23. Rowan A, Churchman M, Jefferey R, Hanby A, Poulsom R, Tomlinson I. In situ analysis of LKB1/STK11 mRNA expression in human normal tissues and tumours. J Pathol 2000; 192: 203-206.
24. Ylikorkala A, Rossi DJ, Korsisaari N etal. Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice. Science 2001; 293: 1323-1326.
25. Yoo LI, Chung DC, Yuan J. LKB1-a master tumour suppressor of the small intestine and beyond. Nat Rev Cancer 2002; 2: 529-535.
26. Conde E, Suarez-Gauthier A, García-García E etal. Specific pattern of LKB1 and phospho-acetyl-CoA carboxylase protein immunostaining in human normal tissues and lung carcinomas. Hum Pathol 2007; 38: 1351-1360.
27. Lizcano JM, Göransson O, Toth R etal. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. EMBO J 2004; 23: 833-843.
28. Baas AF, Kuipers J, van der Wel NN etal. Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD. Cell 2004; 116: 457-466.
29. Benton R, St Johnston D. Drosophila PAR-1 and 14-3-3 inhibit Bazooka/PAR-3 to establish complementary cortical domains in polarized cells. (Published erratum appears in Cell 2004; 116: 139) Cell 2003; 115: 691-704.
30. Cohen D, Brennwald PJ, Rodriguez-Boulan E, Müsch A. Mammalian PAR-1 determines epithelial lumen polarity by organizing the microtubule cytoskeleton. J Cell Biol 2004; 164: 717-727.
31. Hawley SA, Boudeau J, Reid JL etal. Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. J Biol 2003; 2: 28.
32. Woods A, Johnstone SR, Dickerson K etal. LKB1 is the upstream kinase in the AMP-activated protein kinase cascade. Curr Biol 2003; 13: 2004-2008.
33. Shaw RJ, Kosmatka M, Bardeesy N etal. The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc Natl Acad Sci USA 2004; 101: 3329-3335.
34. Shaw RJ, Bardeesy N, Manning BD etal. The LKB1 tumor suppressor negatively regulates mTOR signaling. Cancer Cell 2004; 6: 91-99.
35. Corradetti MN, Inoki K, Bardeesy N, DePinho RA, Guan KL. Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome. Genes Dev 2004; 18: 1533-1538.
36. Inoki K, Zhu T, Guan KL. TSC2 mediates cellular energy response to control cell growth and survival. Cell 2003; 115: 577-590.
37. Ji H, Ramsey MR, Hayes DN etal. LKB1 modulates lung cancer differentiation and metastasis. Nature 2007; 448: 807-810.
38. Tiainen M, Ylikorkala A, Mäkelä TP. Growth suppression by Lkb1 is mediated by a G(1) cell cycle arrest. Proc Natl Acad Sci USA 1999; 96: 9248-9251.
39. Smith DP, Spicer J, Smith A, Swift S, Ashworth A. The mouse Peutz-Jeghers syndrome gene Lkb1 encodes a nuclear protein kinase. Hum Mol Genet 1999; 8: 1479-1485.
40. Tiainen M, Vaahtomeri K, Ylikorkala A, Mäkelä TP. Growth arrest by the LKB1 tumor suppressor: induction of p21 (WAF1/CIP1). Hum Mol Genet 2002; 11: 1497-1504.
41. Sherr CJ, Roberts JM. CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev 1999; 13: 1501-1512.
42. el-Deiry WS, Tokino T, Velculescu VE etal. WAF1, a potential mediator of p53 tumor suppression. Cell 1993; 75: 817-825.
43. Datto MB, Li Y, Panus JF, Howe DJ, Xiong Y, Wang XF. Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism. Proc Natl Acad Sci USA 1995; 92: 5545-5549.
44. Zeng PY, Berger SL. LKB1 is recruited to the p21/WAF1 promoter by p53 to mediate transcriptional activation. Cancer Res 2006; 66: 10701-10708.
45. Karuman P, Gozani O, Odze RD etal. The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death. Mol Cell 2001; 7: 1307-1319.
46. Jones RG, Plas DR, Kubek S etal. AMP-activated protein kinase induces a p53-dependent metabolic checkpoint. Mol Cell 2005; 18: 283-293.
47. Gartel AL, Tyner AL. Transcriptional regulation of the p21((WAF1/CIP1)) gene. Exp Cell Res 1999; 246: 280-289.
48. Setogawa T, Shinozaki-Yabana S, Masuda T, Matsuura K, Akiyama T. The tumor suppressor LKB1 induces p21 expression in collaboration with LMO4, GATA-6, and Ldb1. Biochem Biophys Res Commun 2006; 343: 1186-1190.
49. Marignani PA, Kannai F, Carpenter CL. LKB1 associates with Brg1 and is necessary for Brg-1 induced growth arrest. J Biol Chem 2001; 276: 32415-32418.
50. Scott KD, Nath-Sain S, Agnew MD, Marignani PA. LKB1 catalytically deficient mutants enhance cyclin D1 expression. Cancer Res 2007; 67: 5622-5627.