3-methylcholanthrene induces neurotoxicity in developing neurons derived from human CD34+thy1+ stem cells by activation of aryl hydrocarbon receptor

NeuroMolecular Medicine

Volumn 15, Issue 3, 2013, Pages 570-592

  Singh, Abhishek K ^a   Kashyap, Mahendra P ^a   Kumar, Vivek ^a   Tripathi, Vinay K ^a   Yadav, Dharmendra K ^b   Khan, Firoz ^b   Jahan, Sadaf ^a   Khanna, Vinay K ^a   Yadav, Sanjay ^a   Pant, Aditya B ^a  

^a CSIR INDIAN INSTITUTE OF TOXICOLOGY RESEARCH   (India)

^b CSIR CENTRAL INSTITUTE OF MEDICINAL AND AROMATIC PLANTS   (India)

Author keywords

3 Methylcholanthrene; Aryl hydrocarbon receptor; Developmental neurotoxicity; Human cord blood stem cells; Molecular docking

Indexed keywords

3 METHYLCHOLANTHRENE; AMPA RECEPTOR; AROMATIC HYDROCARBON RECEPTOR; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GLUTATHIONE TRANSFERASE P1; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; TRANSCRIPTION FACTOR ARNTL;

ARTICLE; BINDING AFFINITY; BINDING SITE; CELL DIFFERENTIATION; CELL INTERACTION; CELL METABOLISM; CELL PROLIFERATION; COLONY FORMING UNIT; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION REGULATION; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; HYDROGEN BOND; HYDROPHOBICITY; MOLECULAR DOCKING; MUTATIONAL ANALYSIS; NERVOUS SYSTEM DEVELOPMENT; NEUROTOXICITY; NEUROTRANSMISSION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN PROTEIN INTERACTION; RNA EXTRACTION; SEQUENCE HOMOLOGY; STEM CELL; UMBILICAL CORD BLOOD; UPREGULATION;

ANTIGENS, CD34; ANTIGENS, THY-1; ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BINDING SITES; CELLS, CULTURED; COMPUTER SIMULATION; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; CYTOCHROME P-450 CYP1A1; FETAL BLOOD; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GLUTATHIONE S-TRANSFERASE PI; HEMATOPOIETIC STEM CELLS; HUMANS; METHYLCHOLANTHRENE; MICROSOMES; MOLECULAR DOCKING SIMULATION; NEURAL STEM CELLS; NEUROGENESIS; NEURONS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN INTERACTION MAPPING; RECEPTORS, AMPA; RECEPTORS, ARYL HYDROCARBON; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 84881481230     PISSN: 15351084     EISSN: 15591174     Source Type: Journal    
DOI: 10.1007/s12017-013-8243-0     Document Type: Article

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